CN217483946U - Novel automatic sampler of medicine dissolving-out instrument - Google Patents
Novel automatic sampler of medicine dissolving-out instrument Download PDFInfo
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- CN217483946U CN217483946U CN202221584463.3U CN202221584463U CN217483946U CN 217483946 U CN217483946 U CN 217483946U CN 202221584463 U CN202221584463 U CN 202221584463U CN 217483946 U CN217483946 U CN 217483946U
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Abstract
The utility model provides a novel automatic sampler of a medicine dissolution instrument, which relates to the technical field of medicine dissolution detection, and comprises a dissolution instrument main body, wherein a dissolution cup is arranged on the dissolution instrument main body, a first telescopic driving device is arranged at the top of the dissolution instrument main body, a connecting rod is fixedly connected with the movable end of the first telescopic driving device, when in use, a second telescopic driving device is started to drive a sealing plug to move upwards, so that negative pressure is formed in a sampling tube, the atmospheric pressure pushes the liquid medicine through a rotating tube and a feeding hole to move a first sealing plate to overcome the elasticity of a first elastic piece and open the feeding hole and press the liquid medicine into the sampling tube, then a second telescopic driving device is started to drive the sealing plug to move downwards, so that the liquid medicine in the sampling tube pushes a second sealing plate through a discharging hole to overcome the elasticity of a second elastic piece and open the discharging hole to discharge and collect the liquid medicine, thereby reducing the manual use, the operation technical requirement is reduced, and the risk of collision with a stirring component of the dissolution instrument during sampling is avoided.
Description
Technical Field
The utility model relates to a medicine degree of dissolving out detects technical field, specifically is a novel medicine dissolves out appearance autosampler.
Background
The drug dissolution instrument is an effective alternative method for researching and evaluating in-vivo drug bioavailability in vitro, is an important means for ensuring and measuring whether the production process and the quality of a solid oral preparation are reasonable and stable, is an important content of a pharmaceutical experiment by utilizing the drug dissolution instrument to carry out dissolution test on a drug, changes the dissolution condition of the drug in a dissolution cup on the dissolution instrument along with time, and needs to sample and detect liquid medicine in the dissolution cup on the dissolution instrument in different time periods in order to ensure the reproducibility of dissolution measurement. In the prior art, when the liquid medicine in the dissolution cup is sampled, the liquid medicine is manually extracted by using a suction pipe, the operation technical requirement is high, and the suction pipe has the risk of colliding with a stirring component of the dissolution instrument during sampling.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a novel medicine dissolve out appearance automatic sampler, for artifical straw extraction go on when solving the liquid medicine that dissolves out in the appearance dissolution cup among the prior art, the operation technical requirement is high, the straw has the problem that the appearance stirring member risk is dissolved out in the collision when taking a sample moreover.
In order to achieve the above purpose, the utility model adopts the following technical scheme: the novel automatic sampler of the drug dissolution instrument comprises a dissolution instrument main body, wherein a dissolution cup is arranged on the dissolution instrument main body, a first telescopic driving device is arranged at the top of the dissolution instrument main body, a connecting rod is fixedly connected with the movable end of the first telescopic driving device, a sampling tube and a second telescopic driving device are fixedly connected onto the connecting rod, a sealing plug which is in sliding fit with the inner wall of the sampling tube is fixedly connected with the movable end of the second telescopic driving device, a feeding hole and a discharging hole are formed in the bottom of the sampling tube, the inner wall of the feeding hole is rotatably connected with a rotating tube through a sealing bearing, a stirring rod which is arranged in the dissolution cup is fixedly connected onto the rotating tube, a first elastic piece is fixedly connected to the bottom of the inner wall of the sampling tube, a first sealing plate which is used for sealing the feeding hole is fixedly connected to one end of the first elastic piece, and a second elastic piece is fixedly connected to the bottom of the outer surface of the sampling tube, one end of the second elastic piece is fixedly connected with a second sealing plate used for sealing the discharge hole, and the bottom of the sampling tube is fixedly connected with a driving mechanism used for driving the rotating tube to rotate.
In order to make the utility model discloses have the effect that drives the connecting rod and reciprocate, the utility model discloses a further technical scheme does, a flexible drive arrangement is an electric telescopic handle.
In order to make the utility model discloses have the effect of being convenient for derive the sample, the utility model discloses a further technical scheme does, the bottom fixedly connected with of sampling tube and the passage that the discharge opening corresponds.
