CN217781154U

CN217781154U - DNA, RNA nucleic acid co-extraction and detecting system

Info

Publication number: CN217781154U
Application number: CN202221578109.XU
Authority: CN
Inventors: 张乐
Original assignee: Affiliated Hospital Of Inner Mongolia Medical University Cardiovascular Research Institute Of Inner Mongolia Autonomous Region
Current assignee: Affiliated Hospital Of Inner Mongolia Medical University Cardiovascular Research Institute Of Inner Mongolia Autonomous Region
Priority date: 2022-06-23
Filing date: 2022-06-23
Publication date: 2022-11-11
Anticipated expiration: 2032-06-23

Abstract

The utility model relates to a nucleic acid draws detection area, a DNA is disclosed, RNA nucleic acid draws and detecting system altogether, the load simulator comprises a case, dust cover and two horizontal activity modules, machine case up end both sides lean on the back position to fix respectively and are provided with the bracket, the fixed sideslip support that is provided with between two brackets, sideslip support outside is located to two horizontal activity module slip caps, two horizontal activity module central authorities are fixed has seted up the movable mouth, it is provided with vertical activity module to all slide in two movable mouths, two vertical activity module lower extremes are all fixed and are provided with telescopic cylinder, one of them telescopic cylinder bottom is fixed and is provided with the combination reagent needle among two telescopic cylinder, another one telescopic cylinder bottom is fixed and is provided with the tongs among two telescopic cylinder. The utility model discloses in, with DNA, RNA extraction and detect the function set to same platform on, made things convenient for the operation, utilize the characteristics that sample box sample capacity is many simultaneously, can detect a plurality of samples simultaneously, the practicality is strong.

Description

DNA, RNA nucleic acid co-extraction and detecting system

Technical Field

The utility model relates to a nucleic acid extraction detection area especially relates to a DNA, RNA nucleic acid draw and detecting system altogether.

Background

The nucleic acid extractor is an instrument for automatically finishing the extraction of sample nucleic acid by using a matched nucleic acid extraction reagent, and is widely applied to various fields of disease control centers, clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microorganism detection, food safety detection, animal husbandry, molecular biology research and the like, and the substances for nucleic acid detection are nucleic acids of DNA and RNA.

Through search, the prior patent (publication number: CN 204918581U) discloses a DNA detection sample electric sampler, which is helpful for the DNA detection sample to absorb and prevent the liquid DNA detection sample from coagulating into liquid drops and falling off, but has the problem of incapability of detection, thereby causing poor practicability, therefore, the technical personnel in the field provide a DNA and RNA nucleic acid co-extraction and detection system to solve the problems in the background technology.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the shortcoming that exists among the prior art, and a DNA that proposes, RNA nucleic acid draws and detecting system altogether, this device is with DNA, RNA draws and detects the function and assembles on same platform, the operation is made things convenient for, utilize the characteristics that sample box sample capacity is many simultaneously, can detect a plurality of samples simultaneously, detection efficiency is improved, through setting up the dust cover, external environment has been reduced the influence of external environment to sample detection, detection accuracy has been improved, electric machine has been adopted and the manpower has been replaced, but the swift stability more of the combined reagent needle and the tongs of multi-direction removal, compare in the manual sample detection that draws of tradition, misoperation has been reduced, work efficiency has more been promoted, convenient and fast of concurrent operation, high practicability.

