CN217431742U - Free calcium detection micro-fluidic chip and CRRT waste liquid bag capable of being used for free calcium monitoring - Google Patents
Free calcium detection micro-fluidic chip and CRRT waste liquid bag capable of being used for free calcium monitoring Download PDFInfo
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Abstract
The utility model provides a free calcium detection micro-fluidic chip and can be used to CRRT waste liquid bag of free calcium monitoring relates to medical auxiliary apparatus field, has solved the problem that can't monitor the waste liquid free calcium level in the waste liquid bag directly among the prior art, and the chip includes is provided with the micro-fluidic runner in the base member, and the head and the tail both ends of micro-fluidic runner form the introduction port and go out the appearance mouth on the base member respectively, and the middle section of micro-fluidic runner sets up to the detection zone; the three-electrode chemical sensing module is connected to the matrix and is positioned at the detection area of the microfluidic channel; the sampling micro-needle is connected to the sample inlet of the substrate and is provided with a needle hole communicated with the inside and the outside of the microfluidic flow channel; the mother bag of the CRRT waste liquid bag is provided with a liquid inlet pipe and a liquid outlet pipe, and a sampling micro-needle of the free calcium detection micro-fluidic chip is penetrated into the liquid inlet pipe. The utility model discloses can solve free calcium and detect technical problem, the accessible chip directly detects free calcium from the waste liquid bag and realizes the real-time, the dynamic low-cost detection of calcium after the hemofiltration.
Description
Technical Field
The utility model relates to a medical treatment auxiliary instrument field, specific saying so, a free calcium of micro-fluidic chip detects micro-fluidic chip and can be used to the CRRT waste liquid bag of free calcium monitoring.
Background
The existing waste liquid bag structure is shown in fig. 5, and only has a liquid storage function, so that the detection of electrolyte levels including free calcium levels cannot be realized. The currently popularized approach for detecting free calcium in clinic is mostly to be detected by a blood gas analyzer. Because of a plurality of factors influencing the detection of serum ionized calcium, the blood gas can be collected only through a blood gas needle pre-filled with charge balancing heparin clinically at present, the blood gas is detected through a blood gas electrolyte analyzer, the single blood volume required for loading the machine is about 2ml, the cost is 180 yuan, the detection time required for the first day is 6-8 times, and the subsequent time required for each day is 4-6 times. High cost, frequent blood sampling and infection risk. Research shows that the detection of the calcium in the blood after the filter can be well synchronized by detecting the level of free calcium in the waste liquid bag. However, the current detection technology cannot carry out real-time, rapid and sensitive low-cost monitoring on the free calcium level of the waste liquid in the waste liquid bag.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to design a free calcium detects micro-fluidic chip and can be used to the waste liquid bag of CRRT of free calcium monitoring, can solve free calcium and detect technical problem, accessible chip directly detects free calcium from waste liquid bag and realizes the real-time, the dynamic low-cost detection of calcium after the hemofiltration.
The utility model discloses a following technical scheme realizes:
the utility model provides a free calcium detection micro-fluidic chip, which comprises a substrate, a sampling micro-needle and a three-electrode chemical sensing module of a surface modified calcium ion sensitive film;
a micro-fluidic flow channel is arranged in the matrix, a sample inlet and a sample outlet are respectively formed on the matrix at the head end and the tail end of the micro-fluidic flow channel, and the middle section of the micro-fluidic flow channel is set as a detection zone;
the three-electrode chemical sensing module is connected to the matrix and is positioned at the detection area of the microfluidic flow channel;
the sampling micro-needle is connected to the sample inlet of the substrate and is provided with a pinhole communicated with the inside and the outside of the microfluidic flow channel.
When the structure is arranged, the sampling micro-needle of the free calcium detection micro-fluidic chip is used for puncturing the mother bag, a small amount of waste liquid in the liquid inlet pipe is sucked from the sampling micro-needle through the capillary action of the micro-fluidic channel and enters the detection area of the micro-fluidic channel, calcium ions in the waste liquid can change the potential difference of the electrode surface of the three-electrode chemical sensing module to complete the free calcium level detection of the waste liquid, and therefore under the condition that the electric signal of the three-electrode chemical sensing module is transmitted to the electrochemical workstation to be amplified, the real-time monitoring of the free calcium level in the waste liquid is realized. Free calcium level in the CRRT waste liquid bag can be detected through the free calcium detection micro-fluidic chip, a blood gas analyzer is not needed for detection, and the detection cost can be reduced.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the sample inlet and the sample outlet are respectively positioned on the bottom surface and the top surface of the substrate.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the cross section area of the microfluidic flow channel at the detection area is larger than that of the flow channel connected with the upstream and the downstream of the detection area.
