CN217745202U - Filter for blood purification - Google Patents

Abstract

The embodiment of the application discloses filter for blood purification, including blood input end cover, blood output end cover, casing and membrane silk. This application sets up hydrophilicity macromolecular material layer at the internal surface of membrane silk, strengthen the antipollution and the permeability of membrane silk, simultaneously with the length design of casing for 220-270mm, the internal diameter design of casing is 25-32mm, the packing density of membrane silk in the casing is 47-54%, the filter for blood purification that this application discloses is for the filter for blood purification among the prior art, the length of casing increases, the internal diameter reduces the increase of packing density simultaneously, the pressure differential of dislysate and blood chamber both sides has been increased, increase the convection current, increase the filter for blood purification is to the scavenging capacity of macromolecule.

Description

Filter for blood purification

Technical Field

The application relates to the technical field of medical equipment, in particular to a filter for blood purification.

Background

The blood purification filter simulates the filtration principle of glomeruli, removes solutes by convection and dispersion, introduces blood into the blood purification filter with good permeability, removes the moisture and the solutes by means of the pressure gradient (transmembrane pressure) at two sides of a semipermeable membrane of the blood purification filter under the action of convection and dispersion, specifically filters out substances smaller than the pores of the filtration membrane (including substances required by the organism and substances not required), and maintains the stability of the blood environment by means of the concentration gradient of the substances at two sides of the blood side and the dialysate side.

The blood purification filter can increase internal filtration so as to enhance the capacity of removing medium and small molecules.

Therefore, how to enhance the internal filtration of the blood purification filter is a technical problem that needs to be solved by those skilled in the art.

SUMMERY OF THE UTILITY MODEL

The present application provides a filter for blood purification to enhance the inner filtering ability of the filter for blood purification.

In order to achieve the above object, the present application provides a filter for blood purification, comprising a blood input end cap, a blood output end cap, a housing and membrane filaments,

a dialysate outlet and a dialysate inlet are respectively formed in the side walls of the first end and the second end of the shell, and a blood input end cover and a blood output end cover are respectively arranged at the first end and the second end of the shell;

the shell is filled with the membrane filaments, and the inner surfaces of the membrane filaments are provided with hydrophilic polymer material layers;

the length of the shell is 220-270mm, the inner diameter of the shell is 25-32mm, and the filling density of the membrane filaments in the shell is 47-54%.

Preferably, in the blood purification filter, one ends of the blood input end cap and the blood output end cap, which are far away from the housing, are arc-shaped, and the arc-shaped height is 4-10mm.

Preferably, in the filter for blood purification, the membrane filaments are wavy membrane filaments, the diameter of the membrane filaments is 180 to 240 μm, the crimp length of the membrane filaments is 5 to 12mm, and the amplitude of the membrane filaments is 0.03 to 0.7mm.

Preferably, in the blood purification filter, the blood inlet cap is screwed to the housing.

Preferably, in the blood purification filter, the blood outlet cap is screwed to the housing.

Preferably, in the blood purification filter, the housing is a polycarbonate housing.

The filter for purifying blood provided by the embodiment of the application comprises a blood input end cover, a blood output end cover, a shell and membrane wires. This application sets up hydrophilicity macromolecular material layer at the internal surface of membrane silk, strengthen the antipollution and the permeability of membrane silk, simultaneously with the length design of casing 220-270mm, the internal diameter design of casing is 25-32mm, the filling density design of membrane silk in the casing is 47-54%, for the filter for blood purification of prior art, the length of casing has been increased, the internal diameter of casing has been reduced, the filling density of membrane silk has been increased, thereby the pressure differential of dislysate and blood room both sides has been increased, increase the convection current, increase the scavenging capacity of filter for blood purification to middle macromolecule and middle micromolecule.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is obvious that the drawings in the following description are only some examples or embodiments of the present application, and that for a person skilled in the art, other drawings can be obtained from the provided drawings without inventive effort, and that the present application can also be applied to other similar scenarios from the provided drawings. Unless otherwise apparent from the context, or otherwise indicated, like reference numbers in the figures refer to the same structure or operation.

Fig. 1 is a front view of a blood purification filter according to the present invention;

FIG. 2 is a structural view of a membrane yarn of the blood purification filter according to the present invention;

fig. 3 is a structural view of an end cap of the blood purification filter according to the present invention.

The drawings illustrate the following:

1. blood input end cap 2, blood output end cap 3, casing 31, dislysate export, 32, dislysate import, 4, membrane silk.

