CN218067638U - Biochemical instrument beam split combination detection device - Google Patents

Abstract

The utility model relates to a biochemical appearance field, in particular to biochemical appearance beam split combination detection device, including the frame, be equipped with light source, filter wheel and switching slider in the frame, filter wheel with the switching slider sets gradually on the exit path of light source, be used for placing reagent between filter wheel and the switching slider, filter wheel with the frame rotates to be connected, the annular array has seted up a plurality of filtering holes on the filter wheel, and some filtering hole insides are equipped with the light filter that is used for filtering specific wavelength's light, still be equipped with the switching slider in the frame; the utility model aims at overcoming the not enough of prior art and providing a biochemical appearance beam split combination detection device can solve two kinds of detection modes of beam-splitting and back beam-splitting before the compatible of single instrument, satisfies the detection demand of basic unit low flux sample, reduces use cost and improves instrument detection efficiency and still need constantly research.

Description

Biochemical instrument beam split combination detection device

Technical Field

The utility model relates to a biochemical appearance field especially relates to a biochemical appearance beam split combination detection device.

Background

The existing colorimetric detection biochemical instruments based on the Lambert-beer law include front light splitting type enzyme labeling instruments based on pore plates (96/384 pores) and rear light splitting type biochemical instruments based on rectangular reaction cups. The conventional microplate reader adopts a light filter front-beam-splitting top-reading mode, and cannot be compatible with the detection requirements of a rear-beam-splitting biochemical analyzer which needs simultaneous detection of primary and secondary wavelengths. In practical application scenarios, when a sample is subjected to detection of physiological indexes or physicochemical indexes, the sample is often required to go to a special inspection department for detection by using a large-scale full-automatic biochemical analyzer, or to go to a special physicochemical analysis laboratory for detection by using a microplate reader. In many basic health units at present, because of the restriction of financial resources, material resources, sample volume and site space, a plurality of different types of detecting instruments and large-scale full-automatic biochemical instruments cannot be configured simultaneously, so that the problems of low detection efficiency, high use cost and easy error occurrence are caused.

The invention aims to solve the problem that a single instrument is compatible with two detection modes of a front light splitting type and a rear light splitting type, meet the detection requirement of low-flux samples in basic units, reduce the use cost and improve the detection efficiency of the instrument.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model aims at overcoming prior art's not enough and providing a biochemical appearance beam split combination detection device can solve two kinds of detection mode of beam-splitting and back beam-splitting before the compatible single instrument, satisfies the detection demand of basic unit low flux sample, reduces use cost and improves instrument detection efficiency.

In order to solve the technical problem, the technical scheme of the utility model is that:

the utility model provides a biochemical analyzer beam split combination detection device, includes the frame, be equipped with light source, filter wheel and switching slider in the frame, the filter wheel with the switching slider set gradually in on the exit path of light source the filter wheel with be used for placing reagent between the switching slider, the filter wheel with the frame rotates and connects, the filter takes turns to and has seted up a plurality of light filtering holes, part the inside light filter that is used for filtering specific wavelength's light that is equipped with in light filtering hole, still be equipped with the switching slider in the frame, switch the slider with frame sliding connection, be equipped with back spectral detector and photoelectric receiver on the switching slider.

Compare prior art, the utility model has the advantages that:

when the utility model needs to perform the front light splitting detection, the photoelectric receiver is driven by the switching slide block to move, the photoelectric receiver just rotates the filter wheel to the transmitting lens according to the required wavelength, so that the light emitted by the halogen lamp and positioned between the emergent hole and the incident hole passes through the optical filter, then passes through the reagent photoelectric receiver to receive the spectrum and analyze the spectrum, and the front light splitting detection is completed;

when the post-spectral detection is needed, the switching slide block drives the post-spectral detector to move, the post-spectral detector is opposite to the transmitting lens, the filter wheel is rotated to enable the filter hole without the optical filter to be positioned between the emergent hole and the incident hole, light emitted by the halogen lamp penetrates through the filter hole and irradiates the post-spectral detector to receive the spectrum, the spectrum is subjected to post-spectral detection analysis, and the post-spectral detection is completed.

Preferably, a mounting frame is arranged on the rack, a mounting groove and an exit hole are formed in the mounting frame, the mounting groove is communicated with the exit hole, and the exit hole is located on an exit path of the light source.

Preferably, the mounting frame is provided with a bolt and a pressing piece for pressing against the halogen lamp, and the bolt penetrates through the pressing piece and is in threaded connection with the mounting frame.

Preferably, a pressure spring is sleeved on the outer side of a screw rod of the bolt, and two ends of the pressure spring are respectively abutted against a nut of the bolt and the pressing sheet.

