CN218107697U

CN218107697U - Special resin processing apparatus of heparin sodium and chondroitin sulfate

Info

Publication number: CN218107697U
Application number: CN202221636503.4U
Authority: CN
Inventors: 刘榜惠
Original assignee: Jiangsu Madsen Pharmaceutical Co ltd
Current assignee: Jiangsu Madsen Pharmaceutical Co ltd
Priority date: 2022-06-29
Filing date: 2022-06-29
Publication date: 2022-12-23
Anticipated expiration: 2032-06-29

Abstract

A resin treatment device special for heparin sodium and chondroitin sulfate comprises a resin treatment kettle, wherein a stirring paddle is arranged in the kettle through a stirring shaft, the bottom of the kettle is provided with a discharge port, a partition plate is arranged above the discharge port, a water permeable hole is formed in the partition plate, a rotating shaft for opening or closing the partition plate is installed on the partition plate, and a driving mechanism for forward rotation or reverse rotation of the rotating shaft is arranged outside the kettle; the bottom of the resin treatment kettle is provided with a water inlet, the water inlet is hermetically connected with a water inlet pipeline, the starting end of the water inlet pipeline is connected with a water storage tank, and the water inlet pipeline is communicated with a water pump; the top of the resin treatment kettle is provided with a water outlet, the water outlet is hermetically connected with a water outlet pipeline, and the tail end of the water outlet pipeline is connected with a water storage tank; a water filling port is arranged at the top of the water storage tank; and the water inlet pipeline and/or the water outlet pipeline are/is provided with a filter in a communicating way. The utility model discloses simple structure, convenient to use can thoroughly get rid of the less impurity of proportion through circulating water device and filter, and the environmental protection of just economizing on water.

Description

Special resin processing apparatus of heparin sodium and chondroitin sulfate

Technical Field

The utility model relates to a resin processing technology field, concretely relates to special resin processing apparatus of heparin sodium and chondroitin sulfate.

Background

Heparin sodium and chondroitin sulfate are glycosaminoglycan compounds extracted from animal tissues. Heparin sodium is the anticoagulant which is most used clinically and most widely used. Heparin sodium is widely distributed in the biological world and exists in the lung tissues and the intestinal tissues of higher mammals such as pigs, cows, sheep and the like. Chondroitin sulfate exists in animal cartilage tissues and is a medicine for treating osteoarthritis, at present, in domestic heparin sodium and chondroitin sulfate, the common separation mode mainly comprises the steps of pretreating, grinding and carrying out enzymolysis on animal tissues (pig small intestines and cartilage tissues) to form an enzymolysis solution, and then adding resin for adsorption. Since heparin sodium and chondroitin sulfate are both negatively charged, strongly basic anionic resin is generally used for adsorption, and heparin and chondroitin sulfate can be separated from uncharged or partially positively charged protein impurities and other impurities.

Because the animal tissue enzymolysis solution is difficult to filter and clarify, in order to improve the efficiency, the enzymolysis solution is only coarsely filtered and then is absorbed and extracted by resin, so the solution is very dirty and contains a plurality of undigested residues in the small intestine, tissues without enzymolysis, bone residues, protein and other impurities, meanwhile, the using process of the resin comprises the treatment links of absorption, elution, cleaning, regeneration and the like, and a small amount of broken resin is generated after long-term use. The resin needs to be repeatedly used for a long time, and if the operation is complicated, the production efficiency is greatly reduced; if the resin is not treated properly, the resin becomes more and more dirty, and the pore diameters and gaps on the surface and in the resin are blocked by impurities, so that the adsorption performance of the resin is reduced.

At present, in a resin treatment mode commonly used in China, each resin treatment step is generally filtered by a filter such as a filter bag, the resin is rinsed manually by adopting a simple container, resin regeneration treatment is only carried out by cleaning with solutions such as acid, alkali, salt and the like, the effect of physical separation cannot be achieved, and impurities such as broken resin, undigested residues in small intestines, tissues without enzymolysis, bone residues, proteins and the like which are not removed by filtration cannot be separated.

