CN218272254U

CN218272254U - On-line monitoring device applied to process water in pharmaceutical industry

Info

Publication number: CN218272254U
Application number: CN202220467500.6U
Authority: CN
Inventors: 郭烨; 张文红; 吴文馨; 汪劲松
Original assignee: Anhui Double Crane Pharmaceutical Co Ltd
Current assignee: Anhui Double Crane Pharmaceutical Co Ltd
Priority date: 2022-03-04
Filing date: 2022-03-04
Publication date: 2023-01-10
Anticipated expiration: 2032-03-04

Abstract

One or more embodiments of the present specification provide an online monitoring device applied to pharmaceutical industry process water, including a water supply system and a field centralized sampling module, the water supply system is communicated with a water supply pipeline, the water supply pipeline is provided with a plurality of shunt sampling valves, the shunt sampling valves are connected with capillaries, the capillaries communicate the shunt sampling valves with the field centralized sampling module, the field centralized sampling module is further connected with a field control module through signals, the online monitoring device applied to pharmaceutical industry process water provided by one or more embodiments of the present specification continuously detects water quality without contacting with the process water of a main pipeline, and avoids water pollution; the centralized sampling mode is adopted, so that the workload is reduced; the manual detection frequency is reduced, and the usage amount of chemical reagents and pollutant discharge are reduced.

Description

On-line monitoring device applied to process water in pharmaceutical industry

Technical Field

One or more embodiments of the present disclosure relate to the technical field of pharmaceutical production equipment, and more particularly, to an online monitoring device for process water used in the pharmaceutical industry.

Background

The preparation of process water in the pharmaceutical industry is a quality focus control link in the drug manufacturing process. At present, the industry mostly adopts a detection mode of combining manual sampling detection record and contact type on-line monitoring to ensure the quality controllability and traceability of process water, but has the following defects:

1. the risk of detection data distortion caused by errors of manual sampling detection records exists;

2. manual sampling can only be carried out intermittently, and uninterrupted detection cannot be achieved;

3. manual sampling is large in workload and easy to cause sample pollution due to dispersed sampling points;

4. manual sampling and detection can generate a large amount of chemical reagent waste liquid, and environmental protection treatment is needed, so that a large amount of cost and management risks are increased.

5. In the process of manually detecting the water for injection in the process water, the temperature of a sample needs to be reduced in advance, so that the detection time is too long;

6. the contact type on-line monitoring needs to install a sensor in a main pipeline, and process water and the sensor are in direct contact, so that the risk of secondary pollution is caused during use and maintenance; if the sensor fails in the production state, the sensor is directly contacted with the process water and cannot be replaced in time, and the process treatment procedure is complicated after the replacement is finished, so that a large amount of process water is wasted due to the cleaning procedure;

7. contact on-line monitoring of chemicals during processing of the process can lead to sensor damage or drift.

Disclosure of Invention

In view of the above, an object of one or more embodiments of the present disclosure is to provide an on-line monitoring device for process water in pharmaceutical industry, so as to solve one or all of the above problems.

Based on the above purpose, one or more embodiments of this specification provide an on-line monitoring device for pharmaceutical industry process water, including water supply system and on-the-spot concentrated sampling module, the last intercommunication of water supply system has the water supply pipe, install a plurality of reposition of redundant personnel sampling valve on the water supply pipe, reposition of redundant personnel sampling valve is connected with the capillary, the capillary will reposition of redundant personnel sampling valve with on-the-spot concentrated sampling module is linked together, on-the-spot concentrated sampling module is still signal connection with on-the-spot control module.

Optionally, water supply system includes purification water storage tank and injection water storage tank, purification water storage tank intercommunication has the purification water supply pipe, injection water storage tank intercommunication has the injection water supply pipe, purification water storage tank still intercommunication has the injection water preparation equipment, the injection water preparation equipment with the injection water storage tank is linked together, the reposition of redundant personnel sampling valve divide into purification water reposition of redundant personnel sampling valve and injection water reposition of redundant personnel sampling valve, purification water reposition of redundant personnel sampling valve is installed on the purification water supply pipe, the injection water reposition of redundant personnel sampling valve is installed on the injection water supply pipe.

