CN217646430U - Programmable micro-fluidic chip for liquid drop nondestructive control - Google Patents
Programmable micro-fluidic chip for liquid drop nondestructive control Download PDFInfo
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- CN217646430U CN217646430U CN202221267073.3U CN202221267073U CN217646430U CN 217646430 U CN217646430 U CN 217646430U CN 202221267073 U CN202221267073 U CN 202221267073U CN 217646430 U CN217646430 U CN 217646430U
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Abstract
The utility model discloses a programmable micro-fluidic chip for the nondestructive control of liquid drops, which comprises a super-hydrophobic functional layer, a deformable intermediate layer and a pressure control layer which are arranged from top to bottom in a laminated way; the super-hydrophobic functional layer comprises a functional layer plate and a plurality of micron through holes, and the deformable intermediate layer comprises an intermediate layer plate and a micron column structure; the pressure control layer comprises a control laminate and cavity structures, and the gas pressure of each cavity structure can be independently controlled; the upper surface of the functional layer plate and the inner wall of the micron through hole are of super-hydrophobic structures, the micron column structure is made of hydrophobic materials, and the super-hydrophilic structure is installed at the top of the micron column structure. The utility model can control the height of the super-hydrophilic structure at the top end of the micron column structure relative to the super-hydrophobic surface of the super-hydrophobic functional layer under the action of the external driving pump; by controlling the external driving pump and programming the path and time for activating the micron column structure, the chip can control the directional movement, stop, spreading and other behaviors of the liquid drop.
Description
Technical Field
The utility model relates to an infiltration response function surface and micro-fluidic chip technical field, concretely relates to micro-fluidic chip able to programme for droplet is harmless to be controlled.
Background
The liquid drop on the solid surface has wide application in the fields of micro-fluidic systems, fresh water collection, cell culture, biochemistry and the like. The traditional methods for realizing droplet control include electrowetting, magnetic response, surface infiltration and the like. For example, kim et al in 2003 implemented basic control such as separation, merging and the like of liquid droplets by using electrowetting; in 2013, timonen et al utilize a cylindrical permanent magnet to apply a magnetic field below the magnetofluid droplets, and control the magnetofluid droplets to realize transportation and separation; in 2014, magaridis et al realized droplet control capable of overcoming certain gravity through a wedge-shaped super-hydrophilic pattern of a super-hydrophobic wetting surface; in 2018, the control and transportation of underwater oil drops are realized by using an underwater oleophilic substrate and a super-oleophobic wetted surface. However, electrowetting, magnetic response techniques rely on external energy, with a number of constraints; in the existing research of controlling the liquid drops by soaking the surface, only a single liquid drop control path is involved, once the device is formed, the liquid drops can only be transported along the existing path, and flexible control cannot be achieved.
Disclosure of Invention
Not enough to prior art exists, the utility model aims to provide a micro-fluidic chip able to programme for liquid drop is harmless to be controlled, solve the technique among the prior art and rely on external energy, have a great deal of condition restriction and only relate to single liquid drop and control the route, in case the device shaping, the liquid drop can only be followed and had the route transportation, can't accomplish the problem of controlling in a flexible way.
In order to solve the technical problem, the utility model discloses a following technical scheme realizes: a programmable micro-fluidic chip for liquid drop nondestructive control comprises a super-hydrophobic functional layer, a deformable intermediate layer and a pressure control layer which are arranged in a laminated manner from top to bottom;
the super-hydrophobic functional layer comprises a functional laminate and a plurality of micron through holes which are arranged on the functional laminate in a penetrating manner; the deformable intermediate layer comprises an intermediate layer plate and a micron column structure vertically arranged on the intermediate layer plate; the micron column structure and the micron through hole are coaxially arranged;
the pressure control layer comprises a control laminate and a cavity structure arranged in the control laminate, and the cavity structure is respectively communicated with a communicating gas path arranged in the control laminate;
the pressure control layer comprises a control laminate and a cavity structure arranged in the control laminate, and the gas pressure of the cavity structure can be independently controlled;
the number and the positions of the micron through holes, the micron column structures and the cavity structures are corresponding;
the upper surface of the functional laminate and the inner wall of the micron through hole are of super-hydrophobic structures, the micron column structure is made of hydrophobic materials, and the super-hydrophilic structure is installed at the top of the micron column structure.
