CN217922060U - Scratch experimental device for high-flux drug screening - Google Patents
Scratch experimental device for high-flux drug screening Download PDFInfo
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- CN217922060U CN217922060U CN202222043769.4U CN202222043769U CN217922060U CN 217922060 U CN217922060 U CN 217922060U CN 202222043769 U CN202222043769 U CN 202222043769U CN 217922060 U CN217922060 U CN 217922060U
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Abstract
The utility model provides a high flux is mar experimental apparatus for drug screening. The scratch experimental device for screening the high-flux medicines comprises a plate body; the rubber scratch bar-shaped plate is movably arranged on the plate body; the two inserting blocks are symmetrically and fixedly arranged at the bottom of the rubber scratch rod strip-shaped plate; the two slots are symmetrically formed in the plate body; the clamping groove is formed in the inserting block; the sliding hole is formed in the inner wall of one side of the slot; the fixing mechanism is arranged on the plate body and comprises two clamping rods, and the clamping rods are in sliding connection with the corresponding inner walls of the sliding holes. The utility model provides a high flux is mar experimental apparatus for drug screening has and dismantles the convenience to the installation of rubber mar stick shaped plate, and easy operation has improved the advantage of convenience in use.
Description
Technical Field
The utility model relates to a drug screening technical field especially relates to a high flux is mar experimental apparatus for drug screening.
Background
With the advent of high-throughput methods of genomic, synthetic chemistry, drug screening is facing an increasing number of new targets or potential active ingredients. High throughput screening has been carried out in this context, and a scratch test apparatus is required for drug screening.
Patent document (CN 200910068158.1) discloses a simple and fast scratch experimental device, which is suitable for cell migration research and high-throughput drug screening using cell migration as a target spot. The invention is provided with a detachable rubber scratching head, takes a cell culture plate (6, 12, 24, 96, 384-hole plate and the like) with a plurality of holes as an experimental object, can be accurately sleeved on the cell culture plate, can generate neat and uniform scratches only by slightly pushing, and is convenient for photographing and subsequent statistical analysis. The device is also suitable for an automatic working platform of a high-throughput screening system and is used for rapidly screening drugs taking cell migration as a target spot. In addition, the invention can be repeatedly used, and the rubber scratching head has a detachable function and can be used after being sprayed by alcohol and irradiated by ultraviolet rays. The invention provides a simple, convenient and quick method for a scratch experiment, has great market prospect, but needs to screw a plurality of bolts when the rubber scratch bar-shaped plate is mounted and dismounted, has complex operation and reduces the use convenience.
Therefore, there is a need to provide a new scratch test device for high throughput drug screening to solve the above problems.
SUMMERY OF THE UTILITY MODEL
The utility model provides a technical problem provide a to rubber mar bar shaped plate installation dismantlement convenience, easy operation has improved the high flux for drug screening mar experimental apparatus of convenience of use.
In order to solve the technical problem, the utility model provides a high flux is mar experimental apparatus for drug screening includes: a board body; the rubber scratch bar-shaped plate is movably arranged on the plate body; the two inserting blocks are symmetrically and fixedly arranged at the bottom of the rubber scratch rod strip-shaped plate; the two slots are symmetrically formed in the plate body; the clamping groove is formed in the inserting block; the sliding hole is formed in the inner wall of one side of the slot; the fixing mechanism is arranged on the plate body and comprises two clamping rods, the clamping rods are in sliding connection with the inner walls of the sliding holes correspondingly, and one ends of the clamping rods are movably connected with the inner walls of the clamping grooves correspondingly.
Preferably, a first cavity has been seted up on the board body, first cavity and two the sliding hole communicates, the other end of kelly extends to in the first cavity and fixed mounting has a first wedge, slidable mounting has a second wedge in the first cavity, second wedge and two first wedge looks adaptation.
Preferably, the second cavity has been seted up on the board body, slidable mounting has L shape catch bar in the second cavity, the one end of L shape catch bar extend to in the first cavity and with second wedge fixed connection, slidable mounting has the pull rod on the board body, the one end of pull rod extend to in the second cavity and with L shape catch bar fixed connection.
