CN217938369U

CN217938369U - Vascular repair system

Info

Publication number: CN217938369U
Application number: CN202221900632.XU
Authority: CN
Inventors: 王彩霞; 刘翔; 刘强宪; 余贤涛; 金旻
Original assignee: Minimally Invasive Investment Holdings Ltd
Current assignee: Shanghai Minimally Invasive Medical Technology Co ltd
Priority date: 2022-07-22
Filing date: 2022-07-22
Publication date: 2022-12-02
Anticipated expiration: 2032-07-22

Abstract

The utility model relates to the technical field of medical equipment, a vascular repair system is provided, wherein vascular repair system includes: the laser generation module is used for generating first laser for repairing the inner wall of the blood vessel and second laser for ablating target tissues in the blood vessel, and the wavelength range of the first laser is 600-1064 nm; and the output module is used for being intervened in a blood vessel and transmitting the first laser and the second laser. The utility model discloses a repair system has integrated the function that vascular wall was restoreed and the blood vessel melts, improves and melts efficiency and security, not only falls to the minimum with the operation risk, still utilizes laser restoration to improve treatment, has solved the untimely problem of melting back blood vessel wall restoration of ubiquitous among the vascular operation, has improved the validity and the reliability of operation, and the postoperative complication and the postoperative that significantly reduce are to the reliance of medicine, have reduced the infection rate and the blood vessel restenosis's hidden danger in the operation and after the operation.

Description

Vascular repair system

Technical Field

The utility model relates to the technical field of medical equipment, in particular to blood vessel repair system.

Background

Atherosclerosis is a chronic lesion of the inner wall of a blood vessel characterized by lipid accumulation and inflammation, which is better to occur in large and medium arteries, and the lesion process comprises vascular inflammation, endothelial injury, phenotypic transformation and migration proliferation of vascular smooth muscle cells, foam cell formation, cell death, lipid and cholesterol accumulation, thrombosis and the like.

The existing treatment mode of atherosclerosis is mechanical thrombus removal, and the mechanical thrombus removal has the advantages of high blood vessel recanalization rate, low cerebral hemorrhage incidence rate, recanalization time, prolonged treatment time window and the like. The mechanical thrombus removal has the defects of insufficient accuracy, delayed blood vessel recanalization due to operation preparation and operation, high requirements on operators and equipment and the like.

On the basis, a laser angioplasty method for treating atherosclerosis is provided, wherein a laser product is combined with an optical fiber to be used for porridge-like thrombus and semi-porridge-like thrombus to perform vascular treatment, specifically, the optical fiber is conveyed into a blood vessel, laser is transmitted through the optical fiber, atherosclerotic plaques and thrombus of coronary artery and peripheral blood vessel are opened through laser, and the blood vessel is caused to flow back and forth, so that an effective and novel treatment means is created. The laser ablates atheroma tissue to achieve blood vessel forming by the action mechanisms of thermal effect, photoacoustic injury, photochemistry and the like according to the emission characteristics of radioactive substances and the mode of transmitting energy to the tissue, and the main mechanism is that target tissue is destroyed and ablated by the photochemical and photomechanical action.

Although laser angioplasty can remove thrombus by laser ablation, the safety problem of embolism still exists at present, laser can remove plaque and thrombus, and simultaneously, the inner wall of a blood vessel is easy to be damaged, and the restenosis after the blood vessel operation is easy to occur in the process of wound healing and proliferation of the inner wall of the blood vessel.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a blood vessel repair system, this repair system have integrateed the function of vascular inner wall restoration and blood vessel ablation recanalization, can restore the vascular inner wall after the ablation recanalization, thereby alleviate the neointimal bodiness degree of vascular injury department restoration in-process and prevent and treat the emergence of ablation postoperative restenosis.

The utility model provides a vascular repair system, include:

the laser generation module is used for generating first laser for repairing the inner wall of the blood vessel and second laser for ablating target tissues in the blood vessel, and the wavelength range of the first laser is 600-1064 nm;

and the output module is connected with the laser generation module and used for intervening in a blood vessel and transmitting the first laser and the second laser.

Further, the energy density of the first laser generated by the laser generation module is adjustable.

Further, the wavelength range of the second laser is 198nm to 400nm.

Further, the output module comprises a first output part and a second output part, the first output part is used for transmitting the first laser and enabling the first laser to irradiate the inner wall of the blood vessel, and the second output part is used for transmitting the second laser and enabling the second laser to irradiate the target tissue in the blood vessel.

Further, the vascular repair system further comprises a delivery catheter for implantation into the blood vessel to form a delivery channel, the delivery catheter having a lumen for introducing the first output element or the second output element into the blood vessel through the lumen; or, the conveying catheter is provided with two lumens for leading the first output part and the second output part into the blood vessel through the two lumens respectively.

Further, the first output member is a dispersion optical fiber, a bundle optical fiber or a lateral output optical fiber; and/or the second output member is a bundled optical fiber.

Further, the laser generation module comprises a semiconductor laser and an ultraviolet laser, the semiconductor laser is used for generating the first laser, and the ultraviolet laser is used for generating the second laser.

