CN217594607U

CN217594607U - Acylation kettle for dobutamine hydrochloride synthesis reaction

Info

Publication number: CN217594607U
Application number: CN202221123302.4U
Authority: CN
Inventors: 聂良邓; 褚文川; 王少峰; 余江
Original assignee: Anhui Puli Pharmaceutical Co ltd
Current assignee: Anhui Puli Pharmaceutical Co ltd
Priority date: 2022-05-11
Filing date: 2022-05-11
Publication date: 2022-10-18
Anticipated expiration: 2032-05-11

Abstract

The utility model relates to an acylation cauldron technical field discloses an acylation cauldron of hydrochloric acid dobutamine synthesis reaction, including the cauldron body, the cauldron is internal to be provided with to throw the material pipe, is provided with adjusting device on the cauldron body, and adjusting device is including setting up the cushion rubber piece in throwing the material pipe, horizontal slip in the movable rod of cauldron body one side, cushion rubber piece all around with throw the top of material pipe, bottom and lateral wall sealing connection, and enclose to establish and form and hold the chamber, the one end of movable rod be located hold the intracavity and with cushion rubber piece butt. This application has the effect that effectively reduces to throw and take place to block up in the material pipe.

Description

Acylation kettle for dobutamine hydrochloride synthesis reaction

Technical Field

The application relates to the technical field of acylation kettles, in particular to an acylation kettle for a hydrochloric acid dobutamine synthesis reaction.

Background

At present, china is gradually entering into an aging society, the disease incidence of cardiovascular diseases is increasing year by year, and the demand of dopamine hydrochloride injection is also continuously increasing. In the dopamine-dopamine hydrochloride reaction, an acylation kettle is often used and comprises a kettle body, a kettle cover, a stirring device, an observation port and a feeding group.

In view of the above-mentioned related technologies, the inventor of the present application finds that at least the following technical problems exist in the process of implementing the technical solution of the invention in the embodiment of the present application: however, when the raw materials are charged into the kettle, a large amount of granular materials are sometimes extruded with each other at the position of the charging pipe, which easily causes the charging pipe to be blocked.

Disclosure of Invention

The embodiment of the application solves the problem that blockage easily occurs in a feeding pipe in the prior art by providing the acylation kettle for dobutamine hydrochloride synthesis reaction, and realizes the effect of effectively reducing blockage occurring in the feeding pipe.

The embodiment of the application provides an acylation cauldron of hydrochloric acid dobutamine synthesis reaction, including the cauldron body, the cauldron is internal to be provided with to throw the material pipe, the cauldron is internal to be provided with adjusting device, adjusting device is including setting up in throwing buffer rubber piece, the horizontal slip in the movable rod of cauldron body one side in the material pipe, buffer rubber piece around with throw the top, the bottom and the lateral wall sealing connection of material pipe, and enclose to establish and form and hold the chamber, the one end of movable rod be located hold the intracavity and with buffer rubber piece butt.

Further, be provided with the gliding drive arrangement of drive movable rod horizontal on the cauldron body, drive arrangement sets up in the drive post at cauldron body top, sets up cam on the drive post, sets up in cauldron body top and with the driving motor of drive post end connection, rotate the gyro wheel that sets up in the movable rod other end, the gyro wheel rolls the cooperation with the circumference of cam.

Furthermore, a circle of limiting groove is formed in the circumferential direction of the cam, and the roller is arranged in the limiting groove in a rolling mode.

Further, be provided with spacing subassembly on the cauldron body, spacing subassembly is including setting up pole setting on the cauldron body, setting up in the guide holder of pole setting upper end, the movable rod pass the guide holder and with guide holder sliding fit.

Furthermore, the end part of the movable rod, which is positioned in the accommodating cavity, is provided with a rubber push sheet.

Further, the internal agitating unit that is provided with of cauldron, agitating unit sets up in the internal (mixing) shaft of cauldron, sets up in the epaxial puddler of stirring including rotating, the upper end of (mixing) shaft and the lower extreme fixed connection of drive post.

Furthermore, a plurality of stirring rods are arranged at intervals along the length direction of the stirring shaft, and every two adjacent stirring rods are staggered mutually.

Furthermore, the rubber pushing sheet is obliquely arranged from bottom to top towards one side close to the movable rod.

The technical scheme provided in the embodiment of the application has at least the following technical effects or advantages:

1. owing to adopted adjusting device, so can be through push-and-pull movable rod for the tip of movable rod promotes the cushion rubber piece, makes the material of throwing in the charging tube can be pushed by the extrusion, throws the material entering cauldron body in the charging tube with higher speed, and then effectively reduces and throws the intraductal possibility that takes place to block up of charging.