Detailed Description

The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant application and are not limiting of the application. The described embodiments are only some embodiments of the present application and not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

It should be noted that, for the convenience of description, only the portions related to the related applications are shown in the drawings. The embodiments and features of the embodiments in the present application may be combined with each other without conflict.

It should be understood that "system", "apparatus", "unit" and/or "module" as used herein is a method for distinguishing different components, elements, parts or assemblies at different levels. However, other words may be substituted by other expressions if they accomplish the same purpose.

As used in this application and the appended claims, the terms "a," "an," "the," and/or "the" are not intended to be inclusive in the singular, but rather are intended to be inclusive in the plural unless the context clearly dictates otherwise. In general, the terms "comprises" and "comprising" merely indicate that steps and elements are included which are explicitly identified, that the steps and elements do not form an exclusive list, and that a method or apparatus may include other steps or elements. An element defined by the phrase "comprising a … …" does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.

In the description of the embodiments herein, "/" means "or" unless otherwise specified, for example, a/B may mean a or B; "and/or" herein is merely an association describing an associated object, and means that there may be three relationships, e.g., a and/or B, which may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, in the description of the embodiments of the present application, "a plurality" means two or more than two.

In the following, the terms "first", "second" are used for descriptive purposes only and are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

Flow charts are used herein to illustrate operations performed by systems according to embodiments of the present application. It should be understood that the preceding or following operations are not necessarily performed in the exact order in which they are performed. Rather, the various steps may be processed in reverse order or simultaneously. Meanwhile, other operations may be added to the processes, or a certain step or several steps of operations may be removed from the processes.

As shown in fig. 1-3.

Some embodiments of the present application disclose a filter for blood purification, which comprises a blood input end cap 1, a blood output end cap 2, a shell 3 and membrane filaments 4.

Pack membrane silk 4 in the casing 3, set up dislysate export 31 and dislysate inlet 32 on the lateral wall of the first end of casing 3 and second end respectively, the first end of casing 3 sets up blood input end cover 1 and blood output end cover 2 respectively with the second end.

Blood is supplied into the membrane wires 4 of the shell 3 through the blood input end cap 1, dialysate enters the shell 3 from the dialysate inlet 32 of the shell 3, the dialysate is positioned outside the membrane wires 4, the dialyzed dialysate is discharged through the dialysate outlet 31 of the shell 3, and the blood is discharged through the blood output end cap 2. The flow direction of the dialysate and the blood in the housing 3 are opposite.

The filter for purifying blood disclosed in the present application is provided with a hydrophilic polymer material layer on the inner surface of the membrane wire 4 to enhance the hydrophilicity and permeability of the membrane wire 4, reduce the interaction between the protein and the inner surface of the membrane wire 4, reduce the irreversible adsorption capacity of the protein on the inner surface of the membrane wire 4, improve the contamination resistance of the membrane wire 4, and thus prolong the service life of the filter for purifying blood.

Here, the improvement of the present invention is to add a hydrophilic polymer material layer to the inner surface of the membrane thread 4 of the blood purification filter, and is an improvement of the structure of the membrane thread 4, and does not involve an improvement of the material and the components of the hydrophilic polymer material layer.

The filter for purifying blood disclosed by the application improves the structure of the shell 3 and the structure of the membrane wires 4, specifically, the length of the shell 3 is 220-270mm, the inner diameter of the shell 3 is 25-32mm, and the packing density of the membrane wires 4 in the shell 3 is 47-54%;

one ends of the blood input end cap 1 and the blood output end cap 2, which are far away from the shell 3, are arc-shaped, and the arc-shaped height is 4-10mm;

the membrane silk 4 is a wave-shaped membrane silk, the diameter of the membrane silk 4 is 180-240 mu m, the bending length of the membrane silk 4 is 5-12mm, and the amplitude of the membrane silk 4 is 0.03-0.7mm.

Wherein the filling density is the ratio of the sum of the sectional areas of the membrane filaments to the sectional area of the shell 3.

Table one:

in the table, the pressure drop represents the flow resistance and the dynamic stability, and the smaller the pressure drop value is, the smaller the resistance of the blood purification filter to blood is, and the more stable the flow is; the service life takes the rise of the pressure value after 4 hours of operation as an index, and the smaller the rise value of the pressure is, the longer the service life is; middle and small sizeThe sub-substance has scavenging effect by vitamin VB ₁₂ The removing performance of medium and small molecular substances is taken as an index, and the higher the removing performance of the medium and small molecular substances is, the higher the removing capability of the medium and small molecular substances is represented; the clearance capacity of medium-large molecular substances adopts beta ₂ The clearance ability of the microglobulin is used as an index, and the higher the clearance performance of the medium macromolecule substance is, the higher the clearance ability of the medium macromolecule substance is.

