CN218046496U - Dry crystallization equipment of nanocrystal - Google Patents
Dry crystallization equipment of nanocrystal Download PDFInfo
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- CN218046496U CN218046496U CN202221182044.7U CN202221182044U CN218046496U CN 218046496 U CN218046496 U CN 218046496U CN 202221182044 U CN202221182044 U CN 202221182044U CN 218046496 U CN218046496 U CN 218046496U
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- drying tank
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- tank
- hot air
- nanocrystal
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- 239000002159 nanocrystal Substances 0.000 title claims abstract description 21
- 238000002425 crystallisation Methods 0.000 title claims abstract description 18
- 230000008025 crystallization Effects 0.000 title claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 106
- 230000007246 mechanism Effects 0.000 claims abstract description 51
- 239000000725 suspension Substances 0.000 claims abstract description 21
- 238000010438 heat treatment Methods 0.000 claims abstract description 18
- 239000013078 crystal Substances 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000007921 spray Substances 0.000 claims abstract description 11
- 238000007664 blowing Methods 0.000 claims abstract description 5
- 238000005485 electric heating Methods 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 238000005507 spraying Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 239000003595 mist Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000010981 drying operation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The utility model discloses a nanocrystal drying and crystallizing device, wherein a supporting mechanism comprises a supporting base platform, and a supporting column is fixedly arranged on the top surface of the supporting base platform; an end cover is arranged at the top port of the drying tank; the bottom of the drying tank is provided with a hopper-shaped gathering outlet; the heating mechanism is arranged in the drying tank and used for heating the inside of the drying tank; the liquid guide mechanism is arranged in the drying tank and is used for spraying the suspension liquid in a mist shape in the drying tank; the hot air mechanism is arranged on the drying tank and used for blowing the suspension sprayed by the spray head to the obliquely upper part; the collecting mechanism is arranged on the top surface of the supporting base platform and is positioned under the drying tank, and is used for collecting crystals of the dried crystals. The utility model discloses a dry crystallization equipment of nanocrystal, the hot-blast mechanism that sets up upwards blows hot-blast slope, increases the time that the suspension stops in the inside of drying cylinder, makes its better dry crystallization, and whole process increases simply, conveniently, and dry crystallization effect is better, and the practicality is stronger.
Description
Technical Field
The utility model relates to a medicine preparation technical field especially relates to a dry crystallization equipment of nanocrystal.
Background
The stability of the drug nanocrystal suspension is poor, second phase particle coarsening is easy to occur, and the growth of the particle absorption substances enables the average particle size of drug particles in the suspension to be larger, so that the bioavailability is low, the drug residues in an animal body are excessive, and the drug safety is influenced. Therefore, a drying and crystallizing device is needed to dry and crystallize the drug nanocrystal suspension, so that the stability and the safety of the drug nanocrystal suspension are improved. The existing drying crystallization equipment has short drying time and poor crystallization effect.
SUMMERY OF THE UTILITY MODEL
In view of the above-mentioned drawbacks or deficiencies in the prior art, it would be desirable to provide a nanocrystal drying crystallization apparatus.
The utility model provides a nanocrystal drying and crystallizing device, which comprises a supporting mechanism, a drying tank, a heating mechanism, a liquid guiding mechanism, a hot air mechanism and a collecting mechanism; wherein,
the supporting mechanism comprises a supporting base table, and a supporting column is fixedly arranged on the top surface of the supporting base table;
an end cover is arranged at the top port of the drying tank; the bottom of the drying tank is provided with a hopper-shaped gathering outlet; an annular cavity is arranged inside the annular side wall of the drying tank; an annular support frame is fixedly arranged on the outer side wall surface of the drying tank, and the bottom surface of the annular support frame is fixedly connected with the top surface of the support column and used for supporting the drying tank in the air; an exhaust fan is arranged on the side wall of the drying tank;
the heating mechanism is arranged in the cavity and used for heating the interior of the drying tank;
the liquid guide mechanism is arranged in the drying tank and comprises a main pipeline which penetrates through the end cover and enters the drying tank, one end of the main pipeline, which is positioned in the drying tank, is uniformly communicated with a connecting pipeline along the circumferential direction, and one end of the connecting pipeline, which is far away from the main pipeline, is communicated with an annular pipeline; the bottom of the annular pipeline is uniformly provided with spray heads;
the hot air mechanism is arranged on the drying tank and used for blowing the suspension sprayed by the spray head to the obliquely upper direction;
the collecting mechanism is arranged on the top surface of the supporting base platform and positioned under the drying tank and used for collecting crystals of the dried crystals.
