CN217588588U - Magnetic adsorption separation device with orderly arranged magnetic pole directions - Google Patents
Magnetic adsorption separation device with orderly arranged magnetic pole directions Download PDFInfo
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- CN217588588U CN217588588U CN202221597348.XU CN202221597348U CN217588588U CN 217588588 U CN217588588 U CN 217588588U CN 202221597348 U CN202221597348 U CN 202221597348U CN 217588588 U CN217588588 U CN 217588588U
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Abstract
The utility model discloses a magnetic adsorption separation device with orderly arranged magnetic pole directions, which comprises a frame, a reactor and a magnet assembly arranged outside the reactor, wherein a movable shielding assembly for isolating a magnetic field is arranged between the magnet assembly and the reactor; the magnet assembly comprises a magnetic ring arranged around the reactor, the magnetic ring comprises a plurality of same magnets, and the magnet penetrates through the plane of the reactor to divide the space outside the reactor into a plurality of areas; the magnets in the same area are uniformly arranged around the reactor, the rotating angle of any one magnet in the same area relative to the previous magnet adjacent to the magnet is the same and is not equal to zero, and the rotating direction of any one magnet relative to the previous magnet adjacent to the magnet is the same. Compared with the prior art, the utility model discloses in the direction homogeneous phase that magnetizes of every magnet, adopt different installation orientation, form point source formula gradient distribution's magnetic field in middle separation region, on the basis that satisfies the operation requirement, but greatly reduced cost.
Description
Technical Field
The utility model belongs to the technical field of magnetic bead adsorbs splitter, especially, relate to a magnetic force adsorption separation device and equipment that magnetic pole direction was arranged in order.
Background
Magnetic field adsorption separation technology is widely applied to the fields of biotechnology, biomedicine and the like, such as cell classification, RNA and DNA separation, preparation, purification, sequencing and the like. Wherein the generation of a specifically distributed magnetic field in a separate region is a key technology for this type of system.
In the prior art, chinese patent publication No. CN113628830a discloses a magnet suitable for industrialization of coating of diagnostic reagent magnetic beads, which includes a first magnetic ring and a second magnetic ring respectively coating the left and right sides of the same circle, where the first magnetic ring and the second magnetic ring respectively include more than two magnets, and extension lines of magnetic lines of any two magnets are crossed.
The prior art has the defect that the magnet needs to be magnetized in a specific direction by adopting the structure so as to meet the characteristic that the extension lines of the magnetic lines of force of any two magnets are crossed, so that the cost of the magnet is high.
SUMMERY OF THE UTILITY MODEL
Technical problem to be solved
Based on this, the utility model provides a magnetic force adsorption separation device of magnetic pole orientation is arranged in order, this magnetic force adsorption separation device of magnetic pole orientation is arranged in order aims at solving the magnet that is used for diagnostic reagent magnetism microballon to wrap the industrialization among the prior art and need carry out magnetizing of specific direction to the magnet, leads to the higher technical problem of cost.
(II) technical scheme
In order to solve the technical problem, the utility model provides a magnetic adsorption separation device with orderly arranged magnetic pole directions, which comprises a frame, a reactor for containing liquid medicine and magnetic beads, and a magnet assembly arranged outside the reactor, wherein a movable shielding assembly for isolating a magnetic field is arranged between the magnet assembly and the reactor; the magnetic ring comprises a plurality of same magnets, and the space outside the reactor is divided into a plurality of areas by passing through the plane of the reactor; the magnets in the same area are uniformly arranged around the reactor, the rotating angle of any one magnet in the same area relative to the previous magnet adjacent to the magnet is the same and is not equal to zero, and the rotating direction of any one magnet relative to the previous magnet adjacent to the magnet is the same.
Preferably, the magnet assembly is externally coated with an annular yoke.
