CN218107489U - Immune cell's even device that rocks - Google Patents
Immune cell's even device that rocks Download PDFInfo
- Publication number
- CN218107489U CN218107489U CN202220662888.5U CN202220662888U CN218107489U CN 218107489 U CN218107489 U CN 218107489U CN 202220662888 U CN202220662888 U CN 202220662888U CN 218107489 U CN218107489 U CN 218107489U
- Authority
- CN
- China
- Prior art keywords
- installation box
- box body
- fixedly provided
- support column
- immune cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000002865 immune cell Anatomy 0.000 title claims abstract description 37
- 239000011435 rock Substances 0.000 title description 4
- 238000009434 installation Methods 0.000 claims abstract description 39
- 230000005540 biological transmission Effects 0.000 claims description 18
- 230000006835 compression Effects 0.000 claims description 10
- 238000007906 compression Methods 0.000 claims description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 238000004113 cell culture Methods 0.000 abstract description 5
- 210000004698 lymphocyte Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 230000001095 motoneuron effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
Images
Landscapes
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses an even shaking device for immune cells, which belongs to the technical field of immune cell culture and comprises an installation box body; a plurality of supporting parts which are all arranged on the lower surface of the mounting box body; a vibration motor disposed on a lower surface of the mounting case; the clamping parts are arranged on the upper surface of the mounting box body and comprise clamp mounting boxes; and a driving part which is arranged in the mounting box body and is used for rotating the clamp mounting box. From this, can effectual promotion immune cell's mixing effect and efficiency.
Description
Technical Field
The utility model relates to a shaking device especially relates to an even shaking device of immune cell, belongs to immune cell culture technical field.
Background
Immune cells refer to cells involved in or associated with an immune response. Including lymphocytes, dendritic cells, monocytes/macrophages, granulocytes, mast cells, and the like. Immune cells can be classified into various types, and various immune cells play an important role in the human body. Immune cells are commonly called leukocytes and include innate lymphocytes, various phagocytic cells and the like, and lymphocytes which recognize antigens and produce specific immune responses. After peripheral blood is pretreated, the amplified immune cells are mostly carried out in an immune cell culture bottle, the immune cell culture bottle is placed in an incubator with certain temperature, humidity and carbon dioxide content, and the immune cells are amplified after a period of culture.
The immune cell culture process is static culture generally, and immune cell can subside to the blake bottle bottom because of gravity reason, leads to immune cell to distribute inhomogeneous, has restricted immune cell's amplification to a certain extent, adopts the manual work to rock the blake bottle in order to prevent that immune cell distributes inhomogeneously usually, wastes time and energy, leads to the atress inhomogeneous simultaneously easily, rocks the effect poor.
Therefore, how to develop a device for uniformly shaking immune cells is a problem to be solved.
SUMMERY OF THE UTILITY MODEL
In order to solve at least one of the above problems, the present invention provides an apparatus for uniformly shaking immune cells.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the uniform shaking device for the immune cells is designed, and comprises an installation box body; a plurality of supporting parts which are arranged on the lower surface of the mounting box body; a vibration motor disposed on a lower surface of the mounting case; the clamping parts are arranged on the upper surface of the mounting box body and comprise clamp mounting boxes; and a driving part which is arranged in the mounting box body and is used for rotating the clamp mounting box.
Preferably, the number of the vibration motors is two or more, and the vibration motors are circumferentially arranged on the lower surface of the mounting box body.
Preferably, the supporting part comprises a first supporting column and a second supporting column, the first supporting column is connected with the lower surface of the installation box body, the first supporting column and the second supporting column are both fixedly provided with connecting rings, springs are fixedly arranged between the connecting rings, the springs are both sleeved with the first supporting column and the second supporting column, and an anti-skidding base is fixedly arranged at the bottom of the second supporting column.
Preferably, the driving part comprises a motor, the motor is connected with the lower surface of the installation box body, an output shaft of the motor penetrates through the installation box body, extends to the inside of the installation box body, and is fixedly provided with a transmission shaft, one end of the transmission shaft is rotatably connected with the top of the inner wall of the installation box body, a giant gear is fixedly arranged on the transmission shaft, a plurality of gears are arranged on the giant gear in an equal-angle gear joint mode, transmission columns are fixedly arranged on the gears, and one end of each transmission column penetrates through the installation box body, is rotatably connected with the installation box body, and is fixedly connected with the lower surface of the fixture installation box.