Preferably, two stabilizing rods are symmetrically and fixedly mounted in the second cavity, and both the two stabilizing rods penetrate through the L-shaped push rod and are in sliding connection with the L-shaped push rod.
Preferably, the sliding sleeve is equipped with the spring on the stabilizer bar, the one end of spring and the inner wall fixed connection of second cavity, the other end and the L shape catch bar fixed connection of spring.
Preferably, a limiting groove is formed in the inner wall of one side of the sliding hole, a limiting rod is fixedly mounted in the limiting groove, a connecting block is fixedly mounted on the clamping rod, and one side of the connecting block extends to the corresponding limiting groove and is in sliding connection with the corresponding limiting rod.
Preferably, the sliding sleeve is equipped with the extension spring on the gag lever post, the one end of extension spring with correspond the inner wall fixed connection of spacing groove, the other end of extension spring with correspond connecting block fixed connection.
Preferably, the elastic force of the spring is greater than the tensile force of the tension spring.
Preferably, a first inclined plane is arranged on the clamping rod, a second inclined plane is arranged on the inserting block, and the second inclined plane is matched with the first inclined plane.
Compared with the prior art, the utility model provides a high flux is mar experimental apparatus for drug screening has following beneficial effect:
the utility model provides a high flux is mar experimental apparatus for drug screening, two inserted block symmetry fixed mounting is in the bottom of rubber mar stick shaped plate, two the slot symmetry is seted up on one's body the board can be fixed a position, is favorable to the installation, the draw-in groove is seted up on the inserted block, the slip hole is seted up on one side inner wall of slot, fixed establishment sets up on one's body the board, fixed establishment includes two kellies, the kelly with correspond the inner wall sliding connection in slip hole, the one end of kelly with correspond the inner wall swing joint of draw-in groove, the convenience is installed the dismantlement to rubber mar stick shaped plate, has improved the convenience of use.
Drawings
Fig. 1 is a schematic structural diagram of a scratch experimental apparatus for high throughput drug screening according to a preferred embodiment of the present invention;
FIG. 2 is a schematic top cross-sectional view of the structure of FIG. 1;
FIG. 3 is a schematic view of the securing mechanism shown in FIG. 2;
fig. 4 is a side cross-sectional structural view of fig. 1.
The reference numbers in the figures: 1. a board body; 2. a rubber scratch rod-shaped plate; 3. inserting a block; 4. a slot; 5. a card slot; 6. a slide hole; 7. a fixing mechanism; 701. a clamping rod; 702. a first wedge block; 703. a second wedge block; 704. an L-shaped push rod; 705. a pull rod; 706. a stabilizer bar; 707. a spring; 708. a limiting rod; 709. connecting blocks; 710. a tension spring; 8. a first cavity; 9. a second cavity; 10. a limiting groove.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and embodiments.
Referring to fig. 1-4, the scratch test device for high throughput drug screening includes: a board body 1; the rubber scratch bar-shaped plate 2 is movably arranged on the plate body 1; the two inserting blocks 3 are symmetrically and fixedly arranged at the bottom of the rubber scratch rod strip-shaped plate 2; the two slots 4 are symmetrically formed in the plate body 1; the clamping groove 5 is formed in the inserting block 3; the sliding hole 6 is formed in the inner wall of one side of the slot 4; fixing mechanism 7, fixing mechanism 7 sets up on the board body 1, fixing mechanism 7 includes two kellies 701, kellies 701 and corresponding the inner wall sliding connection of slide opening 6, the one end of kellies 701 with correspond the inner wall swing joint of draw-in groove 5.
The second cavity 9 has been seted up on the board body 1, slidable mounting has L shape catch bar 704 in the second cavity 9, the one end of L shape catch bar 704 extend to in the first cavity 8 and with second wedge 703 fixed connection, slidable mounting has pull rod 705 on the board body 1, the one end of pull rod 705 extend to in the second cavity 9 and with L shape catch bar 704 fixed connection, can make second wedge 703 keep away from two first wedge 702.