Preferably, the magnet subassembly still includes the cladding left semi-ring and the right semi-ring of reactor, the shielding subassembly is including locating mobilizable left shielding unit between left semi-ring and the reactor, the shielding subassembly is including locating mobilizable right shielding unit between right semi-ring and the reactor, the magnet equally divide into two sets ofly, and locates respectively in left semi-ring and the right semi-ring.
Preferably, the magnet is a cuboid, one outer surface of the magnet is set as a bottom surface of the magnet, and the magnetizing direction of the magnet is perpendicular to the bottom surface of the magnet.
Preferably, the magnet is an electromagnet or a permanent magnet.
Preferably, the left side shielding unit includes two left shield plates that set up side by side, every the left side shield plate all links to each other with the frame through a left hinge bar, the right side shielding unit includes two right shield plates that set up side by side, every the right side shield plate all links to each other with the frame through a right hinge bar.
Preferably, the magnetic adsorption separation device with orderly arranged magnetic pole directions further comprises a first linear driving assembly connected with the left half ring and used for driving the left half ring to be close to or far away from the reactor, and the magnetic adsorption separation device with orderly arranged magnetic pole directions further comprises a second linear driving assembly connected with the right half ring and used for driving the right half ring to be close to or far away from the reactor.
Preferably, the number of the magnetic rings is 2-3.
Preferably, the positions of the magnets in each group of magnetic rings are arranged in one-to-one alignment.
Preferably, each magnetic ring comprises 30-40 magnets.
(III) advantageous effects
The utility model discloses compare with prior art, the utility model discloses magnetic force adsorption separation device that magnetic pole direction was arranged in order's beneficial effect mainly includes:
compared with the prior art, the utility model discloses a direction homogeneous phase that magnetizes of every magnet among the magnetic force adsorption separation device of magnetic pole direction range in order adopts different installation orientation, forms point source formula gradient distribution's magnetic field in middle separation region, on the basis that satisfies operation requirement, but greatly reduced cost. The multi-layer magnetic rings are arranged, and the magnetic pole directions of the magnets in the magnetic rings are orderly arranged, so that a high-gradient separation magnetic field can be generated, and the problem of low adsorption speed is solved; by forming a point source type gradient distributed magnetic field, the defect of large adsorption dead zone area is overcome, and the purpose of high-efficiency separation is achieved.
Drawings
The features and advantages of the invention will be more clearly understood by reference to the accompanying drawings, which are schematic and should not be understood as imposing any limitation on the invention, in which:
fig. 1 is a schematic view of the overall structure of a magnetic adsorption separation device with orderly arranged magnetic pole directions according to an embodiment of the present invention;
fig. 2 shows the magnetic adsorption separation device with orderly arranged magnetic pole directions according to the embodiment of the present invention: the first structural diagram of the magnet assembly (in a combined state, the magnet assembly is a double-layer magnetic ring);
fig. 3 shows the magnetic adsorption separation device with orderly arranged magnetic pole directions, according to the embodiment of the present invention: a second structural diagram (an open state, and a double-layer magnetic ring) of the magnet assembly;
fig. 4 shows the magnetic adsorption separation device with orderly arranged magnetic pole directions, according to the embodiment of the present invention: the structure of the magnet is schematic;
FIG. 5 is a schematic view of a part of a magnetic adsorption separation apparatus with orderly arranged magnetic poles according to an embodiment of the present invention (in an operating state, the magnet assembly is close to the reactor);
fig. 6 is a schematic view of a second partial structure of a magnetic adsorption separation device with orderly arranged magnetic poles according to an embodiment of the present invention (in a non-operating state, the magnet assembly is far away from the reactor);
fig. 7 is a schematic structural view of a magnetic ring according to the prior art of the present invention;
FIG. 8 is a schematic diagram showing the distribution of magnetic field in the reactor under the action of the magnetic ring in FIG. 7;
fig. 9 shows the magnetic adsorption separation device with orderly arranged magnetic pole directions according to the embodiment of the present invention: a third structural diagram (in a combined state, a single-layer magnetic ring) of the magnet assembly;
FIG. 10 is a schematic diagram showing the distribution of magnetic field in the reactor under the action of the magnetic ring (single layer) in FIG. 9;
FIG. 11 is a schematic diagram showing the distribution of magnetic field in the reactor under the action of the magnetic ring (double layer) in FIG. 2;
FIG. 12 is a schematic view of a magnet ring having a single cylindrical magnet;
FIG. 13 is a schematic diagram showing the distribution of magnetic field in the reactor under the action of the magnetic ring in FIG. 12.
