CN218256110U - Shearing mechanism in injection microsphere manufacturing process - Google Patents
Shearing mechanism in injection microsphere manufacturing process Download PDFInfo
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- CN218256110U CN218256110U CN202222867155.8U CN202222867155U CN218256110U CN 218256110 U CN218256110 U CN 218256110U CN 202222867155 U CN202222867155 U CN 202222867155U CN 218256110 U CN218256110 U CN 218256110U
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Abstract
The utility model provides a shearing mechanism in microsphere manufacturing process for injection relates to microsphere manufacturing installation technical field, including the blending barrel, the inside of blending barrel is provided with the hybrid chamber, the inside of hybrid chamber is rotated and is connected with defeated material screw rod. The utility model discloses a defeated material screw rod of drive rotates, carry the melting mixture to the extruded sheet department and extrude, drive the high-speed rotation of cutting blade through second servo motor, the melting mixture that utilizes cutting blade to extrude the extruded sheet is cuted, cutting blade continuously rotates the in-process in the guard plate, carry the shower nozzle with outside water pressure boost through booster pump in, utilize the shower nozzle to spray high-pressure rivers and wash cutting blade surface adnexed medicine mixture, thereby avoid cutting blade to cut the emergence and extrude the medicine emergence to glue as far as, the stability of having guaranteed the size of cuting is convenient for back coarse grinding microballon processing, setting through the connecting rod, make the shower nozzle obtain firm the support when spraying rivers.
Description
Technical Field
The utility model relates to a microballon manufacturing installation technical field especially relates to a shearing mechanism in microballon manufacturing process for injection.
Background
Microspheres refer to a particle dispersion system formed by dispersing or adsorbing a drug in a polymer or a polymer matrix, the carrier materials for preparing the microspheres are many, and are mainly divided into natural polymer microspheres (such as starch microspheres, albumin microspheres, gelatin microspheres, chitosan and the like) and synthetic polymer microspheres (such as polylactic acid microspheres), the preparation methods of drug-loaded microspheres are various, common preparation methods include a hot-melt extrusion grinding method, a spray drying method, a phase separation method, a microfluid technology and the like, at present, the hot-melt extrusion grinding method is to melt and mix the drug and a polymer or other auxiliary materials to obtain a bar-shaped product of uniformly distributed PLGA bulk drug, and then the product is ground to obtain granular microspheres, and the distribution state and the grain size of the microsphere drug can be adjusted by controlling the melting temperature and the grinding conditions.
In the prior art, in the process of manufacturing microspheres by a hot-melt extrusion grinding method, the melt-mixed medicine needs to be sheared, but the melt medicine has high temperature and viscosity and is easily attached to a blade when the blade cuts, so that the viscosity is easily generated in the continuous shearing process, the shape of a cut strip-shaped product is uneven, and the subsequent grinding processing is influenced.
SUMMERY OF THE UTILITY MODEL
The utility model aims at solving the in-process that exists among the prior art and extrude the grinding method through the hot melt and make the microballon, need cut the medicine that the melting was mixed, but the melting medicine has higher temperature and viscidity and adheres to on the blade easily when the blade cutting for continuously cut the easy viscidity that takes place among the process, make the strip bulk product shape of cutting inhomogeneous, cause the problem of influence to subsequent abrasive machining, and the shearing mechanism in the microballon manufacture process for the injection that provides.
In order to achieve the above purpose, the utility model adopts the following technical scheme: the utility model provides a shearing mechanism in microballon manufacture process for injection, includes the blending barrel, the inside of blending barrel is provided with the hybrid chamber, the inside of hybrid chamber is rotated and is connected with defeated material screw rod, the one end fixedly connected with extrusion plate of blending barrel, the other end fixedly connected with hopper of blending barrel, the blending barrel is close to the one end outer wall fixedly connected with mounting panel of extrusion plate, one side fixed mounting of mounting panel has second servo motor, second servo motor's output shaft fixedly connected with cutting blade, second servo motor's outer wall fixedly connected with guard plate, the outer wall fixedly connected with connecting rod of guard plate, the outer wall fixed mounting of connecting rod has the shower nozzle, the one end fixedly connected with raceway of shower nozzle, the one end fixedly connected with booster pump of connecting rod, booster pump's one end and raceway fixed connection.