Preferably, the heating mechanism comprises a plurality of electric heating pipes which are arranged in the cavity in a vertical direction, and the electric heating pipes are uniformly arranged along the circumferential direction of the cavity; the cavity is filled with heat-conducting liquid.
Preferably, the hot air mechanism comprises an air heater circumferentially arranged on the top surface of the end cover, an air outlet of the air heater is communicated with a hot air conveying pipeline, and one end of the hot air conveying pipeline penetrates through the end cover and penetrates through the inner portion of the drying tank and is used for conveying hot air to the inner portion of the drying tank.
Preferably, an annular fixing piece is fixedly arranged on the side wall inside the drying tank, an air supply pipe is fixedly arranged on the annular fixing piece, an angle of 45 degrees is formed between two ends of the air supply pipe, one end of the air supply pipe is communicated with the hot air conveying pipeline, and the other end of the air supply pipe obliquely and upwards sends out hot air to increase the retention time of the suspension inside the drying tank.
Preferably, the collecting mechanism comprises a collecting tank arranged on the top surface of the supporting base platform and located under the drying tank, a collecting port is arranged at the top end of the collecting tank, and the collecting port is connected with the bottom end of the hopper type gathering outlet in a communicated mode.
Preferably, the device also comprises a control unit, wherein the control unit comprises a pressure sensor, a temperature sensor, a buzzer and a controller; wherein,
the pressure sensor is arranged on the top surface of the supporting base platform and positioned on the bottom surface of the collecting tank and used for monitoring the weight of the crystals collected in the collecting tank;
the temperature sensor is arranged on the wall surface inside the drying tank and used for monitoring the environment temperature inside the drying tank;
the buzzer is arranged on the side wall of the annular supporting frame and used for giving out sound early warning;
the controller is arranged on the top surface of the supporting base table, and the pressure sensor, the temperature sensor, the buzzer, the electric heating pipe, the air heater and the exhaust fan are all electrically connected with the controller.
Compared with the prior art, the beneficial effects of the utility model are that:
the utility model discloses a nanocrystal drying crystallization device can heat the drying cylinder inside through the heating mechanism that sets up, spray the suspension in the inside of drying cylinder through the drain mechanism that sets up and carry out the drying crystallization, wherein the hot-blast mechanism that sets up blows hot-blast slope upwards, increases the time that the suspension stays in the drying cylinder inside, makes its better drying crystallization; in addition, the collection mechanism is arranged, when the collection tank collects crystals with certain weight, the buzzer sends out sound early warning to timely replace the collection tank, the whole process is simple and convenient to increase, the drying crystallization effect is better, and the practicability is stronger.
It should be understood that what is described in this summary section is not intended to limit key or critical features of embodiments of the invention, nor is it intended to limit the scope of the invention.