Description of reference numerals:
1. the reactor comprises a magnet, a magnet yoke, a left half ring, a right half ring, a reactor, a first linear driving assembly, a second linear driving assembly, a frame and a shielding assembly, wherein the magnet is 2;
11. a magnet bottom surface;
91. left shield, 92 right shield, 93 left hinge rod, 94 right hinge rod.
Detailed Description
In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The invention may be embodied in many other forms different from the embodiments described herein and similar modifications may be made by those skilled in the art without departing from the spirit and scope of the invention and, therefore, the invention is not limited to the embodiments disclosed below.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; the two elements may be mechanically or electrically connected, directly or indirectly connected through an intermediate medium, or connected through the inside of the two elements, or "in transmission connection", that is, connected in a power manner through various suitable manners such as belt transmission, gear transmission, or sprocket transmission. The specific meaning of the above terms in the present invention can be understood as a specific case by those skilled in the art.
The magnetic adsorption separation device with orderly arranged magnetic pole directions of the present invention will be further described with reference to the accompanying drawings 1-6.
The utility model discloses a magnetic adsorption separation device with orderly arranged magnetic pole directions, which comprises a frame 8, a reactor 5 for containing liquid medicine and magnetic beads, and a magnet assembly arranged outside the reactor 5, wherein a movable shielding assembly 9 for isolating a magnetic field is arranged between the magnet assembly and the reactor 5; the magnetic assembly comprises a magnetic ring arranged around the reactor 5, the magnetic ring comprises a plurality of same magnets 1, and the space outside the reactor 5 is divided into a plurality of areas by passing through the plane of the reactor 5; the magnets 1 in the same area are uniformly arranged around the reactor 5, the rotation angle of any one magnet 1 in the same area relative to the previous magnet 1 adjacent to the magnet is the same and is not equal to zero, and the rotation direction of any one magnet 1 relative to the previous magnet 1 adjacent to the magnet is the same.
In the present embodiment, the inside of the reactor 5 is a separation region.
More specifically, as shown in FIG. 1, the reactor 5 is cylindrical. A plane passing through the axis of the reactor 5 divides the space outside the reactor 5 into a plurality of regions.
In practice, the reactor may have other structures besides a cylindrical structure, for example, the reactor has a square shape, and when the reactor has a square shape, the above-mentioned feature that the plane passing through the axis of the reactor 5 divides the space outside the reactor 5 into a plurality of regions is replaced by the feature that the plane passing through the intersection line of the diagonal lines of the upper and lower surfaces of the reactor divides the space outside the reactor into a plurality of regions.
It should be noted that: in the present embodiment, "magnet 1 is the same" means: the shape structure of the magnet 1 is the same, and the magnetizing direction is also the same. In this embodiment, the magnetizing directions of the magnets 1 are the same, so that the manufacturing cost of the magnets 1 can be greatly saved. By rotating the magnet 1, the desired magnetic field direction is obtained.
It should also be noted that: in the present embodiment, the number of the magnets 1 in different regions may be the same or different, and the rotation angles of the magnets 1 in different regions with respect to the previous magnet 1 may be the same or different, but the magnets 1 in the same region are all uniformly arranged. I.e. within the same area: the intervals between the magnets 1 are the same, and the rotation angle of one magnet 1 with respect to the previous magnet 1 adjacent thereto is the same.
The utility model provides an every magnet 1's the direction of magnetizing is the same, adopts different installation directions, forms point source formula gradient distribution's magnetic field in middle separation region, on the basis that satisfies the operation requirement, but greatly reduced cost.
More specifically, the plane passing through the axis of the cylindrical reactor 5 is two planes perpendicular to each other, which divide the space outside the reactor 5 into four regions. By adopting the structure, the geometric angle is taken as a quadrant at every 90 degrees, the number of the magnetic poles in each quadrant can adopt different configurations, and the installation angle of the magnetic poles in each quadrant is determined according to the number of the magnetic poles.
According to the specific embodiment of the utility model, magnet subassembly cladding has annular yoke 2.
In the present embodiment, the yoke 2 is disposed on the outer layer of the magnet assembly, the yoke 2 is an annular yoke having a high magnetic permeability as a whole, and the yoke 2 is used to limit the magnetic field of the magnet assembly within the adsorption region and prevent the magnetic field from overflowing.
According to the utility model discloses a specific embodiment, magnet subassembly still includes left semi-ring 3 and right semi-ring 4 of cladding reactor 5, and shielding subassembly 9 is including locating mobilizable left shielding element between left semi-ring 3 and the reactor 5, and shielding subassembly 9 is including locating mobilizable right shielding element between right semi-ring 4 and the reactor 5, and magnet 1 equally divide into two sets ofly, and locates respectively in left semi-ring 3 and right semi-ring 4.
In this embodiment, left shielding unit and right shielding unit are used for preventing the utility model discloses a magnetic adsorption separation device is when non-operating condition, and the magnetic field of magnet 1 influences the inside liquid of drum.
As shown in FIG. 5, the magnetic adsorption separation device of the present invention is in an operating state, the magnet assembly is close to the reactor 5, the left shielding unit and the right shielding unit are respectively turned over to the side portion, and the left shielding unit and the right shielding unit do not work.
As shown in fig. 6, the magnetic adsorption separation device of the present invention keeps away from the reactor 5 in the non-operating state, the left shielding unit is turned over to the space between the reactor 5 and the left half ring 3, and the right shielding unit is turned over to the space between the reactor 5 and the right half ring 4, so as to avoid the influence of the magnetic field of the magnet 1 on the liquid inside the cylinder.
According to the specific embodiment of the utility model, magnet 1 is the cuboid, establishes a surface of magnet 1 as the magnet bottom surface, and the direction of magnetizing of magnet 1 is perpendicular with the bottom surface of magnet 1.
More specifically, the magnet 1 is a cube with a side length of 20 mm. In the present embodiment, the magnetic pole directions of the plurality of magnets 1 are arranged in order along the periphery of the adsorption region, and each magnetic pole at different positions has a different installation angle. The magnetic pole direction is rotated by 270 degrees every time the geometric angle is rotated by 90 degrees.
More specifically, the magnet 1 is an electromagnet or a permanent magnet.
According to the utility model discloses a specific embodiment, left shielding unit includes two left shield plates 91 that set up side by side, and every left shield plate 91 all links to each other with frame 8 through a left hinge rod 93, and right shielding unit includes two right shield plates 92 that set up side by side, and every right shield plate 92 all links to each other with frame 8 through a right hinge rod 94.
In this embodiment, the power member rotates to drive the hinge rod to rotate, so as to drive the left shielding plate 91 and the right shielding plate 92 to rotate, thereby realizing the switching of the positions of the shielding plates, and the structure is adopted to facilitate the realization of automatic control.
According to the utility model discloses a specific embodiment, magnetic force adsorption and separation device that magnetic pole direction was arranged in order still includes and links to each other and be used for driving left semi-ring 3 and be close to or keep away from reactor 5's first straight line drive assembly 6 with left semi-ring 3, and magnetic force adsorption and separation device that magnetic pole direction was arranged in order still includes and links to each other and be used for driving right semi-ring 4 and be close to or keep away from reactor 5's second straight line drive assembly 7 with right semi-ring 4.