Furthermore, the vascular repair system further comprises a control module, wherein the control module is in communication connection with the laser generation module and is used for selecting the light emitting mode of the laser generation module, and the light emitting mode at least comprises a first laser independent light emitting mode, a second laser independent light emitting mode and a first laser and second laser simultaneous light emitting mode.

Further, the control module is further configured to: and configuring the starting of the first laser single light emitting mode to be after the starting of the second laser single light emitting mode.

Furthermore, the vascular repair system also comprises a power supply module, wherein the power supply module is used for supplying power to the laser generation module and the control module.

Further, the vascular repair system further comprises a blood pressure acquisition unit and an alarm module, wherein the blood pressure acquisition unit and the alarm module are both in communication connection with the control module, and the control module is further configured to: and receiving the blood pressure value of the intervened blood vessel collected by the blood pressure collecting unit, judging whether the blood pressure value is smaller than a set value, and controlling the alarm module to give an alarm if the blood pressure value is smaller than the set value.

To sum up, the utility model provides a blood vessel repair system includes:

and the output module is used for being intervened in a blood vessel and transmitting the first laser and the second laser.

So configured, the output module can irradiate the inner wall of the blood vessel with laser in a certain wavelength range, and utilizes the photobiological regulation effect to generate energy and change on microstructure depending on the absorption of light by chromophore existing in mitochondria and ion channels in cells so as to activate cell signals, up-regulate transcription factors and increase the expression of protective genes. Vascular endothelial cells are the main regulators of vascular tone balance and vascular growth, have very important functions in cardiovascular diseases, and photobiological regulation has protective effects on endothelial cells, and are mainly reflected in the aspects of stimulating cell proliferation, resisting inflammation and apoptosis and the like. In addition, vascular smooth muscle cells are the main component of the artery wall, and laser-inducible smooth muscle cell apoptosis in corresponding wavelength directions is beneficial to reducing the thickening degree of the intima in the process of repairing the vascular injury, thereby preventing and treating restenosis after ablation.

The repair system can generate the first laser and the second laser through the laser generation module, integrates the functions of vessel wall repair and vessel ablation, and improves the safety problem and the effectiveness problem of vessel ablation by using a single ultraviolet laser in the past; the blood vessel damage problem after ultraviolet ablation can be repaired through the laser of dual wavelength, and the whole solution of once laser operation blood vessel plaque ablation and blood vessel wall repair is realized through one set of repair system. Through the application of two kinds of laser in the operation, improve and melt efficiency and security, not only reduce the operation risk to minimum, still utilize laser to restore and improve treatment, solved the general problem of melting back vascular wall repair untimely in the vascular operation, improved the validity and the reliability of operation, the postoperative complication and the postoperative dependence to the medicine that significantly reduce have reduced the infection rate and the blood vessel restenosis's in the operation and after the operation hidden danger.

Drawings

Fig. 1 is a schematic view of a structural system of embodiment 1 of the present invention;

fig. 2 is a schematic diagram of a structural system of embodiment 1 of the present invention;

fig. 3 is a schematic structural diagram of embodiment 1 of the present invention;

fig. 4 is a schematic structural view of a first output element according to embodiment 1 of the present invention;

fig. 5 is a schematic structural view of a second output element according to embodiment 1 of the present invention;

fig. 6 is a schematic structural view of a delivery catheter according to embodiment 1 of the present invention;

fig. 7 is a schematic structural view of a conveying conduit according to embodiment 2 of the present invention;

wherein the reference numbers are as follows:

10-a laser generation module; 11-a semiconductor laser; 12-an ultraviolet laser;

20-an output module; 21-a first output; 211-a dispersive optical fiber; 212-a first conduit; 213-a first joint; 22-a second output; 221-quartz bundled fibers; 222-luer fitting; 223-a second linker;

30-a control module;

40-an alarm module;

50-a power supply module; 51-a first drive power supply; 52-a second drive power supply; 53-switching power supply;

60-delivery catheter, 61-lumen; 61' -a first lumen; 62' -second lumen.

Detailed Description

The wafer alignment apparatus of the present invention will be described in detail with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become more apparent from the following description. It should be noted that the drawings are in simplified form and are not to precise scale, and are provided for convenience and clarity in order to facilitate the description of the embodiments of the present invention.

In the utility model, the "outer diameter" and the "inner diameter" correspond to the diameter size for the circular structure, and for the non-circular structure, the inner diameter refers to the diameter of the inscribed circle and the outer diameter refers to the diameter of the circumscribed circle; "axial" for a cylindrical rod corresponds to the direction of its central axis, and for a non-cylindrical rod corresponds to the length of the rod; in the utility model, the radial direction is the radial direction when the sleeve or the implantation rod is taken as the reference and the sleeve is taken as the reference;

in the present invention, "proximal" and "distal" are relative orientations, relative positions, directions of elements or actions with respect to each other from the perspective of a physician using the product, although "proximal" and "distal" are not limiting, but "proximal" generally refers to the end of the product that is near the physician during normal operation, and "distal" generally refers to the end that is first introduced into the patient.

