CN217856247U - Priming device and exosome extraction equipment - Google Patents
Priming device and exosome extraction equipment Download PDFInfo
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- CN217856247U CN217856247U CN202222228114.4U CN202222228114U CN217856247U CN 217856247 U CN217856247 U CN 217856247U CN 202222228114 U CN202222228114 U CN 202222228114U CN 217856247 U CN217856247 U CN 217856247U
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Abstract
The application discloses priming device and exosome draw equipment relates to exosome and draws the field. The priming device includes support, priming pump, telescopic machanism and carousel subassembly. The liquid injection pump is arranged on the bracket and is provided with an output port; the telescopic mechanism comprises a driving part and a moving part, and the driving part is fixed on the bracket and used for driving the moving part to move relative to the bracket; the rotary table component comprises a rotating mechanism, a rotary table base, an injection rotary table, a mounting seat and a pipe joint, wherein the mounting seat is connected with the moving part; the injection turntable is rotationally connected to the turntable base and is connected with the rotating end of the rotating mechanism; the pipe joint penetrates through the injection turntable, the first end of the pipe joint is connected with the output port through a hose, the second end of the pipe joint is provided with an annular clamping groove, and the annular clamping groove is used for being clamped with the probe head. The application provides a priming device has reduced manual operation's step, has improved efficiency, absorbs or exports quantitative sample reagent through the liquid charge pump, makes its inspiratory capacity stable.
Description
Technical Field
The application relates to an exosome extraction technology field, in particular to an injection device and exosome extraction equipment.
Background
Exosomes are one of extracellular vesicles, have the size of 30-150nm, are released to the outside of cells in an extracellularly secreted form after being fused with cell membranes by intracellular multivesicular bodies, and are widely present in cell culture supernatants and various body fluids, including blood, lymph, saliva, urine, semen, milk and the like.
The existing exosome separation method generally uses an injector to absorb or output body fluid, when the exosome separation method is used, the injector is manually used to absorb a sample, then the injector is fixed on equipment with fixed liquid injection speed, then the injector filled with the sample is connected with a filtering device with a superfine filtering membrane, the liquid injection with the fixed speed is started, the obtained exosome can be enriched on the filtering membrane, redundant liquid is discharged in the liquid injection process, the injector needs to be manually disassembled and taken away from the equipment after the liquid injection is finished, and finally the sample on the filtering membrane can be extracted for next work.
However, the syringe for storing the sample is designed with low precision and operated manually, so that the liquid injection amount of each experiment has large deviation, which is difficult to ensure that the basic parameters of each experiment are consistent, and the basic parameters refer to the injection amount of the syringe to the filter device but the suction amount before the experiment of the syringe. In addition, the injector needs to be disassembled and assembled manually in the experimental process, so that the operation is complex, and the experimental efficiency of the filtering and separating of the exosome is reduced.
SUMMERY OF THE UTILITY MODEL
In view of the above, the present application provides a liquid injection device to solve the problems of unstable syringe suction volume caused by manual operation by using a syringe in the prior art.
The present application provides:
a fluid injection apparatus comprising:
a support;
the liquid injection pump is arranged on the bracket and is provided with an output port;
the telescopic mechanism comprises a driving piece and a moving piece, the driving piece is fixed on the bracket, and the output end of the driving piece is connected with the moving piece and used for driving the moving piece to move relative to the bracket;
the rotary disc component is connected with the moving part and moves along with the moving part;
the rotary disc assembly comprises a rotating mechanism, a rotary disc base, an injection rotary disc, a mounting seat and a pipe joint, wherein the mounting seat is connected with the moving part; the rotating mechanism and the turntable base are respectively arranged on the mounting seat; the injection turntable is rotationally connected to the turntable base and is connected with the rotating end of the rotating mechanism; the pipe joint is provided with a first end and a second end which are arranged oppositely, the pipe joint penetrates through the injection turntable, the first end is connected with the output port through a hose, the second end is provided with an annular clamping groove, and the annular clamping groove is used for being clamped with a probe gun head so that the probe gun head is communicated with the liquid injection pump.
