CN217606094U - Cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy - Google Patents
Cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy Download PDFInfo
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- CN217606094U CN217606094U CN202221398537.4U CN202221398537U CN217606094U CN 217606094 U CN217606094 U CN 217606094U CN 202221398537 U CN202221398537 U CN 202221398537U CN 217606094 U CN217606094 U CN 217606094U
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Abstract
The utility model provides a cell irradiation and dose distribution measuring device in super high dose rate radiotherapy relates to radiotherapy test field. The device comprises a main box body, a top cover plate and a film bracket, wherein the main box body is provided with an upper opening, the top cover plate is detachably arranged on the upper opening, and a containing cavity is formed inside the main box body; the top cover plate is provided with an elongated slot, an adjusting seat is movably arranged in the elongated slot, the moving direction of the adjusting seat is arranged along the length direction of the elongated slot, and the adjusting seat is provided with a tube inserting hole for placing a cell sample tube so as to enable the cell sample tube to be suspended into the accommodating cavity; the film support is arranged in the main box body and provided with a plurality of slots which are distributed at intervals in parallel, positioning surfaces for inserting the detection films are formed on the slots, and the positioning surfaces of the slots and the length direction of the long slots are distributed vertically. The method can be used for testing by combining with a cell sample, measuring the dose distribution condition under the condition of irradiating cells, flexibly adjusting the irradiation position and improving the effectiveness of a radiotherapy irradiation test.
Description
Technical Field
The utility model relates to a radiotherapy test technical field especially relates to a cell is shone and dose distribution measuring device in super high dose rate radiotherapy.
Background
The FLASH radiotherapy technology is mainly characterized by ultra-high dose rate irradiation. In order to study the influence of dose rate difference on subsequent biological effect, namely to ensure effective tumor killing and normal tissue protection, the percentage depth dose distribution and the transverse dose distribution of the FLASH beam current need to be measured.
If the Chinese patent with the publication number of CN104189993B and the publication number of 2016.08.31 discloses a radiotherapy plan design model and a three-dimensional dose distribution testing device, the testing device is specifically disclosed to comprise a device body with an inner cavity with an open top and a top plate for sealing the device body, wherein a cavity applicator fixing plate, two dome applicator fixing plates positioned at two sides of the cavity applicator fixing plate, two A point positioning and marking bead fixing plates respectively positioned at two sides of the cavity applicator fixing plate, two B point positioning and marking bead fixing plates respectively positioned at two sides of the cavity applicator fixing plate and a plurality of film fixing plates for clamping radiation dosimetry films are arranged in the inner cavity; the side wall of the device body, which is opposite to the inner cavity, is provided with slots for fixing a point A positioning mark bead fixing plate, a point B positioning mark bead fixing plate and a uterine cavity applicator fixing plate respectively.
In the prior art, a radiotherapy plan design model and a three-dimensional dose distribution testing device can obtain parallel plane dose distribution in a main range of irradiation of a whole treatment plan through dosimetry films in a uterine cavity applicator fixing plate and dosimetry films at different positions, and further realize three-dimensional dose distribution testing and verification in a space.
However, the biological effect caused by the FLASH beam needs to be studied in combination with a large number of cell experiments, and the existing radiotherapy testing device cannot be tested in combination with a cell sample and cannot measure the dose distribution under the condition of irradiating cells.
SUMMERY OF THE UTILITY MODEL
In order to solve the problem, the utility model aims to provide a cell shines and dose distribution measuring device in super high dose rate radiotherapy to solve current radiotherapy testing arrangement and can't combine the cell sample to test, can not survey out the problem of dose distribution condition under the cell condition of shining.
The utility model discloses a cell irradiation and dose distribution measuring device's technical scheme is among the super high dose rate radiotherapy:
the cell irradiation and dose distribution measuring device in the ultra-high dose rate radiotherapy comprises a main box body, a top cover plate and a film bracket, wherein the main box body is provided with an upper opening, the top cover plate is detachably arranged on the upper opening, and a containing cavity is formed inside the main box body;
the top cover plate is provided with an elongated slot, an adjusting seat is movably arranged in the elongated slot, the moving direction of the adjusting seat is arranged along the length direction of the elongated slot, and the adjusting seat is provided with a tube inserting hole for placing a cell sample tube so as to enable the cell sample tube to be suspended into the accommodating cavity;
the film support is arranged in the main box body and provided with a plurality of slots, the slots are distributed in parallel at intervals, positioning surfaces for inserting the detection films are formed on the slots, and the positioning surfaces of the slots are vertically distributed with the length direction of the long grooves.
