CN217488824U - Radio frequency ablation device and biological tissue detection circuit thereof - Google Patents
Radio frequency ablation device and biological tissue detection circuit thereof Download PDFInfo
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- CN217488824U CN217488824U CN202123194630.1U CN202123194630U CN217488824U CN 217488824 U CN217488824 U CN 217488824U CN 202123194630 U CN202123194630 U CN 202123194630U CN 217488824 U CN217488824 U CN 217488824U
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Abstract
The utility model provides a radio frequency melts device and biological tissue impedance detection circuitry thereof, include: the device comprises a radio frequency energy generation module, a detection wave generation module, a first resistor and a control module, wherein the radio frequency energy generation module is configured to be capable of outputting radio frequency energy to the biological tissue to be detected; the detection wave generation module is connected with a first end of the first resistor, a second end of the first resistor is directly or indirectly connected with a first end of the biological tissue to be detected, and the detection wave generation module is configured to be capable of outputting detection waves to the biological tissue to be detected; the electrical parameter of the detection wave is lower than the electrical parameter of the radio frequency energy; the control module is directly or indirectly connected with the second end of the first resistor to collect target voltage, the target voltage is matched with the voltage of the second end of the first resistor, and different target voltages correspond to different impedance detection values of the biological tissue to be detected.
Description
Technical Field
The utility model relates to a radio frequency melts the field, especially relates to a radio frequency melts biological tissue impedance detection circuitry of device.
Background
The radiofrequency ablation is mainly applied to the fields of treatment of diseases such as tumors, cardiovascular diseases, gynecology and pains, as well as plastic cosmetology. During the radio frequency ablation operation, the biological tissue gradually loses water until necrosis along with the rise of the temperature, and the reduction of the water content directly leads to the increase of the impedance value of the biological tissue, so that the implementation degree of the ablation operation can be known through monitoring the impedance of the biological tissue. Before an ablation operation, the impedance of biological tissues is accurately detected to determine the radio frequency energy actually used in the operation process, so that the treatment effect of the ablation operation can be improved.
In the prior art, the impedance detection process for biological tissues is as follows: the radio frequency energy emitted by the radio frequency energy generation module acts on the biological tissue to be detected, and then the impedance of the resistance value of the biological tissue to be detected is detected through a corresponding detection means, however, the energy output by the radio frequency energy generation module is large, the power output to the biological tissue to be detected can reach 2-3W when the impedance is low, the radio frequency energy is similar to the radio frequency energy in the actual ablation operation process, and unnecessary ablation and injury can be caused to the biological tissue.
SUMMERY OF THE UTILITY MODEL
The utility model provides a radio frequency ablation device's biological tissue impedance detection circuitry to when solving the impedance that detects biological tissue through the radio frequency energy module, because output causes the great problem of unpredictable's ablation and injury.
According to a first aspect of the present invention, there is provided a biological tissue impedance detection circuit of a radio frequency ablation device, comprising:
the device comprises a radio frequency energy generation module, a detection wave generation module, a first resistor and a control module;
the radio frequency energy generation module is directly or indirectly connected with a first end of the biological tissue to be detected, and the radio frequency energy generation module is configured to be capable of outputting radio frequency energy to the biological tissue to be detected;
the detection wave generation module is connected with a first end of the first resistor, a second end of the first resistor is directly or indirectly connected with a first end of the biological tissue to be detected, and the detection wave generation module is configured to be capable of outputting detection waves to the biological tissue to be detected; the electrical parameter of the detection wave is lower than the electrical parameter of the radio frequency energy; the electrical parameter comprises at least one of: voltage amplitude, power, frequency;
the control module is directly or indirectly connected with the second end of the first resistor to collect target voltage, the target voltage is matched with the voltage of the second end of the first resistor, and different target voltages correspond to different impedance detection values of the biological tissue to be detected.
Optionally, the detection wave generation module includes a square wave generator, and an output end of the square wave generator is directly or indirectly connected to the first end of the first resistor.
Optionally, the detection wave generation module further includes a band elimination filter, and the band elimination filter is connected between the output end of the square wave generator and the first end of the first resistor.
Optionally, the system further comprises an amplification feedback module;
the amplifying feedback module is connected between the second end of the first resistor and the control module, and the amplifying feedback module is configured to amplify and feed back the voltage at the second end of the first resistor to the control module.
Optionally, the amplification feedback module includes an amplification unit, an input end of the amplification unit is directly or indirectly connected to the second end of the first resistor, and an output end of the amplification unit is directly or indirectly connected to the control module.