The patent numbers are: CN2015200301418, the patent of the special resin regenerating unit of heparin sodium includes the regeneration cauldron, is equipped with the stirring rake in the regeneration cauldron, and regeneration cauldron bottom is equipped with the discharge port, the position that lies in the stirring rake below in the regeneration cauldron is equipped with the circular baffle perpendicular with the stirring rake axis, has seted up the water hole on the baffle, and the baffle includes at least two fan-shaped boards that dock together, has the pivot perpendicular with the stirring rake axis on each fan-shaped board respectively, regeneration cauldron outside is equipped with the rotatory actuating mechanism of the pivot of telling of drive, still is connected with drive mechanism between actuating mechanism and the pivot. The patent utilizes the partition board to physically separate the resin from the adsorption solution, the cleaning solution, the eluent and impurities with large specific gravity; however, the apparatus in this patent is not effective in removing impurities having a light specific gravity and being unable to be separated due to resin extrusion, but such impurities are relatively large in the solution, so that the solution treated by the apparatus in this patent still contains many impurities having a small specific gravity, and the subsequent cleaning is required, which is very troublesome.

Disclosure of Invention

Aiming at the technical problems, the technical scheme provides the special resin treatment device for heparin sodium and chondroitin sulfate, and most of impurities with low specific gravity can be thoroughly removed by rinsing with water flow through the water inlet pipe, the water outlet pipe and the water storage tank which are connected to one side of the resin treatment kettle and the filtering device connected to the pipeline, so that the water-saving and environment-friendly effects are achieved; the problems can be effectively solved.

The utility model discloses a following technical scheme realizes:

a special resin treatment device for heparin sodium and chondroitin sulfate comprises a resin treatment kettle, wherein a stirring paddle is arranged in the kettle through a stirring shaft, a discharge port is formed in the bottom of the kettle, a partition plate is arranged above the discharge port, a water permeable hole is formed in the partition plate, a rotating shaft for opening or closing the partition plate is installed on the partition plate, and a driving mechanism acting on the rotating shaft to rotate forwards or backwards is arranged outside the kettle; the bottom of the resin treatment kettle is provided with a water inlet, the water inlet is hermetically connected with a water inlet pipeline, the starting end of the water inlet pipeline is connected with a water storage tank, and the water inlet pipeline is communicated and connected with a water pump; the top of the resin treatment kettle is provided with a water outlet, the water outlet is hermetically connected with a water outlet pipeline, and the tail end of the water outlet pipeline is connected with a water storage tank; a water filling port is formed in the top of the water storage tank; and the water inlet pipeline and/or the water outlet pipeline are/is provided with a filter in a communicating way.

Furthermore, the aperture of the water permeable holes on the filter screen in the filter is 80-120 meshes.

Furthermore, the water pump can be arranged at any position of the water inlet pipeline; preferably, the water inlet is installed at a position of 50 to 100 cm close to the water inlet.

Furthermore, the filler opening at water storage tank top is provided with the sealed lid that can open, is provided with the connecting strip between sealed lid and the filler opening.

Furthermore, an internal thread is arranged at the water filling port, an external thread is arranged at the bottom of the sealing cover, and the water filling port is connected with the sealing cover through the thread; a chain is fixedly connected to one side of the water filling port and the cover top of the sealing cover, and when the sealing cover is opened to add liquid, the sealing cover is hung at the water filling port through the chain; the operation of operating personnel is convenient, and the loss of the sealing cover can be avoided.

Further, the baffle plate is arranged in the resin treatment kettle, is positioned below the stirring paddle and is vertical to the axis of the stirring paddle; the partition plate comprises a circular partition plate consisting of at least two fan-shaped plates which are butted together, and a sealing strip is arranged at the butted part of the fan-shaped plates.

Furthermore, each fan-shaped plate is provided with a rotating shaft perpendicular to the axis of the stirring paddle, and the rotating shaft penetrates through the side wall of the resin treatment kettle and extends to the outer side of the resin treatment kettle and is connected with a driving mechanism through a transmission device; the rotating shaft is connected with the side wall of the resin treatment kettle through a sealing ring and a bearing.

