CN217568346U

CN217568346U - Hyaluronic acid tetrasaccharide purification is with eluant configuration jar body

Info

Publication number: CN217568346U
Application number: CN202220994424.4U
Authority: CN
Inventors: 徐林; 金玉; 徐念沁; 鲁锦标; 徐松泉; 常开金
Original assignee: Nanjing Tzong Blotechnology Co ltd
Current assignee: Nanjing Tzong Blotechnology Co ltd
Priority date: 2022-04-27
Filing date: 2022-04-27
Publication date: 2022-10-14
Anticipated expiration: 2032-04-27

Abstract

The utility model discloses an eluent configuration tank for purifying hyaluronic acid tetrasaccharide, which comprises a liquid preparation tank body for configuring eluent for purifying hyaluronic acid tetrasaccharide, wherein the top end surface of the liquid preparation tank body is provided with a sampling structure for extracting sample liquid so as to monitor liquid indexes in the liquid preparation tank body; the sampling structure comprises a lining pipe arranged on the upper part of the liquid distribution tank body, the top end surface of the lining pipe is connected with a squeezing column button, the bottom end surface of the squeezing column button is connected with a connecting rod, and the bottom end surface of the connecting rod is provided with a sealing plug so that the connecting rod and the lining pipe are tightly connected. The utility model discloses a can take out the eluant from the inside of joining in marriage the liquid jar body through pressing the extrusion column button, form the appearance liquid then, follow-up extracting the detection to the appearance liquid, be convenient for detect pH, concentration etc. of eluant, along with getting along with using, it is convenient to use.

Description

Hyaluronic acid tetrasaccharide purification is with eluant configuration jar body

Technical Field

The utility model relates to a hyaluronic acid production technical field specifically is a hyaluronic acid tetrasaccharide purification disposes jar body with eluant.

Background

Hyaluronic acid, also known as hyaluronic acid, has a molecular formula of (C14H 21NO 11) N, and is a disaccharide glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine;

hyaluronic acid is an acidic mucopolysaccharide, which was first isolated from bovine vitreous humor by Meyer et al, university of Columbia, 1934. Hyaluronic acid exhibits various important physiological functions in the body with its unique molecular structure and physicochemical properties, such as lubrication of joints, regulation of permeability of vascular walls, regulation of proteins, diffusion and movement of aqueous electrolytes, promotion of wound healing, and the like.

The existing eluent for purifying hyaluronic acid tetrasaccharide is mostly configured by adopting a closed tank body during configuration, various index data of the eluent cannot be rapidly mastered during configuration, the eluent needs to be sampled after configuration is finished, and then configuration conditions are determined, so that configuration progress is influenced.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a hyaluronic acid tetrasaccharide is eluant configuration jar body for purification to solve and to master its each item index data fast that provides in the above-mentioned background art, need carry out the sample operation to it after the configuration, survey the problem of the configuration condition then.

In order to solve the technical problem, the utility model provides a following technical scheme: an eluent preparation tank for purifying hyaluronic acid tetrasaccharide comprises a liquid preparation tank for preparing eluent for purifying hyaluronic acid tetrasaccharide, wherein a sampling structure for extracting partial eluent as sample liquid is arranged on the top end face of the liquid preparation tank so as to monitor liquid indexes of the liquid preparation tank;

the sampling structure comprises a lining pipe arranged on the upper part of the liquid distribution tank body, the top end surface of the lining pipe is connected with an extrusion column button, the bottom end surface of the extrusion column button is connected with a connecting rod, and the bottom end surface of the connecting rod is provided with a sealing plug so that the connecting rod and the lining pipe are tightly connected.

Preferably, a liquid guide tube is communicated with the lower part of the lining tube so as to lead out the eluent in the lining tube and detect the eluent as sample liquid.

Preferably, the bottom end face of the lining pipe is provided with a liquid suction pipe for absorbing eluent in the liquid preparation tank body.