In addition, the liquid injection device according to the application can also have the following additional technical characteristics:
in some embodiments of the present application, the rotating mechanism includes a driving motor and a transmission member, the driving motor drives the transmission member to rotate, and the transmission member is in transmission connection with the injection turntable;
the driving motor and the turntable base are respectively and fixedly connected to the mounting seat, a through hole is formed in the mounting seat, and the hose penetrates through the through hole and is connected with the first end and the output port.
In some embodiments of the present application, the transmission member is a first gear connected to an output end of the driving motor, and a second gear engaged with the first gear is disposed on the injection turntable; or the transmission part comprises a first belt pulley and a belt, the first belt pulley is connected with the output end of the driving motor, a second belt pulley is arranged on the injection turntable, and the belt is in transmission connection with the first belt pulley and the second belt pulley.
In some embodiments of the present application, the step hole has been seted up to the carousel base, the injection carousel wear to locate with rotating the step hole and with the driving medium is connected.
In some embodiments of the present application, a first bearing is connected between the injection turntable and the hole wall of the stepped hole, and the first bearing is disposed close to the mounting seat.
In some embodiments of the present application, a second bearing is further sleeved on the injection turntable, and the second bearing is located in the stepped hole and away from one side of the mounting seat.
In some embodiments of the present application, the injection turntable includes an outer section, a middle section and an inner section connected in sequence along an axial direction of the pipe joint, and an end of the inner section, which is far away from the middle section, is connected to the transmission member; the second bearing is sleeved in the middle section part, and the first bearing is sleeved in the inner section part.
In some embodiments of the present application, the cross-sectional areas of the outer section, the middle section and the inner section are gradually reduced, and the cross-sectional area of the outer section is larger than the cross-sectional area of the end of the stepped hole far away from the mounting seat.
In some embodiments of the present application, one end of the outer section close to the middle section is provided with a retaining ring, and the retaining ring abuts against a part of the outer ring of the first bearing.
In some embodiments of the present application, the outer section, the middle section, the inner section, and the retainer ring are integrally formed.
In some embodiments of the present application, the pipe joint is provided with a vent hole communicating with the ring-shaped clamping groove.
The application also provides exosome extraction equipment, which comprises the liquid injection device in any embodiment.
Compared with the prior art, the beneficial effects of this application are: the application provides an injection device, with probe rifle head joint on the pipe connector, move through the relative support of driving piece drive motion piece, drive the relative support of carousel subassembly then and remove, rethread slewing mechanism rotates, move the probe rifle head to sample reagent pipe department, start the liquid pump, absorb the sample reagent of fixed quantity from sample reagent pipe through the probe rifle head, remove its filtration module department to exosome extraction equipment again, pour into the sample reagent in the filtration module. In the process, the steps of manual operation are reduced, the efficiency is improved, and meanwhile, quantitative sample reagents are sucked or output through the matching of the liquid injection pump, the pipe joint and the probe gun head, so that the suction volume is stable, and the experiment repetition precision is improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.
FIG. 1 illustrates a schematic perspective view of a fluid injection apparatus according to some embodiments of the present disclosure;
FIG. 2 is a schematic view of the liquid injection device according to some embodiments of the present disclosure;
FIG. 3 isbase:Sub>A schematic sectional view taken along line A-A in FIG. 2;
FIG. 4 is an enlarged schematic view of the portion B of FIG. 3;
FIG. 5 shows a schematic view of the injection carousel in some embodiments of the present application;
FIG. 6 illustrates a schematic structural view of a pipe joint according to some embodiments of the present application;
FIG. 7 shows a schematic cross-sectional view of the C-C cross-section of FIG. 6;
FIG. 8 illustrates an exploded view of a priming device in some embodiments of the present application;
FIG. 9 shows a schematic structural diagram of an exosome extraction device in some embodiments of the present application;
fig. 10 shows a schematic diagram of an exosome extraction device without an injection means in some embodiments of the present application.
Description of the main element symbols:
100-a liquid injection device; 10-a scaffold; 20-a telescoping mechanism; 21-a drive member; 22-a moving part; 30-a liquid injection pump; 31-output port; 40-a rotating mechanism; 41-driving motor; 42-a transmission member; 50-a turntable assembly; 51-a turntable base; 511-stepped bore; 52-an injection carousel; 521-an outer section; 522-middle section; 523-inner section; 524-a second gear; 525-a retainer ring; 53-pipe joints; 531-first end; 532-second end; 533-ring groove; 534-air vent; 54-a first bearing; 55-a second bearing; 56-mounting seat; 561-through holes; 60-probe gun head; 200-exosome extraction device; 201-a filtration module; 202-a rotating member; 203-a base; 204-a loading platform; 205-lateral movement mechanism.