Furthermore, the number of the fan-shaped plates is two, the two fan-shaped plates are both semicircular plates, and rotating shafts on the two fan-shaped plates are arranged in parallel.

Furthermore, the driving mechanism is a piston cylinder, and a piston rod of the piston cylinder extends in the vertical direction and is perpendicular to the rotating shaft; the transmission mechanism comprises a rack connected with the tail end of the piston rod through a connecting part and two gears fixedly arranged on the two rotating shafts respectively, and the rack is meshed with the gears; the rack and the gear are driven to move by the extension and retraction of the piston rod, so that the rotating shaft can be driven to rotate forwards or backwards, and the effect of opening or closing the partition plate is achieved.

Furthermore, a layer of filter screen is arranged on the partition board, and the mesh size of the filter screen is 80-100 meshes.

Advantageous effects

The utility model provides a pair of special resin processing apparatus of heparin sodium and chondroitin sulfate, compared with the prior art, it has following beneficial effect:

(1) This technical scheme is through connecting inlet tube, outlet pipe, the water storage tank and the filter equipment of connection on the pipeline in resin treatment cauldron one side, can reach thoroughly getting rid of the less impurity of most proportion through the rivers rinsing, and water conservation environmental protection.

(2) According to the technical scheme, through the arrangement of the partition board, after the sodium chloride solution is added and the processes of stirring and standing are carried out, impurities with specific gravity larger than that of brine (such as adsorption liquid, cleaning liquid, impurities with specific gravity in eluent: tissue residues, bone residues, dust sand, metal debris, broken resin and the like) can be physically separated from the resin by utilizing the partition board; the operation is very simple and convenient.

(3) The partition plate in the technical scheme is connected with the transmission mechanism and the driving mechanism, so that the partition plate is easier to open and close.

(4) The arrangement of the sealing strip on the partition plate in the technical scheme can prevent resin particles from leaking from the butted part of the sector plates.

Drawings

Fig. 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is a schematic view of the middle partition plate and the transmission mechanism of the present invention.

Fig. 3 is a bottom view of the middle partition plate and the transmission mechanism of the present invention.

The symbols in the drawings are: 1-resin treatment kettle, 11-manhole, 12-discharge port, 13-water inlet, 14-water outlet, 21-stirring motor, 22-stirring shaft, 23-stirring paddle, 3-partition plate, 31-sector plate, 32-rotating shaft, 33-permeable hole, 34-sealing strip, 4-transmission device, 41-connecting part, 42-rack, 43-gear, 5-driving mechanism, 51-piston cylinder, 52-piston rod, 6-water inlet pipeline, 7-water outlet pipeline, 8-water storage tank, 81-water filling port, 9-water pump and 10-filter.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. The described embodiments are only some, but not all embodiments of the invention. Under the prerequisite that does not deviate from the design concept of the utility model, the ordinary person in the art should fall into the protection scope of the utility model to the various changes and improvements that the technical scheme of the utility model made.

Example 1:

as shown in figures 1-3, a special resin treatment device for heparin sodium and chondroitin sulfate comprises a resin treatment kettle 1, wherein a stirring paddle 23 is arranged in the kettle through a stirring shaft 22, a discharge port 12 is arranged at the bottom of the kettle, a partition plate 3 is arranged above the discharge port 12, and a water permeable hole 33 is arranged on the partition plate 3. The partition board 3 is provided with a rotating shaft 32 for opening or closing the partition board 3, and the outside of the kettle is provided with a driving mechanism 5 which acts on the rotating shaft 32 to rotate forwards or backwards.

The partition plate 3 is arranged in the resin treatment kettle 1, is positioned below the stirring paddle 23 and is vertical to the axis of the stirring paddle 23; the partition plate 3 comprises a circular partition plate 3 consisting of at least two fan-shaped plates which are butted together, and a sealing strip 34 is arranged at the butted part of the fan-shaped plates 31. The number of the sector plates 31 is two, the two sector plates 31 are both semicircular plates, and the rotating shafts 32 on the two sector plates 31 are arranged in parallel.