In order to make the utility model discloses have the effect that drives the sealing plug and remove, the utility model discloses a further technical scheme does, the flexible drive arrangement of second is second electric telescopic handle.
In order to make the utility model discloses have the effect of saving the cost, the utility model discloses a further technical scheme does, first elastic component is first extension spring.
In order to make the utility model discloses have the effect of saving the cost, the utility model discloses a further technical scheme does, the second elastic component is the second extension spring.
In order to make the utility model discloses have the effect of protection actuating mechanism, the utility model discloses a further technical scheme does, the bottom fixedly connected with cover of sampling tube is established at the outside protecting crust of actuating mechanism.
In order to make the utility model discloses the utensil improves the effect that leakproofness has between sealing plug and the sampling tube, the utility model discloses a further technical scheme does, the material of sealing plug is rubber.
In order to make the utility model discloses have the effect that drives the commentaries on classics pipe pivoted, the utility model discloses a further technical scheme does, actuating mechanism includes rotation drive device, rotation drive device's output fixedly connected with gear, the tooth toothing of gear has the ring gear of being connected with commentaries on classics outer fixed surface.
In order to make the utility model discloses have the effect that drives gear revolve, the utility model discloses a further technical scheme does, rotation driving device includes motor and reduction gear, the output of motor is connected in the input of reduction gear.
The utility model has the advantages that: by arranging the sampling tube and the second telescopic driving device on the connecting rod, the movable end of the second telescopic driving device is fixedly connected with the sealing plug, the sealing plug is in sliding fit with the inner wall of the sampling tube, the bottom of the sampling tube is provided with the feed hole and the discharge hole, the inner wall of the feed hole is rotatably connected with the rotating tube, the rotating tube is fixedly connected with the stirring rod, the bottom of the inner wall of the sampling tube is fixedly connected with the first elastic piece, the first elastic piece is fixedly connected with the first sealing plate, the bottom of the outer surface of the sampling tube is fixedly connected with the second elastic piece, the second elastic piece is fixedly connected with the second sealing plate, the sampling tube is provided with the driving mechanism for driving the rotating tube to rotate, the driving mechanism drives the rotating tube to rotate, the rotating tube rotates to drive the stirring rod to stir and dissolve out the medicine in the dissolution cup, and when the liquid medicine needs to be sampled, the second telescopic driving device is started to drive the sealing plug to move upwards, make the sampling tube form the negative pressure, thereby make atmospheric pressure move the first closing plate with the liquid medicine through changeing pipe and feed port top and overcome first elastic component elasticity and open the feed port and impress in the sampling tube, start the flexible drive arrangement of second afterwards and drive the sealing plug and move down, make the liquid medicine in the sampling tube move the second closing plate through the discharge opening top and overcome second elastic component elasticity and open the discharge opening and discharge the collection, artificial use has effectively been reduced, the operation technical requirement has been reduced, and the risk that the appearance stirring component was dissolved out in the collision when having avoided the sample.
Drawings
Fig. 1 is a cross-sectional view of an embodiment of the present invention.
Fig. 2 is an enlarged schematic structural diagram of a point a in fig. 1 according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of an embodiment of the present invention.
Fig. 4 is a schematic diagram of the sampling tube for extracting the drug according to the embodiment of the present invention.
Fig. 5 is a schematic view of the drug discharge state of the sampling tube according to the embodiment of the present invention.
In the figure: 1-a dissolution instrument main body, 2-a dissolution cup, 3-a first telescopic driving device, 4-a connecting rod, 5-a sampling tube, 501-a feeding hole, 502-a discharging hole, 6-a second telescopic driving device, 7-a sealing plug, 8-a rotating tube, 9-a stirring rod, 10-a first elastic piece, 11-a first sealing plate, 12-a second elastic piece, 13-a second sealing plate, 14-a driving mechanism, 1401-a rotating driving device, 1402-a gear, 1403-a gear ring, 15-a material guide tube and 16-a protective shell.
Detailed Description
The following description will further describe embodiments of the present invention with reference to the accompanying drawings.