In order to achieve the above purpose, the utility model provides a following technical scheme:

a DNA and RNA nucleic acid co-extraction and detection system comprises a case, a dust cover and two transverse movable modules, wherein brackets are fixedly arranged on two sides of the upper end surface of the case respectively near the rear positions, a transverse support is fixedly arranged between the two brackets, the two transverse movable modules are slidably sleeved outside the transverse support, movable openings are fixedly formed in the centers of the two transverse movable modules, longitudinal movable modules are slidably arranged in the two movable openings, telescopic cylinders are fixedly arranged at the lower ends of the two longitudinal movable modules, a combined reagent needle is fixedly arranged at the bottom end of one of the two telescopic cylinders, and a gripper is fixedly arranged at the bottom end of the other of the two telescopic cylinders;

a kit and a sample platform are fixedly arranged on one side, close to the combined reagent needle, of the upper end surface of the case, a sample box is movably arranged on the upper end surface of the sample platform, a centrifugal oscillation platform and an incubation box are fixedly arranged in the middle of the upper end surface of the case, and a detection electronic box is fixedly arranged on one side, close to the gripper, of the upper end surface of the case;

hinges are arranged on two sides of the upper position of the rear end face of the case, and the dust cover is hinged with the case through the hinges;

through the technical scheme, the movable combined reagent needle is close to the movable combined reagent needle, the reagent is sucked from the reagent box, the reagent is injected into the sample box, if necessary, the sample platform can be used for heating, the movable gripper is used for placing the sample box into the centrifugal oscillation platform, the sample and the reagent are fully mixed, the sample box is moved into the incubation box through the gripper and is kept stand for incubation, ice water can be added into the incubation box according to needs, finally the sample box is placed into the detection electronic box through the gripper for detection, DNA and RNA extraction and detection functions are integrated on the same platform, the operation is facilitated, meanwhile, the characteristic of large sample capacity of the sample box is utilized, a plurality of samples can be detected simultaneously, the detection efficiency is improved, through the arrangement of the dust cover, the influence of the external environment on sample detection is reduced, and the detection accuracy is improved.

Furthermore, an operation platform is fixedly arranged on one side, close to the gripper, of the front end face of the case, a display screen is fixedly arranged on one side, close to the combined reagent needle, of the front end face of the case, and a starting switch is fixedly arranged in the center of the front end face of the case;

through the technical scheme, the device adopts electric mechanism to replace manual operation, through setting up operation platform, does benefit to operating personnel convenient and fast and operates the device, has improved work efficiency, arranges the terminal surface before the quick-witted case in with the display screen, is convenient for carry out data reading, and the testing result is more directly perceived.

Further, the kit is positioned on the rear side of the sample platform, and the centrifugal oscillation platform is positioned on the front side of the incubation box;

through above-mentioned technical scheme, be convenient for make up reagent needle and tongs and operate the sample box, improve work efficiency.

Furthermore, two sterilizing lamps are fixedly arranged at the center of the top surface inside the dust cover;

through above-mentioned technical scheme, through setting up a plurality of sterilamp, be convenient for carry out sterilization to whole quick-witted case multi-angle, reduce and shine the dead angle, avoid the sample to receive the pollution, make the testing result more accurate not have the mistake, if the experiment needs, also can disinfect the deactivation to the sample.

Furthermore, two transverse sliding chutes are fixedly formed in the upper end surfaces of the two transverse moving supports, and longitudinal sliding chutes are respectively and fixedly formed in two sides of the upper end surfaces of the two longitudinal moving modules;

through above-mentioned technical scheme, make horizontal movable mould piece and vertical movable mould piece can more smoothly move steadily, reduce combination reagent needle and tongs and remove the rocking that produces, avoid appearing spilling hourglass in the sample draws the testing process.

Further, the sizes of the sample platform, the centrifugal oscillation platform, the incubation box and the detection electric box are all larger than those of the sample box;

through above-mentioned technical scheme, be convenient for the tongs to take and put the sample box, also be favorable to more firm placing the sample box simultaneously, avoid the sample box to survive to overturn, lead to the sample to spill and leak the pollution device.

Furthermore, a plurality of rubber support legs are fixedly arranged at four corners of the lower end face of the case;

through above-mentioned technical scheme, make the device more firm place on the plane, adopt the rubber material simultaneously, can effectively shock attenuation, antiskid, play protection device's effect.