Other features of the present invention will become apparent from the following description.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments made with reference to the following drawings:
fig. 1 is a schematic structural diagram of a nanocrystal drying and crystallizing device provided by an embodiment of the present invention;
FIG. 2 is a schematic view of the interior of the drying cylinder;
FIG. 3 is a schematic view of the structure of the hot air tunnel duct and the blast pipe;
FIG. 4 is a schematic structural diagram of a top view of the drying cylinder;
FIG. 5 is a schematic structural diagram of a top view of the liquid guiding mechanism;
the reference numbers in the figures: 1. supporting the base table; 2. a support pillar; 3. a drying tank; 4. an end cap; 5. a bucket-type gathering outlet; 6. a cavity; 7. an annular support frame; 8. an exhaust fan; 9. a main pipeline; 10. connecting a pipeline; 11. an annular duct; 12. a spray head; 13. an electric heating tube; 14. a hot air blower; 15. a hot air delivery duct; 16. a ring-shaped fixing member; 17. an air supply pipe; 18. a collection tank; 19. a collection port; 20. a temperature sensor.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and are not limiting of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
It should be noted that, in the case of no conflict, the embodiments and features of the embodiments of the present invention may be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Referring to fig. 1 to 5, an embodiment of the present invention provides a nanocrystal drying and crystallizing apparatus, including a supporting mechanism, a drying tank 3, a heating mechanism, a liquid guiding mechanism, a hot air mechanism, and a collecting mechanism; wherein,
the supporting mechanism comprises a supporting base table 1, and a supporting column 2 is fixedly arranged on the top surface of the supporting base table 1;
a drying tank 3, the top port of which is provided with an end cover 4; the bottom of the drying tank 3 is provided with a hopper-shaped gathering outlet 5; an annular cavity 6 is arranged inside the annular side wall of the drying tank 3; an annular support frame 7 is fixedly arranged on the outer side wall surface of the drying tank 3, and the bottom surface of the annular support frame 7 is fixedly connected with the top surface of the support column 2 and used for supporting the drying tank 3 in the air; an exhaust fan 8 is arranged on the side wall of the drying tank 3;
wherein, the exhaust fan 8 works after one drying operation is finished, and the wet air in the drying tank 3 is exhausted, so that the influence of overlarge air humidity on the next drying operation is avoided.
The heating mechanism is arranged inside the cavity 6 and used for heating the inside of the drying tank 3;
the liquid guiding mechanism is arranged inside the drying tank 3 and comprises a main pipeline 9 which penetrates through the end cover 4 and enters the drying tank 3, one end, located inside the drying tank 3, of the main pipeline 9 is evenly communicated with a connecting pipeline 10 along the circumferential direction, and one end, far away from the main pipeline 9, of the connecting pipeline 10 is communicated with an annular pipeline 11; the bottom of the annular pipeline 11 is uniformly provided with spray heads 12; wherein, a pressure pump can be arranged on the main pipeline 9 for increasing the spraying speed of the spray head 12 and improving the efficiency.
The hot air mechanism is arranged on the drying tank 3 and used for blowing the suspension sprayed by the spray head 12 obliquely upwards;
and the collecting mechanism is arranged on the top surface of the supporting base platform 1 and is positioned right below the drying tank 3, and is used for collecting crystals of the dried crystals.
In a preferred embodiment, the heating mechanism comprises an electric heating pipe 13 which is arranged in the cavity in a vertical direction, and the electric heating pipe 13 is provided with a plurality of electric heating pipes which are uniformly arranged along the circumferential direction of the cavity 6; the cavity 6 is filled with heat-conducting liquid for carrying out high-temperature heating drying crystallization on the suspension inside the drying tank 3.
In a preferred embodiment, the hot air mechanism comprises a hot air blower 14 arranged on the top surface of the end cover 4 along the circumferential direction, an air outlet of the hot air blower 14 is communicated with a hot air conveying pipe 15, and one end of the hot air conveying pipe 15 penetrates through the end cover 4 and penetrates into the drying tank 3 to be arranged for conveying hot air to the inside of the drying tank 3.
In a preferred embodiment, a ring-shaped fixing member 16 is fixedly arranged on the side wall inside the drying tank 3, an air supply pipe 17 is fixedly arranged on the ring-shaped fixing member 16, an angle of 45 degrees is arranged between two ends of the air supply pipe 17, one end of the air supply pipe 17 is connected with a hot air conveying pipeline 15 in a communication mode, and the other end of the air supply pipe 17 obliquely upwards supplies hot air for prolonging the retention time of suspension inside the drying tank 3 and improving the drying crystallization effect.
