CN217594859U

CN217594859U - Centrifugal machine for preparing crude drug of gadolinium contrast agent

Info

Publication number: CN217594859U
Application number: CN202221023208.1U
Authority: CN
Inventors: 聂良邓; 褚文川; 王少峰; 黄明孙
Original assignee: Anhui Puli Pharmaceutical Co ltd
Current assignee: Anhui Puli Pharmaceutical Co ltd
Priority date: 2022-04-29
Filing date: 2022-04-29
Publication date: 2022-10-18
Anticipated expiration: 2032-04-29

Abstract

The utility model relates to a gadolinium contrast agent bulk drug prepares technical field, discloses a centrifuge for preparation of gadolinium contrast agent bulk drug, including the box, rotate and set up straining a section of thick bamboo in the box, be provided with feed arrangement on the box, feed arrangement is including setting up in the conveying pipeline at box top, setting up in the feed cylinder of conveying pipeline lower extreme, and the lower extreme of conveying pipeline passes the box and extends to strain a section of thick bamboo in, and the bottom of feed cylinder runs through the setting, and the feed cylinder activity sets up in straining a section of thick bamboo. This application has the effect that improves material loading efficiency.

Description

Centrifugal machine for preparing crude drug of gadolinium contrast agent

Technical Field

The application relates to the technical field of gadolinium contrast agent raw material medicine preparation, in particular to a centrifuge for preparing gadolinium contrast agent raw material medicine.

Background

Gadolinium-based contrast agents are intravenous drugs used in magnetic resonance imaging or magnetic resonance angiography to improve the contrast of images to facilitate easier lesion finding or more clear visualization of the extent of lesions. A centrifugal machine is often used in the preparation process of a bulk drug of a gadolinium contrast agent, and liquid and impurities in the bulk drug are centrifuged by the centrifugal machine.

In view of the above related technologies, the inventor of the present application finds that at least the following technical problems exist in the process of implementing the technical solution of the invention in the embodiment of the present application: but the feeding of the existing centrifuge is inconvenient, resulting in low working efficiency.

Disclosure of Invention

The embodiment of the application provides a centrifuge for preparation of bulk drug of gadolinium contrast agent, solves the problems of inconvenient material loading and low work efficiency in the prior art, and effectively improves the material loading efficiency and further improves the overall work efficiency.

The embodiment of the application provides a centrifuge for preparation of gadolinium contrast agent bulk drug, set up straining a section of thick bamboo in the box including box, rotation, be provided with feed arrangement on the box, feed arrangement is including setting up in the conveying pipeline at box top, setting up in the feeding section of thick bamboo of conveying pipeline lower extreme, the lower extreme of conveying pipeline passes the box and extends to strain in the section of thick bamboo, the setting is run through to the bottom of feeding section of thick bamboo, feeding section of thick bamboo activity sets up in straining a section of thick bamboo.

Furthermore, a plurality of feeding holes are uniformly formed in the feeding cylinder.

Furthermore, the box body is provided with a power device for driving the feeding cylinder to move, the power device comprises a fixed cylinder fixed on the box body, the lower end of the fixed cylinder penetrates through the box body and is rotatably connected with the filter cylinder, the conveying pipe is inserted into the fixed cylinder and is in threaded connection with the fixed cylinder, and the box body is provided with a power assembly for driving the feeding cylinder to vertically move.

Furthermore, the power assembly comprises a mounting ring rotatably arranged at the end part of the feeding cylinder, a mounting rod arranged on one side of the mounting ring, and a power cylinder arranged on the box body, wherein a piston rod of the power cylinder is fixedly connected with the mounting rod.

Furthermore, a driving device for driving the filter cylinder to rotate is arranged on the box body, the driving device comprises a gear ring arranged on the upper end face of the filter cylinder, a driving motor arranged on the upper end face of the box body, and a gear arranged on an output shaft of the driving motor, the gear is meshed with the gear ring, and the gear ring is sleeved outside the fixed cylinder and is in running fit with the fixed cylinder.

Furthermore, the bottom of the filter cylinder is arranged in a penetrating mode, a material receiving plate is inserted into the bottom of the filter cylinder, and a braking device for driving the material receiving plate to vertically move is arranged in the box body.

