CN218131068U - Protein dialysis ultrafiltration system - Google Patents
Protein dialysis ultrafiltration system Download PDFInfo
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- CN218131068U CN218131068U CN202221342756.0U CN202221342756U CN218131068U CN 218131068 U CN218131068 U CN 218131068U CN 202221342756 U CN202221342756 U CN 202221342756U CN 218131068 U CN218131068 U CN 218131068U
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Abstract
The utility model discloses a protein dialysis ultrafiltration system, which comprises a control system; a dialysis tank; the main output pipe is sequentially connected with a main output valve, an electric diaphragm pump and a first pressure sensor; the main return pipe is sequentially connected with a second pressure sensor and a return valve; the main seepage pipe is sequentially connected with a third pressure sensor, a conductivity detector and a seepage valve; each stage of the N-stage dialysis mechanisms is provided with an ultrafiltration membrane package, a feeding branch pipe, a backflow branch pipe and a material seepage branch pipe. The utility model discloses can carry out the protein dialysis ultrafiltration system of dialysis operation to the protein of different molecular sizes, need not in the use repeated purchase a plurality of equipment or dismantle repeatedly, reduce the damage to the milipore filter, reduce purchasing cost and use cost, improve the production efficiency of enterprise. The system can strictly control the use environment of the ultrafiltration membrane in the use process, and avoids the damage caused by the fact that the pressure does not meet the standard in the use process.
Description
Technical Field
The utility model relates to a protein dialysis technical field, in particular to protein dialysis ultrafiltration system.
Background
In the prior art of biological pharmacy, in the process of separating and purifying proteins, a dialysis method is often used for removing small molecular substances such as salts, hybrid proteins and the like in a protein solution. Because ultrafiltration concentration of proteins with different molecular sizes needs ultrafiltration membranes with different pore diameters, the existing corresponding solution is to repeatedly purchase a plurality of ultrafiltration devices which are correspondingly controlled, or repeatedly disassemble and replace the ultrafiltration membranes in the using process. However, ultrafiltration membranes used in the biopharmaceutical field are mostly of foreign origin, and thus the internal structure of the ultrafiltration membrane is very confidential, and the corresponding costs of procurement and maintenance are very high, and repeated purchases are obviously too costly, and repeated disassembly and reassembly are also very cumbersome.
In addition, the conventional ultrafiltration membrane needs to be strictly controlled in terms of a plurality of aspects such as feeding pressure, return pressure, seepage pressure and the like during use, and if a problem occurs in the aspect of pressure, the ultrafiltration membrane may be damaged, so that the ultrafiltration membrane needs to be strictly monitored during use.
SUMMERY OF THE UTILITY MODEL
To the technical problem who mentions in the background art, the utility model provides a protein dialysis ultrafiltration system.
The utility model adopts the following technical proposal: a protein dialysis ultrafiltration system comprising:
the control system is used for carrying out logic control on the system through a preset program;
a dialysis tank having a volume of protein fluid to be dialyzed therein;
the first end of the main output pipe is communicated with the discharge hole of the dialysis tank, a main output valve, an electric diaphragm pump and a first pressure sensor are sequentially connected onto the main output pipe, and the first pressure sensor is used for detecting the pressure value of the output protein liquid and transmitting the pressure value to the control system so as to control the rotating speed of the main output pump;
the first end of the main return pipe is communicated with the feed inlet of the dialysis tank, a second pressure sensor and a return valve are sequentially connected to the main return pipe, and the second pressure sensor is used for detecting the pressure value of the dialyzed protein liquid and transmitting the pressure value to the control system;
the main seepage pipe is used for discharging dialyzed seepage, a third pressure sensor, a conductivity detector and a liquid flowmeter are sequentially connected onto the main seepage pipe, and the third pressure sensor is used for detecting whether the pressure value of the seepage exceeds a threshold value or not and transmitting the detected pressure value of the seepage to the control system; the conductivity detector is used for detecting whether the protein content in the exudate exceeds a threshold value and transmitting the detected protein content value to the control system;
an N-stage dialysis mechanism, each stage of the dialysis mechanism having:
the pore size of the ultrafiltration membrane is matched with the molecular size of the protein liquid to be dialyzed, and the ultrafiltration membrane is used for dialysis;
a first end of the feeding branch pipe is communicated with a second end of the main output pipe, a second end of the feeding branch pipe is communicated with a feeding hole of the ultrafiltration membrane package, and a feeding control valve is connected to the feeding branch pipe;
a first end of the backflow branch pipe is communicated with a second end of the main backflow pipe, a second end of the backflow branch pipe is communicated with a backflow port of the ultrafiltration membrane package, the backflow pipe is connected with a backflow proportional valve, and the opening and closing amplitude of the backflow proportional valve is adjusted through the pressure value of the dialyzed protein liquid obtained by the control system;
the first end of the material seepage branch pipe is communicated with the first end of the main material seepage pipe, and a backflow control valve is connected to the material seepage branch pipe;
wherein, the N-stage membrane packages have different pore diameters, and N is a positive integer greater than or equal to 2.
