CN217650392U - Nucleic acid detection transfer mechanism and nucleic acid detection sealing device - Google Patents
Nucleic acid detection transfer mechanism and nucleic acid detection sealing device Download PDFInfo
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- CN217650392U CN217650392U CN202221533543.6U CN202221533543U CN217650392U CN 217650392 U CN217650392 U CN 217650392U CN 202221533543 U CN202221533543 U CN 202221533543U CN 217650392 U CN217650392 U CN 217650392U
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Abstract
The application discloses nucleic acid detects transfer mechanism and nucleic acid detects closing device, and wherein, nucleic acid detects transfer mechanism includes: a container holder; a first clamping assembly for clamping the container; a moving assembly having a moving base movable in a set space; the second clamping assembly is arranged on the moving seat and used for clamping the sealing cover or the container, and the second clamping assembly can move up and down; the pipettor is arranged on the movable seat and can move up and down. The container is used for storing a liquid-phase sample or a reagent, and liquid can be transferred through a liquid transfer device, so that the liquid-phase sample and the corresponding reagent are mixed to obtain a reaction liquid; the sealing cover can be opened from the container or covered in the container through the matching of the first clamping assembly and the second clamping assembly. This application can realize functions such as automatic switch lid, mixed liquid and transfer container position.
Description
Technical Field
The utility model relates to a nucleic acid testing equipment field, concretely relates to nucleic acid detects shifts mechanism and nucleic acid detects obturator.
Background
Pathogens are pathogenic agents, including viruses and microorganisms. Nucleic acid detection is the most direct, reliable and sensitive method in pathogen detection methods, and has important applications in the fields of disease diagnosis, epidemic prevention and control, health monitoring and the like.
When nucleic acid detection is performed, the inactivated liquid-phase sample and a corresponding reagent are required to be mixed and then sealed in a reaction device, and then the liquid-phase sample is placed in a reaction controller for reaction and detection to obtain a result. Manual intervention is often required for the operation, which is not only inefficient, but also prone to contamination.
SUMMERY OF THE UTILITY MODEL
The utility model provides an above-mentioned problem, provide a nucleic acid detects shifts mechanism and nucleic acid detects obturator.
The utility model adopts the following technical scheme:
a nucleic acid detection transfer mechanism comprising:
a vessel holder having an insertion hole into which the vessel is inserted;
a first clamping assembly for clamping the container;
a moving assembly having a moving seat capable of moving in a set space;
the second clamping assembly is arranged on the moving seat and used for clamping the sealing cover or the container, the second clamping assembly can move up and down, and the second clamping assembly and the first clamping assembly are matched with each other and can open the sealing cover from the container or cover the sealing cover in the container;
the pipettor is arranged on the movable seat and can move up and down.
The container is used for storing a liquid-phase sample or a reagent, and liquid can be transferred through a liquid transfer device, so that the liquid-phase sample and the corresponding reagent are mixed to obtain a reaction liquid; the sealing cover can be opened from the container or covered in the container through the matching of the first clamping assembly and the second clamping assembly. The nucleic acid detecting and transferring mechanism can realize the functions of automatically opening and closing the cover, mixing liquid, transferring the position of a container and the like.
In one embodiment of the present invention, the moving assembly is a multi-degree-of-freedom manipulator.
In one embodiment of the present invention, the movable seat has a first lifting component and a second lifting component, the second clamping component cooperates with the first lifting component to move up and down, and the liquid transfer device cooperates with the second lifting component to move up and down.
In one embodiment of the present invention, the moving assembly includes:
a first horizontal rail;
the first mounting seat is slidably mounted on the first horizontal rail;
the first driving element is used for driving the first mounting seat to move along the first horizontal rail;
the second horizontal rail is arranged on the first mounting seat, the second horizontal rail is perpendicular to the first horizontal rail, and the moving seat is slidably mounted on the second horizontal rail; and
the second driving element is used for driving the moving seat to move along the second horizontal rail;
the first lifting assembly comprises:
the first vertical guide rail is fixed relative to the moving seat;
the first mounting plate is slidably mounted on the first vertical guide rail; and
the first lifting element is used for driving the first mounting plate to move up and down along a first vertical guide rail, and the second clamping assembly is mounted on the first mounting plate;
the second lifting assembly comprises:
the second vertical guide rail is relatively fixed with the movable base;
the second mounting plate is slidably mounted on the second vertical guide rail; and
and the second lifting element is used for driving the second mounting plate to move up and down along a second vertical guide rail, and the pipettor is mounted on the second mounting plate.