In the present invention, the limitation of parallel and perpendicular should not be understood in a narrow sense as the relation of absolute perpendicular or absolute parallel, and should be understood as allowing the error of the set angle on the premise of corresponding perpendicular or parallel, the set angle is usually ± 5 °, and the specific value of the set angle is determined according to the required working condition;

as used in this application, the singular forms "a", "an" and "the" include plural referents, the term "or" is generally employed in a sense including "and/or," the terms "a", "an" and "the" are generally employed in a sense including "at least one", the terms "at least two" and "two or more" are generally employed in a sense including "two or more", and moreover, the terms "first", "second" and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or imply that there is a number of technical features being indicated. Thus, features defined as "first", "second", "third" may explicitly or implicitly include one or at least two of the features. Furthermore, as used in the present application, the terms "mounted," "connected," and "disposed" on another element should be construed broadly, and generally only mean that there is a connection, coupling, fit, or drive relationship between the two elements, and that the connection, coupling, fit, or drive between the two elements can be direct or indirect through intervening elements, and should not be construed as indicating or implying any spatial relationship between the two elements, i.e., an element can be located in any orientation within, outside, above, below, or to one side of another element unless the content clearly dictates otherwise. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art. Moreover, directional terminology, such as above, below, up, down, upward, downward, left, right, etc., is used with respect to the exemplary embodiments as they are shown in the figures, with the upward or upward direction being toward the top of the corresponding figure and the downward or downward direction being toward the bottom of the corresponding figure.

The elastic fiber of the tunica media of the vessel wall has the function of retracting the expanded vessel, and the collagen fiber has the function of maintaining tension and has the function of supporting. The amorphous matrix in the connective tissue of the vessel wall contains proteoglycans whose composition and water content are slightly different depending on the kind of blood vessel. Restenosis, as a response to injury of the inner wall of a blood vessel, can be considered at least in part as a problem with proliferation or a specific wound healing process. Restenosis is a multifactorial effect with the major pathological change being that the proliferation of medial smooth muscle cells migrates to the intima and produces a large amount of matrix causing vascular remodeling that results in a significant thickening of the intima, a narrowing of the lumen or even a complete occlusion.

Based on the above technical problem, the present embodiment provides a vascular repair system, including:

a laser generation module 10 for generating a first laser for endovascular wall repair and a second laser for endovascular target tissue ablation;

the output module 20 is connected with the laser generation module, and is used for intervening in a blood vessel and transmitting first laser so that the first laser irradiates the inner wall of the blood vessel for repairing the blood vessel; and the laser is also used for transmitting second laser, so that the second laser irradiates target tissues in the blood vessel to ablate the target tissues, the wavelength range of the first laser is 600 nm-1064 nm, and the wavelength range of the second laser is 198 nm-400 nm.

The laser generating module 10 generally uses an existing laser, the output module 20 is used for transmitting laser, and a commonly used medium for transmitting laser is an optical fiber.

The existing implantation mode can be adopted when the output module 20 intervenes in a blood vessel, the existing minimally invasive surgery for blood vessel recanalization needs the puncture of a conveying catheter to build a conveying system, the modes of femoral artery puncture access and radial artery puncture access are generally used in clinic, firstly, a guide wire and a conveying catheter are inserted, the conveying catheter is driven by the guide wire to finally reach a target blood vessel along the artery access, and the output module 20 reaches the guided position through the conveying system built on the conveying catheter;

laser in a certain wavelength range irradiates human tissues to cause mitochondria to generate a biological photochemical effect, so that the catalase activity of the mitochondria is increased. This increases cellular metabolism, increases glycogen content, increases protein synthesis and increases adenosine triphosphate breakdown, thus promoting cellular synthesis, healing of wounds and ulcers, healing of fractures, accelerating regeneration of damaged nerves, and increasing phagocytosis of leukocytes. Meanwhile, the product can be used in combination with special photosensitive dressing for treating acne. The red light or near infrared light can stimulate the increase of ATP of a human body, and cytochrome C oxidase absorbs light, so that the photobiological regulation effects of promoting vascular injury repair, enhancing the function of an immune defense system, promoting metabolism, reducing blood viscosity, regulating blood fat, accelerating the removal of inflammatory mediators and the absorption of tissue edema and the like can be realized.

During the natural repair process of the inner wall of the blood vessel, the secretion of vascular cell adhesion molecules-1 and intercellular adhesion molecules-1 is increased, and leukocytes migrate and adhere to the endothelial injury under the mediation of various chemotactic factors, so as to be gathered under the endothelium, and the leukocytes trigger the local chronic inflammatory reaction of the blood vessel with inflammatory mediators secreted by endothelial cells, thereby mediating the formation of plaques. The research of the implementation finds that the high-low energy density red light or near-infrared light is used for irradiating the inner wall of the blood vessel, and the biological regulation effect is mainly utilized, so that the energy density of the first laser generated by the laser generation module 10 is adjustable, and the low energy density promotes the proliferation of vascular endothelial cells and the anti-inflammatory apoptosis. The vascular smooth muscle cells are the main component of the artery wall, and the red light or near infrared light induced smooth muscle cell apoptosis with high energy density is beneficial to reducing the thickening degree of the intima after the angioplasty so as to prevent and treat the occurrence of restenosis after the ablation; these effects may be related to the following mechanisms: influence the intracellular calcium ion flow, promote the release of NO and stabilize and activate mitochondria.