Optionally, the amplification feedback module further includes a second resistor, and the second resistor is connected between the second end of the first resistor and the input end of the amplification unit.
Optionally, the biological tissue impedance detection circuit of the radiofrequency ablation device further includes a voltage detection module and a current detection module;
the voltage detection module is connected in parallel with two ends of the biological tissue to be detected so as to detect the voltage of the biological tissue to be detected;
the voltage detection module is connected with the control module to feed back the voltage to the control module;
the current detection module is connected in series with the biological tissue to be detected to detect the current of the biological tissue to be detected;
the current detection module is connected with the control module to feed the current back to the control module.
Optionally, the detection wave generation module is further connected to the control module, so as to output the detection wave under the control of the control module.
Optionally, a ratio of the frequency of the radio frequency energy to the frequency of the detection wave is greater than 5: 1.
According to a second aspect of the present invention, there is provided a radio frequency ablation device comprising the biological tissue impedance detection circuit of the first aspect and its alternatives.
The utility model provides an among radiofrequency ablation device and biological tissue impedance detection circuitry thereof, newly increased the detection ripples and taken place the module, and the electrical parameter of its produced detection ripples is less than the electrical parameter of radio frequency energy, and then, can realize the impedance detection under the condition of output detection ripples, and is visible, based on the utility model discloses a circuit framework under the condition that does not carry out the radio frequency ablation, can need not directly to utilize the produced energy of radio frequency energy generation module to realize the impedance detection, has ensured the security that biological tissue impedance detected, has reduced because the radio frequency energy is too high and the unnecessary biological tissue that leads to melts and injures.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
Fig. 1 is a schematic structural diagram of a biological tissue impedance detection circuit of a radio frequency ablation device according to an exemplary embodiment of the present invention
Fig. 2 is a schematic circuit diagram of a biological tissue impedance detection circuit of a radio frequency ablation device according to another exemplary embodiment of the present invention;
fig. 3 is a schematic circuit diagram of a biological tissue impedance detection circuit of a radio frequency ablation device according to another exemplary embodiment of the present invention;
fig. 4 is a schematic diagram of frequency versus impedance in an exemplary embodiment of the invention;
fig. 5 is a schematic processing flow diagram of a control module according to an exemplary embodiment of the present invention;
fig. 6 is a schematic structural diagram of a biological tissue impedance detection circuit of a radio frequency ablation device according to still another exemplary embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
The terms "first," "second," "third," "fourth," and the like in the description and in the claims, as well as in the drawings, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in sequences other than those illustrated or otherwise described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
The technical solution of the present invention will be described in detail with specific examples. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments.
Referring to fig. 1, an embodiment of the present invention provides a biological tissue impedance detection circuit of a radio frequency ablation apparatus, including:
the device comprises a radio frequency energy transmitting module 11, a detection wave generating module 12, a first resistor R1 and a control module 10;
specifically, the radio frequency energy generation module 11 is connected to a first end of the biological tissue 13 to be detected, and is configured to output radio frequency energy to the biological tissue 13 to be detected during an ablation procedure, where a common frequency f of the radio frequency energy 0 200 to 500 kHz.
The output end of the detection wave generation module 12 is connected to the first end of the first resistor R1, the second end of the first resistor R1 is directly or indirectly connected to the first end of the biological tissue 13 to be detected, and the detection wave generation module 12 is configured to output a detection wave to the biological tissue 13 to be detected;
the electrical parameter of the detection wave comprises at least one of: voltage amplitude A, power P, frequency f; and lower than the electrical parameter of the rf energy, for example, if the electrical parameter includes frequency f: frequency f of said radio frequency energy 0 Frequency f of the detection wave 1 The ratio of (d) is greater than 5:1, specifically may be 10: 1.
The control module 10 is directly or indirectly connected to the second end of the first resistor R1 to acquire a target voltage U A The target voltage U A Matched with the voltage at the second end of the first resistor R1 and different target voltages V A Different impedance detection values Z corresponding to the biological tissue 13 to be measured 0 . The control module 10 may be, for example, a control unit (i.e., the MCU100, specifically, the Micro Controller Uni) or a single chip microcomputer.
The detection wave may be at least one of a square wave, a triangular wave and a sine wave.
In the above scheme, the detection wave generation module is additionally arranged, and the electrical parameter of the generated detection wave is lower than the electrical parameter of the radio frequency energy, so that impedance detection can be realized under the condition of outputting the detection wave.