Optionally, the sampling module is concentrated to the scene includes that sample ware and a plurality of injection water concentrate the sample ware including cooler, former water recovery tank, a plurality of purified water, purified water concentrate the sample ware with purified water reposition of redundant personnel sampling valve is linked together, injection water concentrate the sample ware with injection water reposition of redundant personnel sampling valve is linked together, purified water concentrate the sample ware with the cooler is linked together, the cooler with former water recovery tank is linked together, injection water concentrates the sample ware intercommunication and has on-line measuring equipment, on-line measuring equipment with former water recovery tank is linked together, just on-line measuring equipment with on-the-spot control module signal connection, injection water concentrate the sample ware with capillary between the injection water reposition of redundant personnel sampling valve passes the cooler, purified water concentrate the sample ware with all install the detection sensor in the injection water concentrates the sample ware, the detection sensor with on-the-spot control module signal connection.

Optionally, the online detection device is a TOC detector.

From the above, it can be seen that the online monitoring device applied to the process water in the pharmaceutical industry, which is provided in one or more embodiments of the present specification, continuously detects the water quality without contacting the process water of the main pipeline, so as to avoid water pollution; the centralized sampling mode is adopted, so that the workload is reduced, and the sampling efficiency is improved; meanwhile, the manual detection frequency is reduced, the usage amount of chemical reagents and pollutant discharge are reduced, and the cost and the management risk are reduced; the external online monitoring can prevent the sensor from being damaged or deviated due to chemical agents during process treatment; all detected water samples enter the raw water recovery tank to be recovered, so that the cost is saved.

Drawings

In order to more clearly illustrate one or more embodiments or prior art solutions of the present specification, the drawings that are needed in the description of the embodiments or prior art will be briefly described below, it is obvious that the drawings in the description below are only one or more embodiments of the present specification, and that other drawings may be obtained by those skilled in the art without inventive effort.

Fig. 1 is a schematic view of an on-line monitoring device applied to process water in the pharmaceutical industry according to one or more embodiments of the present disclosure;

the device comprises a field centralized sampling module 1, a water supply system 2, a distribution water point 3, a field control module 4, a remote control end 5, a purified water shunt sampling valve 6, an injection water shunt sampling valve 7, a purified water centralized sampling dish 8, a cooler 9, an injection water centralized sampling dish 10, a TOC detector 11 and a capillary tube 12.

Detailed Description

To make the objects, technical solutions and advantages of the present disclosure more apparent, the present disclosure is further described in detail below with reference to specific embodiments.

It is to be understood that unless otherwise defined, technical or scientific terms used in one or more embodiments of the present disclosure should have the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The use of "first," "second," and similar terms in one or more embodiments of the specification is not intended to indicate any order, quantity, or importance, but rather is used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element or item listed before the word covers the element or item listed after the word and its equivalents, but does not exclude other elements or items. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.

One or more embodiments of this description have provided an on-line monitoring device for pharmaceutical industry process water, as shown in fig. 1, concentrate sampling module 1 including water supply system 2 and scene, the intercommunication has water supply pipe on the water supply system 2, install a plurality of reposition of redundant personnel sampling valve on the water supply pipe, reposition of redundant personnel sampling valve is connected with capillary 12, capillary 12 will reposition of redundant personnel sampling valve with the scene is concentrated sampling module 1 and is linked together, the scene is concentrated sampling module 1 and still has on-the-spot control module 4 through signal connection.

Wherein, water supply system 2 supplies water to distribution water consumption point 3, and in the process water who will supply water pipe simultaneously lasts drainage to on-the-spot concentrated sampling module 1 through capillary 12 through the reposition of redundant personnel sampling valve in with the water supply pipe, carries out real-time on-line measuring to the process water, and on-the-spot control module 4 gathers the testing result to with testing result send to remote control end 5, be convenient for to the continuous management and the record of testing result.

In one embodiment, the water supply system 2 comprises a purified water storage tank and an injection water storage tank, the purified water storage tank is communicated with a purified water supply pipeline, the injection water storage tank is communicated with an injection water supply pipeline, the purified water storage tank is also communicated with an injection water preparation device, the injection water preparation device is communicated with the injection water storage tank, the shunt sampling valve is divided into a purified water shunt sampling valve 6 and an injection water shunt sampling valve 7, the purified water shunt sampling valve 6 is installed on the purified water supply pipeline, and the injection water shunt sampling valve 7 is installed on the injection water supply pipeline.

Specific speaking, sampling module 1 is concentrated to on-spot sample utensil 8 and a plurality of injection water are concentrated sample utensil 10 including cooler 9, former water recovery tank, a plurality of purified water, purified water concentrate sample utensil 8 with purified water reposition of redundant personnel sampling valve 6 is linked together, injection water concentrate sample utensil 10 with injection water reposition of redundant personnel sampling valve 7 is linked together, purified water concentrate sample utensil 8 with cooler 9 is linked together, cooler 9 with former water recovery tank is linked together, injection water concentrates sample utensil 10 intercommunication and has on-line measuring equipment, on-line measuring equipment with former water recovery tank is linked together, just on-line measuring equipment with on-site control module 4 signal connection, injection water concentrate sample utensil 10 with capillary 12 between injection water reposition of redundant personnel sampling valve 7 passes cooler 9, purified water concentrate sample utensil 8 with all install the detection sensor in the injection water concentrates sample utensil 10, the detection sensor with on-site control module 4 signal connection.

