CN217359210U - Liquid-based sample analysis system - Google Patents
Liquid-based sample analysis system Download PDFInfo
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- CN217359210U CN217359210U CN202123160810.8U CN202123160810U CN217359210U CN 217359210 U CN217359210 U CN 217359210U CN 202123160810 U CN202123160810 U CN 202123160810U CN 217359210 U CN217359210 U CN 217359210U
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- based sample
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- 239000007788 liquid Substances 0.000 title claims abstract description 97
- 238000007789 sealing Methods 0.000 claims abstract description 88
- 239000000758 substrate Substances 0.000 claims abstract description 75
- 238000004043 dyeing Methods 0.000 claims abstract description 60
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 239000006059 cover glass Substances 0.000 claims abstract description 13
- 230000007246 mechanism Effects 0.000 claims description 35
- 230000007723 transport mechanism Effects 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 18
- 238000007599 discharging Methods 0.000 claims description 15
- 230000033001 locomotion Effects 0.000 claims description 7
- 238000010186 staining Methods 0.000 claims description 2
- 230000032258 transport Effects 0.000 description 11
- 238000010586 diagram Methods 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 2
- 210000000078 claw Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
Abstract
The utility model discloses a liquid-based sample analytic system. The liquid-based sample analysis system comprises a liquid-based sample slice-making dyeing machine, a film-sealing machine arranged adjacent to the liquid-based sample slice-making dyeing machine and a film-reading machine arranged adjacent to the film-sealing machine; the liquid-based sample preparation and dyeing machine is used for bearing the sample on the substrate; the mounting machine is used for receiving the substrate bearing the sample, and covering a cover glass on the substrate bearing the sample to form a mounting; the film reader is used for acquiring the mounting from the mounting machine and reading the mounting; wherein the liquid-based sample slide dyeing machine and the mounting machine convey the substrate through opposite sides; the film sealing machine and the film reading machine convey the sealing films through opposite sides. The utility model provides a liquid-based sample analytic system can realize sample film-making, mounting, the full automatization that the piece was read in the scanning, and the space occupies that the size is little.
Description
Technical Field
The utility model relates to a biology and medical equipment field especially relates to a liquid base sample analytic system.
Background
The mounting (also called slide specimen) needs to be read by a slide reader (such as a slide scanner, an electron microscope, etc.) to obtain information of a sample, and the mounting can be divided into a section, a smear, and a mount according to a manufacturing method. The section is made of slice cut from organism, smear is made of liquid biological material (such as bacteria culture fluid, blood) by smearing, loading is made of small amount of material torn or picked from organism, if sealing piece with long storage time is to be obtained, cover glass is covered on the substrate to protect the sample on the substrate and prevent scraping.
At present, the automation degree of equipment for manufacturing the film seals is low, many steps need manual participation, the film making machine, the film sealing machine and the film reading machine are single-machine type, after the film seals are finished, the substrates need to be manually transferred to the film sealing machine, and after the film seals are manufactured, the substrates need to be manually taken to the film reading machine for film reading. Whole process, consuming time and wasting power, for example, in the chinese patent that publication number is CN212110871U, disclosed a high-efficient stable intelligent wafer sealing machine, this high-efficient stable intelligent wafer sealing machine includes the casing, and the casing includes the bottom plate, is equipped with slide supporting device on the bottom plate, and slide supporting device includes linear guide, and sliding connection has the bearing seat on the linear guide, and the bearing seat is used for placing the slide frame that has a plurality of slide glass, and the slide frame needs the manual work to place.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the prior art, the utility model aims to provide a liquid-based sample analysis system with high automation degree.