In a preferred embodiment, the collecting mechanism comprises a collecting tank 18 arranged on the top surface of the support base 1 and positioned right below the drying tank 3, the top end of the collecting tank 18 is provided with a collecting port 19, and the collecting port 19 is communicated with the bottom end of the bucket-type gathering outlet 5.
In a preferred embodiment, the device further comprises a control unit, wherein the control unit comprises a pressure sensor, a temperature sensor 20, a buzzer and a controller; wherein,
the pressure sensor is arranged on the top surface of the support base table 1 and positioned on the bottom surface of the collecting tank 18 and used for monitoring the weight of the crystals collected in the collecting tank 18;
the temperature sensor is arranged on the wall surface inside the drying tank 3 and used for monitoring the environment temperature inside the drying tank 3;
the buzzer is arranged on the side wall of the annular supporting frame 7 and used for giving out sound early warning;
and the controller is arranged on the top surface of the supporting base table 1, and the pressure sensor, the temperature sensor 20, the buzzer, the electric heating pipe 13, the air heater 14 and the exhaust fan 8 are all electrically connected with the controller.
The utility model discloses a theory of operation: starting a heating mechanism, heating the inside of the drying tank 3, conveying the suspension to the inside of the annular pipeline 11 through the main pipeline 9, continuously spraying the suspension in a fog shape in the drying tank 3 through the spray head 12, wherein the hot air blower 14 works simultaneously, continuously sending hot air into the inside of the drying tank 3, obliquely and upwards blowing the suspension, increasing the retention time of the suspension in the drying tank 3, improving the drying and crystallization effects, and instantly evaporating the moisture in the fog-shaped suspension in the high-temperature environment in the drying tank 3 to obtain dried nanocrystals, and collecting the nanocrystals by entering the inside of the collection tank 18 along the hopper-shaped gathering outlet 5; wherein, the temperature sensor 20 is used for monitoring the annular temperature inside the drying tank 3, when the temperature sensor 20 monitors that the internal environment temperature of the drying tank 3 exceeds the set temperature range, a signal is transmitted to the controller, and the controller controls the electric heating pipe 13 to start or stop working, thereby realizing the temperature control function; when the pressure sensor monitors that the weight of the crystals collected in the collecting tank 18 reaches a set value, a signal is transmitted to the controller, and the controller controls the buzzer to sound to prompt a worker to replace the collecting tank in time.
In the description of the present specification, the terms "connect", "mount", "fix", and the like are to be understood in a broad sense, for example, "connect" may be a fixed connection, a detachable connection, or an integral connection; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as the case may be.
In the description of the present application, the description of the terms "one embodiment," "some embodiments," or the like, means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (6)
1. A nanocrystal drying and crystallizing device is characterized by comprising a supporting mechanism, a drying tank, a heating mechanism, a liquid guide mechanism, a hot air mechanism and a collecting mechanism; wherein,
the supporting mechanism comprises a supporting base table, and a supporting column is fixedly arranged on the top surface of the supporting base table;
an end cover is arranged at the top port of the drying tank; the bottom of the drying tank is provided with a hopper-shaped gathering outlet; an annular cavity is arranged inside the annular side wall of the drying tank; an annular support frame is fixedly arranged on the outer side wall surface of the drying tank, and the bottom surface of the annular support frame is fixedly connected with the top surface of the support column and used for supporting the drying tank in the air; an exhaust fan is arranged on the side wall of the drying tank;
the heating mechanism is arranged in the cavity and used for heating the interior of the drying tank;
the liquid guide mechanism is arranged in the drying tank and comprises a main pipeline which penetrates through the end cover and enters the drying tank, one end of the main pipeline, which is positioned in the drying tank, is uniformly communicated with a connecting pipeline along the circumferential direction, and one end of the connecting pipeline, which is far away from the main pipeline, is communicated with an annular pipeline; the bottom of the annular pipeline is uniformly provided with spray heads;
the hot air mechanism is arranged on the drying tank and used for blowing the suspension sprayed by the spray head to the obliquely upper direction;
the collecting mechanism is arranged on the top surface of the supporting base table and is positioned under the drying tank and used for collecting crystals of the dry crystals.
