CN217828984U

CN217828984U - High-efficient heparin sodium deposits device

Info

Publication number: CN217828984U
Application number: CN202220934665.XU
Authority: CN
Inventors: 丛森; 袁帅
Original assignee: Shandong Wanbang Sainuokang Biochemistry Pharmaceutical Co ltd
Current assignee: Shandong Wanbang Sainuokang Biochemistry Pharmaceutical Co ltd
Priority date: 2022-04-22
Filing date: 2022-04-22
Publication date: 2022-11-18
Anticipated expiration: 2032-04-22

Abstract

The utility model discloses a high-efficient heparin sodium precipitation device, relates to heparin sodium production facility technical field, including the retort main part, the input of retort main part is equipped with the inlet pipe that is used for inputing heparin sodium original solution and ethanol, the top of retort main part is equipped with runs through to its inside refining subassembly that is used for the stirring of heparin sodium original solution, the top of retort main part is located the both sides of refining subassembly and is equipped with the spraying assembly who communicates with external jar body; the refining assembly comprises: the reaction tank comprises a driving motor assembled at the top end of the reaction tank body and a rotating rod assembled at the output end of the driving motor. The utility model discloses under the help of refining subassembly and swing subassembly, will spray the subassembly and spray into the inside sodium chloride solution of retort main part and the quick even fusion of heparin sodium ethanol solution, make heparin sodium deposit fast at last, effectual accelerated the production rhythm under the prerequisite of guaranteeing the quality.

Description

High-efficient heparin sodium deposits device

Technical Field

The utility model relates to a heparin sodium production facility technical field specifically is a high-efficient heparin sodium deposits device.

Background

Heparin sodium is a mucopolysaccharide sulfate anticoagulant, is the most effective anticoagulant with the largest clinical dosage in the world, and is mainly applied to cardiovascular and cerebrovascular diseases and hemodialysis treatment.

In current preparation heparin sodium in-process, need place former solution of heparin in the retort with the dilution of water, add the sodium chloride again, the stirring mixes and makes solution homogeneous mixing, add ethanol in the stirring process, former mixed solution contacts behind the ethanol, the local concentration of ethanol is too high can lead to heparin sodium to deposit, heparin sodium precipitate at this moment can influence the better mixed dissolution of ethanol, ethanol can not better dissolve and lead to the better sediment of heparin sodium again, dissolve for better letting ethanol, need place the jar for 6 to 12 hours, the time of sacrifice is traded for better heparin sodium to deposit, therefore we need develop a high-efficient heparin sodium precipitation device.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a high-efficiency heparin sodium precipitation device to solve the problem of low efficiency of heparin sodium precipitation in the background technology.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

the utility model provides a pair of high-efficient heparin sodium precipitation device, including the retort main part, the input of retort main part is equipped with the inlet pipe that is used for inputing heparin raw solution and ethanol, the top of retort main part is equipped with the refining subassembly that runs through to its inside and is used for stirring heparin raw solution, the top of retort main part is located the both sides of refining subassembly and is equipped with the spraying assembly who communicates with external jar body;

the refining assembly comprises:

the device comprises a driving motor assembled at the top end of the reaction tank main body, a rotating rod assembled at the output end of the driving motor, a packing auger assembled on the outer wall of the rotating rod and not in contact with the inner wall of the reaction tank main body, and baffle plates arranged at the top end of the refining assembly in an equidistant and aligned manner;

the spray assembly comprises:

run through to the conveying pipeline of retort main part inside, with from retort main part top bellows, the assembly in the spray of bellows output is fought, is assembled in the link on spray both sides top of fighting and with retort main part inner wall top is connected through the pivot and is fixed the first rotary disk of assembling on the link top.

Preferably, the outer wall of dwang is located the top of auger and is equipped with the swing subassembly, the swing subassembly includes:

the first bevel gear fixedly assembled with the outer wall of the rotating rod, the second bevel gear meshed with the first bevel gear through clamping teeth, the second bevel gear located at the axis position of the second bevel gear and provided with a connecting shaft, a second rotating disc assembled at one end, far away from the second bevel gear, of the outer wall of the connecting shaft and a swinging arm are arranged at one end, far away from the second bevel gear, of the second rotating disc.

Preferably, the outer wall of the auger is separated from the inner wall of the reaction tank main body by a gap of ten centimeters, so that the heparosan solution flows from the gap when the auger operates to extrude the heparosan solution.