2. Owing to adopted drive arrangement, so can drive the movable rod automatically and carry out the push-and-pull activity, and then can periodically pat the cushion rubber piece for it is internal that the material can fall into the cauldron fast, effectively improves work efficiency.

3. Owing to adopted agitating unit, so through (mixing) shaft and drive column body coupling, can stir the internal material of cauldron simultaneously, also can pat loose to the material of throwing in the material pipe, improve holistic work efficiency and energy saving greatly.

Drawings

Fig. 1 is a schematic structural view of the whole in the embodiment of the present application;

FIG. 2 is a schematic structural view of the inside of a tank in an embodiment of the present application;

in the figure: 1. a kettle body; 11. a support leg; 12. a feeding pipe; 2. an adjustment device; 21. a cushion rubber sheet; 22. a movable rod; 23. a rubber push sheet; 3. a drive device; 31. a drive column; 32. a cam; 33. a drive motor; 34. a roller; 35. a limiting groove; 4. a U-shaped frame; 5. a limiting component; 51. erecting a rod; 52. a guide seat; 6. a stirring device; 61. a stirring shaft; 62. a stirring rod.

Detailed Description

The embodiment of the application discloses an acylation cauldron that provides hydrochloric acid dopol butanamine synthesis reaction drives driving column 31 through driving motor 33 and rotates for movable rod 22's tip intermittent type nature promotes cushion rubber piece 21, makes the material in the feeding pipe 12 can in time be loose, and the material in the feeding pipe 12 gets into the cauldron body 1 with higher speed, effectively reduces the possibility that the material takes place to block up in the feeding pipe 12.

In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.

Referring to fig. 1 and 2, an acylation kettle for dobutamine hydrochloride synthesis reaction comprises a cylindrical kettle body 1, wherein supporting legs 11 are fixedly installed at the bottom of the kettle body 1, feeding pipes 12 communicated with each other are installed at the top of the kettle body 1, discharging pipes communicated with each other are installed at the bottom of the kettle body 1, and valves are installed on the discharging pipes. Install adjusting device 2 on the cauldron body 1 for material to in the feeding pipe 12 loosens, reduces the jam of material in the feeding pipe 12, installs agitating unit 6 in the cauldron body 1, is used for stirring the multiple material of the cauldron body 1.

Referring to fig. 1 and 2, adjusting device 2 includes cushion rubber piece 21, movable rod 22, cushion rubber piece 21 all around with throw material pipe 12 the top, bottom and lateral wall sealing connection, and enclose and establish and form and hold the chamber, the volume that holds the chamber is less than the volume of throwing material pipe 12 half, movable rod 22's one end is stretched into by the outside of the cauldron body 1 and is held the intracavity, and movable rod 22 and cauldron body 1 sliding fit, movable rod 22's one end be located hold the intracavity and with cushion rubber piece 21 butt. The end of the movable rod 22 located in the accommodating cavity is provided with a rubber push sheet 23, and the rubber push sheet 23 is inclined from bottom to top to one side close to the movable rod 22, so that the contact area with the buffer rubber sheet 21 can be increased, and the loosening effect is improved. The buffer rubber sheet 21 can be pushed to move by drawing the movable rod 22, so that the materials in the feeding pipe 12 are loosened.

Referring to fig. 1 and 2, in order to improve efficiency, a driving device 3 is installed on the kettle body 1 and used for driving the movable rod 22 to horizontally slide, the driving device 3 includes a driving column 31, a cam 32, a driving motor 33 and a roller 34, the driving column 31 is rotatably installed at the top of the kettle body 1 and is located at the center of the kettle body 1, the rotating center of the cam 32 is fixed on the driving column 31, the cam 32 is driven to rotate by the driving column 31, a U-shaped frame 4 is fixedly installed on the kettle body 1, the opening of the U-shaped frame 4 faces the top of the kettle body 1 and is erected outside the cam 32 without influencing the rotation of the cam 32, the driving motor 33 is fixedly installed at the top of the U-shaped frame 4, an output shaft of the driving motor 33 is fixedly connected with the upper end of the driving column 31, the roller 34 is rotatably connected to the end of the movable rod 22, and the roller 34 is in circumferential rolling fit with the cam 32. A circle of limiting groove 35 is formed in the circumferential direction of the cam 32, and the roller 34 is arranged in the limiting groove 35 in a rolling manner. The movable bar 22 can be pushed to move along the horizontal direction of the kettle body 1 by the rotation of the cam 32.