Preferably, the outer wall fixed mounting of blending tank has the electric heating board, the bottom surface fixedly connected with first support of electric heating board.
Preferably, one end bottom surface fixedly connected with second support of mixing barrel, the outer wall fixed mounting of one side of second support has the electric cabinet, electric connection between electric cabinet and the electric heating board.
Preferably, the top surface of the feeding hopper is provided with a feeding groove, and a partition plate is arranged inside the feeding groove.
Preferably, both ends of the partition plate are fixedly connected with elastic rubber plates, and one side of each elastic rubber plate is fixedly connected with the inner wall of the feeding groove.
Preferably, the one end of defeated material screw rod is rotated and is connected with the fixed plate, the top of fixed plate and the inner wall fixed connection of hybrid chamber, the defeated material screw rod is close to the one end outer wall fixed connection puddler of fixed plate, the one end fixed mounting that the extrusion plate was kept away from to the blending tank has first servo motor, first servo motor's axle head and the other end fixed connection of defeated material screw rod.
Preferably, a water cooling tank is fixedly connected to the top surface of one end of the first support.
Compared with the prior art, the utility model discloses an advantage lies in with positive effect:
1. the utility model discloses in, it rotates to defeated material screw rod through the drive, carry the melting mixture to the extruded sheet department and extrude, drive the high-speed rotation of cutting blade through second servo motor, the melting mixture that utilizes cutting blade to extrude the extruded sheet is cuted, cutting blade continuously rotates the in-process in the guard plate, carry the shower nozzle with outside water pressure boost through booster pump in, utilize the shower nozzle to spray high-pressure rivers and wash cutting blade surface adnexed medicine mixture, thereby avoid cutting blade to cut the emergence and extrude the medicine and take place the viscidity as far as, the stability of having guaranteed the size of cuting is convenient for back coarse grinding microballon processing, setting through the connecting rod, make the shower nozzle obtain firm support when spraying rivers.
2. The utility model discloses in, start the electrical heating board through the electric cabinet and heat the blending tank, make the raw materials of mixing the intracavity heat the melting and mix, through the setting of puddler for defeated material screw rod drives the puddler and rotates in step when mixing intracavity rotation transport mixture, carries out further stirring to mixing, thereby makes the melting mixture mix more fully.
Drawings
FIG. 1 is a schematic perspective view of a shearing apparatus used in the manufacturing process of microspheres for injection according to the present invention;
FIG. 2 is an enlarged view of the structure A in FIG. 1 of a shearing device in the manufacturing process of microspheres for injection according to the present invention;
FIG. 3 is an enlarged view of the structure B in FIG. 1 of a shearing device used in the manufacturing process of microspheres for injection according to the present invention;
fig. 4 is a cross-sectional view of the internal structure of a shearing device in the manufacturing process of microspheres for injection according to the present invention.
Illustration of the drawings: 1. a mixing barrel; 11. extruding a plate; 12. a mixing chamber; 13. a fixing plate; 14. a material conveying screw rod; 15. a first servo motor; 16. a stirring rod; 2. an electrical heating plate; 21. an electric cabinet; 3. a first bracket; 31. a second bracket; 4. a water-cooling pool; 5. a second servo motor; 51. a cutting blade; 52. mounting a plate; 53. a protection plate; 54. pressurizing the water pump; 55. a connecting rod; 56. a spray head; 57. a water delivery pipe; 6. a feeding hopper; 61. a feed chute; 62. a partition plate; 63. an elastic rubber plate.