Preferably, the quantity of spraying the subassembly is two sets of, two sets of it is the symmetric distribution for the axis along retort main part axle center to spray the subassembly, the conveying pipeline runs through to retort main part back fifteen centimetre position departments reposition of redundant personnel and is two water pipes, two the water pipe communicates with a set of bellows respectively.

Preferably, the inside of spraying fill is seted up the cavity, the inner wall bottom equidistance evenly distributed of cavity has the filtration pore that runs through to spraying fill bottom outer wall.

Preferably, the number of the second bevel gears is two, the two groups of second bevel gears are meshed with the first bevel gears through clamping teeth, the number of the connecting shafts is two, and the two groups of connecting shafts are connected with the top end of the inner wall of the reaction tank main body through bearing seats.

Preferably, the connecting frame is internally provided with a limiting sliding groove matched with the outer wall of the swinging arm, and the outer wall of the swinging arm is provided with a limiting disc for preventing the swinging arm from separating from the limiting sliding groove.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model discloses under the help of refining subassembly and swing subassembly, will spray the subassembly and spray into the inside sodium chloride solution of retort main part and the quick even integration of heparin ethanol mixed liquid, make heparin sodium precipitate fast at last, effectually accelerated the production rhythm under the prerequisite of guarantee quality.

Drawings

The accompanying drawings, which form a part of the specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without unduly limiting the scope of the invention.

In the drawings:

FIG. 1 is a schematic view of the internal structure of the present invention;

FIG. 2 is a schematic view of the present invention;

FIG. 3 is a schematic view of the structure of the leveling assembly of the present invention;

fig. 4 is a schematic view of the position structure of the swing assembly and the spraying assembly of the present invention;

fig. 5 is a schematic structural view of the spraying assembly of the present invention.

In the figure:

100. a reaction tank main body; 200. a feed pipe; 300. a refining assembly; 400. a spray assembly; 500. a swing assembly;

210. a heparosan solution feeding pipe; 220. an ethanol feeding pipe;

310. a drive motor; 320. rotating the rod; 330. a packing auger; 340. a baffle plate;

410. a delivery pipe; 420. a bellows; 430. a spraying hopper; 440. a connecting frame; 450. a first rotating disk;

510. a first bevel gear; 520. a second bevel gear; 530. a connecting shaft; 540. a second rotating disk; 550. a swing arm.

Detailed Description

In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only partial embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances in order to facilitate the description of the embodiments of the application herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

In this application, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings. These terms are used primarily to better describe the present application and its embodiments, and are not used to limit the indicated devices, elements or components to a particular orientation or to be constructed and operated in a particular orientation.

Moreover, some of the above terms may be used to indicate other meanings besides the orientation or positional relationship, for example, the term "on" may also be used to indicate some kind of attachment or connection relationship in some cases. The specific meaning of these terms in this application will be understood by those of ordinary skill in the art as appropriate.

Furthermore, the terms "mounted," "disposed," "provided," "connected," and "coupled" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; can be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements or components. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as the case may be.

Referring to fig. 1 to 5, the present invention provides a high efficiency heparin sodium precipitation device, which includes a reaction tank main body 100, wherein an input end of the reaction tank main body 100 is equipped with a feeding pipe 200 for inputting heparin raw solution and ethanol, a refining assembly 300 penetrating into the reaction tank main body 100 for stirring the heparin raw solution is equipped at a top end of the reaction tank main body 100, and spraying assemblies 400 communicated with an external tank body are equipped at two sides of the refining assembly 300 at the top end of the reaction tank main body 100;

the blending assembly 300 is started front and back, the heparin stock solution and the ethanol injected into the reaction tank main body 100 are stirred by the blending assembly 300, the sodium chloride solution is sprayed into the reaction tank main body 100 by the spraying assembly 400 in the stirring process, and the blending assembly 300 continuously operates to enable the heparin ethanol mixed solution to be fused with the sodium chloride solution;

the refining assembly 300 includes:

a driving motor 310 assembled at the top end of the reaction tank main body 100, a rotating rod 320 assembled at the output end of the driving motor 310, an auger 330 assembled on the outer wall of the rotating rod 320 and not in contact with the inner wall of the reaction tank main body 100, and baffles 340 arranged at the top end of the refining assembly 300 in an equidistant and aligned manner;

