CN218306258U - Crystallizer for cephalosporin antibiotics powder injection - Google Patents
Crystallizer for cephalosporin antibiotics powder injection Download PDFInfo
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- CN218306258U CN218306258U CN202221526635.1U CN202221526635U CN218306258U CN 218306258 U CN218306258 U CN 218306258U CN 202221526635 U CN202221526635 U CN 202221526635U CN 218306258 U CN218306258 U CN 218306258U
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Abstract
The utility model discloses a crystallizer for cephalosporin antibiotics powder injection, which heats raw material liquid through a reboiler, and removes water or solvent in vacuum to achieve the effects of concentrating and crystallizing the raw material liquid; meanwhile, a heat exchange jacket is arranged on the discharge pipe and is cooled by cold raw material liquid, so that the cephalosporin antibiotics can be further promoted to be crystallized and separated out, and the waste heat of crystal mush is secondarily utilized; through set up the agitator on keeping away from circulating device's inner wall, can prevent effectively that cephalo type antibiotic from crystallizing on the inner wall, improve the work efficiency of crystallizer.
Description
Technical Field
The utility model relates to a cephalosporin antibiotics is crystallizer for powder injection.
Background
The crystallizer is used for crystallizing and purifying products, is widely applied to the fields of chemical industry, medicine and the like, and is used more in the production process of powder injection in the medicine field.
In the prior art, a circulating device is generally added in the crystallizer. However, the liquid inlet and the liquid outlet of the circulating device are generally located on the same side of the crystallizer, so that the crystal mush in the crystallizer is not uniform, and the crystal mush is easy to crystallize on the inner wall far away from the circulating device. For a batch crystallizer, the crystallization on the inner walls of the crystallizer is of little influence, since after the next feed the crystals on the inner walls are redissolved or flaked. However, for the continuous crystallizer, the crystallizer inner wall is required to be cleaned continuously, which seriously affects the working efficiency of the crystallizer.
Disclosure of Invention
The utility model discloses a crystallizer for cephalosporin antibiotics powder injection, which heats raw material liquid through a reboiler, and removes water or solvent in vacuum to achieve the effects of concentrating the raw material liquid and crystallizing; meanwhile, a heat exchange jacket is arranged on the discharge pipe and is cooled by cold raw material liquid, so that the cephalosporin antibiotics can be further promoted to be crystallized and separated out, and the waste heat of crystal mush is secondarily utilized; through set up the agitator on keeping away from circulating device's inner wall, can prevent effectively that cephalo type antibiotic from crystallizing on the inner wall, improve the work efficiency of crystallizer.
A crystallizer for a cephalosporin antibiotic powder injection is characterized in that the main body of the crystallizer is a crystallization tower 1, a vacuum pipe 2 is arranged at the top of the crystallization tower 1, a discharge pipe 4 is arranged at the bottom of the crystallization tower 1, and a feed pipe 3 is arranged at the upper part of the crystallization tower 1; a circulating device is arranged on the side edge of the crystallization tower 1 and comprises a circulating pipe 5, and the circulating pipe 5 is sequentially connected with a reboiler 7, a circulating pump 8 and a spray header 6; an agitator 9 is installed on the inner wall of the crystallization tower 1 remote from the circulation device.
Further, the vacuum tube 2 is connected with a condenser.
Furthermore, the discharge pipe 4 is connected to a filter or a centrifuge.
Further, a heat exchange jacket 10 is arranged on the discharge pipe 4, a feed port 11 is arranged on the heat exchange jacket 10, and an outlet of the heat exchange jacket 10 is communicated with the feed pipe 3 through a feed pump 12.
Furthermore, the inside of the tapping pipe 4 has a PTFE coating 13.
Furthermore, the spray header 6 is movably sleeved at the outlet of the circulating pipe 5.
Further, the spray header 6 is in an S shape.
Furthermore, the spray header 6 is provided with a plurality of spray holes 14.
The utility model has the advantages that:
1. the utility model heats the raw material liquid through the reboiler, and then removes water or solvent in vacuum, so as to achieve the effects of concentrating the raw material liquid and crystallizing;
2. the utility model is provided with the heat exchange jacket on the discharging pipe, and the discharging pipe is cooled by cold raw material liquid, thereby further promoting the crystallization of cephalosporin antibiotics and carrying out secondary utilization on the residual heat of crystal slurry;
3. the utility model can effectively prevent the cephalosporin antibiotics from crystallizing on the inner wall by arranging the stirrer on the inner wall far away from the circulating device, thereby improving the working efficiency of the crystallizer;
4. the PTFE coating arranged in the discharge pipe can effectively prevent crystal slurry from crystallizing in the discharge pipe and prevent the discharge pipe from being blocked;
5. the S-shaped spray head is movably sleeved at the outlet of the circulating pipe, and the spray head automatically rotates during circulation to uniformly disperse circulating liquid; the spray head is provided with spray holes for further dispersing the circulating liquid.