The purpose of the utility model is realized by adopting the following technical scheme: a liquid-based sample analysis system, comprising:
a liquid-based sample slide-dyeing machine for carrying the sample onto the substrate;
the mounting device comprises a mounting machine, a liquid-based sample preparation and dyeing machine and a cover glass, wherein the mounting machine is arranged adjacent to the liquid-based sample preparation and dyeing machine and is used for receiving a substrate bearing a sample and covering a cover glass on the substrate bearing the sample to form a mounting; and
the film reading machine is arranged adjacent to the film sealing machine and used for obtaining the sealing film from the film sealing machine and reading the sealing film;
wherein the liquid-based sample slide staining machine and the coverslipper convey substrates through opposite sides; the film sealing machine and the film reading machine transmit the sealing sheets through opposite sides.
As an embodiment, the liquid-based sample analysis system further comprises:
a first transfer arm provided to the liquid-based sample slice-dyeing machine or the coverslipper, the first transfer arm being configured to transfer a slide basket loaded with a substrate from the liquid-based sample slice-dyeing machine to the coverslipper through opposite sides of the liquid-based sample slice-dyeing machine and the coverslipper;
the second transfer arm is used for conveying the slide basket loaded with the seal to the slide reader from the seal through opposite sides of the seal and the slide reader.
As an embodiment, the mounting machine includes a housing, the housing includes a first sidewall, and a second sidewall and a third sidewall respectively connected to two opposite edges of the first sidewall, the second sidewall and the third sidewall are disposed opposite to each other, the second sidewall defines a first opening, and the third sidewall defines a second opening;
the liquid-based sample slide preparation and dyeing machine comprises a material taking station arranged opposite to the first opening, and the first transfer arm is used for conveying the slide basket loaded with the substrate from the material taking station to a first bearing station in the slide sealing machine through the first opening;
the slide reader comprises a receiving station arranged opposite to the second opening, and the second transfer arm is used for conveying the slide basket loaded with the slide seals to the receiving station in the slide reader from the first discharging station in the slide sealing machine through the second opening.
As an embodiment, the first transfer arm includes a first bearing assembly, a second bearing assembly movably connected to the first bearing assembly, and a clamping assembly connected to the second bearing assembly, and the first bearing assembly is mounted on the housing;
the first bearing assembly is used for driving the second bearing assembly to drive the clamping assembly to penetrate through the first opening so as to reciprocate between the material taking station and the first bearing station.
In one embodiment, the slide sealing machine further includes a first conveying mechanism, the first carrying station is disposed on a movement track of the first conveying mechanism, and the first conveying mechanism is used for moving to the first carrying station to receive the slide basket loaded with the substrate.
In one embodiment, a second carrying station is further arranged on the motion track of the first conveying mechanism, and the first conveying mechanism is used for receiving the manually placed slide basket loaded with the substrate at the second carrying station.
As an embodiment, the sealing machine further comprises:
the slide moving device is used for moving the substrate in the slide basket on the first conveying mechanism;
the dispensing and sealing device is used for covering the cover glass on the moved substrate carrying the sample to form the sealing piece;
the slide loading device is used for loading the slides into the empty slide basket and conveying the slide basket carrying the slides to a transfer station;
the second conveying mechanism is used for receiving the slide basket loaded with the sealing sheets at the transfer station and conveying the slide basket loaded with the sealing sheets from the transfer station to the first discharging station.
In one embodiment, the gripper assembly is slidably connected to the second carrier assembly to deliver the unloaded slide basket to the second transport mechanism; the slide loading device includes a gripper assembly for gripping the empty slide basket on the second transport mechanism and a loading assembly for loading a coverslip into the empty slide basket, the gripper assembly also being adapted to transport the slide basket with the coverslip loaded thereon to the transfer station.
In one embodiment, the second conveying mechanism includes a conveying rail and a conveying assembly, the conveying assembly is used for conveying the slide basket loaded with the cover slips along the conveying rail, a first notch is formed in one side, facing the second opening, of the conveying rail, and the second transfer arm is used for conveying the slide basket loaded with the cover slips from the first discharging station to a receiving station in the slide reader sequentially through the first notch and the second opening.