The first laser has a wavelength of 600 nm-1064 nm, preferably 635nm or 810nm, an output average power of 200 mW, and an energy density of 0.2-5J/cm ² Wherein the low energy density is generally 0.2 to 1J/cm ² The high and low energy density is generally 1 to 3J/cm ² The first laser may be output continuously or in pulses.

The utility model discloses further make laser generation module 10 still be used for producing the second laser; the laser generation module 10 includes a semiconductor laser 11 and an ultraviolet laser 12, where the semiconductor laser 11 is configured to generate first laser light, and the ultraviolet laser 12 is configured to generate second laser light.

The semiconductor laser 11 can be a KD type multi-wavelength pluggable semiconductor laser, the energy density of red light or near infrared light generated by the semiconductor laser 11 can be adjusted, and the low energy density range is preferably 0.2-1J/cm ² The vascular repair can be performed by promoting vascular endothelial cell proliferation with low energy and reducing inflammatory reaction, and can also be performed by more than 1J/cm ² The high energy of (a) inhibits smooth muscle cell proliferation and inhibits plaque reformation, wherein specific values of the low energy density and the high energy density can be adaptively adjusted according to individual differences.

The ultraviolet laser 12 can be Gama type high-frequency ultraviolet pulse laser, the wavelength range generated by the ultraviolet laser is 198-400 nm, the ultraviolet high repetition frequency pulse laser with the wavelength of 355nm is preferred, the laser is solid ultraviolet laser, the single pulse energy can reach 125mj, the pulse width is 10ns, the repetition frequency is 100Hz, the step can be adjusted, the repetition frequency is high, the effect on different types of plaques is achieved, the noise is relatively low, the preheating time is short, the ultraviolet lasers of the type series can output lasers with various wavelengths by switching the frequency doubling module, and the lasers with different wavelengths can be freely switched.

The application of the second laser is that the optical fiber is utilized to guide the ultraviolet high-energy laser with nanosecond-level pulse width into the blood vessel cavity, so that the ultraviolet high-energy laser directly acts on the narrow occlusion part, and the target tissue at the narrow occlusion part is crushed into micron-sized particles for ablation by virtue of multiple effects such as photochemistry, photothermy, optomechanical and the like, thereby achieving the effects of reducing volume, expanding the lumen and realizing minimally invasive treatment. This example uses 355nm frequency tripled Nd: YAG solid laser source, laser pulse width is short, higher peak power can be obtained with smaller laser energy, and plaque target tissue can be effectively ablated; meanwhile, the heat effect is small, and the risk of blood vessel perforation is reduced.

The device has simple structure and easy operation, and can adjust the corresponding output laser parameters according to the treatment of different cavity diseases.

Wherein the first laser may be generated after the second laser such that the first laser is used to irradiate the inner wall of the ablated blood vessel.

In order to improve the efficiency of laser ablation of target tissues and the capability of completely calcifying plaques, the energy of the second laser should be increased as much as possible, but the risk brought by the increase of the laser energy is that the probability of damage to the inner wall of a blood vessel is increased, and then great hidden danger is brought to restenosis of the blood vessel. Therefore, although the laser surgical equipment is widely applied to a plurality of clinics at present, the defects of single curative effect, low precision and large damage exist, and the application of the laser surgical equipment in high-precision surgery is limited.

In general, the principle of treatment of major arterial vascular lesions after laser ablation surgery is mainly to restore arterial continuity, the earlier the damaged artery is better repaired, preferably immediately after ablation, and the delay in time will greatly increase the chance of intravascular thrombosis or infection, thus reducing the possibility of restoration of blood circulation; in the embodiment, the functions of inner wall repair of blood vessels and revascularization by ablation are realized, so that the treatment principle of postoperative main arterial vessel injury can be met; the blood vessel repair function in the system can carry out irradiation repair on the inner wall position of the ablated blood vessel, solves the contradiction between laser energy and laser efficiency, improves the curative effect of the minimally invasive surgery and is beneficial to expanding the application field of the laser surgery.

For example, after the target tissue is removed by ablation with the second laser with the wavelength of 355nm, the first laser with the wavelength of 635nm or 810nm can be introduced into the inner wall of the blood vessel, and the irradiation repair treatment is performed on the position on the inner wall of the blood vessel after the target tissue is ablated, so that the vascular repair and the ablation function of the target tissue are complementary, the problem of contradiction between ablation efficiency and inner wall damage of the blood vessel in the ablation process is solved, the laser ablation operation effect is improved, and the application range of the laser operation is expanded.

In addition, in other alternative embodiments, the first laser may be used alone, and the first laser may be used to apply radiation treatment to the inner wall of the blood vessel at an early stage of the disease. The irradiation of the first laser can prevent thrombosis in the initial stage, reduce vasoconstriction active substances, promote vasoconstriction active substances, reduce venous thrombosis components in blood, and is beneficial to avoiding cardiovascular and cerebrovascular thrombosis diseases, such as cerebral apoplexy, cerebral infarction, myocardial infarction, coronary heart disease, etc.