Preferably, the clamping portion further comprises a plurality of inclined through grooves formed in the upper surface of the clamp installation box, clamping blocks are arranged on the inner walls of the inclined through grooves in a sliding connection mode, arc-shaped rubber pads are fixedly arranged on one sides of the clamping blocks, and an adjusting assembly for enabling the clamping blocks to generate displacement is arranged inside the clamp installation box.
Preferably, the adjusting part includes double thread lead screw, the both ends of double thread lead screw all run through the anchor clamps install bin and rotate with the anchor clamps install bin and be connected and fixed the regulation post that is equipped with, double thread lead screw threaded connection is equipped with two movable plates, one side of movable plate all is fixed and is equipped with compression spring, compression spring's one end is all fixed and is equipped with the removal seat, and removes the seat and all cup joint with double thread lead screw mutually, the both sides of removing the seat are all fixed and are equipped with the litter, the both sides of anchor clamps install bin all are equipped with the spout that runs through corresponding with the litter, the litter all cup joints and is equipped with the movable block, and the movable block respectively with press from both sides tight piece fixed connection.
Compared with the prior art, the beneficial effects of the utility model reside in that: under supporting part and vibrating motor's effect, can effectually avoid leading to because vibrating motor is at the vibrations that the during operation produced when improving the immune cell mixing effect the utility model discloses the phenomenon that removes appears, make clamping part drive test tube or culture medium begin to rotate under the drive of drive division, can further promote immune cell's mixing effect, adopt clamping part can fix the not unidimensional culture container that holds immune cell and also can reduce the phenomenon that the container appears damaging at the clamping process as far as possible, make the utility model discloses an applicability is higher.
Specific embodiments of the present invention are disclosed in detail with reference to the following description and the accompanying drawings, which specify the manner in which the principles of the invention may be employed. It should be understood that the embodiments of the present invention are not limited in scope thereby. The embodiments of the invention include many variations, modifications and equivalents within the spirit and scope of the appended claims.
Drawings
The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a front view of a preferred embodiment of the device for uniform shaking of immune cells according to the present invention;
FIG. 2 is a cross-sectional view of a preferred embodiment of the device for uniform shaking of immune cells according to the present invention;
fig. 3 is a structural exploded view at a in fig. 1.
In the figure: 1. installing a box body; 2. a support portion; 3. a vibration motor; 5. a clamping portion; 201. a first supporting column; 202. a second supporting column; 203. a connecting ring; 204. a spring; 205. an anti-slip base; 401. a motor; 402. a drive shaft; 403. a giant gear; 404. a gear; 405. a drive post; 501. a clamp installation box; 502. the groove penetrates through the plate obliquely; 503. a moving block; 504. a slide rod; 505. run through the chute; 506. a movable seat; 507. a double-threaded screw rod; 508. an adjustment column; 509. moving the plate; 510. a compression spring; 511. a clamping block; 512. an arc-shaped rubber pad.
Detailed Description
In the embodiments of the present invention, the terms "first", "second", and the like are used for distinguishing different elements from each other in a descriptive sense, but do not denote any spatial arrangement, temporal order, or the like of the elements, and the elements should not be limited by these terms. The term "and/or" includes any and all combinations of one or more of the associated listed terms. The terms "comprising," "including," "having," and the like, refer to the presence of stated features, elements, components, and do not preclude the presence or addition of one or more other features, elements, components, and elements.
In order to make the technical solutions of the present invention clearer and clearer for those skilled in the art, the present invention will be described in further detail with reference to the following embodiments and the accompanying drawings, but the embodiments of the present invention are not limited thereto.
As shown in fig. 1-3, the uniform shaking apparatus for immune cells provided by the present embodiment comprises a mounting case 1; a plurality of support parts 2 each provided on the lower surface of the installation case 1; a vibration motor 3 provided on the lower surface of the mounting case 1; a plurality of clamping portions 5 each provided on an upper surface of the mounting case 1, the clamping portions 5 including a jig mounting case 501; and a driving unit provided inside the mounting case 1 for rotating the jig mounting case 501.
Further, the number of the vibration motors 3 is two or more, and the vibration motors 3 are circumferentially arranged on the lower surface of the installation box 1.