Furthermore, based on the utility model discloses circuit design, the impedance detection value can be calculated based on following formula and is obtained: z 0 ＝U A R1/(U B -U A ). Wherein, U B Is the voltage of the first end of the first resistor;
furthermore, based on the utility model discloses a circuit framework, wherein after the resistance of first resistance R1 was confirmed, the voltage U of the first end of first resistance B The voltage can be designed to be a safe lower voltage by the design of the circuit.
It can be seen, the utility model discloses a mode that this kind of impedance calculated provides abundant hardware basis, and then, uses the utility model discloses the time, can be under the condition of additionally not introducing voltage, current detection module to comparatively simple circuit design and realize target voltage's feedback, and the impedance based on target voltage calculates.
Referring to fig. 2 and fig. 3, in one embodiment, the detection wave generation module 12 includes a square wave generator 121, and an output end of the square wave generator 121 is connected to a first end of the first resistor R1, so as to provide a basis for detecting the impedance of the biological tissue to be detected;
for some examples, the square wave generator 121 may be connected to the control module, and further, the output square wave may be controlled by the control module 10, for example, the control module 10 may control at least one of the following: the waveform of the square wave, the output timing of the detection wave, specific electrical parameters and the like.
In another example, the square wave generator 121 may also generate the detection wave independently without being controlled by the control module.
In the embodiment shown in fig. 2 and fig. 3, the detection wave generation module 12 further includes a band stop filter 122 (BSF), an input end of the band stop filter 122 is connected to an output end of the square wave generator 121, an output end of the band stop filter 122 is connected to a first end of a first resistor R1, and the band stop filter 122 can be used to suppress interference frequency in the detection wave output by the square wave generator 121, so as to obtain a detection frequency component with a narrow bandwidth.
In other embodiments, no band-stop filter or other filter or filter device may be disposed between the first resistor R1 and the square-wave generator 121.
In one embodiment, referring to fig. 2, the biological tissue impedance detection circuit of the rf ablation device further includes an amplifying feedback module 14, an input end of the amplifying feedback module 14 is connected to the second end of the first resistor R1, an output end of the amplifying feedback module 14 is connected to the control module 13, and the amplifying feedback module 14 is configured to amplify a voltage at the second end of the first resistor R1 and feed the amplified voltage back to the control module 10.
The amplifying feedback module 14 includes an amplifying unit 141 and a second resistor R2, an input terminal of the amplifying unit 15 is directly or indirectly connected to a second terminal of the first resistor R1, and an output terminal of the amplifying unit is connected to the control module 10, and the feedback amplifying module 15 further includes a second resistor R2 connected to the second terminal of the first resistor R1 and the input terminal of the amplifying unit 141.
In one example, the frequency of the detection wave output by the square wave generator 121 is 50kHz, and the frequency of the rf energy output by the rf energy generation module is 500 kHz.
In a standby state, that is, in a state where the radio frequency energy generation module does not output energy, the 50kHz detection wave output by the square wave generator 121 is processed by the band elimination filter 122, and then is input to the first end of the first resistor R1, a partial voltage is formed at a point a between the second end of the first resistor R1 and the input end of the biological tissue 13 to be detected, a signal after the partial voltage is output to the amplification feedback module 14, and in the amplification feedback module 14, the signal is amplified and then output to the control module 10.
The second resistor R2 can be used as a current limiting resistor, for example, to limit the input current of the amplifying unit 141, so as to prevent the amplifying unit 141 from being burnt out by excessive current.
The first end voltage of the first resistor R1 is U B The voltage at the second terminal is U A The impedance of the biological tissue 13 to be measured is Z 0 Derived from said biological tissue impedance detection circuit, Z 0 ＝U A R1/(U B -U A )。
The second end voltage U of the first resistor B As determined by the circuit design, for example, a lower safe voltage may be designed.
The first end voltage U of the first resistor A The resistance value of the first resistor R1 is determined by the circuit design and is a known resistance, which is calculated according to the amplification feedback module 14 and the control module 10.
In the ablation operation process, after the radio frequency energy generation module 11 is started, the radio frequency energy with the frequency of 500kHz is directly or indirectly output to the biological tissue 13 to be detected.
The biological tissue impedance detection circuit of the radiofrequency ablation device further comprises a voltage detection module 15 and a current detection module 16.
The voltage detection module 15 is connected in parallel to two ends of the biological tissue 13 to be detected and is used for detecting the voltage U of the biological tissue 13 to be detected z (ii) a The voltage detection module 15 is also connected to the control module 10 for measuring the voltage U of the biological tissue 13 z Fed back to the control module 10.