Furthermore, the axis of the hole of the tube inserting hole is perpendicular to the plate surface of the top cover plate and extends, the tube inserting hole is in clearance fit with the cell sample tube, and the hole edge of the tube inserting hole is in stop fit with the tube cap of the cell sample tube.
Furthermore, the adjusting seat comprises an upper seat plate and a lower guide block, the upper seat plate is fixedly connected to the upper side of the lower guide block, the upper seat plate is in stop fit with the top cover plate, the lower guide block is in sliding fit with the elongated slot, and the jack hole penetrates through the upper seat plate and the lower guide block.
Furthermore, the surface of the top cover plate is provided with scale marks which are distributed at intervals along the length direction parallel to the long groove, the adjusting seat is provided with a calibration line, and the calibration line is matched with the scale marks so as to measure the position of the adjusting seat relative to the long groove.
Further, the length of the long groove is any size from 100mm to 300mm, the width of the long groove is any size from 10mm to 30mm, the aperture of the tube inserting hole is any size from 10mm to 25mm, and the aperture of the tube inserting hole is smaller than the width of the long groove.
Furthermore, the inner side arm of the main box body is provided with an upper flange, the upper flange is close to the upper opening, and the upper flange is matched with the top cover plate in a blocking mode.
Furthermore, the outline shape of the main box body is cuboid, and the main box body is made of transparent materials.
Furthermore, the vertical projection profile of the film support is in clearance fit with the long groove, so that the upper part of the film support protrudes out of the accommodating cavity through the long groove.
Further, the film support is of a frame structure and comprises an upper boundary beam, a lower boundary beam, a first side column and a second side column, wherein the upper boundary beam and the lower boundary beam are distributed at intervals in parallel, and the first side column and the second side column are respectively and fixedly connected between the upper boundary beam and the lower boundary beam.
Further, the inboard of going up the boundary beam is equipped with the socket, the inboard of boundary beam is equipped with down the socket down, the downside interval of going up the socket is equipped with a plurality of slots, the upside interval of socket is equipped with a plurality of slots down, go up a plurality of slots of socket with a plurality of slots of socket are about just arranging down.
Has the beneficial effects that: the cell irradiation and dose distribution measuring device in the ultra-high dose rate radiotherapy adopts the design form of a main box body, a top cover plate and a film bracket, wherein the main box body is provided with an upper opening, and the top cover plate is detachably arranged on the upper opening of the main box body, so that a containing cavity is formed inside the main box body, and the main box body is filled with water and covered with the top cover plate and then stands for later use; an adjusting seat is movably arranged in an elongated slot of the top cover plate, a cell sample tube can be placed in a tube inserting hole of the adjusting seat, the cell sample tube is filled with centrifuged cell suspension, and cells are settled at the bottom of the sample tube after standing for FLASH radiotherapy beam irradiation.
The film support is arranged in the main box body, corresponding determination films can be inserted through the slots on the film support, the slots are distributed in parallel at intervals, and the positioning surfaces formed by the slots are perpendicular to the length direction of the long slots, so that a plurality of determination films can be arranged in the irradiation direction of the radiotherapy beam and at the back part of the corresponding cell sample tube, the results measured by the films at different positions are beam percentage depth dose distribution, and the result measured by the same film is beam transverse dose distribution.
And according to actual measurement requirements, the front and back positions of the adjusting seat can be changed along the length direction of the long groove to obtain the optimal cell irradiation distance, so that the test can be carried out by combining cell samples, the dose distribution condition can be measured under the condition of irradiating cells, the irradiation position can be flexibly adjusted, and the effectiveness of the radiotherapy irradiation test is improved.
Drawings
Fig. 1 is a schematic perspective view of a cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy according to an embodiment of the present invention;
fig. 2 is a schematic perspective view of a film holder in an embodiment of the device for measuring cell irradiation and dose distribution in ultra-high dose rate radiotherapy of the present invention;
fig. 3 is the utility model discloses a vertical section view schematic diagram of cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy.