It is specific, the staff will hold the culture container of immunocyte when using on arranging clamping part 5 in, press from both sides tightly culture container under clamping part 5's effect, then use the controller to make drive division start work make clamping part 5 drive the container and begin rotatoryly, the symmetry wherein immunocyte carries out the mixing, vibrating motor 3 starts work simultaneously and makes installation box 1 drive clamping part 5 and container carry out anomalous motion, further promote the mixing effect, supporting part 2 can reduce vibrating motor 3 and carry out the interact between the vibrational force that produces at the during operation and ground when providing supporting role, avoid the utility model discloses the phenomenon of removal appears.
In this embodiment, as shown in fig. 2, the supporting portion 2 includes a first supporting column 201 and a second supporting column 202, the first supporting column 201 is connected to the lower surface of the installation box 1, the first supporting column 201 and the second supporting column 202 are both fixedly provided with a connecting ring 203, a spring 204 is fixedly provided between the two connecting rings 203, the spring 204 is both sleeved with the first supporting column 201 and the second supporting column 202, and an anti-slip base 205 is fixedly provided at the bottom of the second supporting column 202.
In this embodiment, as shown in fig. 2, the driving portion includes a motor 401, the motor 401 is connected to the lower surface of the installation box 1, an output shaft of the motor 401 penetrates through the installation box 1, extends into the installation box 1, and is fixedly provided with a transmission shaft 402, one end of the transmission shaft 402 is rotatably connected to the top of the inner wall of the installation box 1, the transmission shaft 402 is fixedly provided with a huge gear 403, the huge gear 403 is in an equiangular toothed connection with a plurality of gears 404, the gears 404 are all fixedly provided with transmission columns 405, one end of each transmission column 405 penetrates through the installation box 1, is rotatably connected to the installation box 1, and is fixedly connected to the lower surface of the clamp installation box 501.
Specifically, when immune cells are uniformly mixed, the controller controls the motor 401 to work to enable the transmission shaft 402 to start rotating, the transmission column 405 drives the clamping portion 5 and the container to start rotating under the transmission of the huge gear 403 and the gear 404, meanwhile, the vibration motor 3 starts working to enable the installation box body 1 to drive the clamping portion 5 and the container to do irregular movement, after vibration force is transmitted to the first support column 201, under the matching of the connecting ring 203 and the spring 204, the spring 204 starts to deform under stress to perform compression energy absorption work, and the strength of the vibration force transmitted to the second support column 202 is effectively reduced.
In this embodiment, as shown in fig. 3, the clamping portion 5 further includes a plurality of oblique through grooves 502 disposed on the upper surface of the clamp mounting box 501, clamping blocks 511 are slidably connected to the inner walls of the oblique through grooves 502, arc-shaped rubber pads 512 are fixedly disposed on one sides of the clamping blocks 511, and an adjusting assembly for displacing the clamping blocks 511 is disposed inside the clamp mounting box 501.
Further, the adjusting component includes double thread lead screw 507, the both ends of double thread lead screw 507 are all run through anchor clamps install bin 501 and are rotated and be connected and fixed and be equipped with the regulation post 508, double thread lead screw 507 threaded connection is equipped with two movable plates 509, one side of movable plate 509 all is fixed and is equipped with compression spring 510, compression spring 510's one end is all fixed and is equipped with and removes seat 506, and remove seat 506 and all cup joint with double thread lead screw 507 mutually, the both sides of removing seat 506 are all fixed and are equipped with litter 504, the both sides of anchor clamps install bin 501 all are equipped with and pass through spout 505 corresponding with litter 504, litter 504 all cup joint and are equipped with the movable block 503, and movable block 503 respectively with press from both sides tight piece 511 fixed connection.
Specifically, when a container containing immune cells is fixed, the container is placed in the middle of the upper surface of the fixture mounting box 501, the adjusting column 508 is rotated to enable the double-thread screw rod 507 to start rotating, the moving plate 509 starts moving under the action of threads, the moving base 506 drives the sliding rod 504 to start moving under the guiding of the through sliding groove 505 under the pulling of the compression spring 510, and the moving block 503 drives the clamping block 511 and the arc-shaped rubber pad 512 to start moving under the guiding of the oblique through groove 502 until the arc-shaped rubber pad 512 is attached to the outer surface of the container and the compression spring 510 is stretched to a certain length.