The utility model discloses still have following technical characteristic:
a control gas circuit is also arranged in the pressure control layer, the communication gas circuit is communicated with a main gas circuit I, and the control gas circuit is communicated with a main gas circuit II;
the control gas path is positioned below the communicating gas path, the area where the control gas path is communicated with the communicating gas path forms a control node, a film covers the control node, and the control node controls whether the communicating gas path circulates or not; when the positive pressure of the control gas path is achieved, the film at the control node is pushed into the communication gas path by the air pressure, and the communication gas path is blocked; when the control gas circuit is supplied with normal pressure or negative pressure, the film at the control node is retracted and communicated with the gas circuit for circulation;
the communicating gas circuit, the control gas circuit and the control node jointly and independently control the gas pressure of each cavity structure in the control laminate.
And the micron through hole array on the super-hydrophobic functional layer is arranged.
The diameter of the micron through hole is 100 micrometers, the diameter of the micron column structure is 30 micrometers, the diameter of the control layer cavity structure is 100 micrometers, and the interval between the micron through holes is 100 micrometers;
the thickness of the super-hydrophobic functional layer is 50 micrometers, the thickness of the deformable middle layer is 15 micrometers, and the thickness of the pressure control layer is 50 micrometers;
the superhydrophobic functional layer, the deformable intermediate layer, and the pressure control layer are all constructed using polydimethylsiloxane.
Compared with the prior art, the utility model, following technological effect has:
the utility model (I) can independently control the gas pressure of each cavity structure in the control layer under the action of an external drive pump, thereby controlling the height of the super-hydrophilic structure at the top end of the deformable middle layer micro-column structure relative to the super-hydrophobic surface of the super-hydrophobic functional layer; when the micro-column structure with the super-hydrophilic structure exceeds the upper surface of the super-hydrophobic functional layer and is contacted with the surface of the liquid drop, the function of the micro-column structure is activated, and the activated micro-column structure can induce the liquid drop to move directionally or stay at the hydrophilic structure position. By controlling the external driving pump and programming the path and time for activating the micron column structure, the chip can control the directional movement, stop, spreading and other behaviors of the liquid drop.
(II) the utility model has the advantages of simple structure, convenient use and great manpower and material saving.
Drawings
FIG. 1 is a schematic view of the present invention;
FIG. 2 is a schematic diagram of the structure of the present invention;
FIG. 3 is a structural dimension diagram of the present invention;
fig. 4 is a control schematic diagram of the present invention;
fig. 5 is a schematic view of the present invention illustrating the operation of liquid droplets;
the various reference numbers in the drawings have the meanings given below:
1-a superhydrophobic functional layer; 2-a deformable intermediate layer; 3-a pressure control layer; 4-super-hydrophilic structure, 5-total gas path I, 6-total gas path II;
1-1 functional laminate and 1-2 micron through holes;
2-1 intermediate layer plate and 2-2 micron column structure;
3-1 control laminate, 3-2 cavity structure;
the following examples are provided to explain the present invention in further detail.
Detailed Description
The following embodiments of the present invention are given, and it should be noted that the present invention is not limited to the following embodiments, and the equivalent transformations made on the basis of the technical solution of the present invention all fall into the protection scope of the present invention.
The terms "upper", "lower", "front", "rear", "top", "bottom", and the like as used herein are used merely for convenience in describing the invention and to simplify the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, "inner" and "outer" refer to the inner and outer of the corresponding component profiles, and the above terms should not be construed as limiting the invention.
In the present invention, the terms "mounting", "connecting", "fixing" and the like are used in a broad sense unless otherwise stated, and may be, for example, fixedly connected, detachably connected or integrated; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or may be connected through the use of two elements or the interaction of two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
All parts of the present invention, unless otherwise specified, are entirely as known in the art.
