CN217608864U

CN217608864U - Suspension device for simulating osteoporosis model

Info

Publication number: CN217608864U
Application number: CN202220944612.6U
Authority: CN
Inventors: 周宜坤; 杨瑞莉
Original assignee: Peking University School of Stomatology
Current assignee: Peking University School of Stomatology
Priority date: 2022-04-22
Filing date: 2022-04-22
Publication date: 2022-10-21
Anticipated expiration: 2032-04-22

Abstract

The embodiment of the application provides a suspension device for simulating an osteoporosis model. The suspension device comprises: a container, a suspension assembly, a vent assembly, and a feeding assembly. Wherein a detachable top cover is arranged at the top of the container; the suspension component is arranged on the top cover; the ventilation assembly is arranged in the top cover and penetrates through the top cover; the feeding assembly is drawably located at the bottom of the container. The suspension device is simple and easy to operate, convenient to observe and record and more stable in effect.

Description

Suspension device for simulating osteoporosis model

Technical Field

The application relates to the field of experimental animal models, in particular to a suspension device for simulating an osteoporosis model.

Background

Osteoporosis occurs in all age groups, previous researches mostly focus on female postmenopausal osteoporosis, in recent years, the proportion of osteoporosis of young and old men caused by disuse reasons is higher and higher, and the establishment of a quick and stable animal model is particularly urgent. The mouse is not used much in the tail suspension experiment, and may be related to the reasons that the weight of the mouse is light, the movement capability is strong, the mouse is easy to turn over and bite off the suspension device to escape, and the like. The tail suspension method was originally proposed in 1979 by Morey et al and is used for the study of simulating the weightless state of astronauts. Researches show that after the tail of a rat is suspended, the flatfish muscle atrophy is obvious, the bone growth is limited, the biomechanical property is degraded, the collagen metabolism is disordered, the bone transformation is enhanced, and serum indexes such as osteocalcin, transforming growth factor beta, prostaglandin E2-and the like are obviously reduced. The tail suspension model reflects the relationship between skeletal muscle and skeleton to a certain extent, and is a method capable of better simulating the osteoporosis process of a human body.

At present, the tail suspension method is mainly performed by rats, but the cortical bone reconstruction activity of the rats is low, so that the method is not suitable for the research of evaluating the medicament capable of promoting the bone Harvard system reconstruction. The mice have various bone metabolism related gene knockout mice, and the mice in the growth period are most sensitive to suspension, so the model is a good model for researching disuse osteoporosis. Therefore, there is a need for an apparatus for simulating an osteoporosis model that is easy to observe.

SUMMERY OF THE UTILITY MODEL

The embodiment of the application provides a suspension device of simulation osteoporosis model, and this suspension device is simple easy to operate, is convenient for observe the record, and the effect is more stable.

As an aspect of an embodiment of the present application, there is provided a suspension device simulating an osteoporosis model, including: a container, a suspension assembly, a vent assembly, and a feeding assembly. Wherein the top of the container is provided with a detachable top cover; the suspension assembly is arranged on the top cover; the air vent assembly is arranged in the top cover and penetrates through the top cover (2); the feeding assembly is drawably located at the bottom of the container.

In one embodiment, the suspension assembly is removably connected to the top cover.

In one embodiment, the top cover (2) comprises a central through hole corresponding to the suspension assembly.

In one embodiment, the suspension assembly is an adjustable mousetrap.

In one embodiment, the adjustable mousetrap includes a knob and a jaw.

In one embodiment, the jaws are provided with a cushion on the inside.

In one embodiment, the container is a transparent device.

In one embodiment, the vent assembly includes an inlet vent and an outlet vent.

In one embodiment, the feeding assembly is a drawer assembly.

The suspension device for simulating the osteoporosis model provided by the embodiment of the application is simple and easy to operate, is convenient to observe and record, can well solve the problem that a mouse easily turns over and bites off the suspension device to escape in a tail suspension experiment, and can be used for short-time tail suspension test.

The foregoing summary is provided for the purpose of description only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the present application will be readily apparent by reference to the drawings and following detailed description.

Drawings

Fig. 1 shows a schematic structural view of a suspension device according to an embodiment of the present application;

FIG. 2 illustrates a top view of a suspension assembly according to an embodiment of the present application;

figure 3 shows a schematic view of a feeding assembly according to an embodiment of the present application.

Reference numerals:

1-a container; 2-a top cover; 3-a suspension assembly; 4-a vent assembly; 5-feeding the assembly; 6-air inlet holes; 7-air outlet holes; 8-food pan; 9-drinking water tray.