Furthermore, the two longitudinal movable modules and the two transverse movable modules are driven by a motor;

through above-mentioned technical scheme, utilize the more swift stability of the vertical movable mould piece of motor drive and horizontal movable mould piece, compare in the manual sample that draws of tradition, reduced misoperation, more promoted work efficiency.

The utility model discloses following beneficial effect has:

1. the utility model provides a DNA, RNA nucleic acid draw and detecting system altogether, this device with DNA, RNA draw with detect the function set to same platform on, made things convenient for the operation, utilize the characteristics that sample box sample capacity is many simultaneously, can detect a plurality of samples simultaneously, improved detection efficiency, through setting up the dust cover, reduced external environment to the influence of sample detection, improved the detection accuracy.

2. The utility model provides a DNA, RNA nucleic acid draw and detecting system altogether, this device have adopted electromechanical to replace the manpower, and combination reagent needle and the swift more stable of tongs that can multi-direction removal compare in the manual sample that draws of tradition, have reduced misoperation, have more promoted work efficiency.

3. The utility model provides a DNA, RNA nucleic acid draw and detecting system altogether, the device design is simple, and the structure is light to less volume has realized that DNA, RNA draw and detect the function, and convenient operation is swift simultaneously, and the practicality is high.

Drawings

FIG. 1 is a schematic axial view of the DNA and RNA nucleic acid co-extraction and detection system of the present invention with the dust cover opened;

FIG. 2 is a schematic top view of the open dust cover of the DNA/RNA nucleic acid co-extraction and detection system of the present invention;

FIG. 3 is a schematic axial view of a closed dust cover of a DNA and RNA nucleic acid co-extraction and detection system according to the present invention;

FIG. 4 is a schematic rear view of the closed dust cover of the DNA/RNA nucleic acid co-extraction and detection system of the present invention.

Illustration of the drawings:

1. a longitudinally movable module; 2. a kit; 3. a combination reagent needle; 4. a sample platform; 5. a centrifugal oscillation platform; 6. an incubation box; 7. an operating platform; 8. detecting an electric box; 9. a gripper; 10. a telescopic cylinder; 11. a transverse chute; 12. transversely moving the bracket; 13. a dust cover; 14. a display screen; 15. starting a switch; 16. a chassis; 17. a sterilizing lamp; 18. a bracket; 19. a longitudinal chute; 20. a transverse movable module; 21. a movable opening; 22. a hinge; 23. a rubber leg; 24. a sample cartridge.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, the present invention provides an embodiment: a DNA and RNA nucleic acid co-extraction and detection system comprises a case 16, a dust cover 13 and two transverse movable modules 20, wherein brackets 18 are fixedly arranged at the positions, close to the back, of the two sides of the upper end face of the case 16 respectively, a transverse support 12 is fixedly arranged between the two brackets 18, the two transverse movable modules 20 are slidably sleeved outside the transverse support 12, so that the transverse movable modules 20 can flexibly move back and forth, movable openings 21 are fixedly formed in the centers of the two transverse movable modules 20, longitudinal movable modules 1 are slidably arranged in the two movable openings 21, telescopic cylinders 10 are fixedly arranged at the lower ends of the two longitudinal movable modules 1, a combined reagent needle 3 is fixedly arranged at the bottom end of one telescopic cylinder 10 of the two telescopic cylinders 10, a gripper 9 is fixedly arranged at the bottom end of the other telescopic cylinder 10 of the two telescopic cylinders 10, and the telescopic cylinders 10 enable the gripper 9 and the combined reagent needle 3 to stably move up and down;

the side, close to the combined reagent needle 3, of the upper end face of the case 16 is fixedly provided with the reagent kit 2 and the sample platform 4, the upper end face of the sample platform 4 is movably provided with the sample box 24, the middle position of the upper end face of the case 16 is fixedly provided with the centrifugal oscillation platform 5 and the incubation box 6, one side, close to the gripper 9, of the upper end face of the case 16 is fixedly provided with the detection electronic box 8, required instruments are arranged on the same working platform in a centralized mode, and working efficiency is greatly improved;