Example 1:
according to the technical scheme, as shown in fig. 1 to 5, a programmable microfluidic chip for droplet nondestructive control comprises a super-hydrophobic functional layer 1, a deformable intermediate layer 2 and a pressure control layer 3 which are stacked from top to bottom;
the super-hydrophobic functional layer 1 comprises a functional layer plate 1-1 and a plurality of micron through holes 1-2 which are arranged on the functional layer plate 1-1 in a penetrating manner; the deformable intermediate layer 2 comprises an intermediate layer plate 2-1 and a micron column structure 2-2 vertically arranged on the intermediate layer plate 2-1; the micron column structure 2-2 and the micron through hole 1-2 are coaxially arranged;
the main body of the functional laminate 1-1 is flat and not easy to deform, and the rolling angle is less than 5 degrees; micron through holes 1-2 which are consistent in shape and size and have the diameter of about 100 microns are distributed on the functional layer plate 1-1 at equal intervals, and the inner walls of the micron through holes 1-2 are of hydrophobic structures.
The diameter of the micron column structure 2-2 is smaller than that of the functional layer through hole; the micro-column structure 2-2 is hydrophobic, and the top of the micro-column structure is modified or decorated to have a super-hydrophilic structure; after the lower surface of the super-hydrophobic functional layer 1 is bonded with the upper surface of the deformable intermediate layer 2, the micron column structure 2-2 is located at the center of the micron through hole 1-2.
The pressure control layer 3 comprises a control laminate 3-1 and a cavity structure 3-2 arranged in the control laminate 3-1, and the cavity structure 3-2 is respectively communicated with a communicating air passage arranged in the control laminate 3-1;
a control gas path is also arranged in the pressure control layer 3, the control gas path is positioned below the communication gas path, a control node is formed by the area where the control gas path is communicated with the communication gas path, and the control node controls whether the communication gas path is communicated;
a control gas path is also arranged in the pressure control layer 3, the communication gas path is communicated with a main gas path I5, and the control gas path is communicated with a main gas path II 6;
the control gas path is positioned below the communicating gas path, the area where the control gas path is communicated with the communicating gas path forms a control node, a film covers the control node, and the control node controls whether the communicating gas path is communicated; when the positive pressure of the control gas path is realized, the thin film at the control node is pushed into the communicating gas path by the air pressure, and the communicating gas path is blocked; when the control gas circuit is supplied with normal pressure or negative pressure, the film at the control node is retracted and communicated with the gas circuit for circulation;
the communicating gas circuit, the control gas circuit and the control node jointly and independently control the gas pressure of each cavity structure 3-2 in the control laminate 3-1.
The horizontal height of the micron column structure 2-2 of the deformable intermediate layer 2 relative to the super-hydrophobic functional layer 1 can be adjusted by changing the gas pressure of the cavity structure 3-2 of the control laminate 3-1;
the number and the positions of the micron through holes 1-2, the micron column structures 2-2 and the cavity structures 3-2 are corresponding;
the upper surface of the functional layer plate 1-1 and the inner wall of the micron through hole 1-2 are of super-hydrophobic structures, the micron column structure 2-2 is made of hydrophobic materials, and the top of the micron column structure 2-2 is provided with a super-hydrophilic structure 4.
When the pressure of the cavity structure 3-2 is reduced and negative pressure is applied to the cavity structure 3-2, the part of the middle layer plate 2-1, which is positioned at the cavity structure 3-2, is concave, so that the top end of the micro-column structure 2-2 is lower than the upper surface of the functional layer plate 1-1, and liquid drops in the area of the surface of the functional layer plate 1-1 can freely slide;
when the pressure of the cavity structure 3-2 is increased and positive pressure is applied to the cavity structure 3-2, the part of the middle layer plate 2-1, which is positioned on the cavity structure 3-2, is protruded upwards, so that the top end of the micro-column structure 2-2 is higher than the upper surface of the functional layer plate 1-1, and the super-hydrophilic structure 4 at the top end of the micro-column structure 2-2 can contact liquid drops to realize the traction and adhesion of the liquid drops;
when the top of the micro-pillar structure 2-2 is lower than the upper surface of the functional layer plate 1-1 again by controlling the pressure of the cavity structure 3-2, the liquid drop on the area of the surface of the functional layer plate 1-1 is restored to a freely slidable state. The external driving pump is controlled through programming to control the pressure of the cavity of the control layer, so that the contact path and time of the micro-column structure 2-2 and the liquid drop are controlled, and the chip can control the directional movement, stop, spreading and other behaviors of the liquid drop.