As shown in fig. 1-5, a novel automatic sampler for a drug dissolution apparatus comprises a dissolution apparatus main body 1, wherein a dissolution cup 2 is arranged on the dissolution apparatus main body 1, the dissolution cup 2 can contain a drug, a first telescopic driving device 3 is arranged at the top of the dissolution apparatus main body 1, a connecting rod 4 is fixedly connected with a movable end of the first telescopic driving device 3, a sampling tube 5 and a second telescopic driving device 6 are fixedly connected on the connecting rod 4, a sealing plug 7 which is in sliding fit with the inner wall of the sampling tube 5 is fixedly connected with a movable end of the second telescopic driving device 6, a feeding hole 501 and a discharging hole 502 are arranged at the bottom of the sampling tube 5, a rotating tube 8 is rotatably connected with the inner wall of the feeding hole 501 through a sealing bearing, a stirring rod 9 arranged inside the dissolution cup 2 is fixedly connected on the rotating tube 8, a first elastic member 10 is fixedly connected with the bottom of the inner wall of the sampling tube 5, a first sealing plate 11 for sealing the feeding hole 501 is fixedly connected with one end of the first elastic member 10, the second telescopic driving device 6 is started to drive the sealing plug 7 to move upwards, so that negative pressure is formed in the sampling tube 5, thereby make atmospheric pressure push up the first closing plate 11 through rotating tube 8 and feed port 501 and overcome first elastic component 10 elasticity and open feed port 501 and impress in sampling tube 5, the bottom fixedly connected with second elastic component 12 of sampling tube 5 surface, the one end fixedly connected with of second elastic component 12 is used for sealing the second closing plate 13 of discharge port 502, start the flexible drive arrangement 6 of second and drive sealing plug 7 and move down, make the liquid medicine in sampling tube 5 push up second closing plate 13 and overcome second elastic component 12 elasticity and open discharge port 502 and discharge the collection through discharge port 502, the bottom fixedly connected with of sampling tube 5 is used for driving rotating tube 8 pivoted actuating mechanism 14, actuating mechanism 14 drives rotating tube 8 and rotates, rotating tube 8 rotates and drives puddler 9 and rotate and dissolve out the medicine in the cup 2 and stir and dissolve out.
When the device is used, a medicine is placed into the dissolution cup 2, the first telescopic driving device 3 is started to move the stirring rod 9 into the dissolution cup 2 through the connecting rod 4, the sampling tube 5 and the rotating tube 8, the driving mechanism 14 drives the rotating tube 8 to rotate, the rotating tube 8 rotates to drive the stirring rod 9 to rotate so as to stir and dissolve the medicine in the dissolution cup 2, when the medicine liquid needs to be sampled, the second telescopic driving device 6 is started to drive the sealing plug 7 to move upwards, negative pressure is formed in the sampling tube 5, so that the atmospheric pressure pushes the medicine liquid to push the first sealing plate 11 through the rotating tube 8 and the feeding hole 501 to overcome the elastic force of the first elastic piece 10, the feeding hole 501 is opened, the medicine liquid is pressed into the sampling tube 5, then the second telescopic driving device 6 is started to drive the sealing plug 7 to move downwards, the medicine liquid in the sampling tube 5 pushes the second sealing plate 13 through the discharging hole 502 to overcome the elastic force of the second elastic piece 12, the discharging hole 502 is opened, the discharging hole 502 is discharged and collected, and manual use is reduced, the technical requirements for operation are reduced, and the risk of collision with a stirring component of the dissolution instrument during sampling is avoided.
Specifically, first flexible drive arrangement 3 is an electric telescopic handle, can drive connecting rod 4 and reciprocate.
Further, the bottom of the sampling tube 5 is fixedly connected with a material guide tube 15 corresponding to the discharge hole 502, so that a sample can be conveniently led out.
Specifically, the second telescopic driving device 6 is a second electric telescopic rod and can drive the sealing plug 7 to move.
Specifically, first elastic component 10 is first extension spring, and the extension spring price is lower can save the cost.
Specifically, the second elastic member 12 is a second tension spring, which is low in price and can save cost.
Further, the bottom of the sampling tube 5 is fixedly connected with a protective shell 16 sleeved outside the driving mechanism 14, the protective shell 16 can protect the driving mechanism 14, and foreign matters outside the part enter a working area of the driving mechanism 14 to influence the working of the driving mechanism 14.
Specifically, the sealing plug 7 is made of rubber, so that the sealing performance between the sealing plug 7 and the sampling tube 5 can be improved.