hinges 22 are arranged on two sides of the upper position of the rear end face of the case 16, and the dust cover 13 is hinged with the case 16 through the hinges 22;

by moving to be close to the combined reagent needle 3, the reagent is sucked from the reagent kit 2, the reagent is injected into the sample box 24, if necessary, the sample platform 4 can be used for heating, the gripper 9 is moved, the sample box 24 is placed into the centrifugal oscillation platform 5, the sample and the reagent are fully mixed, the sample box 24 is moved into the incubation box 6 through the gripper 9 and is placed for incubation, ice water can be added into the incubation box 6 according to needs, finally, the sample box 24 is placed into the detection electric box 8 through the gripper 9 for detection, DNA and RNA extraction and detection functions are integrated on the same platform by the device, the operation is facilitated, the characteristic of large sample capacity of the sample box 24 is utilized, a plurality of samples can be detected simultaneously, the detection efficiency is improved, the influence of the external environment on sample detection is reduced by arranging the dust cover 13, and the detection accuracy is improved.

An operation platform 7 is fixedly arranged on one side, close to a gripper 9, of the front end face of a case 16, a display screen 14 is fixedly arranged on one side, close to a combined reagent needle 3, of the front end face of the case 16, a starting switch 15 is fixedly arranged at the central position of the front end face of the case 16, all the devices adopt an electric mechanism to replace manual operation, the operation platform 7 is arranged, so that an operator can conveniently and quickly operate the device, the working efficiency is improved, the display screen 14 is arranged on the front end face of the case 16, data reading is facilitated, the detection result is more visual, a reagent box 2 is arranged on the rear side of a sample platform 4, a centrifugal oscillation platform 5 is arranged on the front side of an incubation box 6, the combined reagent needle 3 and the gripper 9 can conveniently operate a sample box 24, the working efficiency is improved, two sterilizing lamps 17 are fixedly arranged at the central position of the inner top face of a dust cover 13, and a plurality of sterilizing lamps 17 are arranged, so that the whole case 16 can be conveniently sterilized and disinfected at multiple angles, the irradiation dead angle is reduced, the sample is prevented from being polluted, the detection result is more accurate and error-free, and if needed, the sample can be sterilized;

two transverse sliding grooves 11 are fixedly formed in the upper end faces of two transverse moving supports 12, longitudinal sliding grooves 19 are respectively fixedly formed in two sides of the upper end faces of two longitudinal moving modules 1, so that the transverse moving modules 20 and the longitudinal moving modules 1 can move more smoothly and stably, shaking caused by movement of a combined reagent needle 3 and a gripper 9 is reduced, leakage in a sample extraction and detection process is avoided, a sample platform 4, a centrifugal oscillation platform 5, an incubation box 6 and a detection electronic box 8 are larger than a sample box 24 in size, the gripper 9 can conveniently take and place the sample box 24, meanwhile, the sample box 24 can be placed more stably, overturning of the sample box 24 is avoided, a sample leakage pollution device is caused, a plurality of rubber supporting legs 23 are fixedly arranged at four corners of the lower end face of a case 16, the device can be placed on a plane more stably, meanwhile, rubber materials are adopted, shock absorption and skid prevention can be achieved, the effect of a protection device is achieved, the two longitudinal moving modules 1 and the two transverse moving modules 20 are driven by motors, the longitudinal moving modules 1 and the transverse moving modules 20 are more quickly and more stably driven by the motors, compared with manual operation, the traditional manual detection sample extraction and manual operation errors are reduced, and the working efficiency is improved.