In the embodiment, the functions of vessel wall repair and vessel ablation are integrated in the vessel repair system, the repair system is actually a dual-wavelength laser plaque ablation combined vessel wall repair system and a multifunctional vessel repair system, and the safety problem and the effectiveness problem of vessel ablation performed by a single ultraviolet laser in the past are improved; the blood vessel damage problem after ultraviolet ablation can be repaired through the laser of dual wavelength, and the whole solution of once laser operation blood vessel plaque ablation and blood vessel wall repair is realized through one set of repair system. Through the application of two kinds of laser in the operation, improve and melt efficiency and security, not only reduce the operation risk to minimum, still utilize laser to restore and improve treatment, solved the general problem of melting back vascular wall repair untimely in the vascular operation, improved the validity and the reliability of operation, the postoperative complication and the postoperative dependence to the medicine that significantly reduce have reduced the infection rate and the blood vessel restenosis's in the operation and after the operation hidden danger.

Further, the output module 20 includes a first output 21 and a second output 22, the first output 21 is used for transmitting the first laser and irradiating the first laser to the inner wall of the blood vessel for blood vessel repair, and the second output 22 is used for transmitting the second laser and irradiating the second laser to the target tissue in the blood vessel to ablate the target tissue; the first output 21 and the second output 22 are optical fibers.

The first laser is narrow spectrum and has extremely strong biological tissue penetrability, the first laser is directly transmitted into the blood vessel through the first output part 21, the first output part 21 can be a dispersion optical fiber, a bundle optical fiber and a lateral output optical fiber, and the head of the first output part 21 preferably uses the dispersion optical fiber after special treatment, so that the first laser is uniformly irradiated on the inner wall of the blood vessel.

Referring to fig. 4, the first output element 21 includes a dispersion fiber 211, a first conduit 212, and a first joint 213, wherein a proximal end of the dispersion fiber is located in the first conduit 212, the proximal end of the first conduit 212 is connected to the first joint 213, the proximal end of the dispersion fiber is connected to the first joint 213, the first joint 213 is used for being connected to the semiconductor laser 11, so that the first laser light generated in the semiconductor laser 11 enters the dispersion fiber to be transmitted, a distal end of the dispersion fiber is a dispersion end, and the first laser light emits light through the distal end of the dispersion fiber in a dispersion manner, so that the first laser light uniformly irradiates the inner wall of the blood vessel.

The second output part 22 is an ultraviolet laser fiber bundle which enters the intravascular treatment through the catheter; the second output member 22 is preferably a quartz bundled optical fiber, which is fastened together by a plurality of optical fibers, as shown in fig. 5, the second output member 22 includes a quartz bundled optical fiber 221, a luer 222 and a second connector 223, wherein the quartz bundled optical fiber 221 is connected with the luer 222 and the second connector 223, the luer 222 can inject saline through a syringe, the saline is used for cooling to reduce the thermal effect and can also be used for cleaning the treatment surface, and the second connector 223 is connected to the ultraviolet laser 12; the second output 22 may be purchased from existing equipment, for example the second output 22 may be of the UVLC type, the second output 22 being a laser ablation catheter of nominal 1.54mm outside diameter and nominal 3m length, 10N tensile strength, 500mm minimum bend working radius of the fibre, the second output 22 being ethylene oxide sterilised.

The structures of the first joint and the second joint can adopt the existing joint structures, the semiconductor laser 11 and the ultraviolet laser 12 purchase the existing equipment, and the connection mode of the first joint and the semiconductor laser 11 and the connection mode of the second joint and the ultraviolet laser 12 are the prior art and are not described again;

the first output part 21 and the second output part 22 can enter the blood vessel of the human body through the guide wire on the conveying catheter sleeve and the sheath tube, and the conveying catheter reaches the lesion part along the guide wire;

in this embodiment, the first output member 21 and the second output member 22 are of a split structure, so that in the ablation procedure, the first output member 21 and the second output member 22 enter the blood vessel sequentially, the second output member 22 is firstly conveyed to the vicinity of the target tissue through the blood vessel to start ablation, and after the ablation is finished, the second output member 22 is controlled to retract corresponding to the catheter and is drawn away from the blood vessel of the human body; after being withdrawn, the first output part 21 is conveyed into the blood vessel to carry out irradiation after ablation so as to repair the blood vessel wall; in another alternative embodiment, the first output 21 and the second output 22 may be integrated, both delivered simultaneously to the inside of the blood vessel, and selectively generate the first laser or the second laser based on the requirements of the operation.

Further, the vascular repair system further comprises a control module 30, the control module 30 is in communication connection with the laser generation module 10 and is used for selecting a light emitting mode of the laser generation module 10, and the light emitting mode at least comprises a first laser independent light emitting mode, a second laser independent light emitting mode and a first laser and second laser simultaneous light emitting mode.

The vascular repair system further comprises a power supply module 50, wherein the power supply module 50 is used for supplying power to the laser generation module 10 and the control module 30.