Super-hydrophobic: the contact angle thetac is more than 150 degrees, so the super-hydrophobic material is called.
Super-hydrophilic: contact angle thetac is less than 10 deg. called superhydrophilic.
θ c is the Contact angle (Contact angle), which is a measure of the degree of wetting.
Defining: the contact angle is the angle thetac at which the tangent to the gas-liquid interface at the intersection of the gas, liquid and solid passes through the boundary between liquid and solid-liquid.
The roll angle, similar to the contact angle, is an important method for characterizing the wettability of a particular surface. It is also a common method for measuring the wettability of the surface of a material. The roll angle is the critical angle, denoted α, formed by the inclined surface and the horizontal plane just before the liquid drop rolls on the inclined surface. When a drop of water is placed on a solid inclined surface to reach a critical state before rolling, the angle at which the solid surface is inclined is the roll angle.
As a preference of this embodiment:
a control gas circuit is also arranged in the pressure control layer 3, the communicating gas circuit is communicated with a main gas circuit I5, and the control gas circuit is communicated with a main gas circuit II 6;
the control gas path is positioned below the communicating gas path, the area where the control gas path is communicated with the communicating gas path forms a control node, a film covers the control node, and the control node controls whether the communicating gas path circulates or not; when the positive pressure of the control gas path is achieved, the film at the control node is pushed into the communication gas path by the air pressure, and the communication gas path is blocked; when the control gas path is under normal pressure or negative pressure, the film at the control node retracts to communicate the gas path for circulation;
the communicating gas circuit, the control gas circuit and the control node jointly and independently control the gas pressure of each cavity structure 3-2 in the control laminate 3-1.
As a preference of this embodiment:
and the micron through holes 1-2 on the functional laminate 1-1 are arranged in an array.
As a preference of the present embodiment:
the diameter of the micron through hole 1-2 is 100 micrometers, the diameter of the micron column structure 2-2 is 30 micrometers, the diameter of the control layer cavity structure is 100 micrometers, and the interval between the micron through holes 1-2 is 100 micrometers;
the thickness of the super-hydrophobic functional layer 1 is 50 micrometers, the thickness of the deformable intermediate layer 2 is 15 micrometers, and the thickness of the pressure control layer 3 is 50 micrometers;
the superhydrophobic functional layer 1, the deformable intermediate layer 2 and the pressure control layer 3 are all constructed using polydimethylsiloxane.
When liquid drops are placed on the surface of the super-hydrophobic functional layer 1, the super-hydrophobic functional layer 1 and the micron through holes 1-2 on the super-hydrophobic functional layer are both super-hydrophobic, and the diameter of the micron through holes 1-2 is about 100 microns, so that the liquid drops stay on the surface of the super-hydrophobic functional layer 1 in a spherical form and cannot be immersed into the micron through holes 1-2.
The diameter of a micron through hole 1-2 of a chip super-hydrophobic functional layer 1 used in the embodiment is 100 micrometers, the diameter of a micron column structure 2-2 of a deformable intermediate layer 2 is 30 micrometers, the diameter of a cavity structure 3-2 of a pressure control layer 3 is 100 micrometers, and the interval between the micron through holes 1-2 is 100 micrometers; the thickness of the super-hydrophobic functional layer 1 is 50 micrometers, the thickness of the deformable intermediate layer 2 is 15 micrometers, and the thickness of the pressure control layer 3 is 50 micrometers; the three-layer structure is made of polydimethylsiloxane PDMS, the upper surface of the functional layer is subjected to low surface energy treatment to form a super-hydrophobic wetting surface, the top end of the 2-2 micron column structure is subjected to hydrophilic modification by ultraviolet/ozone, and finally the three-layer structure is bonded to form the programmable micro-fluidic chip.