Detailed Description
In order to make the above objects, features and advantages of the present invention more clearly understood, the present invention will be further described with reference to the accompanying drawings and examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and therefore the present invention is not limited to the limitations of the specific embodiments of the present disclosure.
Embodiment 1, as shown in fig. 1-4, the utility model provides a shearing mechanism in microsphere manufacturing process for injection, including blending tank 1, the inside of blending tank 1 is provided with hybrid chamber 12, the inside of hybrid chamber 12 is rotated and is connected with defeated material screw rod 14, the one end fixedly connected with extruded sheet 11 of blending tank 1, the other end fixedly connected with batch hopper 6 of blending tank 1, blending tank 1 is close to the one end outer wall fixedly connected with mounting panel 52 of extruded sheet 11, one side fixedly mounted of mounting panel 52 has second servo motor 5, the output shaft fixedly connected with cutting blade 51 of second servo motor 5, the outer wall fixedly connected with guard plate 53 of second servo motor 5, the outer wall fixedly connected with connecting rod 55 of guard plate 53, the outer wall fixedly mounted of connecting rod 55 has shower nozzle 56, the one end fixedly connected with raceway 57 of shower nozzle 56, the one end fixedly connected with booster water pump 54 of connecting rod 55, the one end and the raceway 57 fixed connection of booster water pump 54, the one end fixed mounting that blending tank 1 kept away from extruded sheet 11 has first servo motor 15, the axle head of first servo motor 15 and the other end fixed connection of defeated material screw rod 14.
The following concrete setting and effect of this embodiment specifically say, it rotates to drive defeated material screw rod 14 through starting first servo motor 15, carry the melt mixture to extrusion plate 11 department and extrude, drive cutting blade 51 through second servo motor 5 and rotate at a high speed, utilize cutting blade 51 to cut the melt mixture that extrusion plate 11 extruded, cutting blade 51 lasts the rotation in-process in guard plate 53, carry shower nozzle 56 in with outside water pressure boost through booster water pump 54, jet high-pressure rivers through shower nozzle 56 and wash cutting blade 51 surperficial adnexed medicine mixture, thereby avoid cutting blade 51 to cut the emergence and extrude the medicine as far as possible and take place the viscidity, the stability of having guaranteed the size of cutting is convenient for back coarse grinding microsphere processing, setting through connecting rod 55, obtain firm support when making shower nozzle 56 jet stream.
The effect that its whole embodiment reached does, start electric heating plate 2 through electric cabinet 21 and heat blending drum 1, make the raw materials in mixing chamber 12 heat the melting and mix, setting through puddler 16, make defeated material screw rod 14 drive puddler 16 synchronous rotation when the conveying mixture of rotation in mixing chamber 12, carry out further stirring to mixing, thereby it is more abundant to make the melting mixture mix, separate the disconnection to feed chute 61 inside through baffle 62, thereby the person of facilitating the use carries out categorised input when throwing the material, the person of facilitating the use uses, through pouring into cold water in to water-cooling tank 4, the strip bulk product that makes the shearing cut out falls into in the cold water automatically and carries out quick cooling design and collect.
The working principle is as follows: during the use, the user puts into the feed chute 61 with medicine with polymer or other auxiliary materials and gets into in the hybrid chamber 12, heat the hybrid chamber 12 inside through starting electric hot plate 2, make with medicine with polymer or other auxiliary materials melt-mixing, drive defeated material screw 14 through starting first servo motor 15 and rotate, carry the melt mixture to extrusion plate 11 department and extrude, drive cutting blade 51 high-speed the rotation through second servo motor 5, utilize cutting blade 51 to shear the melt mixture that extrusion plate 11 extrudes, cutting blade 51 lasts the rotation in-process in guard plate 53, carry the shower nozzle 56 in with outside water pressure boost through booster pump 54, spout high-pressure rivers through the shower nozzle 56 and wash the medicine mixture that cutting blade 51 surface adheres to, thereby avoid cutting blade 51 to cut to take place with extruding the medicine and take place the stiction as far as possible, guaranteed the stability of cutting size and be convenient for the coarse grinding microsphere processing after, through injecting cold water in the water-cooling pond 4, make the strip product that cuts out carry out quick cooling in the cooling design and collect.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may use the above-mentioned technical contents to change or modify the equivalent embodiment into equivalent changes and apply to other fields, but any simple modification, equivalent change and modification made to the above embodiments according to the technical matters of the present invention will still fall within the protection scope of the technical solution of the present invention.