The partition board 3 is provided with a layer of filter screen, and the mesh size of the filter screen is 80 to 100 meshes.

Each sector plate 31 is respectively provided with a rotating shaft 32 which is vertical to the axis of the stirring paddle 23, the rotating shaft 32 penetrates through the side wall of the resin treatment kettle 1 and extends to the outer side of the resin treatment kettle 1, and the rotating shaft 4 is connected with the driving mechanism 5 through a transmission device; the rotating shaft 32 is connected with the side wall of the resin treatment kettle 1 through a sealing ring and a bearing.

The driving mechanism 5 is a piston cylinder 51, and a piston rod 52 of the piston cylinder 51 extends along the vertical direction and is perpendicular to the rotating shaft 32; the transmission mechanism 4 comprises a rack 42 connected with the tail end of the piston rod 52 through a connecting part 41, and two gears 43 fixedly arranged on the two rotating shafts 32 respectively, and the rack 42 is meshed with the gears 43; the rack 42 and the gear 43 are driven to move by the extension and contraction of the piston rod 52, so that the rotating shaft 32 can be driven to rotate forwards or backwards, and the effect of opening or closing the partition board 3 is achieved.

The side wall of the bottom of the resin treatment kettle 1 is provided with a water inlet 13, the side wall of the resin treatment kettle 1 can be hermetically connected with a pipeline for the heparin sodium or chondroitin sulfate enzymolysis liquid to enter and a pipeline for the sodium chloride solution to enter, and the pipelines are provided with a valve and a water pump (as the part is not relevant to the technical problem to be solved in the embodiment, the part is not shown in the attached drawing).

The water inlet 13 is hermetically connected with a water inlet pipeline 6, the starting end of the water inlet pipeline 6 is connected with a water storage tank 8, and the water inlet pipeline 6 is communicated with a water pump 9; a water outlet 14 is formed in the top of the resin treatment kettle 1, a water outlet pipeline 7 is connected to the position of the water outlet 14 in a sealing mode, and the tail end of the water outlet pipeline 7 is connected with a water storage tank 8; a water filling port 81 is arranged at the top of the water storage tank 8; the water inlet pipe 6 and/or the water outlet pipe 7 are/is provided with a filter 10 in a communicating way, and the aperture of the water permeable holes on the filter screen in the filter 10 is smaller than 80 meshes.

In the present embodiment, the filter 10 is preferably mounted on the outlet conduit 7; if the resin treatment kettle is additionally provided with a pipeline for introducing the heparin sodium or chondroitin sulfate enzymolysis liquid and the sodium chloride solution, the filter 10 can be arbitrarily installed on the water outlet pipeline 7 or the water inlet pipeline 6, and the filter 10 is optimally installed on the water outlet pipeline 7 and the water inlet pipeline 6 at the same time.

The water pump 9 can also be arranged at any position of the water inlet pipeline 6; preferably, it is installed at a position of 50 to 100 cm near the water inlet 13.

The filler 81 department at 8 tops of water storage tank is provided with the sealed lid that can open, is provided with the connecting strip between sealed lid and the filler.

The water filling port 81 is provided with an internal thread, the bottom of the sealing cover is provided with an external thread, and the water filling port is connected with the sealing cover through a thread; a chain is fixedly connected to one side of the water filling port 81 and the cover top of the sealing cover, and when the sealing cover is opened to add liquid, the sealing cover is hung at the water filling port through the chain; the operation of operating personnel is convenient, and the loss of the sealing cover can be avoided.

In this embodiment, the resin processing kettle adopts a stainless steel container with a height-diameter ratio of more than 3 and a specification of 2-5 m thin section; the water storage tank adopts a stainless steel or plastic container with the specification of the volume of more than 500L; check valves with the model number of stainless steel DN 50-110 are arranged at the water inlet and the water outlet; the filter adopts a filter bag type filter, and the diameter of meshes in a filter screen is 80-120 meshes; the water pump is a IHW stainless steel horizontal/pipeline centrifugal pump.