The control layer of the programmable microfluidic chip is shown in fig. 4 and mainly comprises three parts: the first is a cavity structure with the numbers of a, b, c, d and the like; the second gas path is communicated with the cavity structure and comprises communicating gas paths I, II, III and IV, and the first part and the second part are arranged on the upper layer; and the third is the control air channels (1), (2), (3), (4) and (5) which have the function of controlling all the air channels. The control gas circuit is arranged at the lower layer and is positioned below the communicating gas circuit.
The control gas circuits (1), (2), (3), (4) and (5) are communicated with a main gas circuit II, the main gas circuit II is externally connected with a gas pump, and the main gas circuit II controls whether the communicated gas circuits I, II, III and IV are communicated or not by controlling the gas pressure of the control gas circuits (1), (2), (3), (4) and (5);
the communication gas paths I, II, III and IV are communicated with a main gas path I, and the main gas path I is externally connected with an air pump so as to respectively control the air pressure of the communication gas paths I, II, III and IV and further respectively control the air pressure of the cavity structures numbered as a, b, c and d;
for example, when the lower-layer control air path (1) is pressurized, the polydimethylsiloxane films at all control nodes in the control air path (1) are pushed into the upper-layer communicating air path by air pressure, and the communicating air path is blocked; when the control gas circuit (1) is depressurized, the polydimethylsiloxane films at all control nodes in the control gas circuit (1) retract into the control gas circuit, the communication gas circuit circulates, the area where the control gas circuit and the communication gas circuit are connected forms a control node, the control node is covered with a film, and the control node controls whether the communication gas circuit circulates or not;
the distribution of the control nodes accords with the permutation and combination mode, and the air pressure of the cavity is controlled in a 'three-control-one' mode.
The method comprises the following specific steps:
the control nodes for the connection of the control gas paths (1), (2) and (3) and the communication gas path I are A11, A12 and A13, and the control gas paths (4) and (5) are not communicated with the communication gas path I;
the control nodes for controlling the connection of the air channels (1), (2) and (4) and the communication air channel II are A21, A22 and A24; the control gas circuits (3) and (5) are not communicated with the communicating gas circuit I;
the control nodes for controlling the connection of the air passages (1), (2) and (5) and the communication air passage III are A31, A32 and A35; the control gas circuits (4) and (3) are not communicated with the communicating gas circuit I;
the control nodes for controlling the connection of the air channels (1), (3) and (4) and the communication air channel IV are A41, A43 and A44; the control gas circuits (2) and (5) are not communicated with the communicating gas circuit I;
taking the example of designing the droplet to follow the abcd path from cavity a to cavity d:
controlling positive pressure of the air paths (1), (2), (3), (4) and (5), pushing the thin film at all control nodes into the communicated air paths by air pressure, blocking all the communicated air paths at the moment, and enabling the micro-column structure 2-2 to be lower than the surface of the super-hydrophobic functional layer;
firstly, enabling the negative pressure of control gas circuits (1), (2) and (3), retracting the films at control nodes A11, A12 and A13 connected with a communicating gas circuit I, enabling the communicating gas circuit I to circulate, enabling the top end of a micron column structure 2-2 at a position a to be higher than the upper surface of a super-hydrophobic functional layer when a cavity a is positive pressure, and drawing liquid drops to the position a;
then the cavity a is changed into negative pressure, and the micro-column structure 2-2 retracts;
then controlling the positive pressure of the air passage (3), and controlling the film at the node A13 to be jacked up to block the communication air passage I;
finally, the control gas path (4) is under negative pressure, the films at the control nodes A21, A22 and A24 connected with the communicating gas path II retract at the moment, the communicating gas path II circulates, the cavity b is under positive pressure, the top end of the micron column structure 2-2 at the position b is higher than the upper surface of the super-hydrophobic functional layer, and the liquid drops are drawn to the position b;
control is done until the drop is pulled to d.
Controlling the liquid drop to move on the surface of the chip as shown in fig. 5, when the cavity structure 3-2 is under low pressure, the top end of the micro-column structure 2-2 is lower than the upper surface of the functional layer, at this time, the liquid drop on the chip is in a super-hydrophobic state, then after the liquid drop transportation path is determined, the top end of the micro-column structure 2-2 is higher than the upper surface of the functional layer only by controlling the cavity structure 3-2 at the corresponding position, the micro-column structure 2-2 is activated, the surface has a wetting gradient of the combination of a super-hydrophobic surface and a hydrophilic point, and the liquid drop is guided to move from the hydrophobic side to the hydrophilic side. Thus, the liquid drop can be controlled to move on the functional surface by controlling the pressure of the cavity structure 3-2, so that the liquid drop can be controlled without damage by changing the path at will.