In one embodiment of the present invention, the first driving element is a ball screw structure, a conveyor belt structure or a rack-and-pinion structure; the second driving element is a ball screw structure, a conveyor belt structure or a gear rack structure; the first lifting element is a ball screw structure, a conveyor belt structure or a gear rack structure; the second lifting element is of a ball screw structure, a conveyor belt structure or a gear rack structure.
In one embodiment of the present invention, the first clamping assembly and the second clamping assembly each include a power clamping jaw, the power clamping jaw has two clamping portions, each clamping portion has one or more clamping surfaces, and the clamping surfaces of the two clamping portions are in one-to-one correspondence to each other and are used for clamping a container or a sealing cover.
In one embodiment of the present invention, the clamping surface is arc-shaped.
In one embodiment of the present invention, the power clamping jaw is a pneumatic clamping jaw or an electric clamping jaw.
In one embodiment of the present invention, the first clamping assembly further comprises a vibration element engaged with the power clamping jaw, wherein the vibration element is used to vibrate the container in the clamping portion to discharge air bubbles.
In practice, the vibration element may be a vibration motor.
In one embodiment of the present invention, the outer sidewall of the sealing cover has an annular groove, and the clamping surface of the second clamping component is embedded into the annular groove.
In one embodiment of the present invention, the system further comprises a reaction controller.
During actual application, after reaction liquid is obtained through mixing, the sealing cover is covered on a container where the reaction liquid is located, then the second clamping assembly clamps the sealing cover or the container tightly, and the container is placed into the reaction controller to react in cooperation with the moving assembly.
In one embodiment of the present invention, the device further comprises a waste collector.
In one embodiment of the present invention, the liquid transfer device has a needle, the side wall of the needle is connected to a hose, the hose is provided with at least one control valve, and the hose is used for conveying the liquid phase sample.
The application also discloses a nucleic acid detection closing device with the nucleic acid detection transfer mechanism, the nucleic acid detection transfer mechanism is installed in the nucleic acid detection closing device, the closing device also comprises a killing component for killing the internal environment or the internal mechanism of the closing device, and the killing component comprises a killing lamp, a killing agent or an ejector.
In one embodiment of the present invention, the sealing device further comprises a monitoring element for monitoring the operation condition inside the nucleic acid detecting sealing device.
The beneficial effects of the utility model are that: the container is used for storing a liquid-phase sample or a reagent, and liquid can be transferred through a liquid transfer device, so that the liquid-phase sample and the corresponding reagent are mixed to obtain a reaction liquid; the sealing cover can be opened from the container or covered in the container through the matching of the first clamping assembly and the second clamping assembly. The nucleic acid detecting and transferring mechanism can realize the functions of automatically opening and closing the cover, mixing liquid, transferring the position of a container and the like.
Drawings
FIG. 1 is a schematic view of the structure of a nucleic acid detecting transfer mechanism;
FIG. 2 is a schematic view of the nucleic acid detecting transfer mechanism from another angle;
FIG. 3 is an enlarged view at A in FIG. 2;
FIG. 4 is a schematic view of the moving assembly and the second clamping assembly;
FIG. 5 is a schematic view of the first mounting plate shown disengaged from the first vertical rail;
fig. 6 is a partial schematic view of a pipette;
FIG. 7 is a schematic view of a nucleic acid detecting sealing device.