a gap of ten centimeters is formed between the outer wall of the packing auger 330 and the inner wall of the reaction tank main body 100, so that the heparin stock solution flows from the gap when the packing auger 330 operates to extrude the heparin stock solution;

so that the worker starts the power switch of the driving motor 310, the output end of the driving motor 310 drives the rotating rod 320 to rotate, the rotating rod 320 rotates to drive the packing auger 330 to rotate, and the solution in the reaction tank main body 100 is stirred in the rotating process of the packing auger 330;

meanwhile, the auger 330 rotates to apply downward pressure to the solution in the reaction tank main body 100, and the solution extruded by the auger 330 moves towards the inner wall of the reaction tank main body 100 because the inner wall of the reaction tank main body 100 is not in contact with the auger 330, so that the stirring effect on the solution in the reaction tank main body 100 is increased;

the rotation of the packing auger 330 can drive the baffle plates 340 to rotate, and the baffle plates 340 are distributed at the top end of the packing auger 330 in an array manner, so that the baffle plates 340 can stir the solution at different positions in the reaction tank main body 100, and the stirring effect of the material homogenizing assembly 300 is enhanced again;

the spray assembly 400 includes:

a feed delivery pipe 410 penetrating from the top end of the reaction tank main body 100 to the inside of the reaction tank main body 100, a corrugated pipe 420 communicated with the feed delivery pipe 410, a spray hopper 430 assembled at the output end of the corrugated pipe 420, a connecting frame 440 assembled at the top ends of both sides of the spray hopper 430, and a first rotating disc 450 fixedly assembled at the top end of the connecting frame 440 and connected with the top end of the inner wall of the reaction tank main body 100 through a rotating shaft;

so that the sodium chloride solution passes through the material conveying pipe 410 and the corrugated pipe 420 in sequence and then enters the spraying hopper 430, and the sodium chloride solution is sprayed on the solution inside the reaction tank main body 100 through the spraying hopper 430;

foretell structural design is convenient for mix former solution of heparin and ethanol earlier, forms heparin ethanol and mixes the liquid back, will spray subassembly 400 and spray into the inside sodium chloride solution of retort main part 100 and mix the liquid with heparin ethanol and fuse under the help of refining subassembly, makes heparin sodium deposit fast at last, effectually accelerated the production rhythm under the prerequisite of guaranteeing the quality.

Referring to fig. 3 to 5, the swing assembly 500 is assembled on the outer wall of the rotating rod 320 above the packing auger 330, and the swing assembly 500 includes:

a first bevel gear 510 fixedly assembled with the outer wall of the rotating rod 320, a second bevel gear 520 engaged with the first bevel gear 510 through a latch, a connecting shaft 530 assembled at the axial position of the second bevel gear 520, a second rotating disc 540 assembled at the outer wall of the connecting shaft 530 and positioned at one end of the second bevel gear 520, and a swing arm 550 arranged at one end of the second rotating disc 540 far away from the second bevel gear 520;

the kinetic energy that foretell structural design was convenient for swing subassembly 500 through refining subassembly 300 drives and sprays subassembly 400 and be fan-shaped motion for spray subassembly 400 more add even spraying sodium chloride inside retort main part 100, thereby be showing help to the sediment reaction in the follow-up step, concrete operation is as follows:

the rotating rod 320 rotates to drive the first bevel gear 510 to rotate, so as to drive the second bevel gear 520, the second bevel gear 520 rotates to drive the connecting shaft 530 to rotate, so as to drive the second rotating disc 540 to rotate, and the second rotating disc 540 rotates to drive the swinging arm 550 to rotate;

the swing arm 550 rotates to drive the connecting frame 440 and the first rotating disc 450 to fan-move around the rotating shaft, so as to drive the spraying funnel 430 to fan-move, thereby enabling the spraying area of the spraying funnel 430 to be larger.

Please refer to fig. 4 and 5, the number of the spraying assemblies 400 is two, the two spraying assemblies 400 are symmetrically distributed along the axis of the reaction tank main body 100, the material conveying pipe 410 is divided into two water pipes at a position fifteen centimeters behind the reaction tank main body 100, and the two water pipes are respectively communicated with a group of corrugated pipes 420;

foretell structural design is convenient for spray sodium chloride solution more even, and the setting and the wobbling motion mode of symmetric distribution all can improve the efficiency of spraying subassembly 400, and bellows 420's application can make and spray subassembly 400 and keep the transport of sodium chloride solution at the in-process of wobbling motion.