Detailed Description
Reference will now be made in detail to embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise.
In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or may be connected through the use of two elements or the interaction of two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
In this application, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through intervening media. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
Examples
As shown in fig. 1 and fig. 9, an embodiment of the present application provides a liquid injection device 100, which is mainly used for filtration experiment extraction of exosomes, and is specifically disposed on an exosome extraction device 200.
Referring also to fig. 2-4, the priming device 100 includes a stand 10, a priming pump 30, a telescoping mechanism 20, and a turntable assembly 50.
The infusion pump 30 is disposed on the holder 10 and has an output port 31 for sucking or outputting a sample reagent.
The telescopic mechanism 20 comprises a driving part 21 and a moving part 22, the driving part 21 is fixed on the bracket 10, and the output end of the driving part 21 is connected with the moving part 22 and is used for driving the moving part 22 to move relative to the bracket 10;
the turntable assembly 50 is connected to the mover 22 and moves along with the mover 22.
Carousel assembly 50 includes a rotation mechanism 40, a carousel base 51, an injection carousel 52, a mount 56, and a coupling 53. Wherein, the mounting seat 56 is connected with the moving part 22, and the rotating mechanism 40 and the turntable base 51 are respectively arranged on the mounting seat 56; the injection turntable 52 is rotatably connected to the turntable base 51, the injection turntable 52 is connected to the rotating end of the rotating mechanism 40, the rotating mechanism 40 rotates to drive the injection turntable 52 to rotate, and the pipe joint 53 rotates along with the injection turntable 52.
Referring to fig. 7, the pipe joint 53 has a first end 531 and a second end 532 which are oppositely arranged, the pipe joint 53 is inserted into the injection turntable 52, the first end 531 is connected to the output port 31 through a hose, the second end 532 is provided with an annular clamping groove 533, and the annular clamping groove 533 is used for being clamped with the probe gun head 60, so that the probe gun head 60 is detachably connected to the pipe joint 53, and finally the probe gun head 60 is communicated with the injection pump 30.
The priming device 100 that the embodiment of this application provided, when using, with probe rifle head 60 joint on coupling 53, move through driving piece 21 drive motion piece 22 relative support 10, then drive carousel subassembly 50 relative support 10 and move, rethread slewing mechanism 40 rotates, move probe rifle head 60 to sample reagent pipe department, start the priming pump 30, absorb the sample reagent of fixed quantity from the sample reagent pipe through probe rifle head 60, move it to the filtration module 201 department of exosome extraction equipment 200 again, pour into sample reagent in the filtration module 201. In the process, the steps of manual operation are reduced, the efficiency is improved, and meanwhile, quantitative sample reagent is sucked or output through the matching of the liquid injection pump 30, the pipe joint 53 and the probe gun head 60, so that the suction amount is stable, and the repetition precision of the experiment is improved.
It should be noted that, the driving member 21 of the telescoping mechanism 20 can be a hydraulic cylinder or an air cylinder, and the moving member 22 can be a push rod, so that the operation is convenient and simple. Of course, in other embodiments, a linear motor may be used for the retraction mechanism 20.
As shown in fig. 3 and 8, in some embodiments of the present application, optionally, the rotating mechanism 40 includes a driving motor 41 and a transmission member 42, the driving motor 41 drives the transmission member 42 to rotate, and the transmission member 42 is in transmission connection with the injection turntable 52;
referring to fig. 4, the driving motor 41 and the turntable base 51 are respectively and fixedly connected to the mounting base 56, a through hole 561 is formed in the mounting base 56, and the hose is inserted into the through hole 561 and connected to the first end 531 and the output port 31. The tube connector 53 is connected to the output port 31 of the infusion pump 30 by a hose so that the hose has a telescopic and flexible function when the tube connector 53 is moved relative to the output port 31, facilitating the movement of the tube connector 53.