2. The nanocrystal drying and crystallization device as claimed in claim 1, wherein the heating mechanism comprises a plurality of electric heating pipes arranged in a vertical direction inside the cavity, and the electric heating pipes are uniformly arranged along a circumferential direction of the cavity; the cavity is filled with heat-conducting liquid.
3. The nanocrystal drying and crystallizing device as claimed in claim 2, wherein the hot air mechanism comprises a hot air blower circumferentially disposed on the top surface of the end cap, an air outlet of the hot air blower is connected to a hot air delivery pipe, and one end of the hot air delivery pipe passes through the end cap and penetrates into the interior of the drying tank for delivering hot air to the interior of the drying tank.
4. The nanocrystal drying and crystallizing device as claimed in claim 3, wherein a ring-shaped fixing member is fixedly arranged on the side wall inside the drying tank, an air supply pipe is fixedly arranged on the ring-shaped fixing member, an angle of 45 ° is arranged between two ends of the air supply pipe, one end of the air supply pipe is connected with the hot air delivery pipeline, and the other end of the air supply pipe obliquely upwards sends out hot air for increasing the residence time of the suspension inside the drying tank.
5. The nanocrystal drying and crystallization device as claimed in claim 4, wherein the collection mechanism comprises a collection tank disposed on the top surface of the support base platform and located right below the drying tank, and a collection port is disposed at the top end of the collection tank and connected to the bottom end of the hopper-shaped gathering outlet in a communicating manner.
6. The nanocrystal drying and crystallization device of claim 5, further comprising a control unit, wherein the control unit comprises a pressure sensor, a temperature sensor, a buzzer and a controller; wherein,
the pressure sensor is arranged on the top surface of the supporting base platform and positioned on the bottom surface of the collecting tank and used for monitoring the weight of the crystals collected in the collecting tank;
the temperature sensor is arranged on the wall surface inside the drying tank and used for monitoring the environment temperature inside the drying tank;
the buzzer is arranged on the side wall of the annular supporting frame and used for giving out sound early warning;
the controller is arranged on the top surface of the supporting base table, and the pressure sensor, the temperature sensor, the buzzer, the electric heating pipe, the air heater and the exhaust fan are electrically connected with the controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221182044.7U CN218046496U (en) | 2022-05-17 | 2022-05-17 | Dry crystallization equipment of nanocrystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221182044.7U CN218046496U (en) | 2022-05-17 | 2022-05-17 | Dry crystallization equipment of nanocrystal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218046496U true CN218046496U (en) | 2022-12-16 |
Family
ID=84431680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221182044.7U Active CN218046496U (en) | 2022-05-17 | 2022-05-17 | Dry crystallization equipment of nanocrystal |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218046496U (en) |
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2022
- 2022-05-17 CN CN202221182044.7U patent/CN218046496U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231122 Address after: North Tower 407, Building 4, Rongchuang Rongsheng Square, Binhai Zhongguancun Science and Technology Park, Binhai New Area Economic and Technological Development Zone, Tianjin, 300453 Patentee after: Carbon Hydrogen Oxygen (Tianjin) Technology Co.,Ltd. Address before: Room 1704-9179, Block A, Queshi International Building, Xiangluowan, Tianjin Binhai New Area Pilot Free Trade Zone (Central Business District) 300457 Patentee before: Tianjin ConocoPhillips New Material Technology Co.,Ltd. |