In one embodiment, the second transfer arm is provided in the sealing machine.
As an embodiment, the second transfer arm includes a pushing assembly mounted on the housing, and the pushing assembly is configured to push the slide basket loaded with the cover slips from the first discharging station to a receiving station in the slide reader through the first notch and the second opening in sequence.
As an embodiment, the first side wall is located at a main operation side, and the first opening is formed at an end of the second side wall far away from the first side wall; and/or the second opening is formed at one end of the third side wall close to the first side wall.
In one embodiment, the liquid-based sample slide-dyeing machine includes a first detector for detecting whether the slide basket carrying a substrate is present at the take-out station; and/or the presence of a gas in the atmosphere,
the liquid-based sample preparation and dyeing machine further comprises a second detector, and the second detector is used for detecting whether the first transfer arm extends to the material taking station or not.
The utility model provides a liquid-based sample analysis system, which is provided with a liquid-based sample slice-making dyeing machine to bear the sample on the substrate; covering a cover glass on a substrate by arranging a sealing machine to form a sealing piece; by arranging the film reader, the film can be obtained from the film sealing machine and read; and the substrate is automatically conveyed into the film sealing machine through the liquid-based sample film-making dyeing machine and the opposite side of the film sealing machine, and the sealed film is automatically conveyed into the film reading machine through the opposite side of the film sealing machine and the opposite side of the film reading machine. Therefore, the embodiment of the utility model provides a liquid-based sample analytic system can realize that sample film-making, mounting, scanning read the full automatization of piece, and liquid-based sample film-making dyeing machine and mounting machine are through the side transmission substrate in opposite directions, and the mounting machine with read the piece machine through the side transmission mounting in opposite directions, therefore the shared space size of liquid-based sample analytic system is little.
Drawings
Fig. 1 is a schematic structural diagram of a viewing angle of a mounting machine according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of another view angle of the mounting machine according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of a viewing angle of a liquid-based sample analysis system according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of another view angle of a liquid-based sample analysis system according to an embodiment of the present invention;
fig. 5 is a schematic structural diagram of a view angle of the mounting machine removing housing according to an embodiment of the present invention;
fig. 6 is a schematic structural view of the first transfer arm clamping the slide basket according to the first embodiment of the present invention;
fig. 7 is a schematic view of an assembly structure of the first transfer arm, the first conveying mechanism and the second conveying mechanism according to the first embodiment of the present invention;
fig. 8 is a schematic structural view of another view angle of the mounting machine removing housing according to an embodiment of the present invention;
FIG. 9 is a schematic view of a slide loading device with a slide basket clamped therein according to an embodiment of the present invention;
fig. 10 is a schematic view illustrating an assembly structure of a second transport mechanism and a second transfer arm according to a first embodiment of the present invention;
fig. 11 is a schematic structural view of a conveying assembly according to an embodiment of the present invention;
fig. 12 is a schematic structural view of a pushing assembly according to a first embodiment of the present invention;
fig. 13 is a block diagram of a slide basket, a first detector and a second detector according to an embodiment of the present invention.
In the figure:
100. liquid-based sample slice-making and dyeing machine; 101. a first detector; 102. a second detector;
200. a sealing machine;
10. a housing; 11. a first side wall; 111. a third opening; 112. a fourth opening; 12. a second side wall; 121. a first opening; 13. a third side wall; 131. a second opening;
20. a first conveyance mechanism;
30. a first positioning mechanism;
40. a slide removing device;
50. a dispensing and sealing device;
60. a slide loading device; 61. a clamping assembly; 62. a loading assembly;
70. a second conveyance mechanism; 71. a transport track; 711. a first notch; 712. a delivery through hole; 72. a transport assembly; 721. a pusher dog; 7211. a first claw part; 7212. a second claw portion; 722. a fourth guide rail; 723. a fourth power assembly; 73. a second positioning mechanism;
300. a first transfer arm; 301. a first load bearing assembly; 3011. a first power assembly; 3012. a first guide rail; 302. a second load bearing assembly; 3021. a second power assembly; 3022. a second guide rail; 303. a gripping assembly; 304. a third load bearing assembly; 3041. a third power assembly; 3042. a third guide rail;
400. a second transfer arm; 401. a pushing assembly; 4011. a pushing part; 4012. a fifth guide rail; 4013. a fifth power assembly;
500. a slide basket;
600. a piece reading machine.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that the embodiments or technical features described below can be arbitrarily combined to form a new embodiment without conflict.