In the present embodiment, the rotating mechanism 40 is composed of a driving motor 41 and a transmission member 42, and the driving motor 41 drives the transmission member 42 to rotate, so as to drive the injection turntable 52 to rotate. Meanwhile, the driving motor 41 is fixed to the mount 56.
When the driving member 21 moves the moving member 22, the moving member 22 drives the mounting seat 56 to move, and further drives the driving motor 41 and the turntable assembly 50 to move.
In the above embodiment of the present application, as shown in fig. 4, optionally, the transmission member 42 is a first gear, the first gear is connected to the output end of the driving motor 41, and the injection turntable 52 is provided with a second gear 524 engaged with the first gear. Thus, the driving motor 41 drives the first gear to rotate and drives the second gear 524 to rotate, thereby driving the injection turntable 52 to rotate.
Of course, in other embodiments, the transmission member 42 may also use a belt transmission mechanism, such as that the transmission member 42 includes a first belt pulley and a belt, the first belt pulley is connected with the output end of the driving motor 41, and a second belt pulley is disposed on the injection turntable 52, and the belt transmission is connected with the first belt pulley and the second belt pulley. The driving motor 41 drives the first belt pulley to rotate, and drives the second belt pulley to rotate through the belt, so as to drive the injection turntable 52 to rotate.
It should be noted that the transmission member 42 is not limited to the above structure, and the transmission member 42 may also use a chain wheel and chain structure, that is, the transmission member 42 includes a chain and a first chain wheel, the output end of the driving motor 41 is connected with the first chain wheel, and the injection turntable 52 is provided with a second chain wheel, and the chain is connected with the first chain wheel and the second chain wheel in a transmission manner. In use, the driving motor 41 drives the first chain wheel to rotate, and the second chain wheel is driven to rotate by the chain, so as to drive the injection turntable 52 to rotate.
It should be understood that in other embodiments, the transmission member 42 may alternatively be driven by a planetary or worm gear mechanism.
As shown in fig. 4, in some embodiments of the present application, the turntable base 51 is opened with a stepped hole 511, and the injection turntable 52 is rotatably disposed through the stepped hole 511 and connected to the transmission member 42. Such as injection dial 52, is drivingly connected at one end to the first gear via second gear 524.
Specifically, a first bearing 54 is connected between the injection rotary table 52 and the wall of the stepped hole 511, and the first bearing 54 is disposed close to the mounting seat 56.
In the present embodiment, in order to make the rotation between the injection dial 52 and the dial base 51 smoother and reduce the radial gap wobble, the first bearing 54 is provided to realize the rotation fixing relationship between the injection dial 52 and the dial base 51, and the first bearing 54 realizes the rotation function of reducing the friction force.
In the present embodiment, the first bearing 54 is a deep groove ball bearing, and further, friction generated by the rotation of the injection dial 52 and the dial base 51 is reduced. Of course, in other embodiments, other bearings may be used for the first bearing 54.
In the above embodiment, the injection dial 52 is further sleeved with a second bearing 55, and the second bearing 55 is located on a side of the stepped hole 511 away from the mounting seat 56.
In the present embodiment, the first bearing 54 may be provided, and the second bearing 55 may be provided on the injection dial 52. Of course, the injection turntable 52 and the turntable base 51 may be rotatably connected by directly providing the second bearing 55 on the injection turntable 52 without providing the first bearing 54.
In this embodiment, since the pipe joint 53 is in axial contact with the filter module 201 of the exosome extraction device 200, a certain axial force must be present in order to ensure the sealing effect. In this way, the axial force is borne by the arrangement of the second bearing 55, and specifically, the second bearing 55 uses a thrust cylindrical roller bearing, and the axial force is borne by the thrust cylindrical roller bearing, so that the axial force between the injection turntable 52 and the turntable base 51 is reduced, and the friction generated by the rotation between the two is reduced.
In the present embodiment, a thrust cylindrical roller bearing is used as the second bearing 55. Of course, in other embodiments, other bearings may be used for the second bearing 55.
As shown in fig. 4 and 5, in some embodiments of the present application, the injection dial 52 includes an outer section 521, a middle section 522 and an inner section 523, which are connected in sequence, along the axial direction of the pipe joint 53.
Specifically, one end of the inner section 523, which is far away from the middle section 522, is connected to the transmission member 42, a part of the middle section 522 and the inner section 523 are located in the stepped hole 511, the second bearing 55 is sleeved on the middle section 522, and the first bearing 54 is sleeved on the inner section 523.