Furthermore, a liquid flow meter is connected to the main seepage pipe and used for detecting whether the flow of the seepage liquid exceeds a threshold value and transmitting a measured flow value to the control system.
Furthermore, the control system adopts a PLC-touch screen control system to perform program control.
Compared with the prior art, the utility model has the advantages of: the utility model provides a protein dialysis ultrafiltration system can dialyse the operation to the protein of different molecular sizes, need not the repeated ultrafiltration membrane package of purchasing a plurality of equipment or dismantling the different models of installation repeatedly, reduces the damage to ultrafiltration membrane package self, reduces purchasing cost and use cost, improves the production efficiency of bio-pharmaceuticals enterprise. Meanwhile, the system can strictly control the use environment of the ultrafiltration membrane in the use process, avoid damage caused by the fact that the pressure does not meet the standard in the use process, and reduce the maintenance cost.
Drawings
FIG. 1 is a schematic diagram of the overall structure of an embodiment of the ultrafiltration system for protein dialysis according to the present invention;
wherein:
1-dialysis tank, 2-main output pipe, 3-main output valve, 4-electric diaphragm pump, 5-first pressure sensor, 6-main return pipe, 7-second pressure sensor, 8-return valve, 9-main seepage pipe, 10-third pressure sensor, 11-conductivity detector, 12-liquid flowmeter, 13-dialysis mechanism, 14-seepage valve,
13-1-ultrafiltration membrane package, 13-2-feeding branch pipe, 13-3-feeding control valve, 13-4-reflux branch pipe, 13-5-reflux proportional valve, 13-6-seepage branch pipe and 13-7-backflow control valve.
Detailed Description
Hereinafter, in order to facilitate understanding of the technical solutions of the present invention by those skilled in the art, further description will be made with reference to the accompanying drawings. It should be understood that the description is intended for purposes of illustration only and is not intended to limit the scope of the present disclosure.
In the following detailed description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of the embodiments of the invention. It may be evident, however, that one or more embodiments may be practiced without these specific details. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
Please refer to fig. 1, which is a schematic diagram of the overall structure of an embodiment of the ultrafiltration system for protein dialysis of the present invention, comprising a control system, a dialysis tank 1, a main output pipe 2, a main return pipe 6, a main seepage pipe 9 and an N-stage dialysis mechanism 13, wherein the control system is used for performing logic control on the system through a preset program. According to the embodiment, the PLC-touch screen control system is adopted for program control, the whole process is visualized, and automatic selection of the multistage dialysis mechanism is realized.
A certain amount of protein liquid to be dialyzed is introduced into the dialysis tank 1, and during specific implementation, the parameters of the certain amount of protein liquid to be dialyzed are recorded into the control system in advance, so that the control system can conveniently select the dialysis mechanism 13 according to the parameter information of the protein liquid.
In this embodiment, the first end of the main output pipe 2 is communicated with the discharge port of the dialysis tank 1, and the main output valve 3, the electric diaphragm pump 4 and the first pressure sensor 5 are sequentially connected to the main output pipe 2. The first pressure sensor 5 is used for detecting the pressure value of the output protein liquid and transmitting the pressure value to the control system so as to control the rotating speed of the electric diaphragm pump 4. In the specific implementation of the embodiment, the pressure of the protein liquid flowing out of the dialysis tank 1 is obtained through the first pressure sensor 5 and is fed back to the control system, and when the pressure of the output protein liquid exceeds the threshold range of the liquid inlet pressure which can be borne by the ultrafiltration membrane in the subsequent dialysis mechanism 13, the control system sends a control instruction to the electric diaphragm pump 4 to adjust the rotating speed of the electric diaphragm pump, so that the effect of adjusting the liquid inlet pressure is achieved.
In this embodiment, the first end of main back flow 6 and the feed inlet intercommunication of dialysis tank 1 have connected gradually second pressure sensor 7 and backward flow valve 8 on the main back flow 6, and second pressure sensor 7 is used for detecting the pressure value of the albumen liquid after the dialysis and transmits for control system, and the control system of being convenient for monitors the size of backward flow pressure.