Preferably, the optical fiber light source further comprises an entrance hole, an optical fiber and an emission lens, the filter wheel, the entrance hole, the optical fiber, the emission lens and the switching slider are sequentially arranged along an exit path of the light source, two ends of the optical fiber respectively face the entrance hole and the emission lens, and the emission lens and the rear spectral detector are oppositely arranged at intervals.

Preferably, a connecting beam is arranged on the rack, a switching sliding groove is formed in the connecting beam, the switching sliding groove is connected with the switching sliding block in a sliding mode, a switching handle is fixedly arranged on the switching sliding block, and one end of the switching handle extends out of the inside of the switching sliding groove.

Preferably, a gear ring is arranged on the filter wheel, and the gear ring is meshed with a driving gear.

Preferably, the rack is further provided with a pore plate for placing a reagent and a mounting seat for placing the pore plate, the mounting seat is provided with an incubation bin, and the incubation bin is located on the emergent path of the light source.

Drawings

Fig. 1 is a schematic structural view of the present invention;

fig. 2 is a schematic structural view of the spectroscopic detection mechanism of the present invention;

FIG. 3 is a partially enlarged schematic view of the front light splitting mechanism;

FIG. 4 is a schematic structural view of a front light splitting mechanism;

FIG. 5 isbase:Sub>A schematic cross-sectional view taken at A-A of FIG. 4;

FIG. 6 is an enlarged schematic structural axial view of the coupling beam;

fig. 7 is an enlarged view of the structure of the connection beam.

Reference numerals: 10. a frame; 11. a pipetting mechanism; 20. a mounting frame; 21. a halogen lamp; 22. a driving gear; 23. a toothed ring; 24. a light filtering hole; 25. an optical filter; 26. a smooth wheel; 27. mounting grooves; 28. an exit aperture; 29. entering a perforation hole; 30. an optical fiber; 31. a bolt; 32. a pressure spring; 33. tabletting; 40. a connecting beam; 41. an emission lens; 42. switching the slide block; 43. switching the sliding chute; 44. a post-spectroscopic detector; 45. a photoelectric receiver; 46. a switching handle; 47. a mounting seat; 48. an orifice plate.

Detailed Description

The following detailed description of the embodiments of the present invention is made with reference to the accompanying drawings, so that the technical solution of the present invention can be more easily understood and grasped.

Referring to fig. 1 to 4, the present embodiment provides a spectroscopic combination detection apparatus for a biochemical analyzer, which can solve two detection modes of a single instrument compatible with a front spectroscopic type and a rear spectroscopic type, and satisfy the detection requirement of low-flux samples in the unit of the base level, and it is still necessary to continuously research on reducing the use cost and improving the detection efficiency of the instrument.

Including frame 10, be equipped with light source 21, filter wheel 26 and switch slider 42 in frame 10, filter wheel 26 with switch slider 42 set gradually in on the exit path of light source 21 filter wheel 26 with be used for placing reagent between the switch slider 42, filter wheel 26 with frame 10 rotates and is connected, annular array has seted up a plurality of filtration holes 24 on filter wheel 26, and some the inside light filter 25 that is used for filtering specific wavelength's light that is equipped with of filtration hole 24, still be equipped with on frame 10 and switch slider 42, switch slider 42 with frame 10 sliding connection, be equipped with back spectral detector 44 and photoelectric receiver 45 on the switch slider 42. ( It is worth mentioning that: the filter wheel 26 is preferably provided with 8 filter holes 24, at least one filter hole 24 being reserved for the passage of continuous light, which is shared by the rear spectroscopic detector 44; the remaining filter holes 24 may be pre-loaded with filters 25, the filters 25 preferably allowing passage of wavelengths: 340nm,405nm,450nm,492nm,520nm,550nm,570nm,595nm,620nm,650nm,690nm,740nm and the like, wherein more than 8 optical filters 25 can be reserved, and users can automatically replace the optical filters according to use requirements. )

As shown in fig. 1 and fig. 2, in order to facilitate the installation of the light source 21 and the overall layout of the device, an entrance hole 29 and an emission lens 41 are sequentially arranged on an exit path of the light source 21, the entrance hole 29 and the emission lens 41 are both located between the filter wheel 26 and the switching slider 42, the emission lens 41 and the rear split detector 44 are arranged in opposite intervals, an optical fiber 30 is arranged between the entrance hole 29 and the emission lens 41, two ends of the optical fiber 30 respectively face the entrance hole 29 and the emission lens 41, the light transmission direction is changed by the arrangement of the optical fiber 30, and further, the position of the light source 21 is changed so as to facilitate the overall layout of the device.