Referring to fig. 1 and 2, in order to improve the sliding stability of the movable rod 22, a limiting component 5 is mounted on the kettle body 1, the limiting component 5 includes a vertical rod 51 and a guide seat 52, the vertical rod 51 is vertically fixed on the top of the kettle body 1 and is located between the driving column 31 and the feeding pipe 12, the guide seat 52 is fixedly mounted on the upper end of the vertical rod 51, and the movable rod 22 passes through the guide seat 52 and is in sliding fit with the guide seat 52.

Referring to fig. 2, the stirring device 6 includes a stirring shaft 61, stirring rods 62, the stirring shaft 61 is installed inside the kettle body 1 in a rotating manner, and is arranged along the height direction of the kettle body 1, the upper end of the stirring shaft 61 is fixedly connected with the lower end of the driving column 31, the stirring rods 62 are fixedly installed in the circumferential direction of the stirring shaft 61, and the stirring rods 62 are arranged in a plurality along the length direction of the stirring shaft 61 at intervals, two adjacent stirring rods 62 are staggered with each other, the stirring shaft 61 can be driven to rotate by the driving motor 33, and the materials in the kettle body 1 are stirred, so that the materials are uniformly mixed.

The working principle of the embodiment of the application is as follows: drive the drive column 31 through driving motor 33 and rotate, make movable rod 22's tip intermittent type nature promote cushion rubber piece 21, make the material in feeding pipe 12 can in time be loose, material in feeding pipe 12 gets into cauldron body 1 with higher speed, effectively reduce the possibility that the material takes place to block up in feeding pipe 12, driving motor 33 can also drive (mixing) shaft 61 and rotate simultaneously, in time stir the material in the cauldron body 1, whole work efficiency is improved.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

The above description is only for the preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can substitute or change the technical solution and its concept of the present application within the technical scope disclosed in the present application, and shall be covered by the scope of the present application.

Claims

1. The utility model provides a dobutamine hydrochloride synthesis reaction's acylation cauldron, includes the cauldron body (1), be provided with feeding pipe (12) on the cauldron body (1), its characterized in that, be provided with adjusting device (2) on the cauldron body (1), adjusting device (2) are including setting up buffer rubber piece (21), the movable rod (22) of horizontal slip in cauldron body (1) one side in feeding pipe (12), buffer rubber piece (21) all around with the top, bottom and the lateral wall sealing connection of feeding pipe (12), and enclose to establish and form and hold the chamber, the one end of movable rod (22) is located and holds the intracavity and with buffer rubber piece (21) butt.

2. The acylation kettle for the synthesis reaction of dopamine-butanamine hydrochloride according to claim 1, wherein the kettle body (1) is provided with a driving device (3) for driving the movable rod (22) to horizontally slide, the driving device (3) comprises a driving column (31) rotatably arranged at the top of the kettle body (1), a cam (32) arranged on the driving column (31), a driving motor (33) arranged at the top of the kettle body (1) and connected with the end of the driving column (31), and a roller (34) rotatably arranged at the other end of the movable rod (22);

the roller (34) is in rolling engagement with the circumference of the cam (32).

3. The acylation kettle for synthesis reaction of dobutamine hydrochloride according to claim 2, characterized in that a circle of limiting groove (35) is formed in the circumferential direction of the cam (32), and the roller (34) is arranged in the limiting groove (35) in a rolling manner.

4. The acylation kettle for dopamine hydrochloride synthesis reaction according to claim 2, wherein the kettle body (1) is provided with a limiting component (5), the limiting component (5) comprises a vertical rod (51) arranged on the kettle body (1) and a guide seat (52) arranged at the upper end of the vertical rod (51), and the movable rod (22) passes through the guide seat (52) and is in sliding fit with the guide seat (52).

5. The acylation kettle for synthesis reaction of dobutamine hydrochloride as claimed in claim 1, characterized in that the end of the movable rod (22) located at the containing cavity is provided with a rubber push piece (23).

6. The acylation kettle for the synthesis reaction of dobutamine hydrochloride according to claim 2, characterized in that a stirring device (6) is arranged in the kettle body (1), the stirring device (6) comprises a stirring shaft (61) rotatably arranged in the kettle body (1) and a stirring rod (62) arranged on the stirring shaft (61), and the upper end of the stirring shaft (61) is fixedly connected with the lower end of the driving column (31).

7. The acylation kettle for synthesis reaction of dobutamine hydrochloride according to claim 6, characterized in that the stirring rods (62) are arranged at intervals along the length direction of the stirring shaft (61), and two adjacent stirring rods (62) are staggered with each other.

8. The acylation kettle for synthesis reaction of dobutamine hydrochloride according to claim 5, wherein the rubber push sheet (23) is disposed in an inclined manner from bottom to top on the side close to the movable rod (22).