When adopting above-mentioned structure that sets up, this kind of sectional area change of detection zone can be detained and get into wherein wait to detect the waste liquid, is favorable to the detection of three electrode chemical sensing module to the waste liquid.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the three-electrode chemical sensing module is connected with a data analysis transmission module, and a signal transmission module of the data analysis transmission module is a wired signal transmission module or a wireless signal transmission module.
When the structure is adopted, the data analysis transmission module enables the free calcium detection micro-fluidic chip to analyze and transmit the detection result through the circuit and the three-electrode chemical sensing module.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the sampling micro-needle is connected to the sample inlet of the substrate and provided with a pinhole communicated with the inside and the outside of the microfluidic flow channel.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the sampling micro-needle is arranged to be of an array needle head structure or a single needle head structure.
When the structure is adopted, the plurality of needle heads of the sampling micro-needle are arranged in an array form, so that large substances can be effectively prevented from entering the micro-fluidic flow channel.
The utility model also provides a CRRT waste liquid bag for monitoring free calcium, which comprises a mother bag and the free calcium detection micro-fluidic chip;
the mother bag is provided with a liquid inlet pipe and a liquid outlet pipe;
and the sample inlet of the free calcium detection micro-fluidic chip is communicated with the liquid inlet pipe.
Adopt above-mentioned when setting up the structure, free calcium detection micro-fluidic chip is gone up in the waste liquid bag setting that can be used to free calcium monitoring, can break through the limitation that free calcium detected from the technical aspect, combine with the waste liquid bag simultaneously, free calcium detection technical problem has been solved, and can provide more safe and reliable and cheap serum free calcium in clinical and detect the substitute means, can directly detect free calcium from the waste liquid bag and realize the detection of calcium after the hemofiltration, and can be real-time, dynamic detection, later stage accessible wireless transmission mode, directly look over in real time from the dull and stereotyped terminal of cell-phone.
The utility model also provides another CRRT waste liquid bag for monitoring free calcium, which comprises a mother bag and the free calcium detection micro-fluidic chip;
the mother bag is provided with a liquid inlet pipe and a liquid outlet pipe;
and a sampling micro-needle of the free calcium detection micro-fluidic chip penetrates into the liquid inlet pipe.
Adopt above-mentioned when setting up the structure, free calcium detection micro-fluidic chip is gone up in the waste liquid bag setting that can be used to free calcium monitoring, can break through the limitation that free calcium detected from the technical aspect, combine with the waste liquid bag simultaneously, free calcium detection technical problem has been solved, and can provide more safe and reliable and cheap serum free calcium in clinical and detect the substitute means, can directly detect free calcium from the waste liquid bag and realize the detection of calcium after the hemofiltration, and can be real-time, dynamic detection, later stage accessible wireless transmission mode, directly look over in real time from the dull and stereotyped terminal of cell-phone.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the liquid inlet pipe comprises a first liquid inlet branch pipe, a second liquid inlet branch pipe and a third liquid inlet branch pipe, wherein the second liquid inlet branch pipe and the third liquid inlet branch pipe are respectively connected with the first liquid inlet branch pipe; and a sampling microneedle of the free calcium detection microfluidic chip penetrates into the first liquid inlet branch pipe and is positioned in the second liquid inlet branch pipe and the downstream of the third liquid inlet branch pipe.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: free calcium detects micro-fluidic chip with female bag sets up to components of a whole that can function independently connection structure or free calcium detects micro-fluidic chip with female bag is a structure of packaging, if free calcium detects micro-fluidic chip with female bag sets up to components of a whole that can function independently connection structure, then the waste liquid bag that can be used to free calcium monitoring still include the chip paste the board, the chip paste the board connect in female bag the bag body or first feed liquor branch pipe, free calcium detect micro-fluidic chip bond in the board is pasted to the chip.
When the structure is adopted, the free calcium detection micro-fluidic chip can be connected to the mother bag when in use.
Further: the first liquid inlet branch pipe is provided with a microneedle sampling hole, a pierceable membrane is arranged at the microneedle sampling hole, and the sampling microneedle pierces the pierceable membrane and extends into the interior of the pierceable membrane.