In the figure: 1-a main box body, 10-an upper flange, 2-a top cover plate, 20-a long groove, 21-an adjusting seat, 22-a jack hole, 23-a scale mark, 24-an upper seat plate and 25-a lower guide block;
3-film support, 30-slot, 31-upper edge beam, 32-lower edge beam, 33-first side column, 34-second side column, 35-upper socket and 36-lower socket;
4-cell sample tube, 40-tube cap, 5-determination film.
Detailed Description
The following detailed description of the embodiments of the present invention is provided with reference to the accompanying drawings and examples. The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention.
The utility model discloses a cell irradiation and dose distribution measuring device's in ultrahigh dose rate radiotherapy concrete embodiment 1, as shown in fig. 1-3, cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy includes main tank body 1, lamina tecti 2 and film support 3, and main tank body 1 is equipped with the upper portion and opens, and lamina tecti 2 detachable mounting is in the upper portion of main tank body 1 and opens, and the inside of main tank body 1 is formed with the holding cavity; the top cover plate 2 is provided with a long groove 20, an adjusting seat 21 is movably installed in the long groove 20, the moving direction of the adjusting seat 21 is arranged along the length direction of the long groove 20, and the adjusting seat 21 is provided with a cannula hole 22 for placing the cell sample tube 4, so that the cell sample tube 4 is suspended in the accommodating cavity; the film support 3 is arranged in the main box body 1, the film support 3 is provided with a plurality of slots 30, the slots 30 are distributed at intervals in parallel, the slots 30 are provided with positioning surfaces for inserting the measuring films 5, and the positioning surfaces of the slots 30 are vertically distributed with the length direction of the long grooves 20.
The cell irradiation and dose distribution measuring device in the ultra-high dose rate radiotherapy adopts the design form of a main box body 1, a top cover plate 2 and a film bracket 3, wherein the main box body 1 is provided with an upper opening, the top cover plate 2 is detachably arranged on the upper opening of the main box body 1, so that a containing cavity is formed inside the main box body 1, and the main box body 1 is filled with water and is kept stand for later use after being covered with the top cover plate 2; an adjusting seat 21 is movably arranged in an elongated slot 20 of the top cover plate 2, a cell sample tube 4 can be placed through a cannula hole 22 of the adjusting seat 21, the cell sample tube 4 contains centrifuged cell suspension, and after standing, cells are precipitated at the bottom of the sample tube for FLASH radiotherapy beam irradiation.
The film support 3 is arranged in the main box body 1, the corresponding determination films 5 can be inserted through the slots 30 on the film support 3, the slots 30 are distributed in parallel at intervals, and the positioning surface formed by the slots 30 is vertical to the length direction of the long slot 20, so that the determination films 5 can be arranged in the irradiation direction of the radiotherapy beam and at the back part corresponding to the cell sample tube 4, the results measured by the films at different positions are beam percentage depth dose distribution, and the result measured by the same film is beam transverse dose distribution. In addition, according to the actual measurement requirement, the front and back positions of the adjusting seat 21 can be changed along the length direction of the long groove 20 to obtain the optimal cell irradiation distance, so that the test can be carried out by combining with the cell sample, the dose distribution condition can be measured under the condition of irradiating the cells, the irradiation position can be flexibly adjusted, and the effectiveness of the radiotherapy irradiation test is improved.
In this embodiment, the hole axis of the tube-inserting hole 22 is perpendicular to the plate surface of the top cover plate 2 and extends, the tube-inserting hole 22 is in clearance fit with the cell sample tube 4, and the hole edge of the tube-inserting hole 22 is in blocking fit with the tube cap 40 of the cell sample tube 4, so that the tube body of the cell sample tube 4 can be suspended into the accommodating cavity, the FLASH radiation beam can accurately irradiate the FLASH radiation beam, and the tube cap 40 is in blocking fit with the hole edge of the tube hole 22, so that the cell sample tube 4 is prevented from falling into the main box 1.