In this embodiment, utilize first linear drive assembly 6 to drive left semi-ring 3 and remove, utilize second linear drive assembly 7 to drive right semi-ring 4 and remove for left semi-ring 3 and right ring can surround into the ring form or open, can further improve the utility model discloses an degree of automation. In specific implementation, the linear driving assembly may be of various structures capable of providing linear reciprocating power, for example, the linear driving member is an oil cylinder or an air cylinder, or a screw transmission structure using a motor as power.
According to the specific embodiment of the present invention, the number of the magnetic rings is 2-3. The number of magnetic rings has a direct influence on the distribution of the magnetic field in the reactor 5.
It should be noted that: the number of the magnetic rings can also be 1. The more the number of the magnetic rings is, the stronger the magnetic field in the circular channel is, but the cost is increased correspondingly.
As shown in fig. 2, when the number of the magnetic rings is 2-3, the magnets 1 in each group of magnetic rings are arranged in one-to-one alignment. In the present embodiment, this structure is advantageous for generating a high-gradient separation magnetic field.
According to a specific embodiment of the present invention, each magnetic ring comprises 30-40 magnets 1. It should be noted that the number of each magnetic ring is related to the overall size of the magnetic ring and the rule of the single magnets 1.
The effect of the magnetic ring structure of the present invention will be specifically described with reference to fig. 7-13.
The magnetic rings shown in fig. 7, 9, 2 and 12 are simulated in MATKAB software, and simulation parameters are set as follows: magnetic bead diameter =1.08um, magnetic bead density =1.7g/cm 3 And susceptibility =3. Through the effect contrast, explain the utility model discloses magnet subassembly's beneficial effect.
Simulation object: medium magnetic ring of background technology
Simulation analysis was performed on the magnetic ring (solution of the background art) in fig. 7, and the magnetic field distribution in the reactor is shown in fig. 8. The magnetic field distribution is significantly inhomogeneous.
(2) Simulation object: the utility model discloses a magnet subassembly (single-layer magnetic ring structure)
Simulation analysis was performed on the magnetic ring in fig. 9, and the magnetic field distribution in the reactor is shown in fig. 10. As can be seen, the magnetic field is confined within the barrel region.
(3) Simulation object: the second kind of magnet assembly (double-layer magnetic ring structure)
The magnetic ring in fig. 2 was subjected to simulation analysis, and the magnetic field distribution in the reactor is shown in fig. 11. As can be seen, the magnetic field is confined to the cylindrical region.
(4) Simulation object: magnet ring with one whole cylindrical magnet
The magnetic ring in fig. 12 was subjected to simulation analysis, and the magnetic field distribution in the reactor is shown in fig. 11. As can be seen, the magnetic field diverges over the entire area.
From the above simulation results, it can be seen that:
after the structure of the magnet assembly of the utility model is adopted, the uniformity of the distribution of the magnetic rings in the cylinder is obviously superior to that of the background technology.
Adopt the utility model discloses a magnet assembly's structure back, the magnetic ring of a monoblock cylindric magnet is obviously superior to in the magnetic ring distribution homogeneity in the drum.
In specific implementation, according to different adsorption requirements, one, two or even multiple layers of magnetic rings can be arranged on the magnetic poles along the periphery of the separation area, and the more the number of the arranged magnetic rings is, the higher the magnetic field intensity in the separation area is.
The magnet assembly of the utility model can form a magnetic field of a magnetic field with point source type gradient distribution in the middle separation area. The method specifically comprises the following steps: by orderly arranging the magnetic pole directions of the magnets, a high-gradient separation magnetic field can be generated, and the adsorption separation speed is high; the defect of large adsorption dead zone area is overcome by forming a point source type gradient distributed magnetic field.