Referring to fig. 2, the control module 30 is communicatively connected to the semiconductor laser 11 and the ultraviolet laser 12;

the power supply module 50 includes a first driving power supply 51, a second driving power supply 52 and a switching power supply 53, the first driving power supply 51 is electrically connected with the semiconductor laser 11 for supplying power to the semiconductor laser 11, the second driving power supply 52 is electrically connected with the ultraviolet laser 12 for supplying power to the ultraviolet laser 12, the switching power supply 53 is electrically connected with the control module 30 for supplying power to the switching power supply 53, the first output element 21 is connected with the semiconductor laser 11, and the second output element 22 is connected with the ultraviolet laser 12; wherein the first driving power supply 51 and the second driving power supply 52 may be IGBT chopper power supplies with pulse width modulated.

The control module 30 preferably adopts a dual-wavelength control system, the control module 30 may adopt a PLC or a single chip, please refer to fig. 3, the control module 30 includes a main control board, an LCD operation panel, a preparation/emission indicator, a foot switch, a water flow switch and a water temperature sensor, wherein the foot switch is connected with the main control board and is used for controlling the on/off of the control module 30, the water flow switch is connected with the main control board and is used for controlling the on/off and the cooling flow of the cooling system, the water temperature sensor is connected with the main control board and is used for acquiring water temperature information at a designated position of the cooling system and transmitting the water temperature information to the main control board and displaying the water temperature information on the LCD operation panel, the LCD operation panel is connected with the main control board in a communication manner and is used for displaying related information, such as the water temperature information of the cooling system, the on information of the ultraviolet laser 11 and the ultraviolet laser 12, the current of the power supply module 50, the information of the output duration, and the LCD operation panel is further used for outputting operation instructions and controlling the power supply module 50 and the laser generation module 10, for example, the LCD operation panel can be used for inputting the current of the first drive power supply 51 or the second drive power supply 52, outputting laser energy, and controlling the laser emission parameters, and controlling the laser emission efficiency, and controlling the laser emission frequency, and controlling the laser emission parameters, and controlling the laser emission efficiency; the preparation/emission indicator light is used for displaying the laser emission state and represents that the laser is prepared to be emitted or is emitting when the preparation/emission indicator light is lightened;

referring to fig. 3, the laser power supply in fig. 3 integrates a first driving power supply 51 and a second driving power supply 52, the red laser in fig. 3 is the semiconductor laser 11, the ultraviolet laser is the ultraviolet laser 12, wherein the laser power supply is in communication connection with the main control board, the first driving power supply 51 in the laser power supply is electrically connected with the red laser, the second driving power supply 52 in the laser power supply is electrically connected with the ultraviolet laser, and the active board is in communication connection with the ultraviolet laser and the red laser;

referring to fig. 3, the blood vessel repairing system of the present embodiment further includes a cooling system, an emergency stop switch, a key switch and an air switch, the cooling system is connected to the red laser and the ultraviolet laser for providing cooling liquid for the red laser and the ultraviolet laser, and the cooling system is further electrically connected to the switching power supply 53; the emergency stop switch is electrically connected with the laser power supply and the switch power supply 53 and used for emergently disconnecting the laser power supply and the switch power supply 53 so as to emergently stop the machine; the air switch is connected with the key switch, and the key switch is connected with the emergency switch;

referring to fig. 3, in order to better improve the light-emitting effect, in this embodiment, an optical module, such as an optical fiber coupling device, is further disposed, and the optical performance of the laser is improved by the optical module;

the optical module can also comprise a beam combining device and a PBS (polarization beam splitter) attenuation device, wherein the beam combining device is used for combining the aiming light and the second laser beam; the PBS attenuation device consists of a half-wave plate, a PBS and a beam terminator, and the laser energy coupled into the optical fiber can be controlled by rotating the half-wave plate; the coupling device consists of a DOE homogenizing sheet and a coupling lens, homogenizes the laser, and then couples the laser into the optical fiber through the coupling lens.

The control module 30 controls the first driving power supply 51 and the second driving power supply 52 simultaneously or in a time-sharing manner, so as to drive the semiconductor laser 11 and the ultraviolet laser 12 to emit laser light; the control mode has a first laser independent light emitting mode, a second laser independent light emitting mode and a first laser and second laser simultaneous light emitting mode, the first laser independent light emitting mode is that the semiconductor laser 11 independently emits first laser, at the moment, the first laser independent light emitting mode is that the ultraviolet laser 12 independently emits second laser, at the moment, the second laser independent light emitting mode is used for vessel ablation and then re-communication, the first laser and second laser simultaneous light emitting mode is that the semiconductor laser 11 and the ultraviolet laser 12 simultaneously generate corresponding laser, at the moment, the first laser and the second laser simultaneously output and act on a target position, when the first laser independent light emitting mode is adopted, only the semiconductor laser 11 needs to be started, when the second laser independent light emitting mode is adopted, only the ultraviolet laser 12 needs to be started, when the first laser and second laser simultaneous light emitting mode is adopted, simultaneously, the semiconductor laser 11 and the ultraviolet laser 12 can be started, so the control module 30 can also be two switches for controlling the starting of the semiconductor laser 11 and the ultraviolet laser 12, and then switching the light emitting modes.