Optionally, the online detection device is a TOC detector 11.

When the device is used, purified water in the purified water storage tank flows to the purified water centralized sampling vessel 8 through the purified water shunt sampling valve 6, a detection sensor in the purified water centralized sampling vessel 8 detects the water quality, and the purified water overflows into the cooler 9 and finally flows to the raw water recovery tank; the injection water in the injection water storage tank flows to an injection water centralized sampling vessel 10 through an injection water shunt sampling valve 7, when the injection water passes through a cooler 9, the injection water is cooled by purified water passing through the cooler 9, the injection water flows into a TOC detector 11 for detection and finally flows into a raw water recovery tank, and a field control module 4 acquires a detection result and sends the detection result to a remote control end 5;

the on-line monitoring device applied to the process water in the pharmaceutical industry provided by one or more embodiments of the specification can continuously and continuously detect the water quality without contacting the process water of the main pipeline, so that the water pollution is avoided; the centralized sampling mode is adopted, so that the workload is reduced, and the sampling efficiency is improved; meanwhile, the manual detection frequency is reduced, the usage amount of chemical reagents and pollutant discharge are reduced, and the cost and the management risk are reduced; external on-line monitoring does not cause sensor damage or deviation during process handling due to chemicals.

Those of ordinary skill in the art will understand that: the discussion of any embodiment above is meant to be exemplary only, and is not intended to intimate that the scope of the disclosure, including the claims, is limited to these examples; features from the above embodiments, or from different embodiments, may also be combined, steps may be implemented in any order, and there are many other variations of the different aspects of one or more embodiments of the present description, as described above, which are not provided in detail for the sake of brevity.

It is intended that the one or more embodiments of the present specification embrace all such alternatives, modifications and variations as fall within the broad scope of the appended claims. Therefore, any omissions, modifications, substitutions, improvements, and the like that may be made without departing from the spirit and principles of one or more embodiments of the present disclosure are intended to be included within the scope of the present disclosure.

Claims

1. Be applied to on-line monitoring device of pharmaceutical industry process water, its characterized in that concentrates sampling module including water supply system and scene, the last intercommunication of water supply system has water supply pipe, install a plurality of reposition of redundant personnel sampling valve on the water supply pipe, reposition of redundant personnel sampling valve is connected with the capillary, the capillary will reposition of redundant personnel sampling valve with the scene is concentrated sampling module and is linked together, the scene is concentrated sampling module and still has on-the-spot control module through signal connection.

2. The on-line monitoring device applied to the process water in the pharmaceutical industry according to claim 1, wherein the water supply system comprises a purified water storage tank and an injection water storage tank, the purified water storage tank is communicated with a purified water supply pipeline, the injection water storage tank is communicated with an injection water supply pipeline, the purified water storage tank is further communicated with an injection water preparation device, the injection water preparation device is communicated with the injection water storage tank, the shunt sampling valve comprises a purified water shunt sampling valve and an injection water shunt sampling valve, the purified water shunt sampling valve is installed on the purified water supply pipeline, and the injection water shunt sampling valve is installed on the injection water supply pipeline.

3. The on-line monitoring device applied to the process water in the pharmaceutical industry according to claim 2, wherein the on-site centralized sampling module comprises a cooler, a raw water recovery tank, a plurality of purified water centralized sampling vessels and a plurality of injection water centralized sampling vessels, the purified water centralized sampling vessels are communicated with the purified water diversion sampling valve, the injection water centralized sampling vessels are communicated with the injection water diversion sampling valve, the purified water centralized sampling vessels are communicated with the cooler, the cooler is communicated with the raw water recovery tank, the injection water centralized sampling vessels are communicated with an on-line detection device, the on-line detection device is communicated with the raw water recovery tank and is in signal connection with the on-site control module, a capillary tube between the injection water centralized sampling vessels and the injection water diversion sampling valve passes through the cooler, detection sensors are installed in the purified water centralized sampling vessels and the injection water centralized sampling vessels, and are in signal connection with the on-site control module.

4. The on-line monitoring device applied to the process water in the pharmaceutical industry according to claim 3, wherein the on-line detection equipment is a TOC detector.