When the structure is adopted, the mother bag can puncture the membrane completely when not connected with the free calcium detection micro-fluidic chip, and is used for organizing foreign substances to enter the liquid inlet pipe.
Further for better realization the utility model discloses, adopt the following structure that sets up very much: the top of the female bag is provided with a fixing strip, a central fixing hole and a strip-shaped through hole.
The utility model has the advantages of it is following and beneficial effect:
(1) the utility model discloses in, free calcium detects micro-fluidic chip's sampling micropin is used for pricking in the mother bag, the waste liquid that the capillary action of accessible micro-fluidic runner was in a small amount of absorption feed liquor pipe from sampling micropin enters into the detection zone of micro-fluidic runner, calcium ion in the waste liquid can make the potential difference on three electrode chemistry sensing module's electrode surface change and accomplish the free calcium level detection of waste liquid, thereby can be under the condition that the signal of telecommunication with three electrode chemistry sensing module is transmitted electrochemical workstation and is enlargied the processing, realize free calcium horizontally real-time supervision in the waste liquid. The free calcium level in the CRRT waste liquid bag can be detected by the free calcium detection micro-fluidic chip, and a blood gas analyzer is not needed for detection, so that the detection cost can be reduced;
(2) the utility model discloses in, can be used to free calcium monitoring's CRRT waste liquid bag sets up free calcium detection micro-fluidic chip, can break through the limitation that free calcium detected from the technical aspect, combine with the waste liquid bag simultaneously, free calcium detection technical problem has been solved, and can provide more safe and reliable and cheap serum free calcium in clinical and detect the substitute means, can directly detect free calcium from the waste liquid bag and realize the detection of calcium after the hemofiltration, and can be real-time, the dynamic detection, later stage accessible wireless transmission mode, directly look over in real time from the dull and stereotyped terminal of cell-phone.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the description below are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 shows the overall layout pattern of a free calcium detection microfluidic chip;
FIG. 2 shows the connection of the free calcium detection microfluidic chip with the mother bag;
FIG. 3 is a schematic diagram of one configuration of a CRRT waste bag that can be used for free calcium monitoring;
FIG. 4 is a schematic diagram of another configuration of CRRT waste bags that can be used for free calcium monitoring;
FIG. 5 is a schematic structural view of a prior art CRRT waste bag;
labeled as:
01. a free calcium detection micro-fluidic chip;
1. a substrate; 11. a microfluidic flow channel; 111. a detection zone; 12. a sample inlet; 13. a sample outlet;
2. sampling the microneedle;
3. a three-electrode chemical sensing module; 31. a lead wire;
4. a data analysis transmission module;
5. a mother bag; 51. a liquid inlet pipe; 51a, a first liquid inlet branch pipe; 51a1, microneedle sampling holes; 51a2, anti-reflux; 51b, a second liquid inlet branch pipe; 51c, a third liquid inlet branch pipe; 52. a liquid outlet pipe; 53. a fixing strip; 54. a central fixation hole; 55. a strip-shaped through hole;
6. a chip bonding plate;
7. an electrochemical workstation.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. It is to be understood that the embodiments described are only some embodiments of the invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
In the description of the present invention, it is to be noted that, unless otherwise specified, "a plurality" means two or more; the terms "upper", "lower", "left", "right", "inner", "outer", "front", "rear", "head", "tail", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood as the case may be, by those of ordinary skill in the art.
Example 1:
a free calcium detection micro-fluidic chip can solve the technical problem of free calcium detection, can realize real-time and dynamic low-cost detection of calcium after hemofiltration by directly detecting the free calcium from a waste liquid bag through the chip, and is particularly set to be in the following structure as shown in figures 1, 2, 3 and 4:
the free calcium detection micro-fluidic chip comprises a substrate 1 and a three-electrode chemical sensing module 3 with a surface modified with a calcium ion sensitive film, wherein the substrate 1 can be made of conventional glass or organic glass, and the three-electrode chemical sensing module 3 can be designed and manufactured according to the conventional structure.
The matrix 1 is approximately a rectangular sheet structure, a micro-fluidic flow channel 11 which is through from front to back is arranged in the matrix 1, a sample inlet 12 and a sample outlet 13 are respectively formed at the head end and the tail end of the micro-fluidic flow channel 11 on the matrix 1, the sample inlet 12 and the sample outlet 13 are respectively positioned on the bottom surface and the top surface of the matrix 1, and the middle section of the micro-fluidic flow channel 11 is set as a detection area 111.