Specifically, the driving mechanism 14 includes a rotation driving device 1401, an output end of the rotation driving device 1401 is fixedly connected with a gear 1402, teeth of the gear 1402 are meshed with a gear ring 1403 fixedly connected with the outer surface of the rotating pipe 8, the rotation driving device 1401 can drive the gear 1402 to rotate, the gear 1402 rotates to drive the gear ring 1403 to rotate, and the gear ring 1403 rotates to drive the rotating pipe 8 to rotate.
Specifically, the rotation driving device 1401 includes a motor and a speed reducer, and an output end of the motor is connected to an input end of the speed reducer, and can drive the gear 1403 to rotate.
In the description of the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. The novel automatic sampler of the drug dissolution instrument is characterized by comprising a dissolution instrument main body (1), wherein a dissolution cup (2) is arranged on the dissolution instrument main body (1), a first telescopic driving device (3) is arranged at the top of the dissolution instrument main body (1), a connecting rod (4) is fixedly connected with the movable end of the first telescopic driving device (3), a sampling tube (5) and a second telescopic driving device (6) are fixedly connected onto the connecting rod (4), a sealing plug (7) which is in sliding fit with the inner wall of the sampling tube (5) is fixedly connected with the movable end of the second telescopic driving device (6), a feeding hole (501) and a discharging hole (502) are formed in the bottom of the sampling tube (5), the inner wall of the feeding hole (501) is rotatably connected with a rotating tube (8) through a sealing bearing, a stirring rod (9) which is arranged in the dissolution cup (2) is fixedly connected onto the rotating tube (8), the bottom fixedly connected with of sampling tube (5) inner wall first elastic component (10), the one end fixedly connected with of first elastic component (10) is used for sealing first closing plate (11) of feed port (501), the bottom fixedly connected with second elastic component (12) of sampling tube (5) surface, the one end fixedly connected with of second elastic component (12) is used for sealing second closing plate (13) of discharge port (502), the bottom fixedly connected with of sampling tube (5) is used for driving commentaries on classics pipe (8) pivoted actuating mechanism (14).
2. The new drug dissolution meter autosampler according to claim 1, wherein the first telescopic drive means (3) is a first electric telescopic rod.
3. The novel automatic sampler of the drug dissolution instrument according to claim 1, wherein a material guide tube (15) corresponding to the discharge hole (502) is fixedly connected to the bottom of the sampling tube (5).
4. The new drug dissolution meter autosampler according to claim 1, wherein said second telescoping drive means (6) is a second electric telescoping rod.
5. The novel drug dissolution meter autosampler of claim 1, wherein said first resilient member (10) is a first tension spring.
6. The novel drug dissolution meter autosampler of claim 1, wherein said second resilient member (12) is a second tension spring.
7. The novel automatic sampler of a drug dissolution instrument according to claim 1, characterized in that a protective shell (16) sleeved outside the driving mechanism (14) is fixedly connected to the bottom of the sampling tube (5).
8. The new drug dissolution meter autosampler according to claim 1, wherein the material of the sealing plug (7) is rubber.
9. A novel drug dissolution meter autosampler according to any of claims 1 to 8, wherein said drive mechanism (14) comprises a rotational drive means (1401), the output of said rotational drive means (1401) being fixedly connected to a gear wheel (1402), the teeth of said gear wheel (1402) engaging with a toothed ring (1403) fixedly connected to the outer surface of the rotating tube (8).
10. The new drug dissolution meter autosampler according to claim 9, wherein said rotational drive means (1401) comprises a motor and a reducer, an output of said motor being connected to an input of said reducer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221584463.3U CN217483946U (en) | 2022-06-23 | 2022-06-23 | Novel automatic sampler of medicine dissolving-out instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221584463.3U CN217483946U (en) | 2022-06-23 | 2022-06-23 | Novel automatic sampler of medicine dissolving-out instrument |
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| CN217483946U true CN217483946U (en) | 2022-09-23 |
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| CN202221584463.3U Active CN217483946U (en) | 2022-06-23 | 2022-06-23 | Novel automatic sampler of medicine dissolving-out instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118513004A (en) * | 2024-07-17 | 2024-08-20 | 洛阳迅源化工科技有限公司 | Medical intermediate reaction device and method |
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2022
- 2022-06-23 CN CN202221584463.3U patent/CN217483946U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118513004A (en) * | 2024-07-17 | 2024-08-20 | 洛阳迅源化工科技有限公司 | Medical intermediate reaction device and method |
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