Furthermore, the braking device comprises an installation assembly arranged in the box body and a braking cylinder arranged in the installation assembly, and a piston rod of the braking cylinder penetrates through the installation assembly and is fixedly connected with the bottom of the material receiving plate.

Further, the installation component comprises a protection cylinder arranged in the box body and fixing rods arranged on two opposite sides of the protection cylinder, the other end of each fixing rod is fixedly connected with the inner wall of the box body, the brake cylinder is located in the protection cylinder, and the bottom of the protection cylinder penetrates through the installation component.

The technical scheme provided in the embodiment of the application has at least the following technical effects or advantages:

1. due to the adoption of the feeding device, the filter cylinder can rotate and feed materials simultaneously, so that the filter cylinder rotates and does not interfere with the feeding of the conveying pipeline, the problems of inconvenient feeding and low working efficiency in the prior art are effectively solved, the feeding efficiency is effectively improved, and the whole working efficiency is further improved.

2. Owing to adopted power device, so can be when the feeding, the drive conveying pipeline rotates and downstream, improves the homogeneity of defeated material, and the conveying pipeline drives the feed cylinder pivoted in, can effectively throw away the liquid in the bulk drug, can effectively improve and carry out preliminary centrifugal filtration to the material that gets into in straining a section of thick bamboo, improves the purity to the bulk drug preparation.

3. Due to the adoption of the braking device, the raw materials can be conveniently taken out after the raw materials are centrifuged, and the working efficiency is effectively improved.

Drawings

Fig. 1 is a schematic structural view of the whole in the embodiment of the present application;

FIG. 2 is a schematic view of the internal structure of the case in the embodiment of the present application;

FIG. 3 is an enlarged schematic view at A in FIG. 2;

in the figure: 1. a box body; 11. a positioning ring; 12. a support leg; 2. a filter cartridge; 3. a feeding device; 31. a delivery pipe; 32. a feeding cylinder; 321. a feed port; 4. a power plant; 41. a fixed cylinder; 42. a power assembly; 421. a mounting ring; 422. mounting a rod; 423. a power cylinder; 5. a drive device; 51. a toothed ring; 52. a drive motor; 53. a gear; 6. a material receiving plate; 7. a braking device; 71. mounting the component; 711. a protective cylinder; 712. fixing the rod; 72. and (5) braking the air cylinder.

Detailed Description

The embodiment of the application discloses a centrifuge that is used for gadolinium contrast agent bulk drug to prepare is provided, through setting up feed arrangement 3, can feed in raw material simultaneously when straining a section of thick bamboo 2 and rotate for strain a section of thick bamboo 2 and rotate and not take place to interfere with the feeding of conveying pipeline 31, it is inconvenient effectively to have solved the material loading in the prior art, leads to the problem that work efficiency is low, has realized effectively improving material loading efficiency, and then has improved whole work efficiency.

In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.

Referring to fig. 1 and 2, the centrifuge for preparing the raw material medicine of the gadolinium contrast agent comprises a box body 1 and a filter cartridge 2, wherein the box body 1 is integrally cylindrical, the bottom of the box body 1 is conical, and a discharge hole is formed in the bottom of the box body 1. The discharge hole is provided with a valve. The outer side of the box body 1 is fixedly provided with a positioning ring 11, the lower end face of the positioning ring 11 is fixedly provided with a support leg 12, the box body 1 is convenient to install, the filter cylinder 2 is installed in the box body 1, the side wall of the filter cylinder 2 and the inner wall of the box body 1 are arranged at intervals, and the filter cylinder 2 is rotatably installed in the box body 1 and used for centrifuging impurities in the raw material medicines.

Referring to fig. 1 and 2, a feeding device 3 is installed on a box body 1, the feeding device 3 comprises a feed delivery pipe 31, a feed cylinder 32, the feed delivery pipe 31 is installed at the top of the box body 1, the axis of the feed delivery pipe 31 coincides with the axis of the box body 1, the feed cylinder 32 is fixedly installed at the lower end of the feed delivery pipe 31, the feed cylinder 32 is communicated with the feed delivery pipe 31, the upper end opening of the feed delivery pipe 31 is located above the box body 1, a sealing plug can be plugged at the upper end of the feed delivery pipe 31 during operation, the bottom opening of the feed cylinder 32 is plugged at the lower end of the feed delivery pipe 31 in the interior of a filter cylinder 2, and the feed cylinder 32 is movably arranged in the filter cylinder 2 and used for conveying materials into the filter cylinder 2. A plurality of feeding holes 321 are uniformly arranged on the feeding cylinder 32.