In this embodiment, the middle section 522 and the inner section 523 are rotatably disposed in the stepped hole 511 and are engaged with the first bearing 54 and the second bearing 55, so that the injection turntable 52 can rotate on the turntable base 51, and the rotation of the injection turntable 52 on the turntable base 51 is more stable.
Further, the cross-sectional areas of the outer section 521, the middle section 522 and the inner section 523 are gradually reduced, and the cross-sectional area of the outer section 521 is greater than that of the end of the stepped hole 511 far away from the mounting seat 56. Thus, the outer step 521 is disposed outside the turntable base 51, the middle step 522 and the inner step 523 are inserted into the stepped hole 511, and the outer step 521 also blocks the stepped hole 511.
In addition, a cross section among the cross sectional areas of the outer step 521, the middle step 522, and the inner step 523 is a cross section perpendicular to the moving direction of the mover 22. In the present embodiment, the injection dial 52 has a truncated cone shape, and specifically, the cross sections of the outer section 521, the middle section 522, and the inner section 523 are circular.
As shown in fig. 4, further, one end of the outer step 521 near the middle step 522 is provided with a retaining ring 525, and the retaining ring 525 abuts against a part of the outer ring of the second bearing 55.
In the present embodiment, the retainer ring 525 is provided so that the retainer ring 525 can abut against a part of the outer ring of the second bearing 55 when the second bearing 55 is attached, and thus the retainer ring 525 blocks the second bearing 55 from being displaced to a position away from the center thereof. In addition, the retaining ring 525 forms an annular groove with the end surface of the outer step portion 521 and the middle step portion 522, and when the second bearing 55 is mounted, a part of the second bearing 55 is located in the annular groove, thereby facilitating the mounting of the second bearing 55.
In some embodiments of the present application, the outer section 521, the middle section 522, the inner section 523, and the retaining ring 525 are integrally formed.
In the present embodiment, the outer section 521, the middle section 522, the inner section 523, and the retaining ring 525 may be formed by injection molding of a plastic material or by casting of a rotating metal material. Thus, the structural strength of the outer stage 521, the middle stage 522, the inner stage 523, and the stopper 525 is improved, and the probability of breakage between the outer stage 521, the middle stage 522, the inner stage 523, and the stopper 525 is reduced. In addition, the outer section 521, the middle section 522, the inner section 523 and the retainer ring 525 are integrally formed, so that the production and the manufacture are convenient, the production cost of the product is reduced, and the market competitiveness of the product is improved.
As shown in fig. 6 and 7, in some embodiments of the present application, a vent 534 is optionally disposed on the pipe joint 53 and communicates with the annular clamping groove 533. Therefore, when the probe tips 60 at the annular clamping grooves 533 are scraped by the tip scraping blade, the air entering from the vent holes 534 can generate a certain atmospheric pressure on the probe tips 60 at the annular clamping grooves 533, so that the probe tips 60 can be scraped conveniently.
As shown in fig. 9 and 10, an embodiment of the present application further provides an exosome extraction apparatus 200, including the infusion device 100 described in any of the embodiments above.
Optionally, the exosome advancing device further comprises a rotating member 202, a base 203, a loading table 204 and a filtering module 201, wherein the filtering module 201 is placed on the loading table 204, and the rotating member 202 is rotatably arranged on the base 203.
Specifically, a motor for driving the rotation member 202 to rotate is disposed on the base 203, and the rotation member 202 is driven to rotate by the motor. Meanwhile, the injection device 100 is connected to the rotating member 202, so that the rotating member 202 can be driven to drive the whole injection device 100 to rotate.
In addition, the lateral movement mechanism 205 may be further installed on the rotating member 202, and the injection device 100 may be installed on the lateral movement mechanism 205, so that the injection device 100 may be moved in a direction parallel to the lateral movement mechanism 205, and further, a rack for placing sample reagents may be placed at more positions, which is convenient for operation.
The exosome extraction device 200 provided in this embodiment has the liquid injection device 100 in any of the embodiments described above, and therefore, has all the beneficial effects of the liquid injection device 100 in any of the embodiments described above, which are not described herein again.