The pressure activity of the control layer cavity structure 3-2 can be controlled to nondestructively control the movement, the stay and the like of liquid drops at any position on the functional surface, and a solution can be provided for the research in the fields of microfluidic systems, fresh water collection, cell culture and the like.
The above description is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can be covered by the present invention without any changes or substitutions that are not thought of by the inventive work within the technical scope of the present invention.
Claims (4)
1. A programmable micro-fluidic chip for liquid drop nondestructive control is characterized by comprising a super-hydrophobic functional layer (1), a deformable intermediate layer (2) and a pressure control layer (3) which are arranged in a laminated manner from top to bottom;
the super-hydrophobic functional layer (1) comprises a functional layer plate (1-1) and a plurality of micron through holes (1-2) which are arranged on the functional layer plate (1-1) in a penetrating manner;
the deformable middle layer (2) comprises a middle layer plate (2-1) and a micron column structure (2-2) vertically arranged on the middle layer plate (2-1);
the micron column structure (2-2) and the micron through hole (1-2) are coaxially arranged;
the pressure control layer (3) comprises a control laminate (3-1) and a cavity structure (3-2) arranged in the control laminate (3-1), and the gas pressure of the cavity structure (3-2) can be independently controlled;
the number and the positions of the micron through holes (1-2), the micron column structures (2-2) and the cavity structures (3-2) are corresponding;
the upper surface of the functional layer plate (1-1) and the inner wall of the micron through hole (1-2) are of super-hydrophobic structures, the micron column structure (2-2) is made of hydrophobic materials, and the top of the micron column structure (2-2) is provided with a super-hydrophilic structure (4).
2. The programmable micro-fluidic chip for droplet nondestructive control according to claim 1, wherein a communicating gas path is further disposed in the pressure control layer (3), the cavity structures (3-2) are respectively communicated with the communicating gas path disposed in the control laminate (3-1), a control gas path is further disposed in the pressure control layer (3), the communicating gas path is communicated with the main gas path i (5), and the control gas path is communicated with the main gas path ii (6);
the control gas path is positioned below the communicating gas path, the area where the control gas path is communicated with the communicating gas path forms a control node, a film covers the control node, and the control node controls whether the communicating gas path circulates or not; when the positive pressure of the control gas path is realized, the thin film at the control node is pushed into the communicating gas path by the air pressure, and the communicating gas path is blocked; when the control gas path is under normal pressure or negative pressure, the film at the control node retracts to communicate the gas path for circulation;
the communicating gas circuit, the control gas circuit and the control node jointly and independently control the gas pressure of each cavity structure (3-2) in the control laminate (3-1).
3. Programmable microfluidic chip for the lossless manipulation of droplets according to claim 1, characterized in that the functional layer (1-1) has an array of through-micro-vias (1-2).
4. The programmable microfluidic chip for droplet nondestructive manipulation according to claim 3, wherein the diameter of the micro through holes (1-2) is 100 μm, the diameter of the micro post structures (2-2) is 30 μm, the diameter of the control layer cavity structure is 100 μm, and the micro through holes (1-2) are spaced by 100 μm;
the thickness of the super-hydrophobic functional layer (1) is 50 micrometers, the thickness of the deformable intermediate layer (2) is 15 micrometers, and the thickness of the pressure control layer (3) is 50 micrometers;
the super-hydrophobic functional layer (1), the deformable intermediate layer (2) and the pressure control layer (3) are all constructed by polydimethylsiloxane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202221267073.3U CN217646430U (en) | 2022-05-24 | 2022-05-24 | Programmable micro-fluidic chip for liquid drop nondestructive control |
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| CN202221267073.3U CN217646430U (en) | 2022-05-24 | 2022-05-24 | Programmable micro-fluidic chip for liquid drop nondestructive control |
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