Referring to fig. 1 and 2, a power device 4 is installed on a box body 1 and used for driving a feed cylinder 32 to move, so as to reduce the situation that materials in the feed cylinder 32 are blocked, the power device 4 comprises a fixed cylinder 41 and a power assembly 42, the fixed cylinder 41 is fixedly installed on the box body 1, the upper end of the fixed cylinder 41 is higher than the upper end surface of the box body 1, the lower end of the fixed cylinder 41 penetrates through the box body 1 and is in rotating fit with the upper end surface of a filter cartridge 2, a feed delivery pipe 31 is inserted into the fixed cylinder 41 and is in threaded connection with the fixed cylinder 41, the power assembly 42 is installed on the box body 1, the power assembly 42 comprises an installation ring 421, an installation rod 422 and a power cylinder 423, the installation ring 421 is rotatably connected to the feed pipe 31 and is close to the upper end of the feed pipe 31, the installation rod 422 is fixedly installed on one side of the installation ring 421, the other end of the installation rod 422 horizontally extends in the direction far away from the installation ring 421, the power cylinder 423 is fixedly installed on the upper end surface of the box body 1, a piston rod of the power cylinder 423 vertically extends upwards and is fixedly connected to the end of the installation rod 422, the telescopic cylinder 423 can drive the feed pipe 31 to drive the fixed cylinder 31 to move vertically along the height direction of the feed pipe 31, and can move vertically and can move to the feed cylinder 31, and can move to the feed cylinder 31 uniformly.

Referring to fig. 2 and 3, a driving device 5 is mounted on the housing 1 and used for driving the filter cartridge 2 to rotate, the driving device 5 includes a gear ring 51, a driving motor 52 and a gear 53, the gear ring 51 is fixedly mounted on the upper end surface of the filter cartridge 2, the axis of the gear ring 51 coincides with the axis of the filter cartridge 2, the driving motor 52 is fixedly mounted on the upper end surface of the housing 1, the output shaft of the driving motor 52 passes through the housing 1 and extends above the filter cartridge 2, the gear 53 is fixedly mounted on the output shaft of the driving motor 52, the gear 53 is meshed with the gear ring 51, and the gear ring 51 is sleeved outside the fixed cylinder 41 and is in running fit with the fixed cylinder 41.

Referring to fig. 1 and 2, the bottom of the filter cartridge 2 is arranged in a penetrating manner, a material receiving plate 6 is inserted into the bottom of the filter cartridge 2, and a braking device 7 is installed in the box body 1, so that the material receiving plate 6 can be driven to descend conveniently to take out raw materials in the filter cartridge 2. The braking device 7 comprises a mounting assembly 71 and a braking cylinder 72, wherein the mounting assembly 71 is mounted in the box body 1 and is close to the bottom of the box body 1, the mounting assembly 71 comprises a protection cylinder 711 and a fixing rod 712, the protection cylinder 711 is located at the center of the box body 1 and is close to the bottom of the box body 1, the upper end of the protection cylinder 711 is sealed, the bottom of the protection cylinder 711 is of an opening structure, the fixing rod 712 is provided with two fixing rods, the two fixing rods are fixedly mounted on two opposite sides of the protection cylinder 711 respectively, the other end of the fixing rod 712 is fixedly connected with the inner wall of the box body 1 respectively, the braking cylinder 72 is fixedly mounted in the protection cylinder 711, and a piston rod of the braking cylinder 72 penetrates through the top of the protection cylinder 711 and is fixedly connected with the lower end face of the material receiving plate 6. Through starting brake cylinder 72, can drive and connect flitch 6 vertical lift for the bottom of straining a section of thick bamboo 2 is opened, conveniently takes out the raw materials, and is further, connects the lateral wall of flitch 6 and the inner wall normal running fit who strains a section of thick bamboo 2, in order to reduce and connect flitch 6 and the friction of straining a section of thick bamboo 2, can make the external diameter that connects flitch 6 slightly less than strain an internal diameter of a section of thick bamboo 2.