The figures are numbered:
1. a container holder; 11. a jack; 2a, a first clamping component; 2b, a second clamping component; 21. a powered jaw; 22. a clamping portion; 23. a clamping surface; 3. a container; 4. a sealing cover; 41. an annular neck; 5. a moving assembly; 51. a first horizontal rail; 52. a first mounting seat; 53. a first drive element; 54. a second horizontal rail; 55. a movable seat; 56. a second drive element; 57. a first lifting assembly; 571. a first vertical guide rail; 572. a first mounting plate; 573. a first lifting element; 58. a second lifting assembly; 581. a second vertical guide rail; 582. a second mounting plate; 583. a second lifting element; 6. a pipettor; 61. a needle head; 62. a hose; 7. a waste collector; 8. a reaction controller.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.
In the description of the present application, it should be noted that the terms "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the application usually place when using, and are only used for convenience in describing the present application and simplifying the description, but do not indicate or imply that the devices or elements that are referred to must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present application. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
In the description of the present application, it is also to be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
The present invention will be described in detail with reference to the accompanying drawings.
As shown in fig. 1, 2 and 3, a nucleic acid detecting transfer mechanism includes:
a container holder 1 having an insertion hole 11 into which the container 3 is inserted;
a first gripping assembly 2a for gripping the container 3;
a moving unit 5 having a moving base 55 movable in a set space;
the second clamping component 2b is arranged on the moving seat 55 and is used for clamping the sealing cover 4 or the container 3, the second clamping component 2b can move up and down, and the second clamping component 2b and the first clamping component 2a are matched with each other to open the sealing cover 4 from the container 3 or cover the sealing cover 4 in the container 3;
and a pipette 6 provided on the movable seat 55, the pipette 6 being movable up and down.
The container 3 is used for storing a liquid-phase sample or a reagent, and liquid can be transferred through the liquid transfer device 6, so that the liquid-phase sample and the corresponding reagent are mixed to obtain a reaction liquid; the sealing lid 4 can be opened from the container 3 or the sealing lid 4 can be set in the container 3 by the cooperation of the first clamp assembly 2a and the second clamp assembly 2 b. The nucleic acid detecting and transferring mechanism can realize the functions of automatically opening and closing the cover, mixing liquid, transferring the position of the container 3 and the like.
In this embodiment, the moving base 55 has a first lifting component 57 and a second lifting component 58, the second holding component 2b is matched with the first lifting component 57 to move up and down, and the pipette 6 is matched with the second lifting component 58 to move up and down.
As shown in fig. 1, 2, 4 and 5, in the present embodiment, the moving assembly 5 includes:
a first horizontal rail 51;
a first mounting seat 52 slidably mounted on the first horizontal rail 51;
a first driving element 53 for driving the first mounting seat 52 to move along the first horizontal rail 51;
a second horizontal rail 54 disposed on the first mounting base 52, the second horizontal rail 54 being perpendicular to the first horizontal rail 51, the moving base 55 being slidably mounted on the second horizontal rail 54; and
a second driving element 56 for driving the moving seat 55 to move along the second horizontal rail 54;
the first elevating assembly 57 includes:
a first vertical guide 571 fixed opposite to the moving seat 55;
a first mounting plate 572 slidably mounted on the first vertical rail 571; and
a first lifting member 573 for driving the first mounting plate 572 up and down along the first vertical guide 571, the second clamping assembly 2b being mounted on the first mounting plate 572;
the second lift assemblies 58 each include:
a second vertical guide 581 fixed opposite to the moving seat 55;
a second mounting plate 582 slidably mounted on second vertical rail 581; and
and the second lifting element 583 is used for driving the second mounting plate 582 to move up and down along the second vertical guide 581, and the pipettor 6 is mounted on the second mounting plate 582.
In other embodiments, the moving assembly 5 may also be a multi-degree-of-freedom robot. At the moment, the second clamping assembly 2b and the pipettor 6 can be driven to move through the multi-degree-of-freedom manipulator.
In actual use, the first driving element 53 is a ball screw structure, a conveyor belt structure or a rack and pinion structure; the second drive element 56 is a ball screw arrangement, a conveyor belt arrangement, or a rack and pinion arrangement; the first lifting element 573 is of a ball screw structure, a conveyor belt structure or a rack and pinion structure; the second lifting element 583 is a ball screw structure, a conveyor belt structure, or a rack and pinion structure.