Detailed Description

In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present application. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.

Figure 1 illustrates a suspension device simulating an osteoporosis model according to embodiments of the present application. As shown in fig. 1, the suspension apparatus includes: a container 1, a suspension assembly 3, a vent assembly 4 and a feeding assembly 5.

The top of the container 1 is provided with a removable top cover 2. The suspension unit 3 is provided on the top cover 2. The vent assembly 4 is disposed on the top cap 2. The feeding assembly 5 is located at the bottom of the container 1.

The suspension component 3 is detachably connected with the top cover 2. The detachable connection greatly enhances the convenience in use.

The suspension assembly 3 may be an adjustable tail trap. As shown in particular in fig. 2. The adjustable mousetrap includes a jaw and a knob. A soft pad is arranged at the inner side of the forceps holder. The setting of this cushion has increased the cushioning degree for can prevent that the rat tail from receiving the damage when increasing the resistance, can adjust the elasticity of clip through the knob.

The top cover 2 is used for receiving the suspension component 3 and the ventilation component 4.

The container 1 is a transparent device. The container 1 and the top cover 2 are made of acrylic materials. The transparent device made of acrylic materials is convenient for observing the conditions of feeding, defecation and the like of the mouse and monitoring at any time.

The vent assembly 4 includes an inlet vent 6 and an outlet vent 7. The air inlet 6 and the air outlet 7 can be connected with ventilation circulating equipment in an SPF laboratory, so that the consistency of the other variables of the tail suspension group and the control group is ensured, or the tail suspension group and the control group are used for carrying out experiments such as controlling the respiratory circulation of the mouse and the like.

The feeding assembly 5 and the container 1 are combined in a drawer type push-pull mode, and the feeding assembly 5 comprises a food tray 8 and a drinking tray 9. The feeding assembly 5 is shown in figure 3. Padding can be placed in the feeding assembly 5, food necessary for the survival of the mice can be placed in the food tray 8, and water necessary for the survival of the mice can be placed in the drinking tray 9. The drawer type push-pull combination mode is convenient for replacing padding and adding food drinking water on the basis of not influencing the tail suspension experiment.

This hanging device is when using as shown in figure 1, puts into the hanging device with the mouse, and the mouse tail is worn out from the central through-hole of ya keli top cap, fixes on adjustable mouse tail presss from both sides, through the elasticity of rotatory adjustable tail clamp, applicable in the mouse of different weight scopes.

In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; the connection can be mechanical connection, electrical connection or communication; they may be directly connected or indirectly connected through intervening media, or may be connected through the use of two elements or the interaction of two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.

In this application, unless expressly stated or limited otherwise, the recitation of a first feature "on" or "under" a second feature may include the recitation of the first and second features being in direct contact, and may also include the recitation of the first and second features not being in direct contact, but being in contact with another feature between them. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly above and obliquely above the second feature, or simply meaning that the first feature is at a lesser level than the second feature.

The above disclosure provides many different embodiments or examples for implementing different structures of the application. The components and arrangements of specific examples are described above to simplify the present disclosure. Of course, they are merely examples and are not intended to limit the present application. Moreover, the present application may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.

The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive various changes or substitutions within the technical scope of the present application, and these should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A suspension device for simulating an osteoporosis model, comprising:

the container comprises a container (1), wherein a detachable top cover (2) is arranged at the top of the container (1);

a suspension assembly (3), the suspension assembly (3) being disposed on the top cover (2);

a vent assembly (4), the vent assembly (4) being disposed in the overcap (2) and extending through the overcap (2);

a feeding assembly (5), the feeding assembly (5) being drawably located at the bottom of the container (1).

2. The suspension arrangement according to claim 1, characterized in that the suspension assembly (3) is detachably connected with the roof (2).

3. The suspension arrangement according to claim 1, characterized in that the top cover (2) comprises a central through hole corresponding to the suspension assembly (3).

4. The suspension device according to claim 1, wherein the suspension assembly (3) is an adjustable mousetrap.

5. The suspension device of claim 4, wherein the adjustable mousetrap comprises a knob and a jaw.

6. A suspension device according to claim 5, wherein the jaws are provided with a cushion on the inside.

7. The suspension device according to claim 1, characterized in that the container (1) is a transparent device.

8. The suspension device according to claim 1, characterized in that the ventilation assembly (4) comprises an air inlet hole (6) and an air outlet hole (7).

9. The suspension arrangement according to claim 1, wherein the feeding assembly (5) is a drawer assembly.

10. The suspension arrangement according to claim 1, wherein the feeding assembly (5) comprises one or more of a drinking tray and a food tray.