Specifically, the adjusting seat 21 includes an upper seat plate 24 and a lower guide block 25, the upper seat plate 24 is fixedly connected to the upper side of the lower guide block 25, the upper seat plate 24 is in blocking fit with the top cover plate 2, the lower guide block 25 is in sliding fit with the elongated slot 20, and the jack hole 22 is arranged to penetrate through the upper seat plate 24 and the lower guide block 25. The adjusting seat 21 is provided with an upper seat plate 24 and a lower guide block 25 to ensure that the cell sample tube 4 can be stably carried, and the adjusting precision of the forward and backward movement of the adjusting seat 21 is improved by the sliding fit of the lower guide block 25 of the adjusting seat 21 and the long groove 20 of the top cover plate 2.
The length of the long groove 20 is any size from 100mm to 300mm, the width of the long groove 20 is any size from 10mm to 30mm, the aperture of the tube inserting hole 22 is any size from 10mm to 25mm, and the aperture of the tube inserting hole 22 is smaller than the width of the long groove 20. As a further preferable scheme, the length of the long groove 20 is 190mm, the width of the long groove 20 is 20mm, the width of the upper seat plate 24 is 30mm, the aperture of the cannula hole 22 is 17mm, the cell sample tube 4 is a 15mL centrifuge tube, the volume of the contained cell suspension is more than 10mL, and the cell sample tube 4 can be smoothly inserted into the cannula hole 22 and forms a stopping function with the hole edge through the tube cap 40.
In this embodiment, the top cover plate 2 has scale marks 23 on the surface thereof, the scale marks 23 are spaced apart from each other in a direction parallel to the length direction of the elongated slot 20, the adjustment seat 22 has calibration lines, and the calibration lines of the adjustment seat 22 are matched with the scale marks 23 to determine the position of the adjustment seat 22 relative to the elongated slot 20, so as to accurately obtain distance data between the cell sample tube 4 and the radiation source and distance data between the cell sample tube 4 and the measurement film 5.
In addition, the inner side arm of the main box body 1 is provided with an upper flange 10, the upper flange 10 is arranged close to the upper opening, the upper flange 10 is matched with the top cover plate 2 in a blocking way, the disassembly and assembly operation of the top cover plate 2 is simple, and the film bracket 3 and the measuring film 5 can be conveniently put into or taken out of the main box body 1. The main box body 1 is cuboid, the main box body 1 is made of transparent materials, concretely, the main box body 1 is cuboid, the outline dimension is 210mm & 235mm (long & wide & high), the box bottom thickness is 10mm, the box wall thickness is 5mm, the outline shape of the containing cavity is square, the outline dimension is 200mm & 200mm (long & wide & high), the width and thickness of the upper flange 10 are both 5mm, the main box body 1 is made of organic glass (PMMA), the material density is 1.18g/cm 3 Can be used for FLASH radiotherapy beam to smoothly irradiate and pass.
In addition, the vertical projection profile of the film support 3 is in clearance fit with the long groove 20, so that the upper part of the film support 3 protrudes out of the accommodating cavity through the long groove 20. The film bracket 3 is of a frame structure and comprises an upper edge beam 31, a lower edge beam 32, a first side column 33 and a second side column 34, wherein the upper edge beam 31 and the lower edge beam 32 are distributed at intervals in parallel, and the first side column 33 and the second side column 34 are respectively and fixedly connected between the upper edge beam 31 and the lower edge beam 32.
And, the inboard of roof side rail 31 is equipped with upper socket 35, and the inboard of rocker 32 is equipped with lower socket 36, and the downside interval of upper socket 35 is equipped with a plurality of slots 30, and the upside interval of lower socket 36 is equipped with a plurality of slots 30, and a plurality of slots 30 of upper socket 35 and a plurality of slots 30 of lower socket 36 are the upper and lower just to arranging. Firstly, inserting a plurality of measuring films 5 into slots 30 corresponding to film supports 3, putting the film supports 3 and the measuring films 5 into a main box body 1, and adjusting the left and right positions of the film supports 3 to enable the film supports to be opposite to a beam path; then, the top cover plate 2 is closed to project the upper part of the film holder 3 through the elongated slot 20, and the position of the film holder 3 can be moved in the longitudinal direction of the elongated slot 20 to adjust the distance between the measurement film 5 and the cell sample tube 4.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and replacements can be made without departing from the technical principle of the present invention, and these modifications and replacements should also be regarded as the protection scope of the present invention.