Drawings
FIG. 1 is an overall schematic view of a crystallizer according to the present invention;
FIG. 2 is a cross-sectional view of a discharge pipe of the present invention;
fig. 3 is a top view of the shower head of the present invention;
in the figure, 1-crystallization tower, 2-vacuum tube, 3-feeding tube, 4-discharging tube, 5-circulating tube, 6-spray header, 7-reboiler, 8-circulating pump, 9-stirrer, 10-heat exchange jacket, 11-feeding hole, 12-feeding pump, 13-PTFE coating, 14-jet hole
Detailed Description
Example 1
As shown in figure 1, the main body of the crystallizer for the cephalosporin antibiotics powder injection is a crystallization tower 1, the top of the crystallization tower 1 is provided with a vacuum pipe 2, the bottom of the crystallization tower 1 is provided with a discharge pipe 4, a PTFE coating 13 is arranged inside the discharge pipe 4, and a feed pipe 3 is arranged at the upper part of the crystallization tower 1; a circulating device is arranged on the side edge of the crystallization tower 1, the circulating device comprises a circulating pipe 5, the circulating pipe 5 is sequentially connected with a reboiler 7, a circulating pump 8 and a spray header 6, the spray header 6 is movably sleeved at the outlet of the circulating pipe 5, the spray header 6 is S-shaped, and a plurality of spray holes 14 are formed in the spray header 6; a stirrer 9 is arranged on the inner wall of the crystallization tower 1 far away from the circulating device; a heat exchange jacket 10 is arranged on the discharge pipe 4, a feed inlet 11 is arranged on the heat exchange jacket 10, and an outlet of the heat exchange jacket 10 is communicated with the feed pipe 3 through a feed pump 12; the vacuum pipe 2 is connected with a condenser, and the discharge pipe 4 is connected with a filter or a centrifuge.
When the crystallizer works, the feed inlet continuously supplies materials to the feed pipe through the feed pump, and the circulating pipe continuously pumps the crystal slurry at the bottom of the crystallization tower to the upper spray header and sprays the crystal slurry under the action of the circulating pump; the reboiler is a heating device, and the stirrer improves the disturbance degree of the crystal slurry near the inner wall far away from the circulating device; the S-shaped spray header can automatically rotate during spraying, so that the circulating liquid is uniformly dispersed; the crystal mush in the discharging pipe is cooled by cold raw material liquid in the heat exchange jacket, and the PTFE coating can prevent the crystal mush from crystallizing in the discharging pipe.
And finally: the above description is only for the preferred embodiment of the present invention and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A crystallizer for cephalosporin antibiotics powder injection is characterized in that: the main body of the crystallizer is a crystallization tower, the top of the crystallization tower is provided with a vacuum pipe, the bottom of the crystallization tower is provided with a discharge pipe, and a feed pipe is arranged at the upper part of the crystallization tower; a circulating device is arranged on the side edge of the crystallization tower and comprises a circulating pipe, and the circulating pipe is sequentially connected with a reboiler, a circulating pump and a spray header; and a stirrer is arranged on the inner wall of the crystallization tower far away from the circulating device.
2. The crystallizer of claim 1, wherein: the vacuum tube is connected with a condenser.
3. The crystallizer of claim 1, wherein: the discharge pipe is connected with a filter or a centrifuge.
4. The crystallizer of claim 1, wherein: the discharging pipe is provided with a heat exchange jacket, a feeding hole is formed in the heat exchange jacket, and an outlet of the heat exchange jacket is communicated with the feeding pipe through a feeding pump.
5. The crystallizer of claim 4, wherein: and a PTFE coating is arranged inside the discharge pipe.
6. The crystallizer of claim 1, wherein: the spray header is movably sleeved at the outlet of the circulating pipe.
7. The crystallizer of claim 6, wherein: the spray header is S-shaped.
8. The crystallizer of claim 6, wherein: the spray header is provided with a plurality of spray holes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221526635.1U CN218306258U (en) | 2022-06-17 | 2022-06-17 | Crystallizer for cephalosporin antibiotics powder injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221526635.1U CN218306258U (en) | 2022-06-17 | 2022-06-17 | Crystallizer for cephalosporin antibiotics powder injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218306258U true CN218306258U (en) | 2023-01-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202221526635.1U Active CN218306258U (en) | 2022-06-17 | 2022-06-17 | Crystallizer for cephalosporin antibiotics powder injection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118420028A (en) * | 2024-07-03 | 2024-08-02 | 天津高能时代水处理科技有限公司 | Continuous crystallizer with automatic defoaming and salt-forming preventing functions |
-
2022
- 2022-06-17 CN CN202221526635.1U patent/CN218306258U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118420028A (en) * | 2024-07-03 | 2024-08-02 | 天津高能时代水处理科技有限公司 | Continuous crystallizer with automatic defoaming and salt-forming preventing functions |
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