The present invention has been described in connection with specific embodiments, but it should be clear to a person skilled in the art that these descriptions are intended to be illustrative and not limiting to the scope of the invention. Various modifications and adaptations of the present invention may occur to those skilled in the art, which are within the spirit and scope of the present invention.
Claims (6)
1. A device for evenly shaking immune cells is characterized by comprising,
installing a box body (1);
a plurality of support parts (2) each provided on a lower surface of the installation case (1);
a vibration motor (3) provided on the lower surface of the mounting case (1);
a plurality of clamping portions (5) each provided on an upper surface of the mounting case (1), the clamping portions (5) including a jig mounting case (501);
and a drive unit which is provided inside the mounting case (1) and rotates the jig mounting case (501).
2. The device for uniformly shaking immune cells as defined in claim 1, wherein the number of the vibration motors (3) is two or more, and the vibration motors (3) are arranged circumferentially on the lower surface of the mounting case (1).
3. The device for uniformly shaking immune cells according to claim 1, wherein the support part (2) comprises a first support column (201) and a second support column (202), the first support column (201) is connected with the lower surface of the installation box body (1), the first support column (201) and the second support column (202) are both fixedly provided with a connecting ring (203), a spring (204) is fixedly arranged between the two connecting rings (203), the spring (204) is sleeved with the first support column (201) and the second support column (202), and the bottom of the second support column (202) is fixedly provided with an anti-skidding base (205).
4. The uniform shaking device for the immune cells as claimed in claim 1, wherein the driving part comprises a motor (401), the motor (401) is connected with the lower surface of the installation box body (1), an output shaft of the motor (401) penetrates through the installation box body (1) and extends into the installation box body (1) and is fixedly provided with a transmission shaft (402), one end of the transmission shaft (402) is rotatably connected with the top of the inner wall of the installation box body (1), the transmission shaft (402) is fixedly provided with a giant gear (403), the giant gear (403) is in equiangular gear connection with a plurality of gears (404), the gears (404) are respectively and fixedly provided with a transmission column (405), and one end of the transmission column (405) penetrates through the installation box body (1) and is rotatably connected with the installation box body (1) and is fixedly connected with the lower surface of the clamp installation box (501).
5. The device for uniformly shaking immune cells according to claim 1, wherein the clamping part (5) further comprises a plurality of inclined through grooves (502) arranged on the upper surface of the clamp installation box (501), the inner walls of the inclined through grooves (502) are respectively provided with a clamping block (511) in a sliding connection manner, one side of each clamping block (511) is fixedly provided with an arc-shaped rubber pad (512), and an adjusting component for displacing the clamping blocks (511) is arranged inside the clamp installation box (501).
6. The uniform shaking device for the immune cells according to claim 5, wherein the adjusting component comprises a double-threaded lead screw (507), two ends of the double-threaded lead screw (507) penetrate through a clamp installation box (501) to be rotatably connected with the clamp installation box (501) and are fixedly provided with adjusting columns (508), the double-threaded lead screw (507) is provided with two moving plates (509) in a threaded connection manner, one side of each moving plate (509) is fixedly provided with a compression spring (510), one end of each compression spring (510) is fixedly provided with a moving seat (506), the moving seats (506) are sleeved with the double-threaded lead screw (507), two sides of each moving seat (506) are fixedly provided with sliding rods (504), two sides of the clamp installation box (501) are respectively provided with a through sliding groove (505) corresponding to the sliding rods (504), the sliding rods (504) are sleeved with moving blocks (503), and the moving blocks (503) are respectively and fixedly connected with the clamping blocks (511).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220662888.5U CN218107489U (en) | 2022-03-25 | 2022-03-25 | Immune cell's even device that rocks |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220662888.5U CN218107489U (en) | 2022-03-25 | 2022-03-25 | Immune cell's even device that rocks |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218107489U true CN218107489U (en) | 2022-12-23 |
Family
ID=84494469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220662888.5U Expired - Fee Related CN218107489U (en) | 2022-03-25 | 2022-03-25 | Immune cell's even device that rocks |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218107489U (en) |
-
2022
- 2022-03-25 CN CN202220662888.5U patent/CN218107489U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20221223 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |