CN217593623U - Esophagus local photosensitizer infiltration device for photodynamic targeted therapy - Google Patents
Esophagus local photosensitizer infiltration device for photodynamic targeted therapy Download PDFInfo
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- CN217593623U CN217593623U CN202220939529.XU CN202220939529U CN217593623U CN 217593623 U CN217593623 U CN 217593623U CN 202220939529 U CN202220939529 U CN 202220939529U CN 217593623 U CN217593623 U CN 217593623U
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- Prior art keywords
- tube
- infiltration
- esophagus
- pipe
- air bag
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- 230000008595 infiltration Effects 0.000 title claims abstract description 61
- 238000001764 infiltration Methods 0.000 title claims abstract description 61
- 210000003238 esophagus Anatomy 0.000 title claims abstract description 51
- 239000003504 photosensitizing agent Substances 0.000 title claims abstract description 40
- 238000002626 targeted therapy Methods 0.000 title claims abstract description 10
- 238000002791 soaking Methods 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 238000003780 insertion Methods 0.000 claims abstract description 15
- 230000037431 insertion Effects 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 12
- 230000001502 supplementing effect Effects 0.000 claims abstract description 3
- 238000002347 injection Methods 0.000 claims description 24
- 239000007924 injection Substances 0.000 claims description 24
- 230000000903 blocking effect Effects 0.000 claims description 11
- 239000013589 supplement Substances 0.000 claims description 11
- 230000008685 targeting Effects 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 2
- 230000006378 damage Effects 0.000 abstract description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 208000014674 injury Diseases 0.000 abstract description 2
- 230000002503 metabolic effect Effects 0.000 abstract description 2
- 239000003973 paint Substances 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000002428 photodynamic therapy Methods 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000002165 photosensitisation Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 206010012455 Dermatitis exfoliative Diseases 0.000 description 1
- 206010041303 Solar dermatitis Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000004526 exfoliative dermatitis Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000025402 neoplasm of esophagus Diseases 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
Images
Abstract
The utility model discloses an esophagus local photosensitizer soaking device for photodynamic targeted therapy, which comprises an esophagus inserting tube, wherein an inflation tube is arranged in the esophagus inserting tube, one end of the esophagus inserting tube is communicated with a tip soaking tube, the periphery of the tip soaking tube is provided with a plurality of soaking agent replenishing strips communicated with the interior of the tip soaking tube, and the outer side of each soaking agent replenishing strip is provided with a plurality of permeation holes; a collecting and releasing groove is formed between every two impregnating compound supplementing strips, a collecting and releasing air bag is arranged in each collecting and releasing groove, a soaking sponge is arranged on the outer side of each collecting and releasing air bag, a hollow inflating end portion is arranged at one end, away from the esophagus insertion tube, of the end soaking tube, each collecting and releasing air bag is communicated with the inflating end portion, and a communicating tube used for communicating the inflating tube with the inflating end portion is arranged in the end soaking tube. The utility model discloses can carry out the local infiltration to patient's esophagus and paint the photosensitizer, the metabolic cycle is fast, reaches accurate medical purpose to do not need the light-resistant, alleviate the injury that causes patient's physiology and psychology.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to local photosensitizer infiltration device of esophagus for photodynamic targeting therapy.
Background
Photodynamic therapy (PDT) is a new method for treating neoplastic diseases using photosensitizing drugs and laser activation. The tumor site is irradiated with specific wavelength to activate the photosensitive medicine gathered selectively in tumor tissue and trigger photochemical reaction to destroy tumor. Photosensitizing drugs in the next generation of photodynamic therapy (PDT) transfer energy to the surrounding oxygen, producing highly active singlet oxygen. Singlet oxygen can generate oxidation reaction with nearby biomacromolecules to generate cytotoxicity so as to kill tumor cells. PDT has the advantage over traditional tumour therapy that it enables precise and effective treatment with minimal side effects.
The metabolism speed of the photosensitizer in normal cells is far higher than that of tumor cells, the photosensitizer is smeared on the surface of skin, normal cells can be completely metabolized within 2-4 hours, but the tumor cells need a metabolism period of 24 hours, and then the laser can be used for targeted therapy by utilizing the metabolism period difference. The esophagus tumor is difficult to be smeared with the photosensitizer, the prior art can only adopt a method of intravenous systemic injection of the photosensitizer, the systemic injection of the photosensitizer can lead the photosensitizer to be metabolized very slowly, the photosensitizer can be completely metabolized within 1-2 months, the patient needs to be protected from light during the period, otherwise, the solar dermatitis can be caused, and the serious patient can be suffered from the exfoliative dermatitis, so the treatment is greatly limited, and the physiological and psychological damage of the patient can be caused.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a local photosensitizer infiltration device of esophagus for photodynamic targeting treatment can carry out the local infiltration to patient's esophagus and paint the photosensitizer, and metabolic cycle is fast, can carry out the targeting treatment fast, reaches the purpose of accurate medical treatment to do not need the light-resistant, alleviate the injury that leads to the fact patient's physiology and psychology.
The above technical object of the present invention can be achieved by the following technical solutions:
an esophagus local photosensitizer infiltration device for photodynamic targeted therapy comprises an esophagus insertion tube, wherein an inflation tube is arranged in the esophagus insertion tube, one end of the esophagus insertion tube is connected with a hollow end infiltration tube communicated with the esophagus insertion tube, the periphery of the end infiltration tube is provided with a plurality of hollow infiltration agent supplement strips communicated with the inside of the end infiltration tube, and the outer side of each infiltration agent supplement strip is provided with a plurality of permeation holes;
a retraction groove is formed between every two impregnating compound supplementing strips, a retraction air bag is arranged in each retraction groove, each retraction air bag is connected with the bottom of the corresponding retraction groove, one side, far away from the end portion infiltration pipe, of each retraction air bag is provided with infiltration sponge, one end, far away from the esophagus insertion pipe, of the end portion infiltration pipe is provided with a hollow inflation end portion, each retraction air bag is communicated with the inflation end portion, and a communication pipe used for communicating the inflation pipe with the inflation end portion is arranged in the end portion infiltration pipe;
the esophagus intubate is kept away from the one end of tip infiltration pipe is sealed and the side intercommunication has the treating compound injection pipe, the gas tube is kept away from the one end of tip infiltration pipe is worn out the tip intercommunication of esophagus intubate has the gas injection pipe, the treating compound injection pipe reaches the free end of gas injection pipe all is connected with the syringe connector.
By adopting the technical scheme, when the local photosensitizer in the esophagus needs to be soaked, firstly, the end part is soaked through the esophagus insertion tube and sent to the designated position of the esophagus, air or normal saline is injected into the inflation injection tube by the injector, the air or the normal saline passes through the inflation tube, the communicating tube and the inflation end part, each retractable air bag is expanded, the retractable air bags are expanded to enable the soaking sponge to be contacted with the inner wall of the esophagus, the photosensitizer is injected into the soaking agent injection tube by the injector, and the photosensitizer is gradually absorbed by the soaking sponge from the permeation hole after passing through the esophagus insertion tube, the end part soaking tube and the soaking agent supplement strip, so that the effect of soaking the inner wall of the esophagus by the photosensitizer is achieved;
when the device needs to be taken out, firstly, the injector is used for exhausting air to the impregnating compound injection tube, so that negative pressure generated by the permeation hole can draw away the impregnated sponge and the residual photosensitizer at the periphery as far as possible, then, the injector is used for exhausting air to the inflation injection tube, the retractable air bag is contracted, the impregnated sponge is also contracted, and the device can be easily taken out.
The utility model discloses a further set up to: each soaking sponge is composed of a plurality of pieces of flaky sponges distributed in an outward radial mode, and one side of each flaky sponge is connected with the outer side of the corresponding air bag.
By adopting the technical scheme, the infiltration sponge can be spread and then wrapped by the infiltration agent supplement strip, so that the infiltration sponge can absorb the photosensitizer flowing out of the permeation hole conveniently.
The utility model discloses a further set up to: one end of the inflating end part, which is far away from the end part infiltration pipe, is connected with a blocking air bag, and one end of the inflating end part, which is far away from the end part infiltration pipe, is provided with a plurality of through holes communicated with the blocking air bag.
By adopting the technical scheme, the blocking air bag is attached to the inner wall of the esophagus after being inflated, and the photosensitizer is prevented from contacting other tissues along the esophagus.
The utility model discloses a further set up to: each syringe connector is a rubber connector.
Compared with the prior art, the utility model discloses following beneficial effect has:
the utility model can partially soak the esophagus of a patient and smear photosensitizer, has quick metabolism cycle, can quickly carry out targeted therapy, achieves the aim of precise medical treatment, does not need to be protected from light, and reduces the harm to the physiology and the psychology of the patient;
secondly, the utility model controls the contraction and expansion of the sponge by the retractable air bag, and the esophagus photosensitizer is soaked by the expanded soaked sponge, so the operation is simple and convenient;
thirdly, the utility model discloses a prevent that the photosensitizer from flowing along the esophagus after stopping the gasbag and strutting, prevent that the in-process from letting normal tissue unnecessary contact photosensitizer.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a view mainly showing the state of contraction of the sponge at the infiltration tube portion at the end;
FIG. 3 is a view showing the connection of the deploying and retracting air bag and the infiltration sponge with the end infiltration tube;
fig. 4 is mainly used for showing the communicating pipe in the end infiltration pipe.
In the figure: 1. inserting an esophagus into the pipe; 11. an impregnating agent injection tube; 2. an inflation tube; 21. an inflation injection tube; 3. an end infiltration pipe; 31. impregnating compound supplement strips; 32. a penetration hole; 33. retracting and releasing the groove; 4. deploying and retracting the air bag; 5. soaking sponge; 6. an inflatable end portion; 61. a communicating pipe; 62. a through hole; 7. a barrier airbag; 8. the syringe connector.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
In the embodiment, referring to fig. 1-4, an esophageal local photosensitizer infiltration device for photodynamic targeted therapy comprises an esophageal cannula 1, wherein an inflation tube 2 is arranged in the esophageal cannula 1, one end of the esophageal cannula 1 is connected with a section of hollow end infiltration tube 3 communicated with the hollow end portion, seven hollow infiltration agent supplement strips 31 communicated with the inside of the end portion infiltration tube 3 are arranged on the periphery of the end portion infiltration tube 3, and six penetration holes 32 distributed along the length direction of each infiltration agent supplement strip 31 are formed in the outer side of the infiltration agent supplement strip 31.
A retraction groove 33 is formed between every two impregnating compound replenishing strips 31, a retraction air bag 4 is arranged in each retraction groove 33, each retraction air bag 4 is connected with the bottom of the corresponding retraction groove 33, one side of each retraction air bag 4, which is far away from the end portion impregnating pipe 3, is provided with one piece of impregnating sponge 5, each impregnating sponge 5 consists of a plurality of pieces of flaky sponges which are distributed in an outward radial mode, the impregnating sponges 5 can wrap the impregnating compound replenishing strips 31 after being unfolded, the impregnating sponges 5 can absorb photosensitizer flowing out of the permeation holes 32 conveniently, one side of each flaky sponge is connected with the outer side of the corresponding retraction air bag 4, the impregnating sponges 5 can be unfolded outwards after the retraction air bags 4 are expanded to be attached to the inner wall of the esophagus, one end, which is far away from the esophagus insertion pipe 1, of each end portion impregnating pipe 3 is provided with a hollow inflating end portion 6, each retraction air bag 4 is communicated with the inflating end portion 6, and a communicating pipe 61 for communicating the inflating pipe 2 with the inflating end portion 6 is arranged in the end portion impregnating pipe 3.
One end of the inflating end part 6, which is far away from the end part infiltration pipe 3, is connected with a blocking air bag 7, one end of the inflating end part 6, which is far away from the end part infiltration pipe 3, is provided with a plurality of through holes 62 communicated with the blocking air bag 7, the blocking air bag 7 is attached to the inner wall of the esophagus after being inflated, and the photosensitizer is prevented from contacting other tissues along the esophagus. One end of the esophagus insertion tube 1 far away from the end infiltration tube 3 is sealed, the side edge of the end of the esophagus insertion tube 1 is communicated with an infiltration agent injection tube 11, one end of the inflation tube 2 far away from the end infiltration tube 3 penetrates out of the end of the esophagus insertion tube 1 to be communicated with an inflation injection tube 21, the free ends of the infiltration agent injection tube 11 and the inflation injection tube 21 are both connected with injector connectors 8, and each injector connector 8 is a rubber connector.
The use method comprises the following steps: when local photosensitizer in the esophagus is needed to be infiltrated, firstly, the end part is infiltrated and sent to the designated position of the esophagus through the esophagus cannula 1, air or normal saline is injected into the inflation injection tube 21 by an injector, the air or the normal saline passes through the inflation tube 2, the communicating tube 61 and the inflation end part 6, each folding and unfolding air bag 4 and the blocking air bag 7 are expanded, the folding and unfolding air bags 4 are expanded to ensure that the infiltration sponge 5 is contacted with the inner wall of the esophagus, the blocking air bags 7 are expanded to be directly contacted with the inner wall, the photosensitizer is injected into the infiltration injection tube 11 by the injector, and the photosensitizer is gradually absorbed by the infiltration sponge 5 from the permeation hole 32 after passing through the esophagus cannula 1, the end infiltration tube 3 and the infiltrant supplement strip 31, so that the function of infiltrating the inner wall of the esophagus by the photosensitizer is achieved;
when the device needs to be taken out, firstly, the injector is used for pumping air to the impregnating compound injection pipe 11, so that negative pressure is generated in the permeation hole 32 to pump away the impregnated sponge 5 and the residual photosensitizer around the impregnated sponge as far as possible, and then the injector is used for pumping air to the inflation injection pipe 21, so that the retractable air bag 4 and the blocking air bag 7 are contracted, the impregnated sponge 5 is also contracted, and the device can be easily taken out.
The specific embodiments are only for explaining the present invention, and it is not a limitation to the present invention, and those skilled in the art can make modifications to the embodiments without inventive contribution as required after reading the present specification, but all the embodiments are protected by patent law within the scope of the claims of the present invention.
Claims (4)
1. The utility model provides a local photosensitizer infiltration device of esophagus for photodynamic targeting therapy, includes esophagus intubate (1), its characterized in that: an inflation tube (2) is arranged in the esophagus insertion tube (1), one end of the esophagus insertion tube (1) is connected with a hollow end infiltration tube (3) communicated with the end portion infiltration tube, a plurality of hollow impregnating compound supplement strips (31) communicated with the interior of the end portion infiltration tube (3) are arranged on the periphery of the end portion infiltration tube, and a plurality of permeation holes (32) are formed in the outer side of each impregnating compound supplement strip (31);
a retraction groove (33) is formed between every two impregnating compound supplementing strips (31), a retraction air bag (4) is arranged in each retraction groove (33), each retraction air bag (4) is connected with the bottom of the corresponding retraction groove (33), one side, away from the end infiltration pipe (3), of each retraction air bag (4) is provided with infiltration sponge (5), one end, away from the esophagus insertion pipe (1), of the end infiltration pipe (3) is provided with a hollow inflation end part (6), each retraction air bag (4) is communicated with the inflation end part (6), and a communication pipe (61) for communicating the inflation pipe (2) with the inflation end part (6) is arranged in the end infiltration pipe (3);
esophagus intubate (1) is kept away from the sealed and side intercommunication of one end of tip infiltration pipe (3) has infiltration agent injection pipe (11), gas tube (2) are kept away from the one end of tip infiltration pipe (3) is worn out the tip intercommunication of esophagus intubate (1) has gas injection pipe (21), infiltration agent injection pipe (11) reach the free end of gas injection pipe (21) all is connected with syringe connector (8).
2. The esophageal local photosensitizer infiltration device for photodynamic targeted therapy according to claim 1, characterized in that: each soaking sponge (5) is composed of a plurality of flaky sponges which are distributed in an outward radial mode, and one side of each flaky sponge is connected with the outer side of the corresponding air bag (4).
3. The esophageal local photosensitizer infiltration device for photodynamic targeted therapy according to claim 1, characterized in that: one end, far away from the end soaking pipe (3), of the inflating end portion (6) is connected with a blocking air bag (7), and one end, far away from the end soaking pipe (3), of the inflating end portion (6) is provided with a plurality of through holes (62) communicated with the blocking air bag (7).
4. The esophageal local photosensitizer infiltration device for photodynamic targeted therapy according to claim 1, characterized in that: each syringe connector (8) is a rubber connector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220939529.XU CN217593623U (en) | 2022-04-22 | 2022-04-22 | Esophagus local photosensitizer infiltration device for photodynamic targeted therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220939529.XU CN217593623U (en) | 2022-04-22 | 2022-04-22 | Esophagus local photosensitizer infiltration device for photodynamic targeted therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217593623U true CN217593623U (en) | 2022-10-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220939529.XU Expired - Fee Related CN217593623U (en) | 2022-04-22 | 2022-04-22 | Esophagus local photosensitizer infiltration device for photodynamic targeted therapy |
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| Country | Link |
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| CN (1) | CN217593623U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116440399A (en) * | 2023-06-15 | 2023-07-18 | 山东诺心生物科技有限公司 | Esophagus local photosensitizer infiltration device for targeted therapy |
-
2022
- 2022-04-22 CN CN202220939529.XU patent/CN217593623U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116440399A (en) * | 2023-06-15 | 2023-07-18 | 山东诺心生物科技有限公司 | Esophagus local photosensitizer infiltration device for targeted therapy |
| CN116440399B (en) * | 2023-06-15 | 2023-11-24 | 青岛市市立医院 | Esophagus local photosensitizer infiltration device for targeted therapy |
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|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20221018 |