According to the first table, the hydrophilic polymer material layer is arranged on the inner surface of the membrane wire 4 to enhance the anti-pollution performance and permeability of the membrane wire, and meanwhile, compared with the prior art, the length of the shell 3 is designed to be 220-270mm, the inner diameter of the shell 3 is reduced, and the packing density is increased, and as can be seen by referring to the data in the first table, the rise value of the pressure of the blood purification filter after 4 hours of operation is reduced to 20% -30% of the rise value of the pressure of the prior art after 4 hours of operation, compared with the rise value of the pressure of the prior art after 4 hours of operation, which shows that the service life of the blood purification filter is obviously prolonged.

The relatively high packing density can ensure that the dialysate is fully contacted with the membrane wires, fully exerts the cleaning performance of the blood purification filter, and simultaneously improves the internal filtering capacity of the blood purification filter.

According to the table one, the blood purification filter disclosed by the application reduces the proportion of the sectional area of the shell 3 to the length of the shell 3, increases the filling density of the membrane wires 4 in the shell 3, increases the pressure difference between dialysate and two sides of a blood chamber, and increases convection, thereby increasing the removal capacity of the macromolecules.

The height of blood input end cover and blood output end cover is highly low can reduce the pressure that the end cover goes out, influences the stability of blood, and the height of end cover is too high can cause blood to be detained in end cover department, influences the stability of blood equally, and this application still relates to the improvement to the arc height of end cover, reduces the arc height of end cover to the influence of the homogeneity that blood flows and the stability that blood flows in the cerini dialyser cerini.

In some embodiments of the present application, the blood input end cap 1 is threadably connected to the housing 3;

the blood output end cap 2 is connected with the shell 3 by screw threads.

The blood input end cap 1 and the blood output end cap 2 are not limited to be connected with the housing 3 by screw threads, and may be connected with the housing 3 in other ways that the blood input end cap 1 and the blood output end cap 2 can be detachably connected.

Preferably, the housing 3 is a polycarbonate housing. The material for manufacturing the housing 3 is not limited to polycarbonate, and may be other materials that can be used for manufacturing the housing in the art, and is not particularly limited herein.

The above description is only for the purpose of illustrating the preferred embodiments of the present application and the technical principles applied, and is not intended to limit the present application. Various modifications and changes may occur to those skilled in the art. The scope of the application referred to in the present application is not limited to the specific combinations of the above-mentioned features, and it is intended to cover other embodiments in which the above-mentioned features or their equivalents are arbitrarily combined without departing from the spirit of the application. For example, the above features may be replaced with (but not limited to) features having similar functions disclosed in the present application.

Claims (6)

1. A filter for purifying blood is characterized by comprising a blood input end cover (1), a blood output end cover (2), a shell (3) and membrane wires (4),

a dialysate outlet (31) and a dialysate inlet (32) are respectively formed in the side walls of the first end and the second end of the shell (3), and a blood input end cover (1) and a blood output end cover (2) are respectively arranged at the first end and the second end of the shell;

the shell (3) is filled with the membrane filaments (4), and the inner surfaces of the membrane filaments (4) are provided with hydrophilic polymer material layers;

the length of the shell is 220-270mm, the inner diameter of the shell is 25-32mm, and the filling density of the membrane filaments (4) in the shell is 47-54%.

2. The filter for blood purification according to claim 1, wherein the ends of the blood input end cap (1) and the blood output end cap (2) far away from the housing (3) are arc-shaped, and the arc-shaped height is 4-10mm.

3. The filter for blood purification according to claim 2, wherein the membrane filaments (4) are wavy membrane filaments, the diameter of the membrane filaments (4) is 180 to 240 μm, the crimp length of the membrane filaments (4) is 5 to 12mm, and the amplitude of the membrane filaments (4) is 0.03 to 0.7mm.

4. A filter for blood purification according to claim 1, wherein the blood inlet cap (1) is screwed to the housing (3).

5. A filter for blood purification according to claim 1, wherein the blood outlet cap (2) is screwed to the housing (3).

6. The filter for blood purification according to claim 1, wherein the housing (3) is a polycarbonate housing.

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