Preferably, the lower part of the lining pipe is connected with a valve plate through a hinge shaft, and the valve plate is arranged on the top end surface of the pipette; the valve plate that sets up closes the pipette in the in-process that the extrusion post button moved down, and the in-process that the extrusion post button moved up is linked together the pipette in the inside lining pipe.

Preferably, be provided with the spring under the pole that links up for the elastic movement of linking the pole uses more convenient laborsaving.

Preferably, the bottom end surface of the spring is provided with a bearing plate so that the spring is connected in the lining pipe.

Preferably, the top end of the liquid guide pipe is connected with a spray pipe, and the spray pipe is arranged on the top end surface of the liquid preparation tank body and used for guiding out subsequent sample liquid.

Preferably, the top end of the liquid preparation tank body is provided with a motor for mixing eluent raw materials in the liquid preparation tank body, and the top end face of the liquid preparation tank body is provided with a feed inlet for introducing eluent raw materials.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model discloses a sample structure that sets up can take out the eluent from the inside of joining in marriage the liquid jar body through pressing the extrusion post button, forms sample liquid then, and follow-up is drawing the detection to sample liquid, is convenient for detect pH, the concentration etc. of eluent, and it is convenient to use along with getting.

Drawings

Fig. 1 is a schematic overall structure diagram of an embodiment of the present invention;

FIG. 2 is a schematic cross-sectional view of an embodiment of the present invention;

fig. 3 is an enlarged schematic view of a structure at a position a in the embodiment of the present invention;

fig. 4 is a schematic view of the valve plate structure according to the embodiment of the present invention.

In the figure: 1. a liquid preparation tank body; 2. a motor; 3. extruding the post button; 301. a connecting rod; 302. a sealing plug; 303. a bearing plate; 304. a spring; 305. a valve plate; 306. a hinge axis; 307. a liner tube; 308. a pipette; 309. a catheter; 310. a nozzle; 4. and (4) feeding a material inlet.

Detailed Description

In order to solve present unable its each item index data of mastering fast, need carry out sampling operation to it after the configuration, survey the problem of configuration condition then, the embodiment of the utility model provides a hyaluronic acid tetrasaccharide is eluant configuration jar body for purification. The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.

Referring to fig. 1-4, the utility model provides an eluent preparation tank for purifying hyaluronic acid tetrasaccharide, which comprises a liquid preparation tank 1 for preparing purified hyaluronic acid tetrasaccharide eluent, wherein a sampling structure for extracting partial eluent as sample liquid is arranged on the top end surface of the liquid preparation tank 1 to monitor the liquid index of the liquid preparation tank 1; the top end of the liquid preparation tank body 1 is provided with a motor 2 for mixing eluent raw materials in the liquid preparation tank body 1, and the top end face of the liquid preparation tank body 1 is provided with a feed inlet 4 for introducing the eluent raw materials;

the sampling structure comprises a lining pipe 307 arranged at the upper part of the liquid distribution tank body 1, the top end surface of the lining pipe 307 is connected with an extrusion column button 3, the bottom end surface of the extrusion column button 3 is connected with a joint rod 301, and the bottom end surface of the joint rod 301 is provided with a sealing plug 302 so as to enable the joint rod 301 and the lining pipe 307 to be tightly connected;

a liquid guide tube 309 is communicated with the lower part of the lining tube 307 so as to lead out the eluent in the lining tube 307 and detect the eluent as sample liquid; a pipette 308 is arranged on the bottom end surface of the lining pipe 307 and is used for sucking the eluent in the liquid preparation tank 1; a valve plate 305 is connected to the lower portion of the liner tube 307 via a hinge shaft 306, and the valve plate 305 is disposed on the top end surface of the pipette 308; the inner lining pipe 307307 is used as a transfer pipe of the eluent, and can quickly collect the eluent and lead the eluent out.