The working principle is as follows: before use, a discharge port and a partition plate at the bottom of the resin treatment kettle need to be closed; then pumping the filtered heparin sodium or chondroitin sulfate enzymolysis liquid. When the filtered heparin sodium or chondroitin sulfate enzymolysis liquid is pumped in, the liquid can be pumped in from a feed inlet (additionally arranged or other pipeline openings) at the top of the resin treatment kettle through a pipeline; or the heparin sodium or chondroitin sulfate enzymolysis liquid can be led into a water storage tank in advance for storage and standby application, and then the liquid is led into the resin treatment kettle from a water inlet through a water pump. When the heparin sodium or chondroitin sulfate enzymolysis liquid is introduced by adopting the mode, a filter is not arranged on the water inlet pipeline.

Introducing the liquid into a closed resin treatment kettle, and then adding resin to carry out operations of stirring, adsorption, cleaning and elution. When the resin is regenerated, the driving mechanism and the transmission mechanism are controlled to open the partition plate, and then the sodium chloride solution is added.

Adding a required prepared sodium chloride solution into the kettle through a water storage tank, a water inlet pipeline and a water pump, wherein the sodium chloride solution can be added from a feed inlet at the top of the resin treatment kettle through a pipeline; or the sodium chloride solution is prepared to be introduced into the water storage tank in advance for use, and then the liquid is introduced into the resin treatment kettle from the water inlet through the water pump. When the sodium chloride solution is introduced in this way, no filter is installed on the water inlet pipe; or the diameter of the mesh of the filter screen of the filter arranged on the water inlet pipeline is larger than that of sodium chloride molecules (smaller than the diameter of the resin or 80-120 meshes).

After the sodium chloride solution is added into the resin treatment kettle, the stirring paddle motor is started, and drives the stirring shaft to rotate, so that the stirring paddle is driven to rotate, the liquid in the resin treatment kettle is stirred, and the sodium chloride solution is fully blended into the original liquid. After stirring and standing for a period of time, the impurities in the solution and resin with a specific gravity greater than that of the brine settle to the bottom of the kettle, while the resin with a specific gravity less than that of the brine and most of the insoluble impurities float to the surface of the solution.

Treat resin and impurity complete separation back, utilize actuating mechanism to make the baffle closed, the baffle separates resin and the great impurity of proportion this moment, and the less impurity of resin and proportion is located the baffle top, and the great impurity of proportion is located the baffle below, opens the discharge port of cauldron, discharges the impurity of baffle downside totally, closes the discharge port.

Then the valves of the kettle bottom water inlet and the kettle top water outlet are opened, the water pump connected with the water inlet is opened, the water pump introduces the clean water in the water storage tank into the resin treatment kettle, the clean water is added for standby after the sodium chloride solution is introduced into the resin treatment kettle in the water storage tank, the resin in the kettle is dispersed by the water flow, the impurities with small specific gravity are discharged from the water outlet along the water flow and enter the water storage tank, and when the solution in the resin treatment kettle enters the water storage tank, the addition of the clean water in the water storage tank is stopped.

At the moment, the operation of the water pump enables the liquid in the resin treatment kettle, the water outlet pipe, the water storage tank and the water inlet pipe to form an internal circulation; after the liquid is internally circulated for multiple times, the liquid is repeatedly rinsed after passing through the filtering device on the connecting pipe for multiple times, so that the effluent liquid at the water gap has no impurities, and the water pump stops working; in this way, the solution can be completely removed from the impurities with low specific gravity and insoluble impurities.