Two stabilizing rods 706 are symmetrically and fixedly installed in the second cavity 9, and the two stabilizing rods 706 both penetrate through the L-shaped pushing rod 704 and are in sliding connection with the L-shaped pushing rod 704, which is beneficial to improving the motion stability of the L-shaped pushing rod 704.
A spring 707 is slidably sleeved on the stabilizing rod 706, one end of the spring 707 is fixedly connected with the inner wall of the second cavity 9, and the other end of the spring 707 is fixedly connected with the L-shaped pushing rod 704, so that the L-shaped pushing rod 704 drives the second wedge-shaped block 703 to move.
The utility model discloses a bayonet catch 701, including slide hole 6, gag lever post 708, gag lever post 701, connecting block 709, gag lever post 708, gag lever post 701 is last fixed mounting has a connecting block 709, one side of connecting block 709 extends to corresponding in the gag lever post 10 and with correspond gag lever post 708 sliding connection can improve bayonet catch 701's motion stability.
The sliding sleeve is equipped with extension spring 710 on the gag lever post 708, the one end of extension spring 710 with correspond the inner wall fixed connection of spacing groove 10, the other end of extension spring 710 with correspond connecting block 709 fixed connection can make two kellies 701 shift out two draw-in grooves 5.
The elastic force of the spring 707 is greater than the pulling force of the tension spring 710, so that the two clamping rods 701 can enter the two clamping grooves 5.
The clamping rod 701 is provided with a first inclined surface, the inserting block 3 is provided with a second inclined surface, the second inclined surface is matched with the first inclined surface, and the pull rod 705 does not need to be pulled when the clamping rod is installed, so that the installation is convenient.
The utility model provides a high flux is mar experimental apparatus for drug screening's theory of operation as follows:
in the device, a tension spring 710 is in a tension and power storage state;
when the rubber scratch bar-shaped plate 2 needs to be disassembled, the pull rod 705 is pulled, the pull rod 705 drives the L-shaped push rod 704 to move, at the moment, the two springs 707 are in a compression force accumulation state, the L-shaped push rod 704 drives the second wedge-shaped block 703 to move towards the direction far away from the two first wedge-shaped blocks 702, at the moment, the second wedge-shaped block 703 does not extrude the two first wedge-shaped blocks 702 any more, at the moment, the two clamping rods 701 move towards the direction close to each other and move out of the two clamping grooves 5 under the action of the two tension springs 710, and at the moment, the rubber scratch bar-shaped plate 2 can be disassembled; during the installation, insert corresponding slot 4 with inserted block 3, under the cooperation on second inclined plane and first inclined plane, two kelly 701 are towards the direction motion that is close to each other, when two draw-in grooves 5 correspond with two kellies 701, under the effect of two springs 707, drive two first wedge 702 towards the direction motion of keeping away from each other through second wedge 703, two first wedge 702 drive two kellies 701 towards the direction motion of keeping away from each other get into two draw-in grooves 5 in, this moment, the installation is accomplished, the operation is thus simple, be convenient for install the dismantlement to rubber mar stick strip shaped plate 2, the convenience of use has been improved.
Compared with the prior art, the utility model provides a high flux is mar experimental apparatus for drug screening has following beneficial effect:
the utility model provides a high flux is mar experimental apparatus for drug screening, two 3 symmetry fixed mounting of inserted block are in rubber mar bar shaped plate 2's bottom, two 4 symmetries of slot are seted up on the body of plate 1, can fix a position, are favorable to the installation, draw-in groove 5 is seted up on the inserted block 3, slip hole 6 is seted up on one side inner wall of slot 4, fixed establishment 7 sets up on the body of plate 1, fixed establishment 7 includes two kellies 701, kellies 701 and corresponds the inner wall sliding connection of slip hole 6, kellies 701's one end and corresponding the inner wall swing joint of draw-in groove 5, the convenience is installed the dismantlement to rubber bar shaped plate 2, has improved mar convenience of use.