Please refer to fig. 4 and 5, a cavity is formed inside the spraying funnel 430, and filtering holes penetrating through the outer wall of the bottom end of the spraying funnel 430 are uniformly distributed at the bottom end of the inner wall of the cavity at equal intervals;

the above-mentioned structural design is convenient for all the filtering holes to spray the sodium chloride solution, the cavity can store the sodium chloride solution temporarily, and the filtering holes distributed all over the outer wall of the bottom end of the spraying hopper 430 can spray the sodium chloride solution to the reaction tank main body 100 when the cavity is full of the sodium chloride solution.

Referring to fig. 3 to 4, the number of the second bevel gears 520 is two, the two second bevel gears 520 are engaged with the first bevel gears 510 by means of a latch, the number of the connecting shafts 530 is two, and the two connecting shafts 530 are connected to the top end of the inner wall of the reaction tank main body 100 by means of bearing seats;

a limiting sliding groove matched with the outer wall of the swinging arm 550 is formed in the connecting frame 440, and a limiting disc used for preventing the swinging arm 550 from being separated from the limiting sliding groove is arranged on the outer wall of the swinging arm 550;

when foretell structural design was convenient for first bevel gear 510 and is rotated, two sets of second bevel gear 520 pivoted directions were opposite each other to the swing direction that has leaded to two sets of spray hoppers 430 is staggered, thereby made the contact of sodium chloride solution have more areas with retort main part 100 inside heparin ethanol mixed liquid, had the promotion of inequality to accelerating heparin sodium sedimentation speed.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a high-efficient heparin sodium deposits device, includes the retort main part, its characterized in that: the device comprises a reaction tank body, a material mixing component, a spraying component and a stirring component, wherein the input end of the reaction tank body is provided with a feeding pipe for inputting heparin raw solution and ethanol, the top end of the reaction tank body is provided with the material mixing component penetrating into the reaction tank body and used for stirring the heparin raw solution, and the spraying component communicated with an external tank body is arranged at two sides of the material mixing component at the top end of the reaction tank body;

the refining assembly comprises:

the device comprises a driving motor assembled at the top end of the reaction tank main body, a rotating rod assembled at the output end of the driving motor, a packing auger assembled on the outer wall of the rotating rod and not in contact with the inner wall of the reaction tank main body, and a baffle sheet arranged at the top end of the refining assembly in an equidistant manner;

the spray assembly comprises:

2. The high-efficiency heparin sodium precipitation device according to claim 1, wherein: the top that the outer wall of dwang is located the auger is equipped with swing assembly, swing assembly includes:

3. The high-efficiency heparin sodium precipitation device according to claim 1, wherein: the outer wall of auger and the inner wall of retort main part interval ten centimetres gaps to make the former solution of heparin flow from the gap when the former solution of heparin is extruded in the operation of auger.

4. The high-efficiency heparin sodium precipitation device according to claim 1, wherein: the quantity of spraying the subassembly is two sets of, and is two sets of it is the symmetric distribution for the axis along retort main part axle center to spray the subassembly, the conveying pipeline runs through to retort main part back fifteen centimetre position departments reposition of redundant personnel and is two water pipes, two the water pipe communicates with a set of bellows respectively.

5. The high-efficiency heparin sodium precipitation device according to claim 1, wherein: the cavity has been seted up to the inside of spraying fill, the inner wall bottom equidistance evenly distributed of cavity has the filtration pore that runs through to spraying fill bottom outer wall.

6. The high-efficiency heparin sodium precipitation device according to claim 2, wherein: the number of the second bevel gears is two, the two second bevel gears are meshed with the first bevel gears through clamping teeth, the number of the connecting shafts is two, and the two connecting shafts are connected with the top end of the inner wall of the reaction tank main body through bearing seats.

7. The high-efficiency heparin sodium precipitation device according to claim 2, wherein: the connecting frame is characterized in that a limiting sliding groove matched with the outer wall of the swinging arm is formed in the connecting frame, and a limiting disc used for preventing the swinging arm from being separated from the limiting sliding groove is arranged on the outer wall of the swinging arm.