As shown in fig. 2 and 3, in the present embodiment, each of the first clamping assembly 2a and the second clamping assembly 2b includes a power clamping jaw 21, the power clamping jaw 21 has two clamping portions 22, each clamping portion 22 has one or more clamping surfaces 23, and the clamping surfaces 23 of the two clamping portions 22 are correspondingly engaged with each other to clamp the container 3 or the sealing cap 4.
In this embodiment, the first clamping assembly 2a further comprises a vibration element cooperating with the power jaw, the vibration element being adapted to vibrate the container 3 in the clamping portion to discharge air bubbles. In practical application, the vibration element may be a vibration motor.
In the present embodiment, the clamping surface 23 is arc-shaped.
In practice, the power jaw 21 may be a pneumatic jaw or an electric jaw.
In the embodiment shown in fig. 3, the sealing cover 4 has a ring-shaped slot 41 on the outer side wall, and the clamping surface 23 of the second clamping component 2b is used to be inserted into the ring-shaped slot 41.
As shown in FIG. 2, the nucleic acid detecting and transferring mechanism of the present embodiment further comprises a reaction controller 8. After the reaction liquid is obtained by mixing, the sealing cover 4 is covered on the container 3 where the reaction liquid is located, then the second clamping component 2b clamps the sealing cover 4 or the container 3, and the container 3 is placed into the reaction controller 8 to react in cooperation with the moving component 5.
As shown in FIGS. 2 and 3, the nucleic acid detecting and transferring mechanism of the present embodiment further comprises a waste collector 7.
As shown in fig. 6, the pipette 6 has a needle 61, a flexible tube 62 is connected to a side wall of the needle 61, at least one control valve is mounted on the flexible tube 62, and the flexible tube 62 is used for conveying a liquid phase sample. The liquid transfer device is configured to receive a liquid-phase sample from another mechanism through the flexible tube, inject the liquid-phase sample into an empty container or a container containing a reagent, and normally suck and push the liquid when the control valve of the flexible tube 62 is closed.
As shown in FIG. 7, this example also discloses a closed nucleic acid detecting device having the nucleic acid detecting and transferring mechanism of this example, the nucleic acid detecting and transferring mechanism is installed in the closed nucleic acid detecting device, the closed device further comprises a sterilizing assembly for sterilizing the environment or internal mechanisms inside the closed device, and the sterilizing assembly comprises a sterilizing lamp, a sterilizing agent or an injector.
In actual use, the closed device is also internally provided with a monitoring element for monitoring the operation condition inside the nucleic acid detection closed device.
The above only is the preferred embodiment of the present invention, not therefore the limit the patent protection scope of the present invention, all applications the equivalent structure transformation made by the contents of the specification and the drawings of the present invention is directly or indirectly applied to other related technical fields, and all the same principles are included in the protection scope of the present invention.
Claims (13)
1. A nucleic acid detecting and transferring mechanism, comprising:
a container holder having an insertion hole into which the container is inserted;
a first clamping assembly for clamping the container;
a moving assembly having a moving base movable in a set space;
the second clamping assembly is arranged on the moving seat and used for clamping the sealing cover or the container, the second clamping assembly can move up and down, and the second clamping assembly and the first clamping assembly are matched with each other and can open the sealing cover from the container or cover the sealing cover in the container;
the liquid transfer device is arranged on the moving seat and can move up and down;
a waste collector.
2. The nucleic acid detecting and transferring mechanism according to claim 1, wherein the moving member is a multi-degree-of-freedom robot.
3. The nucleic acid detecting and transferring mechanism according to claim 1, wherein the moving base has a first lifting unit and a second lifting unit, the second holding unit is engaged with the first lifting unit to move up and down, and the pipette is engaged with the second lifting unit to move up and down.