A spring 304 is arranged right below the joint rod 301 and used for elastic movement of the joint rod 301; the bottom end face of the spring 304 is provided with a bearing plate 303, so that the spring 304 is connected in the lining pipe 307; the spring 304 is arranged to jack the compression plunger button 3 up, and to drive the sealing plug 302 to move.

The top end of the liquid guide tube 309 is connected with a spray pipe 310, and the spray pipe 310 is arranged on the top end surface of the liquid preparation tank body 1 and used for leading out the subsequent sample liquid.

The utility model provides a pair of hyaluronic acid tetrasaccharide purification is with the theory of operation of the eluent configuration jar body as follows: pressing the extrusion column knob 3, pressing the spring 304 in the lining pipe 307 by the sealing plug 302 connected with the bottom end of the connecting rod 301, enabling the connecting rod 301 to be connected with the bottom end bottom plate to move downwards, discharging air in the connecting rod through the spray pipe 310, then blocking the spray pipe 310, loosening acting force on the extrusion column knob 3, weakening stress of the spring 304, generating elastic extension, driving the sealing plug 302 at the bottom end of the connecting rod 301 to move upwards, enabling the lining pipe 307 to be in a vacuum state, sucking eluent in the liquid distribution tank body 1 into the lining pipe 307 through the valve plate 305, then resetting the valve plate 305, and storing a certain amount of eluent above the valve plate 305 in the lining pipe 307 at the moment;

the blockage effect of the hand on the spray pipe 310 is released, the compression column knob 3 is pressed again, the connecting rod 301 moves downwards, eluent in the lining pipe 307 is led out through the spray pipe 310, and then sample liquid taking is completed.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A hyaluronic acid tetrasaccharide purification is with eluant configuration jar body which characterized in that: the device comprises a liquid preparation tank body (1) for preparing purified hyaluronic acid tetrasaccharide eluent, wherein a sampling structure for extracting partial eluent as sample liquid is arranged on the top end surface of the liquid preparation tank body (1) so as to monitor the liquid index of the liquid preparation tank body (1);

the sampling structure comprises a lining pipe (307) arranged on the upper portion of the inner side of the liquid distribution tank body (1), wherein the upper portion of the lining pipe (307) is connected with a squeezing column button (3), the bottom end face of the squeezing column button (3) is connected with a connecting rod (301), and the bottom end face of the connecting rod (301) is provided with a sealing plug (302) so that the connecting rod (301) and the lining pipe (307) are connected tightly.

2. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 1, characterized in that: the lower part of the lining pipe (307) is communicated with a liquid guide pipe (309) so that eluent in the lining pipe (307) can be led out to be used as sample liquid for detection.

3. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 2, characterized in that: the bottom end surface of the lining pipe (307) is provided with a liquid suction pipe (308) for sucking the eluent in the liquid preparation tank body (1).

4. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 3, characterized in that: the lower part of the lining pipe (307) is connected with a valve plate (305) through a hinge shaft (306), and the valve plate (305) is arranged on the top end surface of a liquid suction pipe (308).

5. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 1, characterized in that: a spring (304) is arranged right below the joint rod (301) and used for elastic movement of the joint rod (301).

6. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 5, characterized in that: the bottom end face of the spring (304) is provided with a bearing plate (303) so that the spring (304) is connected in the lining pipe (307).

7. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 2, characterized in that: the top end of the liquid guide pipe (309) is connected with a spray pipe (310), and the spray pipe (310) is arranged on the top end face of the liquid distribution tank body (1) and used for guiding out the subsequent sample liquid.

8. The eluent preparation tank for purifying hyaluronic acid tetrasaccharide according to claim 1, characterized in that: the top of the liquid preparation tank body (1) is provided with a motor (2) for mixing eluent raw materials in the liquid preparation tank body (1), and the top end face of the liquid preparation tank body (1) is provided with a feed inlet (4) for leading in the eluent raw materials.