In the description herein, reference to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present application have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present application, and that variations, modifications, substitutions and alterations may be made to the above embodiments by those of ordinary skill in the art within the scope of the present application.
Claims (10)
1. A priming device, comprising:
a support;
the liquid injection pump is arranged on the bracket and is provided with an output port;
the telescopic mechanism comprises a driving piece and a moving piece, the driving piece is fixed on the bracket, and the output end of the driving piece is connected with the moving piece and used for driving the moving piece to move relative to the bracket;
the rotary disc component is connected with the moving part and moves along with the moving part;
the rotary table assembly comprises a rotating mechanism, a rotary table base, an injection rotary table, a mounting seat and a pipe joint, wherein the mounting seat is connected with the moving part; the rotating mechanism and the turntable base are respectively arranged on the mounting seat; the injection turntable is rotationally connected to the turntable base and is connected with the rotating end of the rotating mechanism; the pipe joint is provided with a first end and a second end which are arranged oppositely, the pipe joint penetrates through the injection turntable, the first end is connected with the output port through a hose, the second end is provided with an annular clamping groove, and the annular clamping groove is used for being clamped with a probe gun head so that the probe gun head is communicated with the liquid injection pump.
2. The liquid injection device according to claim 1, wherein the rotation mechanism includes a driving motor and a transmission member, the driving motor drives the transmission member to rotate, and the transmission member is in transmission connection with the injection turntable;
the driving motor and the turntable base are respectively and fixedly connected to the mounting seat, a through hole is formed in the mounting seat, and the hose penetrates through the through hole and is connected with the first end and the output port.
3. The liquid injection device according to claim 2, wherein the transmission member is a first gear, the first gear is connected with an output end of the driving motor, and a second gear engaged with the first gear is arranged on the injection turntable; or the transmission part comprises a first belt pulley and a belt, the first belt pulley is connected with the output end of the driving motor, a second belt pulley is arranged on the injection turntable, and the belt is in transmission connection with the first belt pulley and the second belt pulley.
4. The liquid injection device according to claim 2, wherein the turntable base is provided with a step hole, and the injection turntable is rotatably disposed through the step hole and connected to the transmission member.
5. The injection device as defined in claim 4, wherein a first bearing is connected between the injection turntable and the wall of the stepped bore, and the first bearing is disposed adjacent to the mounting seat.
6. The liquid injection device according to claim 5, wherein a second bearing is further sleeved on the injection turntable, and the second bearing is located on one side of the stepped hole far away from the mounting seat.
7. The liquid injection device according to claim 6, wherein the injection turntable comprises an outer section part, a middle section part and an inner section part which are sequentially connected along the axial direction of the pipe joint, and one end of the inner section part, which is far away from the middle section part, is connected with the transmission part; a part of the middle section part and the inner section part are positioned in the step hole, the second bearing is sleeved on the middle section part, and the first bearing is sleeved on the inner section part.
8. The liquid injection device according to claim 7, wherein the cross-sectional areas of the outer section, the middle section and the inner section are gradually reduced, and the cross-sectional area of the outer section is larger than that of one end of the stepped hole, which is far away from the mounting seat.
9. The liquid injection device according to any one of claims 1 to 8, wherein a vent hole communicating with the annular clamping groove is formed in the pipe joint.
10. An exosome extraction device comprising the liquid injection device according to any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222228114.4U CN217856247U (en) | 2022-08-23 | 2022-08-23 | Priming device and exosome extraction equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222228114.4U CN217856247U (en) | 2022-08-23 | 2022-08-23 | Priming device and exosome extraction equipment |
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| Publication Number | Publication Date |
|---|---|
| CN217856247U true CN217856247U (en) | 2022-11-22 |
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| CN202222228114.4U Active CN217856247U (en) | 2022-08-23 | 2022-08-23 | Priming device and exosome extraction equipment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115404149A (en) * | 2022-08-23 | 2022-11-29 | 珠海圣美生物诊断技术有限公司 | Exosome extraction device and exosome extraction method |
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2022
- 2022-08-23 CN CN202222228114.4U patent/CN217856247U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115404149A (en) * | 2022-08-23 | 2022-11-29 | 珠海圣美生物诊断技术有限公司 | Exosome extraction device and exosome extraction method |
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