Although the embodiments of the present invention have been described in conjunction with the accompanying drawings, those skilled in the art may make various modifications and variations without departing from the spirit and scope of the invention, and such modifications and variations fall within the scope defined by the appended claims.
Claims (10)
1. A magnetic adsorption separation device with orderly arranged magnetic pole directions comprises a rack (8), a reactor (5) for containing liquid medicine and magnetic beads, and a magnet assembly arranged outside the reactor (5), wherein a movable shielding assembly (9) for isolating a magnetic field is arranged between the magnet assembly and the reactor (5); the reactor is characterized in that the magnet assembly comprises a magnetic ring arranged around the reactor (5), the magnetic ring comprises a plurality of same magnets (1), and the space outside the reactor (5) is divided into a plurality of areas by passing through the plane of the reactor (5); the magnets (1) in the same region are uniformly arranged around the reactor (5), the rotating angle of any one magnet (1) in the same region relative to the previous magnet (1) adjacent to the magnet is the same and is not equal to zero, and the rotating direction of any one magnet (1) relative to the previous magnet (1) adjacent to the magnet is the same.
2. The magnetic force adsorption separation device with orderly arranged magnetic pole directions according to claim 1, characterized in that the magnet assembly is wrapped by a circular magnetic yoke (2).
3. The magnetic force adsorptive separation device according to claim 2, wherein said magnetic assembly further comprises a left half ring (3) and a right half ring (4) covering said reactor (5), said shielding assembly (9) comprises a movable left shielding unit disposed between said left half ring (3) and said reactor (5), said shielding assembly (9) comprises a movable right shielding unit disposed between said right half ring (4) and said reactor (5), said magnets (1) are divided into two equal groups and disposed in said left half ring (3) and said right half ring (4), respectively.
4. The magnetic adsorption separation device with orderly arranged magnetic pole directions according to claim 3, wherein the magnet (1) is a cuboid, one outer surface of the magnet (1) is set as a magnet bottom surface (11), and the magnetizing direction of the magnet (1) is perpendicular to the bottom surface of the magnet (1).
5. The magnetic force adsorption separation device with orderly arranged magnetic pole directions of claim 4 is characterized in that the magnet (1) is an electromagnet or a permanent magnet.
6. The magnetic force adsorption separation device with orderly arranged magnetic pole directions of claim 5, wherein the left shielding unit comprises two left shielding plates (91) arranged side by side, each left shielding plate (91) is connected with the frame (8) through a left hinge rod (93), the right shielding unit comprises two right shielding plates (92) arranged side by side, and each right shielding plate (92) is connected with the frame (8) through a right hinge rod (94).
7. The magnetic adsorptive separation device with ordered magnetic pole direction according to claim 6, further comprising a first linear driving assembly (6) connected to said left half ring (3) for driving said left half ring (3) to approach or move away from said reactor (5), and a second linear driving assembly (7) connected to said right half ring (4) for driving said right half ring (4) to approach or move away from said reactor (5).
8. The magnetic force adsorptive separation device according to any one of claims 1 to 7, wherein the number of said magnetic rings is 2 to 3.
9. The magnetic force adsorption separation device with orderly arranged magnetic pole directions of claim 8 is characterized in that the magnets (1) in each group of magnetic rings are arranged in one-to-one alignment.
10. The magnetic force adsorptive separation device according to claim 9, wherein each magnetic ring comprises 30-40 magnets (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221597348.XU CN217588588U (en) | 2022-06-23 | 2022-06-23 | Magnetic adsorption separation device with orderly arranged magnetic pole directions |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221597348.XU CN217588588U (en) | 2022-06-23 | 2022-06-23 | Magnetic adsorption separation device with orderly arranged magnetic pole directions |
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| CN217588588U true CN217588588U (en) | 2022-10-14 |
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| CN202221597348.XU Active CN217588588U (en) | 2022-06-23 | 2022-06-23 | Magnetic adsorption separation device with orderly arranged magnetic pole directions |
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