Referring to fig. 1 and 2, in order to perform detection and analysis on reagents in batches, a well plate 48 for placing the reagents and a mounting seat 47 for placing the well plate 48 are further provided on the rack 10, the well plate 48 is preferably a 96/384 well plate kit, an incubation device is provided inside the mounting seat 47, the incubation device includes an incubation chamber having a linear guide rail inside, the top and the bottom of the incubation chamber are provided with a light source 21 incident position and a photoelectric detection position which are scanned transversely and perpendicular to the linear guide rail, the bottom of the 96/384 well plate kit corresponding to the detection position is light-permeable, and a driving device connected through the connecting beam 40 drives the connecting beam 40 to move along the linear guide rail to perform detection and analysis on the reagents mounted on the 96/384 well plate kit.

Specifically, the method comprises the following steps:

referring to fig. 3 and 4, in order to facilitate switching between the front spectroscopic detection and the rear spectroscopic detection, a connecting beam 40 is disposed on the frame 10, a switching sliding groove 43 is disposed on the connecting beam 40, the switching sliding groove 43 is slidably connected to the switching sliding block 42, a switching handle 46 is fixedly disposed on the switching sliding block 42, one end of the switching handle 46 extends from the inside of the switching sliding groove 43, and the switching handle 46 is disposed to facilitate controlling the sliding of the switching sliding block 42.

As shown in fig. 3 and 4, in order to facilitate controlling the rotation of the filter wheel 26, a gear ring 23 is disposed on the filter wheel 26, the gear ring 23 is engaged with the driving gear 22, and the rotation of the gear ring 23 is controlled by the driving gear 22, so as to further control the rotation of the filter wheel 26.

Referring to fig. 3 and 5, in order to avoid light loss, a mounting frame 20 is disposed on the frame 10, a mounting groove 27 and an exit hole 28 are formed in the mounting frame 20, the mounting groove 27 is communicated with the exit hole 28, the exit hole 28 is located on an exit path of the light source 21, and light emitted by the light source 21 is emitted from the exit hole 28 only through the mounting groove 27 and the exit hole 28, so that light loss is avoided.

As shown in fig. 3, 4 and 5, in order to facilitate replacement of the light source 21, a bolt 31 and a pressing piece 33 for pressing against the light source 21 are disposed on the mounting bracket 20, the bolt 31 penetrates through the pressing piece 33 and is in threaded connection with the mounting bracket 20, the bolt 31 and the pressing piece 33 are disposed, and the pressing piece 33 is separated from the light source 21 by detaching the bolt 31, so that the light source 21 is conveniently detached for replacement.

As shown in fig. 3, 4 and 5, in order to further facilitate replacement of the light source 21, a compression spring 32 is sleeved outside a screw of the bolt 31, two ends of the compression spring 32 respectively abut against a nut of the bolt 31 and the pressing piece 33, and the light source 21 can be replaced without detaching and separating the bolt 31 and the pressing piece 33 through the arrangement of the compression spring 32.

In order to save cost, the light source 21 is a halogen lamp.

Referring to fig. 1, in order to realize high-precision liquid transfer of a reagent and a sample, a liquid transfer mechanism 11 is further arranged on the rack 10, the liquid transfer mechanism 11 comprises a liquid storage device, a three-axis execution device and a steel needle cleaning device, the reagent and the sample are subjected to high-precision liquid transfer through the three-axis execution device, and after liquid transfer is completed, the inside and the outside of the steel needle are cleaned through the steel needle cleaning device;

in order to regulate the temperature of the reagent sample, the pipetting mechanism 11 is regulated to further comprise a temperature control device for regulating the storage temperature of the reagent sample, as shown in fig. 1.

In order to realize high-precision liquid transfer of reagents and samples, the three-axis mechanical execution device for the reagents comprises a transverse driving device installed on a vertical plate, a longitudinal translation device capable of being driven by the transverse driving device to translate, and an independently driven vertical steel needle liquid taking and discharging device, and realizes high-precision liquid transfer of the reagents and the samples through the longitudinal translation device and the independently driven vertical steel needle liquid taking and discharging device.

The implementation principle is as follows: when the reagent needs to be detected, the reagent is added into the reagent bottle through the liquid-transferring mechanism 11, after the reagent is added, the reagent bottle is arranged on the pore plate 48, the pore plate 48 is arranged on the mounting seat 47, and the reagent bottle on the pore plate 48 is positioned between the switching slide block 42 and the emission lens 41;

when front light splitting detection is required, a switching handle 46 is manually slid, the switching handle 46 drives a photoelectric receiver 45 to move through a switching slide block 42, the photoelectric receiver 45 is over against an emission lens 41, a driving gear 22 drives a toothed ring 23 to rotate, the toothed ring 23 drives a filter wheel 26 to rotate, a specified optical filter 25 is positioned between an emergent hole 28 and an incident hole 29 according to required wavelength, light emitted by a light source 21 passes through the optical filter 25 through the emergent hole 28, then the light passes through the reagent through the incident hole 29 and an optical fiber 30 through the emission lens 41, the photoelectric receiver 45 receives a spectrum and analyzes the spectrum, and front light splitting detection is completed;