The three-electrode chemical sensing module 3 is connected to the substrate 1, three electrodes of the three-electrode chemical sensing module 3 are embedded in the substrate 1 and located in the detection area 111 of the microfluidic channel 11, and the electrodes can contact with waste liquid in the detection area 111 to complete free calcium level detection.
The sample inlet 12 of the free calcium detection micro-fluidic chip 01 in this embodiment is used for connecting the liquid inlet tube 51 on the mother bag 5, a small amount of waste liquid in the liquid inlet tube 51 can be sucked into the detection area 111 of the micro-fluidic flow channel 11 through the capillary action of the micro-fluidic flow channel 11, calcium ions in the waste liquid can change the potential difference of the electrode surface of the three-electrode chemical sensing module 3 to complete the free calcium level detection of the waste liquid, so that the real-time monitoring of the free calcium level in the waste liquid can be realized under the condition that the electric signal of the three-electrode chemical sensing module 3 is transmitted to an electrochemical workstation for amplification treatment. Free calcium level in the CRRT waste liquid bag can be detected through the free calcium detection micro-fluidic chip 01, a blood gas analyzer is not needed for detection, and detection cost can be reduced.
As a preferable arrangement scheme of the microfluidic channel 11 in this embodiment, the cross-sectional area of the microfluidic channel 11 at the detection region 111 is larger than the cross-sectional area of the channel connecting the upstream and downstream of the detection region 111, so that the sectional area change of the detection region 111 can retain the waste liquid to be detected, which enters the detection region, and is beneficial to the detection of the three-electrode chemical sensing module 3 on the waste liquid.
Example 2:
this embodiment is further optimized on the basis of above-mentioned embodiment, and further for better realization the utility model discloses, adopt the following structure that sets up very much:
the base body 1 is connected with a data analysis transmission module 4, the data analysis transmission module 4 adopts the conventional module, and the signal transmission module of the data analysis transmission module 4 is a wired signal transmission module or a wireless signal transmission module. And each electrode of the three-electrode chemical sensing module 3 is connected with the data analysis transmission module 4. The data analysis transmission module 4 is connected with the electrochemical workstation through a signal line or a wireless signal transmission module, so that the free calcium detection microfluidic chip 01 can analyze and transmit the detection result. The data analysis and transmission module 4 can also be directly arranged in a computer for analyzing and transmitting results.
Example 3:
this embodiment is further optimized on the basis of the above embodiment 1 or 2, and further, is a better realization the utility model discloses, adopt the following setting structure in particular:
the free calcium detection micro-fluidic chip in the embodiment further comprises a sampling micro-needle 2, the sampling micro-needle 2 is provided with a micro-needle hole communicated with the inside and the outside of the micro-fluidic flow channel 11, the sampling micro-needle 2 is connected to the sample inlet 12 of the substrate 1, and the needle head of the sampling micro-needle 2 protrudes out of the surface of the substrate 1. The sampling micro-needle 2 can adopt a multi-needle structure besides a single-needle structure, and under the multi-needle structure, all needles are arranged in an array form to form an array needle structure, so that large substances can be effectively prevented from entering the microfluidic channel 11 by the needle structure.
In the embodiment, the sampling microneedle 2 of the free calcium detection microfluidic chip 01 is used for puncturing the mother bag 5, a small amount of waste liquid in the liquid inlet pipe 51 is sucked from the sampling microneedle 2 through the capillary action of the microfluidic channel 11 and enters the detection area 111 of the microfluidic channel 11, calcium ions in the waste liquid can change the potential difference of the electrode surface of the three-electrode chemical sensing module 3 to complete the detection of the free calcium level of the waste liquid, and therefore the real-time monitoring of the free calcium level in the waste liquid can be realized under the condition that the electric signal of the three-electrode chemical sensing module 3 is transmitted to an electrochemical workstation for amplification treatment. Free calcium level in the CRRT waste liquid bag can be detected through the free calcium detection micro-fluidic chip 01, a blood gas analyzer is not needed for detection, and detection cost can be reduced.
Example 4:
this example further provides a CRRT waste liquid bag for free calcium monitoring based on the above examples 1, 2 or 3, and particularly adopts the following arrangement:
the CRRT waste liquid bag for monitoring free calcium comprises a mother bag 5 and a free calcium detection microfluidic chip 01 in the embodiment 2.