Claims

1. A resin treatment device special for heparin sodium and chondroitin sulfate comprises a resin treatment kettle (1), wherein a stirring paddle (23) is arranged in the kettle through a stirring shaft, a discharge port (12) is formed in the bottom of the kettle, a partition plate (3) is arranged above the discharge port (12), a water permeable hole (33) is formed in the partition plate (3), a rotating shaft (32) used for opening or closing the partition plate (3) is installed on the partition plate (3), and a driving mechanism (5) acting on the rotating shaft (32) to rotate forwards or backwards is arranged outside the kettle; the method is characterized in that: a water inlet (13) is formed in the bottom of the resin treatment kettle (1), a water inlet pipeline (6) is hermetically connected to the water inlet (13), a water storage tank (8) is connected to the starting end of the water inlet pipeline (6), and a water pump (9) is communicated and connected to the water inlet pipeline (6); a water outlet (14) is formed in the top of the resin treatment kettle (1), a water outlet pipeline (7) is connected to the water outlet (14) in a sealing mode, and the tail end of the water outlet pipeline (7) is connected with a water storage tank (8); a water filling port (81) is arranged at the top of the water storage tank (8); the water inlet pipeline (6) and/or the water outlet pipeline (7) are/is provided with a filter (10) in a communication way.

2. The special resin processing device for heparin sodium and chondroitin sulfate according to claim 1, characterized in that: the aperture of the water permeable holes on the filter screen in the filter (10) is 80-120 meshes.

3. The special resin processing device for heparin sodium and chondroitin sulfate according to claim 1, characterized in that: the water pump (9) can also be arranged at any position of the water inlet pipeline (6); preferably, the water inlet (13) is installed at a position of 50 to 100 cm near the water inlet.

4. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in claim 1, wherein: the water filling port at the top of the water storage tank (8) is provided with an openable sealing cover, and a connecting strip is arranged between the sealing cover and the water filling port.

5. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in claim 4, wherein: the water filling port (81) is provided with an internal thread, the bottom of the sealing cover is provided with an external thread, and the water filling port (81) is connected with the sealing cover through a thread; a chain is fixedly connected to one side of the water filling port (81) and the top of the sealing cover, and when the sealing cover is opened to add liquid, the sealing cover is hung at the water filling port (81) through the chain; the operation of operating personnel is convenient, and the loss of the sealing cover can be avoided.

6. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in claim 1, wherein: the partition plate (3) is arranged in the resin treatment kettle (1), is positioned below the stirring paddle (23) and is vertical to the axis of the stirring paddle (23); the partition plate (3) comprises a circular partition plate consisting of at least two fan-shaped plates (31) which are butted together, and a sealing strip (34) is arranged at the butted part of the fan-shaped plates (31).

7. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in claim 6, wherein: each fan-shaped plate (31) is provided with a rotating shaft (32) which is vertical to the axis of the stirring paddle (23), and the rotating shaft (32) penetrates through the side wall of the resin treatment kettle (1) and extends to the outer side of the resin treatment kettle (1) to be connected with a driving mechanism (5) through a transmission device (4); the rotating shaft (32) is connected with the side wall of the resin treatment kettle (1) through a sealing ring and a bearing.

8. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in claim 7, wherein: the fan-shaped plates (31) are two in total, the two fan-shaped plates (31) are semicircular plates, and rotating shafts (32) on the two fan-shaped plates (31) are arranged in parallel.

9. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in claim 8, wherein: the driving mechanism (5) is a piston cylinder (51), and a piston rod (52) of the piston cylinder (51) extends in the vertical direction and is perpendicular to the rotating shaft (32); the transmission device (4) comprises a rack (42) connected with the tail end of the piston rod (52) through a connecting part (41), and two gears (43) fixedly installed on the two rotating shafts (32) respectively, wherein the rack (42) is meshed with the gears (43); the piston rod (52) stretches and retracts to drive the rack (42) and the gear (43) to move, so that the rotating shaft (32) can be driven to rotate forwards or backwards, and the effect of opening or closing the partition board (3) is achieved.

10. The special resin treatment device for heparin sodium and chondroitin sulfate as claimed in any one of claims 1, 6, 7, 9, wherein: the partition board (3) is provided with a layer of filter screen, and the mesh size of the filter screen is 80-100 meshes.