The current detection module 16 is connected in series with the biological tissue 13 to be detected and is used for detecting the current I of the biological tissue 13 to be detected z (ii) a The current detection module 16 is also connected to the control module 10 for measuring the current I of the biological tissue 13 z Fed back to the control module 10.
The voltage U of the biological tissue 13 to be measured is obtained according to the measurement z And current I z Calculating to obtain the biological group to be detectedImpedance Z of fabric 13 0 ＝U z /I z 。
Wherein, the impedance is obtained by calculation after the voltage detection module 15 and the current detection module 16 are used for detection, and the impedance is the real impedance when the ablation is carried out at the specific frequency of 500KHZ, so that the detection is more real and reliable.
Furthermore, the embodiment of the present invention provides an embodiment, through the combination of two impedance testing means, can carry out impedance detection before starting to ablate, know the return circuit impedance condition, for the information support that begins to ablate provides, but does not influence the radio frequency energy passageway again.
Meanwhile, different detection modes can be adapted to detection under different frequencies, wherein when the radio frequency energy acts on the biological tissue to be detected, the frequency is higher, and the mode of directly feeding back the radio frequency energy to the control module by using the amplification feedback module is difficult to detect in a timely and adaptive manner, so that the voltage detection module and the current detection module are introduced, and the requirement of fine detection under high frequency is met.
Referring to fig. 4, the biological tissue 13 to be measured belongs to a capacitive impedance, which is the electric energy stored in the resistor in the form of an electric field, and the frequency-impedance curve is shown in fig. 4, the impedance Z of the biological tissue 13 to be measured 0 Presenting different impedance characteristics at different detection frequencies f.
Usually, the impedance value Z for the waveform (such as radio frequency energy) of 500kHz acting on the bio-impedance to be measured 500 And an impedance value Z of 50kHz when a waveform (such as radio frequency energy) is applied to the bio-impedance to be measured 50 The impedance correction coefficient X of the biological tissue 13 to be detected can be obtained by derivation, and the following conditions are satisfied: correction formula Z 500 ＝X×Z 50 For example, X is 0.8.
According to different radio frequency ablation frequencies output by the radio frequency energy generation module 11 and the detection wave frequencies output by the detection wave module 12, the correction coefficient X can be modified correspondingly.
In one example, the correction process can be implemented in the control module in a software manner by using the flow shown in fig. 5. In particular, where radiofrequency ablation has been initiated, it may be based on voltageThe detection results of the detection module 15 and the current detection module 16 pass through Z 0 ＝U z /I z Calculating the impedance detection value of the biological tissue to be detected; under the condition that the radio frequency ablation is not started, the controllable square wave generator 121 sends out a detection wave, and collects a signal output by the amplifying unit 141 so as to represent the voltage U at the second end of the first resistor R1 by using the signal A Then through Z 0 ＝U A R1/(U B -U A ) The impedance detection value of the biological tissue to be measured before correction is calculated, and then the impedance detection value before correction is multiplied by a correction coefficient (for example, 0.8), thereby obtaining the impedance detection value after correction.
For another example, referring to fig. 6, a modification module 17 may be introduced to achieve a similar modification effect by a circuit manner, wherein the biological tissue impedance detection circuit of the radiofrequency ablation device further includes the modification module 17, and further: the amplifying unit 141 is connected to the control module 10 directly, and is connected to the control module through the correction module 17, and the second end voltage U of the first resistor R1 can be realized through the correction module A Correcting;
specifically, in the case that the rf ablation has been started, the control module may pass through Z based on the detection results of the voltage detection module 15 and the current detection module 16 0 ＝U z /I z Calculating the impedance detection value of the biological tissue to be detected; under the condition that the radio frequency ablation is not started, the control module can control the wave generator 121 to emit a detection wave, and on one hand, the control module can directly acquire a signal output by the amplifying unit 141 to represent the second end voltage U of the first resistor R1 by using the signal A On the other hand, the correction module 17 may correct the signal output by the amplifying unit 141 to obtain the representation X × U A A signal of this value; then, Z can be utilized 0 ＝X*U A R1/(U B -U A ) And calculating the corrected impedance detection value of the biological tissue to be detected. In this way, the correction coefficient X can be freely changed by adjusting the correction module. For further example, the modification module 17 may be implemented by a multiplier, for example, the multiplier may obtain the signal output by the amplifying unit 141A sign, and a signal matching the correction factor (characterizing the correction factor), which may be adjusted manually or automatically, to effect an adjustment of the correction factor X.