The liquid inlet pipe 51 is a three-fork four-way pipe, and includes a first liquid inlet branch pipe 51a, and a second liquid inlet branch pipe 51b and a third liquid inlet branch pipe 51c connected to the left and right sides of the first liquid inlet branch pipe 51a, respectively, the bottom end of the first liquid inlet branch pipe 51a is inserted into the bag body of the mother bag 5 and fixedly connected to the bag body of the mother bag 5, and the end of the first liquid inlet branch pipe 51a is provided with an anti-reverse flow device 51a 2.
The free calcium detection micro-fluidic chip 01 can adopt a pinless style as in embodiment 1 or 2, at this time, the sample inlet 12 of the free calcium detection micro-fluidic chip 01 is directly communicated with the liquid inlet pipe 51, the communication point of the sample inlet 12 on the liquid inlet pipe 51 is located at the downstream of the second liquid inlet branch pipe 51b and the third liquid inlet branch pipe 51c, and the free calcium detection micro-fluidic chip 01 is fixed on the mother tape. The free calcium detection microfluidic chip 01 can also adopt a needle head style in embodiment 3, at this time, the sampling microneedle 2 of the free calcium detection microfluidic chip 01 pierces and is connected with the inside of the first liquid inlet branch pipe 51a, the piercing point position of the sampling microneedle 2 is located at the downstream positions of the second liquid inlet branch pipe 51b and the third liquid inlet branch pipe 51c, and the free calcium detection microfluidic chip 01 pierces through the sampling microneedle 2 to the inside of the liquid inlet pipe 51 and can be used for sucking waste liquid flowing through the liquid inlet pipe.
The free calcium detection micro-fluidic chip 01 and the mother bag 5 can be arranged into a split connection structure or a packaging integrated structure. When the free calcium detection micro-fluidic chip 01 adopts a pinless style, the free calcium detection micro-fluidic chip 01 and the mother bag 5 generally adopt an encapsulation integrated structure.
If the free calcium detection microfluidic chip 01 and the mother bag 5 are designed to be in a split connection structure, the free calcium detection microfluidic chip 01 is not directly mounted on the mother bag 5 like an integrally packaged structure, but needs to be mounted on the mother bag 5 when in use, so that the mother bag 5 needs to be provided with a place capable of fixing the free calcium detection microfluidic chip 01, and therefore, a chip pasting plate 6 with the shape approximately the same as that of the substrate 1 is designed at the corner on one side of the top of the bag body of the mother bag 5 or on the first liquid inlet branch pipe 51 a.
When the free calcium detection micro-fluidic chip 01 adopts a needle type, the first liquid inlet branch pipe 51a is provided with a microneedle sampling hole 51a1 for penetrating the sampling microneedle 2, and a pierceable membrane which can be pierced by a pointed needle of the sampling microneedle 2 is arranged at the microneedle sampling hole 51a 1. The sampling micro-needle 2 of the free calcium detection micro-fluidic chip 01 is aligned to the micro-needle sampling hole 51a1, so that the sampling micro-needle 2 pierces the pierceable membrane and extends into the first liquid inlet branch pipe 51a, and the bottom surface of the substrate 1 is bonded to the adhesive layer arranged on the chip bonding plate 6 to complete fixation.
Can be used to free calcium monitoring's CRRT waste liquid bag sets up a free calcium detection micro-fluidic chip 01 on it in this embodiment, can break through the limitation that free calcium detected from the technical aspect, combine with the waste liquid bag simultaneously, free calcium detection technical problem has been solved, and can provide more safe and reliable and cheap serum free calcium in clinical and detect the substitute means, can directly detect free calcium from the waste liquid bag and realize the detection of calcium after the hemofiltration, and can be real-time, dynamic detection, later stage accessible wireless transmission mode, directly look over in real time from cell-phone tablet terminal.
The mother bag 5 can pierce the membrane completely when not connected with the free calcium detection microfluidic chip 01, and is used for preventing external substances from entering the liquid inlet pipe 51. The free calcium detection micro-fluidic chip 01 and the mother bag 5 are arranged in a split connection structure, and can be connected to the mother bag 5 when the free calcium detection micro-fluidic chip 01 needs to be used.
When the CRRT waste liquid bag for monitoring free calcium is used, three electrodes of the three-electrode chemical sensing module 3 can be connected to the electrochemical workstation 7 through the leads 31, or the three-electrode chemical sensing module 3 is connected with the data analysis module and then is connected to the electrochemical workstation 7 through a wired or wireless signal transmission mode.
The above description is only for the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art can easily think of the changes or substitutions within the technical scope of the present invention, and all should be covered within the protection scope of the present invention.