In this embodiment, the main seepage pipe 9 is used for discharging seepage liquid after dialysis, and the main seepage pipe 9 is sequentially connected with a third pressure sensor 10, a conductivity detector 11 and a seepage valve 14. Wherein, the third pressure sensor 10 is used for detecting whether the pressure value of the exudate exceeds a threshold value, and transmitting the detected pressure value of the exudate to the control system, so that the control system can monitor the magnitude of the exudation pressure of the ultrafiltration membrane package. The conductivity detector 11 is used for detecting whether the protein content in the exudate exceeds a threshold value and transmitting the detected protein content value to the control system, the conductivity detector 11 confirms whether the dialysis effect of the ultrafiltration membrane package meets the standard or not by detecting the protein content in the exudate, if not, the ultrafiltration membrane package 13-1 is possibly reduced in filtering effect or damaged, and maintenance is needed in time. The embodiment realizes effective monitoring of the dialysis mechanism by detecting the pressure value and the protein content of the exudate and timely feeding back the detection data to the control system.
In the present embodiment, an N-stage dialysis unit 13 is included, where N is a positive integer equal to or greater than 2. In specific implementation, the number can be configured according to the required situation. An ultrafiltration membrane package 13-1, a feed branch pipe 13-2, a reflux branch pipe 13-4 and a seepage branch pipe 13-6 are arranged in each stage of dialysis mechanism 13. Wherein, the aperture of the ultrafiltration membrane package 13-1 is matched with the molecular size of the protein liquid to be dialyzed, and is used for dialysis operation. During specific installation, the ultrafiltration membrane package 13-1 with the adaptive pore size can be correspondingly installed according to the molecular size of the protein to be dialyzed. The first end of the feeding branch pipe 13-2 is communicated with the second end of the main output pipe 2, and the second end of the feeding branch pipe 13-2 is communicated with the feed inlet of the ultrafiltration membrane package 13-1. The feeding branch pipe 13-2 is also connected with a feeding control valve 13-3, and the feeding control valve 13-3 is opened and closed under the instruction of a control system. The first end of the backflow branch pipe 13-4 is communicated with the second end of the main backflow pipe 6, the second end of the backflow branch pipe 13-4 is communicated with a backflow port of the ultrafiltration membrane package 13-1, the backflow branch pipe 13-4 is connected with a backflow proportional valve 13-5, and the opening and closing amplitude of the backflow proportional valve 13-5 is adjusted through the pressure value of the dialyzed protein liquid obtained by the control system. If the reflux pressure exceeds the bearing threshold value of the ultrafiltration membrane package, the control system increases the opening amplitude of the reflux proportional valve 13-5, thereby reducing the reflux pressure value. The first end of the material permeating branch pipe 13-6 is communicated with the first end of the main material permeating pipe 9, the material permeating branch pipe 13-6 is connected with a backflow control valve 13-7, the material permeating branch pipe 13-6 is connected with the backflow control valve 13-7, and the backflow control valve 13-7 is switched on and off by receiving an instruction of a control system.
As shown in fig. 1, the operation will be described by taking the two-stage dialysis mechanism 13 as an example. The system is operated as follows: firstly, the protein liquid product to be dialyzed is put into a dialysis tank 1, an ultrafiltration membrane package is selected according to the process, and a corresponding valve is opened. If the membrane pack A is selected for dialysis treatment, the control system first opens the main output valve 3, the feed control valve 13-3 with the reference number a, the backflow control valve 13-7 with the reference number b, the backflow proportional valve 13-5 with the reference number c and the seepage valve 14, and then starts the electric diaphragm pump 4. The control system controls the rotating speed of the electric diaphragm pump 4 according to the hydraulic demand, and the first pressure sensor 5 is used for detecting the pressure value of the output protein liquid in real time and transmitting the pressure value to the control system so as to control the rotating speed of the electric diaphragm pump 4. When the protein liquid dialyzes and reflows from the ultrafiltration membrane package A, the control system adjusts the reflow proportional valve 13-5 with the reference number c according to the obtained pressure value of the second pressure sensor 7 so as to control the reflow pressure. And the dialyzed percolate flows out through the percolate branch pipe 13-6, the third pressure sensor 10 detects whether the pressure value of the percolate exceeds a threshold value or not, and the detected pressure value of the percolate is transmitted to the control system, so that the control system can monitor the seepage pressure of the ultrafiltration membrane package. Similarly, when the membrane package B is selected, the feed control valve 13-3 designated by a, the reverse flow control valve 13-7 designated by B, and the reflux proportional valve 13-5 designated by c are closed, the feed control valve 13-3 designated by a1, the reverse flow control valve 13-7 designated by B1, and the reflux proportional valve 13-5 designated by c1 are opened, and the other operations are repeated.