The working principle is as follows: by moving the combined reagent needle 3 close to, the reagent is sucked from the reagent kit 2, the reagent is injected into the sample box 24, if necessary, the sample platform 4 can be used for heating, the gripper 9 is moved, the sample box 24 is placed into the centrifugal oscillation platform 5, the sample and the reagent are fully mixed, the sample box 24 is moved into the incubation box 6 through the gripper 9 and is kept still for incubation, ice water can be added into the incubation box 6 according to the needs, finally, the sample box 24 is placed into the detection electric box 8 through the gripper 9 for detection, DNA and RNA extraction and detection functions are integrated on the same platform by the device, the operation is facilitated, the characteristic of large sample capacity of the sample box 24 is utilized, a plurality of samples can be detected simultaneously, the detection efficiency is improved, the influence of the external environment on sample detection is reduced by arranging the dust cover 13, and the detection accuracy is improved.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions on some technical features, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of the present invention.

Claims

1. The utility model provides a DNA, RNA nucleic acid co-extraction and detecting system, includes quick-witted case (16), dust cover (13) and two horizontal movable mould piece (20), its characterized in that: brackets (18) are fixedly arranged at the positions, close to the rear, of two sides of the upper end face of the case (16), a transverse support (12) is fixedly arranged between the two brackets (18), the two transverse movable modules (20) are slidably sleeved outside the transverse support (12), movable openings (21) are fixedly formed in the centers of the two transverse movable modules (20), longitudinal movable modules (1) are slidably arranged in the two movable openings (21), telescopic cylinders (10) are fixedly arranged at the lower ends of the two longitudinal movable modules (1), a combined reagent needle (3) is fixedly arranged at the bottom end of one telescopic cylinder (10) of the two telescopic cylinders (10), and a gripper (9) is fixedly arranged at the bottom end of the other telescopic cylinder (10) of the two telescopic cylinders (10);

a kit (2) and a sample platform (4) are fixedly arranged on one side, close to the combined reagent needle (3), of the upper end face of the case (16), a sample box (24) is movably arranged on the upper end face of the sample platform (4), a centrifugal oscillation platform (5) and an incubation box (6) are fixedly arranged in the middle of the upper end face of the case (16), and a detection electronic box (8) is fixedly arranged on one side, close to the hand grip (9), of the upper end face of the case (16);

hinges (22) are arranged on two sides of the upper position of the rear end face of the case (16), and the dust cover (13) is hinged to the case (16) through the hinges (22).

2. The system for co-extracting and detecting DNA and RNA nucleic acid as claimed in claim 1, wherein: an operation platform (7) is fixedly arranged on one side, close to the gripper (9), of the front end face of the case (16), a display screen (14) is fixedly arranged on one side, close to the combined reagent needle (3), of the front end face of the case (16), and a starting switch (15) is fixedly arranged in the center of the front end face of the case (16).

3. The system for co-extracting and detecting DNA and RNA nucleic acid as claimed in claim 1, wherein: the kit (2) is positioned on the rear side of the sample platform (4), and the centrifugal shaking platform (5) is positioned on the front side of the incubation box (6).

4. The system for co-extracting and detecting DNA and RNA nucleic acid as claimed in claim 1, wherein: two sterilizing lamps (17) are fixedly arranged at the center of the top surface in the dust cover (13).

5. The system for co-extracting and detecting DNA and RNA nucleic acid as claimed in claim 1, wherein: two transverse sliding grooves (11) are fixedly formed in the upper end faces of the two transverse moving supports (12), and longitudinal sliding grooves (19) are respectively and fixedly formed in two sides of the upper end faces of the two longitudinal moving modules (1).

6. The system for co-extracting and detecting DNA and RNA nucleic acid as claimed in claim 1, wherein: the sizes of the sample platform (4), the centrifugal oscillation platform (5), the incubation box (6) and the detection electric box (8) are all larger than the size of the sample box (24).

7. The system for co-extracting and detecting DNA and RNA nucleic acids of claim 1, wherein: and a plurality of rubber support legs (23) are fixedly arranged at the four-angle positions of the lower end surface of the case (16).

8. The system for co-extracting and detecting DNA and RNA nucleic acid as claimed in claim 1, wherein: the two longitudinal movable modules (1) and the two transverse movable modules (20) are driven by a motor.