4. The nucleic acid detecting transfer mechanism of claim 3, wherein the moving assembly comprises:
a first horizontal rail;
the first mounting seat is slidably mounted on the first horizontal rail;
the first driving element is used for driving the first mounting seat to move along the first horizontal rail;
the second horizontal rail is arranged on the first mounting seat, the second horizontal rail is perpendicular to the first horizontal rail, and the moving seat is slidably mounted on the second horizontal rail; and
the second driving element is used for driving the moving seat to move along the second horizontal rail;
the first lifting assembly comprises:
the first vertical guide rail is fixed relative to the moving seat;
the first mounting plate is slidably mounted on the first vertical guide rail; and
the first lifting element is used for driving the first mounting plate to move up and down along a first vertical guide rail, and the second clamping assembly is mounted on the first mounting plate;
the second lifting assembly comprises:
the second vertical guide rail is fixed relative to the moving seat;
the second mounting plate is slidably mounted on the second vertical guide rail; and
and the second lifting element is used for driving the second mounting plate to move up and down along a second vertical guide rail, and the pipettor is mounted on the second mounting plate.
5. The nucleic acid detecting and transferring mechanism according to claim 4, wherein the first driving element is a ball screw structure, a conveyor belt structure or a rack and pinion structure; the second driving element is a ball screw structure, a conveyor belt structure or a gear rack structure; the first lifting element is a ball screw structure, a conveyor belt structure or a gear rack structure; the second lifting element is of a ball screw structure, a conveyor belt structure or a gear rack structure.
6. The nucleic acid detecting and transferring mechanism according to claim 1, wherein the first clamping assembly and the second clamping assembly each comprise a power clamping jaw, the power clamping jaw has two clamping portions, the clamping portions have one or more clamping surfaces, and the clamping surfaces of the two clamping portions are matched in a one-to-one correspondence manner to clamp the container or the sealing cover.
7. The nucleic acid detecting and transferring mechanism according to claim 6, wherein the holding surface is arc-shaped.
8. The nucleic acid detecting and transferring mechanism according to claim 6, wherein the power clamping jaw is a pneumatic clamping jaw or an electric clamping jaw; the first clamp assembly further includes a vibratory element engaged with the power jaw for vibrating the container in the clamp to expel air bubbles.
9. The nucleic acid detecting and transferring mechanism according to claim 6, wherein the sealing cover has an outer sidewall with a circular slot, and the clamping surface of the second clamping component is configured to be inserted into the circular slot.
10. The nucleic acid detecting and transferring mechanism according to claim 1, further comprising a reaction controller.
11. The nucleic acid detecting and transferring mechanism of claim 1, wherein the pipette has a needle, a flexible tube is connected to a side wall of the needle, and at least one control valve is installed on the flexible tube, and the flexible tube is used for conveying the liquid phase sample.
12. A nucleic acid detection closed device with the nucleic acid detection transfer mechanism of claim 1, wherein the nucleic acid detection transfer mechanism is installed in the nucleic acid detection closed device, the closed device further comprises a killing component for killing the environment or internal mechanisms in the closed device, and the killing component comprises a killing lamp, a killing agent or an ejector.
13. The nucleic acid detecting closure device according to claim 12, wherein the closure device further comprises a monitoring element for monitoring the operation of the interior of the nucleic acid detecting closure device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221533543.6U CN217650392U (en) | 2022-06-17 | 2022-06-17 | Nucleic acid detection transfer mechanism and nucleic acid detection sealing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221533543.6U CN217650392U (en) | 2022-06-17 | 2022-06-17 | Nucleic acid detection transfer mechanism and nucleic acid detection sealing device |
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| CN217650392U true CN217650392U (en) | 2022-10-25 |
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| CN202221533543.6U Active CN217650392U (en) | 2022-06-17 | 2022-06-17 | Nucleic acid detection transfer mechanism and nucleic acid detection sealing device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114940476A (en) * | 2022-06-17 | 2022-08-26 | 启思半导体(杭州)有限责任公司 | Nucleic acid detection transfer mechanism and nucleic acid detection sealing device |
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2022
- 2022-06-17 CN CN202221533543.6U patent/CN217650392U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114940476A (en) * | 2022-06-17 | 2022-08-26 | 启思半导体(杭州)有限责任公司 | Nucleic acid detection transfer mechanism and nucleic acid detection sealing device |
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