The working principle of the embodiment of the application is as follows: through in importing the material to feed cylinder 32 from conveying pipeline 31, start power cylinder 423 simultaneously, drive feed cylinder 32 and go up and down along the direction of height of box 1 to rotate, with the material in the feed cylinder 32 drop into strain a section of thick bamboo 2 in, through drive arrangement 5, make and strain a section of thick bamboo 2 and carry out the centrifugation to the material, through arresting gear 7 at last, make and connect flitch 6 to open the lower terminal surface of straining a section of thick bamboo 2, take out the raw materials.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

The above description is only for the preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can substitute or change the technical solution and its concept of the present application within the technical scope disclosed in the present application, and shall be covered by the scope of the present application.

Claims

1. A centrifugal machine for preparing a bulk drug of a gadolinium contrast agent comprises a box body (1) and a filter cylinder (2) rotatably arranged in the box body (1), and is characterized in that a feeding device (3) is arranged on the box body (1), the feeding device (3) comprises a material conveying pipe (31) arranged at the top of the box body (1) and a feeding cylinder (32) arranged at the lower end of the material conveying pipe (31),

the lower end of the feed delivery pipe (31) penetrates through the box body (1) and extends into the filter cylinder (2), the bottom of the feed cylinder (32) is arranged in a penetrating mode, and the feed cylinder (32) is movably arranged in the filter cylinder (2).

2. The centrifuge for preparing raw material medicines of gadolinium contrast agents as claimed in claim 1, wherein the feeding cylinder (32) is provided with a plurality of feeding holes (321) uniformly.

3. The centrifuge for preparing raw material medicines of gadolinium contrast agents as claimed in claim 1, wherein the box body (1) is provided with a power device (4) for driving the feeding cylinder (32) to move, the power device (4) comprises a fixed cylinder (41) fixed on the box body (1),

the lower end of the fixed cylinder (41) penetrates through the box body (1) and is rotatably connected with the filter cylinder (2), the conveying pipe (31) is inserted into the fixed cylinder (41) and is in threaded connection with the fixed cylinder (41), and a power assembly (42) for driving the feeding cylinder (32) to vertically move is arranged on the box body (1).

4. The centrifuge for preparing raw material medicines of gadolinium contrast agents as claimed in claim 3, wherein the power assembly (42) comprises a mounting ring (421) rotatably arranged at the end of the feeding cylinder (32), a mounting rod (422) arranged at one side of the mounting ring (421), and a power cylinder (423) arranged on the box body (1), and a piston rod of the power cylinder (423) is fixedly connected with the mounting rod (422).

5. The centrifuge for preparing raw material medicines of gadolinium contrast agents as claimed in claim 3, wherein the box body (1) is provided with a driving device (5) for driving the filter cartridge (2) to rotate, the driving device (5) comprises a gear ring (51) arranged on the upper end face of the filter cartridge (2), a driving motor (52) arranged on the upper end face of the box body (1), and a gear (53) arranged on the output shaft of the driving motor (52),

the gear (53) is meshed with a gear ring (51), and the gear ring (51) is sleeved outside the fixed cylinder (41) and is in running fit with the fixed cylinder (41).

6. The centrifuge for preparing raw material medicines of gadolinium contrast agents according to claim 1, wherein the bottom of the filter cartridge (2) is arranged in a penetrating manner, a material receiving plate (6) is inserted into the bottom of the filter cartridge (2), and a braking device (7) for driving the material receiving plate (6) to vertically move is arranged in the box body (1).

7. The centrifuge for preparing raw material medicines of gadolinium contrast agents according to claim 6, wherein the braking device (7) comprises a mounting assembly (71) arranged in the case (1), and a braking cylinder (72) arranged in the mounting assembly (71), and a piston rod of the braking cylinder (72) passes through the mounting assembly (71) and is fixedly connected with the bottom of the receiving plate (6).

8. The centrifuge for the preparation of a gadolinium contrast agent drug according to claim 7, wherein the mounting assembly (71) comprises a protective cylinder (711) disposed in the case (1), fixing rods (712) disposed at opposite sides of the protective cylinder (711),

the other end of the fixing rod (712) is fixedly connected with the inner wall of the box body (1), the brake cylinder (72) is located in the protection cylinder (711), and the bottom of the protection cylinder (711) is arranged in a penetrating mode.