Preferably, the control module configures the starting of the first laser single light emitting mode to be after the starting of the second laser single light emitting mode, that is, the first laser is generated after the second laser, and then the second laser is generated for revascularization, and then the first laser is generated for repairing the inner wall at the vascular ablation site.

The vascular repair system further includes a delivery catheter 60 for implantation into the blood vessel to form a delivery channel, the delivery catheter 60 having one lumen for introducing the first output 21 or the second output 22 into the blood vessel therethrough, or two lumens for simultaneously introducing the first output 21 and the second output 22 into the blood vessel through both the lumens, respectively.

Referring to fig. 6, the delivery catheter 60 has a lumen 61, and a single lumen is used for introducing only a single instrument at a time, so that the first output member 21 and the second output member 22 are introduced sequentially, for example, the second output member 22 is introduced first, and after the operation is completed, the second output member 22 is taken out and then introduced into the first output member 21;

referring to fig. 7, the delivery catheter 60 has two lumens, namely a first lumen 61 'and a second lumen 62', so that the first output element 21 can be introduced through the first lumen 61 'and the second output element 22 can be introduced through the second lumen 62', so that the first output element 21 and the second output element 22 can be simultaneously introduced into the target position, and the first laser and the second laser can simultaneously act on the target position;

the blood vessel repair system also comprises a blood pressure acquisition unit and an alarm module 40, wherein the blood pressure acquisition unit and the alarm module 40 are both in communication connection with the control module 30; the control module 30 is further configured to: and receiving the blood pressure value of the intervened blood vessel collected by the blood pressure collecting unit, judging whether the blood pressure value is smaller than a set value, and controlling the alarm module 40 to give an alarm if the blood pressure value is smaller than the set value.

An alarm module 40 in communication or electrical communication with the control module 30, the alarm module 40 being integrated on the laser generating module 10 or in the control module 30, the alarm module 40 being configured to issue an alarm, such as by audio tone, visual signal, tactile feedback and/or controlling the laser generating module 10 to be deactivated to form an audible/visual alarm or other alarm; for example, the alarm module 40 may be an alarm lamp that flashes to alarm through the alarm lamp, or the alarm module 40 may be a buzzer that sounds to alarm, and the alarm module 40 may also be an alarm sign integrated with a display interface of the LCD operation screen;

the blood pressure acquisition unit is a pressure sensor, for example, an FOP type optical fiber pressure sensor is adopted, the sensor is widely applied to the cardiovascular department, the application of the sensor is the prior art, and the detailed description is omitted; the pressure sensor may be integrated on the first output 21 and the second output 22 and delivered into the blood vessel following the first output 21 and the second output 22 for detecting the blood pressure of the blood vessel, or the pressure sensor may be integrated on the delivery catheter and delivered into the blood vessel following the delivery catheter for detecting the blood pressure of the blood vessel; the pressure sensor is in communication connection with the control module to send the acquired blood pressure value to the control module for comparison with a set value, so as to avoid clinical risks, for example, if the pressure sensing threshold of the carotid sinus is 0.08-0.24atm, which is far lower than the standard working pressure of a balloon used clinically, the alarm module 40 gives an alarm, because clinically, the pressure needs to be slowly increased and slowly released in the process of balloon expansion, but hypotension and cerebral ischemia risk occur during operation, the set value of the blood pressure is obtained according to a pressure safety boundary, and clinical safety is ensured through the alarm module 40.

The device has solved the untimely problem of the back of melting hemorrhage and vascular wall restoration of ubiquitous among the vascular operation, has improved the validity of operation, and the complication that significantly reduces and the reliance to the medicine still can adjust the laser parameter that semiconductor laser 11 and ultraviolet laser 12 sent through control module 30, does benefit to and falls to minimum with the operation risk according to the actual operation operating mode, still utilizes the second laser to reduce the infection rate in the operation and after the operation to vascular restoration.

In the embodiment, the control module 30 controls the laser generation module 10 to start, and outputs the first laser for vascular repair and/or the second laser for target tissue ablation in a blood vessel; and/or the presence of a gas in the atmosphere,

and controlling the second laser to be independently output into the blood vessel, and controlling the first laser to be independently output into the blood vessel after delaying preset time.

The delay preset time can be set through the control module or manually determined according to the actual site of the actual operation, wherein the first laser and the second laser can be independently output and used, or the first laser and the second laser can be mutually matched for use, and the matching modes are two, one mode is that the first laser and the second laser are simultaneously output and irradiated, the other mode is that the first laser and the second laser are sequentially output, and the second laser is positioned behind the first laser; because the first laser is generated by the semiconductor laser 11 and the second laser is generated by the ultraviolet laser 12, the starting sequence of the semiconductor laser 11 and the ultraviolet laser 12 can be manually controlled to further control the delay preset time, and the output mode and the output sequence of the first laser and the second laser can be controlled, and of course, the output mode and the output sequence of the first laser and the second laser can also be controlled by the control module;

for example, in the same operation, the ultraviolet laser 12 is controlled to emit second laser, the second laser is used for intravascular ablation through the second output component 22, the semiconductor laser 11 is controlled to emit first laser, the first laser is used for intravascular wall repair after ablation through the first output component 21, the functions of intravascular plaque ablation and intravascular wall repair after ablation are respectively realized through time-sharing control of the control module 30 in action time, or only the semiconductor laser 11 is controlled to emit the first laser, and the first laser is used for intravascular wall repair through the first output component 21.