Claims (7)
1. A shearing device in the manufacturing process of microspheres for injection comprises a mixing barrel (1), and is characterized in that: the inside of blending bucket (1) is provided with hybrid chamber (12), the inside of hybrid chamber (12) is rotated and is connected with defeated material screw rod (14), one end fixedly connected with extrusion plate (11) of blending bucket (1), the other end fixedly connected with batch hopper (6) of blending bucket (1), one end outer wall fixedly connected with mounting panel (52) that blending bucket (1) is close to extrusion plate (11), one side fixed mounting of mounting panel (52) has second servo motor (5), the output shaft fixedly connected with cutting blade (51) of second servo motor (5), the outer wall fixedly connected with guard plate (53) of second servo motor (5), the outer wall fixedly connected with connecting rod (55) of guard plate (53), the outer wall fixed mounting of connecting rod (55) has shower nozzle (56), the one end fixedly connected with raceway (57) of shower nozzle (56), the one end fixedly connected with booster water pump (54) of connecting rod (55), the one end and raceway (57) fixed connection of booster water pump (54).
2. The shearing device in the manufacturing process of microspheres for injection according to claim 1, wherein: the outer wall fixed mounting of tempering tank (1) has electric heating plate (2), the bottom surface fixedly connected with first support (3) of electric heating plate (2).
3. The shearing device in the manufacturing process of microspheres for injection according to claim 2, wherein: one end bottom surface fixedly connected with second support (31) of blending tank (1), one side outer wall fixed mounting of second support (31) has electric cabinet (21), electric connection between electric cabinet (21) and electric heating board (2).
4. The shearing device in the manufacturing process of microspheres for injection according to claim 1, wherein: the top surface of the feeding hopper (6) is provided with a feeding groove (61), and a partition plate (62) is arranged inside the feeding groove (61).
5. The shearing device for manufacturing process of microspheres for injection according to claim 4, wherein: the two ends of the partition plate (62) are fixedly connected with elastic rubber plates (63), and one side of each elastic rubber plate (63) is fixedly connected with the inner wall of the feeding groove (61).
6. The shearing device in the manufacturing process of microspheres for injection according to claim 1, wherein: defeated material screw rod's (14) one end is rotated and is connected with fixed plate (13), the top of fixed plate (13) and the inner wall fixed connection of hybrid chamber (12), defeated material screw rod (14) are close to one end outer wall fixedly connected with puddler (16) of fixed plate (13), the one end fixed mounting who extrudes board (11) is kept away from in blending bunker (1) has first servo motor (15), the axle head of first servo motor (15) and the other end fixed connection of defeated material screw rod (14).
7. The shearing device in the manufacturing process of microspheres for injection according to claim 2, wherein: and the top surface of one end of the first bracket (3) is fixedly connected with a water cooling tank (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222867155.8U CN218256110U (en) | 2022-10-30 | 2022-10-30 | Shearing mechanism in injection microsphere manufacturing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222867155.8U CN218256110U (en) | 2022-10-30 | 2022-10-30 | Shearing mechanism in injection microsphere manufacturing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218256110U true CN218256110U (en) | 2023-01-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202222867155.8U Active CN218256110U (en) | 2022-10-30 | 2022-10-30 | Shearing mechanism in injection microsphere manufacturing process |
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| Country | Link |
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| CN (1) | CN218256110U (en) |
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2022
- 2022-10-30 CN CN202222867155.8U patent/CN218256110U/en active Active
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