In addition, in some examples, a first control switch may be further disposed between the second end of the first resistor and the control module, and a control end of the first control switch may be connected to the control module, so that the control module may control the first control switch to be turned on when ablation is not started, and control the first control switch to be turned off when ablation is started. Furthermore, the amplification feedback module can be prevented from feeding back corresponding signals when the radio frequency energy generation module outputs the radio frequency energy, and the safety is guaranteed.
In another example, the circuit may further include a second control switch, a first end of the second control switch is connected to the rf energy generation module 11, a second end of the second control switch is connected to the second end of the biological tissue to be detected and the second end of the first resistor, respectively, and a control end of the second control switch may be connected to the control module, so that the control module may control the second control switch to turn off when ablation is not started, and control the second control switch to turn on when ablation is started. Furthermore, the detection result when the radiofrequency energy generation module is started accidentally to affect the ablation is avoided.
The embodiment of the utility model also provides a radio frequency ablation device, wherein include radio frequency ablation device's biological tissue impedance detection circuitry, be used for detecting the impedance of the biological tissue that awaits measuring.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention.
Claims (10)
1. A biological tissue impedance detection circuit for a radio frequency ablation device, comprising: the device comprises a radio frequency energy generation module, a detection wave generation module, a first resistor and a control module;
the radio frequency energy generation module is directly or indirectly connected with a first end of the biological tissue to be detected, and the radio frequency energy generation module is configured to be capable of outputting radio frequency energy to the biological tissue to be detected;
the detection wave generation module is connected with a first end of the first resistor, a second end of the first resistor is directly or indirectly connected with a first end of the biological tissue to be detected, and the detection wave generation module is configured to be capable of outputting detection waves to the biological tissue to be detected; the electrical parameter of the detection wave is lower than the electrical parameter of the radio frequency energy; the electrical parameter comprises at least one of: voltage amplitude, power, frequency;
the control module is directly or indirectly connected with the second end of the first resistor to acquire target voltage, the target voltage is matched with the voltage of the second end of the first resistor, and different target voltages correspond to different impedance detection values of the biological tissue to be detected.
2. The biological tissue impedance detection circuit of a radio frequency ablation device according to claim 1, wherein the detection wave generation module comprises a square wave generator, and an output end of the square wave generator is directly or indirectly connected with a first end of the first resistor.
3. The biological tissue impedance detection circuit of a radio frequency ablation device according to claim 2, wherein the detection wave generation module further comprises a band-stop filter connected between the output of the square wave generator and the first end of the first resistor.
4. The biological tissue impedance detection circuit of the radio frequency ablation device according to any one of claims 1 to 3, further comprising an amplification feedback module;
the amplification feedback module is connected between the second end of the first resistor and the control module, and is configured to amplify and feed back the voltage at the second end of the first resistor to the control module.
5. The biological tissue impedance detection circuit of the radiofrequency ablation device as set forth in claim 4, wherein the amplification feedback module comprises an amplification unit, an input end of the amplification unit is directly or indirectly connected to the second end of the first resistor, and an output end of the amplification unit is directly or indirectly connected to the control module.
6. The biological tissue impedance detection circuit of an rf ablation device according to claim 5, wherein the amplification feedback module further comprises a second resistor connected between a second end of the first resistor and the input of the amplification unit.
7. The biological tissue impedance detection circuit of the radiofrequency ablation device of any one of claims 1 to 3, further comprising a voltage detection module, and a current detection module;
the voltage detection module is connected in parallel with two ends of the biological tissue to be detected so as to detect the voltage of the biological tissue to be detected;
the voltage detection module is connected with the control module to feed back the voltage to the control module;
the current detection module is connected in series with the biological tissue to be detected so as to detect the current of the biological tissue to be detected;
the current detection module is connected with the control module to feed the current back to the control module.
8. The biological tissue impedance detection circuit of a radio frequency ablation device according to any one of claims 1 to 3, wherein the detection wave generation module is further connected to the control module to output the detection wave under the control of the control module.
9. The biological tissue impedance detection circuit of a radio frequency ablation device according to any one of claims 1 to 3, wherein a ratio of a frequency of the radio frequency energy to a frequency of the detected wave is greater than 5: 1.
10. A radio frequency ablation device comprising a biological tissue impedance detection circuit of the radio frequency ablation device of any of claims 1 to 9.
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