Claims (10)
1. A free calcium detection micro-fluidic chip is characterized in that: the three-electrode chemical sensing module comprises a substrate (1) and a three-electrode chemical sensing module (3) with a surface modified with a calcium ion sensitive film;
a micro-fluidic flow channel (11) is arranged in the substrate (1), a sample inlet (12) and a sample outlet (13) are respectively formed in the substrate (1) at the head end and the tail end of the micro-fluidic flow channel (11), and a detection area (111) is arranged in the middle section of the micro-fluidic flow channel (11);
the three-electrode chemical sensing module (3) is connected to the substrate (1) and is positioned at a detection area (111) of the microfluidic flow channel (11).
2. The free calcium detection microfluidic chip according to claim 1, wherein: the sample inlet (12) and the sample outlet (13) are respectively positioned on the bottom surface and the top surface of the substrate (1).
3. The free calcium detection microfluidic chip according to claim 1, wherein: the cross section area of the microfluidic flow channel (11) at the detection area (111) is larger than that of the upstream and downstream flow channels connecting the detection area (111).
4. The free calcium detection microfluidic chip according to claim 1, wherein: the three-electrode chemical sensing module (3) is connected with a data analysis transmission module (4), and a signal transmission module of the data analysis transmission module (4) is a wired signal transmission module or a wireless signal transmission module.
5. The free calcium detection microfluidic chip according to any one of claims 1 to 4, wherein: still include sampling micropin (2), sampling micropin (2) connect in introduction port (12) department of base member (1), sampling micropin (2) have the intercommunication the pinhole inside and outside micro-fluidic flow path (11).
6. The free calcium detection microfluidic chip according to claim 5, wherein: the sampling micro-needle (2) is arranged to be of an array needle head structure or a single needle head structure.
7. The utility model provides a CRRT waste liquid bag that can be used to free calcium monitoring which characterized in that: comprises a mother bag (5) and a free calcium detection micro-fluidic chip (01) of any one of claims 1 to 5;
the mother bag (5) is provided with a liquid inlet pipe (51) and a liquid outlet pipe (52);
and a sample inlet (12) of the free calcium detection micro-fluidic chip (01) is communicated with the liquid inlet pipe (51).
8. The utility model provides a CRRT waste liquid bag that can be used to free calcium monitoring which characterized in that: comprises a mother bag (5) and the free calcium detection micro-fluidic chip (01) of claim 6;
the mother bag (5) is provided with a liquid inlet pipe (51) and a liquid outlet pipe (52);
and a sampling micro-needle (2) of the free calcium detection micro-fluidic chip (01) pierces into the liquid inlet pipe (51).
9. The CRRT waste fluid bag for free calcium monitoring according to claim 7 or 8, wherein: the liquid inlet pipe (51) comprises a first liquid inlet branch pipe (51a), a second liquid inlet branch pipe (51b) and a third liquid inlet branch pipe (51c) which are respectively connected with the first liquid inlet branch pipe (51a), and the first liquid inlet branch pipe (51a) is connected with the bag body of the mother bag (5); and a sampling microneedle (2) of the free calcium detection microfluidic chip (01) pierces the first liquid inlet branch pipe (51a) at the inner part of the downstream of the second liquid inlet branch pipe (51b) and the third liquid inlet branch pipe (51 c).
10. The CRRT waste fluid bag for free calcium monitoring according to claim 9 wherein: free calcium detects micro-fluidic chip (01) with female bag (5) is a package body structure, or, the CRRT waste liquid bag that can be used to free calcium monitoring still includes chip paste board (6), chip paste board (6) connect in the bag body of female bag (5) or first feed liquor branch pipe (51a), free calcium detect micro-fluidic chip (01) bond in board (6) is pasted to the chip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122934599.4U CN217431742U (en) | 2021-11-26 | 2021-11-26 | Free calcium detection micro-fluidic chip and CRRT waste liquid bag capable of being used for free calcium monitoring |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122934599.4U CN217431742U (en) | 2021-11-26 | 2021-11-26 | Free calcium detection micro-fluidic chip and CRRT waste liquid bag capable of being used for free calcium monitoring |
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| Publication Number | Publication Date |
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| CN217431742U true CN217431742U (en) | 2022-09-16 |
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| CN202122934599.4U Active CN217431742U (en) | 2021-11-26 | 2021-11-26 | Free calcium detection micro-fluidic chip and CRRT waste liquid bag capable of being used for free calcium monitoring |
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