The above only is the embodiment of the present invention, not limiting the scope of the present invention, all the equivalent structures or equivalent processes of the present invention are used in the specification and the attached drawings, or directly or indirectly applied to other related technical fields, and the same principle is included in the protection scope of the present invention.
Claims (9)
1. The utility model provides a high throughput is mar experimental apparatus for drug screening which characterized in that includes:
a board body;
the rubber scratch bar-shaped plate is movably arranged on the plate body;
the two inserting blocks are symmetrically and fixedly arranged at the bottom of the rubber scratch rod strip-shaped plate;
the two slots are symmetrically formed in the plate body;
the clamping groove is formed in the inserting block;
the sliding hole is formed in the inner wall of one side of the slot;
the fixing mechanism is arranged on the plate body and comprises two clamping rods, the clamping rods are in sliding connection with the inner walls of the sliding holes correspondingly, and one ends of the clamping rods are movably connected with the inner walls of the clamping grooves correspondingly.
2. The scratch experiment device for high-throughput drug screening, according to claim 1, wherein a first cavity is formed on the plate body, the first cavity is communicated with the two sliding holes, the other end of the clamping rod extends into the first cavity and is fixedly provided with a first wedge-shaped block, a second wedge-shaped block is slidably provided in the first cavity, and the second wedge-shaped block is adapted to the two first wedge-shaped blocks.
3. The scratch experiment device for high-throughput drug screening, according to claim 2, wherein a second cavity is formed in the plate body, an L-shaped push rod is slidably mounted in the second cavity, one end of the L-shaped push rod extends into the first cavity and is fixedly connected with the second wedge block, a pull rod is slidably mounted on the plate body, and one end of the pull rod extends into the second cavity and is fixedly connected with the L-shaped push rod.
4. The scratch experiment device for high-throughput drug screening of claim 3, wherein two stabilizing rods are symmetrically and fixedly installed in the second cavity, and both of the two stabilizing rods penetrate through and are slidably connected with the L-shaped push rod.
5. The scratch experiment device for high-throughput drug screening of claim 4, wherein a spring is slidably sleeved on the stabilizer bar, one end of the spring is fixedly connected with the inner wall of the second cavity, and the other end of the spring is fixedly connected with the L-shaped push rod.
6. The scratch test device for high throughput drug screening of claim 1, wherein a limiting groove is formed on an inner wall of one side of the sliding hole, a limiting rod is fixedly installed in the limiting groove, a connecting block is fixedly installed on the clamping rod, and one side of the connecting block extends into the corresponding limiting groove and is slidably connected with the corresponding limiting rod.
7. The scratch experiment device for high-throughput drug screening, according to claim 6, wherein a tension spring is slidably sleeved on the limiting rod, one end of the tension spring is fixedly connected with the corresponding inner wall of the limiting groove, and the other end of the tension spring is fixedly connected with the corresponding connecting block.
8. The scratch test device for high throughput drug screening according to claim 5, wherein the spring force of the spring is greater than the tension of the tension spring.
9. The scratch test device for high throughput drug screening of claim 7, wherein the rod is provided with a first inclined surface, the insert block is provided with a second inclined surface, and the second inclined surface is adapted to the first inclined surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222043769.4U CN217922060U (en) | 2022-08-04 | 2022-08-04 | Scratch experimental device for high-flux drug screening |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222043769.4U CN217922060U (en) | 2022-08-04 | 2022-08-04 | Scratch experimental device for high-flux drug screening |
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| CN217922060U true CN217922060U (en) | 2022-11-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202222043769.4U Active CN217922060U (en) | 2022-08-04 | 2022-08-04 | Scratch experimental device for high-flux drug screening |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116144462A (en) * | 2023-04-23 | 2023-05-23 | 四川若斌生物科技有限责任公司 | Push-pull device, full-automatic photographing microorganism incubator and photographing method |
-
2022
- 2022-08-04 CN CN202222043769.4U patent/CN217922060U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116144462A (en) * | 2023-04-23 | 2023-05-23 | 四川若斌生物科技有限责任公司 | Push-pull device, full-automatic photographing microorganism incubator and photographing method |
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