Claims (10)
1. A cell irradiation and dose distribution measuring device in ultra-high dose rate radiotherapy is characterized by comprising a main box body, a top cover plate and a film bracket, wherein the main box body is provided with an upper opening;
the top cover plate is provided with an elongated slot, an adjusting seat is movably arranged in the elongated slot, the moving direction of the adjusting seat is arranged along the length direction of the elongated slot, and the adjusting seat is provided with a tube inserting hole for placing a cell sample tube so as to enable the cell sample tube to be suspended into the accommodating cavity;
the film support is arranged in the main box body, a plurality of slots are formed in the film support, the slots are distributed in parallel at intervals, positioning surfaces for inserting detection films are formed in the slots, and the positioning surfaces of the slots and the length direction of the long slots are vertically distributed.
2. The device for measuring cell irradiation and dose distribution in ultra-high dose rate radiotherapy as claimed in claim 1, wherein the axis of the hole of the tube insertion hole extends perpendicular to the plate surface of the top cover plate, the tube insertion hole is in clearance fit with the cell sample tube, and the hole edge of the tube insertion hole is in stop fit with the tube cap of the cell sample tube.
3. The device for measuring cell irradiation and dose distribution in ultra-high dose rate radiotherapy as claimed in claim 2, wherein the adjusting seat comprises an upper seat plate and a lower guide block, the upper seat plate is fixedly connected to the upper side of the lower guide block, the upper seat plate is in stop fit with the top cover plate, the lower guide block is in sliding fit with the elongated slot, and the cannula hole is arranged to penetrate through the upper seat plate and the lower guide block.
4. The device for measuring cell irradiation and dose distribution in ultra-high dose rate radiotherapy as claimed in claim 1, wherein the top cover plate has scale marks on its surface, the scale marks are spaced apart from each other in a direction parallel to the length of the elongated slot, and the adjustment seat is provided with calibration lines, which are matched with the scale marks to determine the position of the adjustment seat relative to the elongated slot.
5. The device for measuring cell irradiation and dose distribution in ultra-high dose rate radiotherapy according to claim 1, wherein the length of the elongated slot is any size from 100mm to 300mm, the width of the elongated slot is any size from 10mm to 30mm, the aperture of the cannula hole is any size from 10mm to 25mm, and the aperture of the cannula hole is smaller than the width of the elongated slot.
6. The apparatus of claim 1, wherein the inner arm of the main housing has an upper flange near the upper opening, and the upper flange is engaged with the top cover plate.
7. The apparatus for measuring cell irradiation and dose distribution in ultra-high dose rate radiotherapy as claimed in claim 1, wherein the main casing has a rectangular parallelepiped shape and is made of a transparent material.
8. The apparatus according to claim 1, wherein the vertical projection profile of the film holder is in clearance fit with the elongated slot, so that the upper portion of the film holder protrudes out of the accommodating cavity through the elongated slot.
9. The apparatus of claim 8, wherein the film frame is a frame structure comprising an upper edge beam, a lower edge beam, a first side column and a second side column, the upper edge beam and the lower edge beam are parallel and spaced apart from each other, and the first side column and the second side column are respectively and fixedly connected between the upper edge beam and the lower edge beam.
10. The apparatus as claimed in claim 9, wherein the upper side of the upper edge beam is provided with an upper socket, the lower side of the lower edge beam is provided with a lower socket, the lower side of the upper socket is provided with a plurality of slots at intervals, the upper side of the lower socket is provided with a plurality of slots at intervals, and the plurality of slots of the upper socket and the plurality of slots of the lower socket are arranged in a vertically opposite manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221398537.4U CN217606094U (en) | 2022-06-06 | 2022-06-06 | Cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221398537.4U CN217606094U (en) | 2022-06-06 | 2022-06-06 | Cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217606094U true CN217606094U (en) | 2022-10-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221398537.4U Active CN217606094U (en) | 2022-06-06 | 2022-06-06 | Cell irradiation and dose distribution measuring device in ultrahigh dose rate radiotherapy |
Country Status (1)
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|---|---|
| CN (1) | CN217606094U (en) |
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2022
- 2022-06-06 CN CN202221398537.4U patent/CN217606094U/en active Active
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