In this embodiment, a liquid flow meter 12 is further connected to the main seepage pipe 9, and the liquid flow meter 12 is configured to detect whether the flow rate of the seepage liquid exceeds a threshold value and transmit the detected flow rate value to the control system. The control system can control the rotating speed of the main output valve 3 according to the flow of the exudate, and further realizes the control of the flow rate of the output protein liquid.
To sum up, the utility model provides a protein dialysis ultrafiltration system can carry out the protein dialysis ultrafiltration system of dialysis operation to the protein of different molecular sizes, need not in the use repeated a plurality of equipment of purchasing or dismantle repeatedly, reduces the damage to the milipore filter, reduces purchasing cost and use cost, improves the production efficiency of enterprise. Meanwhile, the system can strictly control the use environment of the ultrafiltration membrane in the use process, including the inlet hydraulic pressure, the return pressure, the seepage pressure and the flow, so that the damage of the ultrafiltration membrane caused by the fact that the pressure does not meet the standard in the use process is avoided, the labor intensity of maintenance personnel is reduced, and the maintenance cost is reduced.
The above-mentioned embodiments are only for describing the preferred embodiments of the present invention, and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art without departing from the design spirit of the present invention should fall into the protection scope defined by the claims of the present invention.
Claims (3)
1. A protein dialysis ultrafiltration system, comprising:
the control system is used for carrying out logic control on the system through a preset program;
a dialysis tank (1), wherein a certain amount of protein liquid to be dialyzed is arranged in the dialysis tank (1);
the first end of the main output pipe (2) is communicated with the discharge hole of the dialysis tank (1), the main output pipe (2) is sequentially connected with a main output valve (3), an electric diaphragm pump (4) and a first pressure sensor (5), and the first pressure sensor (5) is used for detecting the pressure value of the output protein liquid and transmitting the pressure value to the control system so as to control the rotating speed of the electric diaphragm pump (4);
the first end of the main return pipe (6) is communicated with the feed inlet of the dialysis tank (1), a second pressure sensor (7) and a return valve (8) are sequentially connected onto the main return pipe (6), and the second pressure sensor (7) is used for detecting the pressure value of the dialyzed protein liquid and transmitting the pressure value to the control system;
the main seepage pipe (9) is used for discharging dialyzed seepage liquid, a third pressure sensor (10), a conductivity detector (11) and a seepage valve (14) are sequentially connected to the main seepage pipe (9), the third pressure sensor (10) is used for detecting whether the pressure value of the seepage liquid exceeds a threshold value or not, and the detected pressure value of the seepage liquid is transmitted to the control system; the conductivity detector (11) is used for detecting whether the protein content in the exudate exceeds a threshold value and transmitting the detected protein content value to the control system;
a dialysis mechanism (13) of N stages, each dialysis mechanism (13) having:
an ultrafiltration membrane package (13-1), the pore size of which is matched with the molecular size of the protein liquid to be dialyzed, and is used for dialysis operation;
a first end of the feeding branch pipe (13-2) is communicated with a second end of the main output pipe (2), a second end of the feeding branch pipe is communicated with a feeding hole of the ultrafiltration membrane package (13-1), and the feeding branch pipe (13-2) is connected with a feeding control valve (13-3);
a first end of the backflow branch pipe (13-4) is communicated with a second end of the main backflow pipe (6), a second end of the backflow branch pipe is communicated with a backflow port of the ultrafiltration membrane package (13-1), the backflow branch pipe (13-4) is connected with a backflow proportional valve (13-5), and the opening and closing amplitude of the backflow proportional valve (13-5) is adjusted through the pressure value of the dialyzed protein liquid obtained by the control system;
a first end of the seepage branch pipe (13-6) is communicated with a first end of the main seepage pipe (9), and a backflow control valve (13-7) is connected to the seepage branch pipe (13-6);
wherein the apertures of the N-stage ultrafiltration membrane packages (13-1) are different, and N is a positive integer greater than or equal to 2.
2. Protein dialysis ultrafiltration system according to claim 1, wherein a fluid flow meter (12) is further connected to the main permeate tube (9), said fluid flow meter (12) being adapted to detect whether the amount of permeate flow exceeds a threshold value and to transmit the measured flow value to the control system.
3. The protein dialysis ultrafiltration system of claim 1, wherein the control system is programmed with a PLC-touch screen control system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221342756.0U CN218131068U (en) | 2022-05-31 | 2022-05-31 | Protein dialysis ultrafiltration system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221342756.0U CN218131068U (en) | 2022-05-31 | 2022-05-31 | Protein dialysis ultrafiltration system |
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| CN218131068U true CN218131068U (en) | 2022-12-27 |
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| CN202221342756.0U Active CN218131068U (en) | 2022-05-31 | 2022-05-31 | Protein dialysis ultrafiltration system |
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