In addition, during operation, the blood pressure value in the blood vessel is collected in real time, and the size of the blood pressure value relative to a set value is judged; and if the blood pressure value is greater than or equal to the set value, controlling the laser generation module 10 to generate the first laser and/or the second laser.

Specifically, a blood pressure value of a blood vessel is acquired through a pressure sensor integrated on a first output part, a second output part or a delivery catheter, the pressure sensor transmits the acquired blood pressure value to a control module for comparison with a set value, and if the blood pressure value is greater than or equal to the set value, the laser generation module 10 is controlled to generate the first laser and/or the second laser; in the real-time detection process, if the blood pressure value is smaller than the set value, which indicates that the blood pressure value is not suitable for the operation environment, the laser generation module 10 is turned off to stop generating laser.

To sum up, the utility model provides a vascular repair system includes:

the laser generation module is used for generating first laser and second laser, and the wavelength range of the first laser is 600 nm-1064 nm;

and the output module is used for implanting into a blood vessel, transmitting the first laser for repairing the inner wall of the blood vessel and transmitting the second laser for ablating target tissues in the blood vessel.

With such a configuration, the output module 20 can irradiate the inner wall of the blood vessel with laser in a certain wavelength range, mainly utilizes the photobiological regulation effect, the smooth muscle cells of the blood vessel are the main components of the artery wall, and laser-inducible smooth muscle cell apoptosis in the corresponding wavelength direction is beneficial to reducing the thickening degree of the intima after angioplasty so as to prevent and treat restenosis after ablation;

the repair system integrates the functions of vessel wall repair and vessel ablation, and improves the safety problem and the effectiveness problem of the vessel ablation by using single ultraviolet laser in the past; the blood vessel damage problem after ultraviolet ablation can be repaired through the laser of dual wavelength, and the whole solution of once laser operation blood vessel plaque ablation and blood vessel wall repair is realized through one set of repair system. Through the application of two kinds of laser in the operation, improve and melt efficiency and security, not only reduce the operation risk to minimum, still utilize laser to restore and improve treatment, solved the general problem of melting back vascular wall repair untimely in the vascular operation, improved the validity and the reliability of operation, the postoperative complication and the postoperative dependence to the medicine that significantly reduce have reduced the infection rate and the blood vessel restenosis's in the operation and after the operation hidden danger.

The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.

The above description is only for the preferred embodiment of the present invention and is not intended to limit the scope of the present invention, and any modification and modification made by those skilled in the art according to the above disclosure are all within the scope of the claims.

Claims

1. A vascular repair system, comprising:

2. The vascular repair system of claim 1, wherein the energy density of the first laser light generated by the laser generation module is adjustable.

3. The vascular repair system of claim 1, wherein the second laser has a wavelength in the range of 198nm to 400nm.

4. The vascular repair system of claim 1, wherein the output module includes a first output for transmitting the first laser light and directing the first laser light toward an interior wall of the blood vessel and a second output for transmitting the second laser light and directing the second laser light toward a target tissue within the blood vessel.

5. The vascular repair system of claim 4, further comprising a delivery catheter for implantation within the blood vessel to form a delivery channel, the delivery catheter having a lumen for introduction of the first output member or the second output member into the blood vessel through the lumen; alternatively, the delivery catheter has two lumens for simultaneously introducing the first output and the second output into the blood vessel through the two lumens, respectively.

6. The vascular repair system of claim 4, wherein the first output member is a dispersion optical fiber, a bundle optical fiber, or a side output optical fiber; and/or the second output member is a bundled optical fiber.

7. The vascular repair system of claim 1, wherein the laser generation module includes a semiconductor laser for generating the first laser light and an ultraviolet laser for generating the second laser light.

8. The vascular repair system of claim 1, further comprising a control module communicatively connected to the laser generation module for selecting the light exit mode of the laser generation module, wherein the light exit mode at least includes a first laser single light exit mode, a second laser single light exit mode, and a first laser and second laser simultaneous light exit mode.

9. The vascular repair system of claim 8, wherein the control module is further configured to: and configuring the starting of the first laser single light emitting mode to be after the starting of the second laser single light emitting mode.

10. The vascular repair system of claim 8, further comprising a power module for powering the laser generation module and the control module.

11. The vascular repair system of claim 8, further comprising a blood pressure acquisition unit and an alarm module, both communicatively coupled to the control module, the control module further configured to: and receiving the blood pressure value of the intervened blood vessel collected by the blood pressure collecting unit, judging whether the blood pressure value is smaller than a set value, and controlling the alarm module to give an alarm if the blood pressure value is smaller than the set value.