when post-spectral detection is required, the switching handle 46 is manually slid, the switching handle 46 drives the post-spectral detector 44 to move through the switching slider 42, the post-spectral detector 44 faces the emission lens 41, the driving gear 22 drives the gear ring 23 to rotate, the gear ring 23 drives the filter wheel 26 to rotate, the filter hole 24 without the optical filter 25 is positioned between the emergent hole 28 and the incident hole 29, light emitted by the light source 21 passes through the filter hole 24 through the emergent hole 28, then passes through the reagent through the incident hole 29 and the optical fiber 30 through the emission lens 41, the post-spectral detector 44 receives a spectrum and performs post-spectral detection analysis on the spectrum, and the post-spectral detection is completed;

when the front light splitting and the rear light splitting are performed, the connecting beam 40 is driven to move by the driving mechanism, and the transmitting lens 41 and the switching slide block 42 are driven by the connecting beam 40 to move in the direction of the transverse groove, so that the reagent at the transverse groove is subjected to front light splitting and rear light splitting detection and analysis;

when the light source 21 is aged or damaged, the pressing piece 33 is rotated, the pressing spring 32 continuously applies the pressing force to the pressing piece 33 in the process, the pressing piece 33 is separated from the light source 21, and the light source 21 is taken out and replaced.

Above only the typical example of the utility model discloses, in addition, the utility model discloses can also have other multiple concrete implementation manners, all adopt the technical scheme that equivalent replacement or equivalent transform formed, all fall in the utility model discloses the scope of claiming.

Claims (8)

1. The utility model provides a biochemical analyzer beam split combination detection device, its characterized in that, includes frame (10), be equipped with light source (21), filter wheel (26) and switch slider (42) in frame (10), filter wheel (26) with switch slider (42) and set gradually in on the exit path of light source (21) filter wheel (26) with be used for placing the reagent between switch slider (42), filter wheel (26) with frame (10) rotate to be connected, annular array has seted up a plurality of light filtering holes (24) on filter wheel (26), and part light filtering hole (24) inside is equipped with light filter (25) that are used for filtering specific wavelength's light, still be equipped with on frame (10) and switch slider (42), switch slider (42) with frame (10) sliding connection, be equipped with back beam split detector (44) and photoelectric receiver (45) on the switch slider (42).

2. The combined detection device of the biochemical analyzer light splitting according to claim 1, wherein the frame (10) is provided with a mounting rack (20), the mounting rack (20) is provided with a mounting groove (27) and an exit hole (28), the mounting groove (27) is communicated with the exit hole (28), and the exit hole (28) is located on an exit path of the light source (21).

3. The combined detection device of the biochemical analyzer spectrometer according to claim 2, wherein a bolt (31) and a pressing plate (33) for pressing the light source (21) are disposed on the mounting bracket (20), and the bolt (31) penetrates through the pressing plate (33) to be connected with the mounting bracket (20) by screw thread.

4. The biochemical analyzer spectroscopic combination detection device according to claim 3, wherein a compression spring (32) is sleeved outside a screw of the bolt (31), and two ends of the compression spring (32) are respectively pressed against a nut of the bolt (31) and the pressing sheet (33).

5. The combined detection device of the biochemical analyzer spectrometer, according to claim 1, further comprising an entrance hole (29), an optical fiber (30), and an emission lens (41), wherein the filter wheel (26), the entrance hole (29), the optical fiber (30), the emission lens (41), and the switching slider (42) are sequentially disposed along an exit path of the light source (21), two ends of the optical fiber (30) respectively face the entrance hole (29) and the emission lens (41), and the emission lens (41) faces the rear spectroscopic detector (44) at an interval.

6. The biochemical analyzer light splitting combination detection device according to claim 1, wherein a connection beam (40) is disposed on the frame (10), a switching sliding slot (43) is disposed on the connection beam (40), the switching sliding slot (43) is slidably connected to the switching sliding block (42), a switching handle (46) is fixedly disposed on the switching sliding block (42), and one end of the switching handle (46) extends from the inside of the switching sliding slot (43).

7. The combined detection device of biochemical analyzer spectroscopy according to claim 1, wherein the filter wheel (26) is provided with a gear ring (23), and the gear ring (23) is engaged with the driving gear (22).

8. The spectrographic combined detection device of a biochemical analyzer according to claim 1, characterized in that the frame (10) is further provided with a well plate (48) for placing a reagent and a mounting seat (47) for placing the well plate (48), the mounting seat (47) is provided with an incubation chamber, and the incubation chamber is located on the exit path of the light source (21).

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