The first embodiment is as follows:
referring to fig. 1 to 3, the present invention provides a liquid-based sample analysis system, which includes a liquid-based sample slide-making and dyeing machine 100, a slide sealing machine 200 disposed adjacent to the liquid-based sample slide-making and dyeing machine 100, and a slide reading machine 600 disposed adjacent to the slide sealing machine 200; the liquid-based sample slide-dyeing machine 100 is used to carry the sample onto the substrate; the coverslipper 200 is used for receiving the substrate carrying the sample and covering the substrate carrying the sample with a cover glass to form a coverslip; the slide reader 600 is used for obtaining the seal from the slide sealing machine 200 and reading the seal; wherein the liquid-based sample sheet-making and dyeing machine 100 and the sheet sealer 200 convey the substrate through opposite sides; the sealing machine 200 and the slide reader 600 convey the sealing sheets through the opposite sides. In this embodiment, the opposite side refers to a side where two adjacent devices are arranged facing each other, and in fig. 1 to 3, a first side portion (not shown) of the liquid-based sample slice-dyeing machine 100 close to the material-taking station and a second side wall 12 of the sheet sealing machine 200 with a first opening 121 are opposite sides of the liquid-based sample slice-dyeing machine 100 and the sheet sealing machine 200; the third side wall 13 of the sealing machine 200, described below, in which the second opening 131 described below is formed, and the second side of the reader 600, described below, which is close to the receiving station are opposite sides of the sealing machine 200 and the reader 600. The coverslipper 200 may also be referred to as a coverslipper or coverslipper device.
When the slide reading machine is used, the liquid-based sample slide-making dyeing machine 100 carries a sample on a substrate, the substrate is conveyed into the slide sealing machine 200 through the opposite side between the liquid-based sample slide-making dyeing machine 100 and the slide sealing machine 200, the slide sealing machine 200 covers a cover glass on the substrate to form a seal, and the seal is conveyed into the slide reading machine 600 through the opposite side between the slide sealing machine 200 and the slide reading machine 600 to be used for the slide reading machine 600 to read.
By adopting the technical scheme, the liquid-based sample preparation and dyeing machine 100 is arranged to load the sample on the substrate, and the loading can be completed without manual participation; by arranging the sealing machine 200, the cover glass is covered on the substrate to form the sealing piece, which can be completed without manual participation; by arranging the film reader 600, the mounting is obtained from the film sealing machine 200 and the reading of the mounting is carried out without manual participation; moreover, the substrate is automatically conveyed into the slide sealing machine 200 through the opposite sides of the liquid-based sample slide-making and dyeing machine 100 and the slide sealing machine 200, and the slide is automatically conveyed into the slide reading machine 600 through the opposite sides of the slide sealing machine 200 and the slide reading machine 600, so that the space occupation size of the liquid-based sample analysis system composed of the liquid-based sample slide-making and dyeing machine 100, the slide sealing machine 200 and the slide reading machine 600 is small. The embodiment of the utility model provides a liquid-based sample analytic system, the detection information from beginning preparation substrate to scanning mounting can be accomplished under the condition that does not need artifical the participation, and degree of automation is high, and the space occupies that the size is little.
Referring to fig. 4 and 5, the liquid-based specimen analysis system further includes a first transfer arm 300 and a second transfer arm 400, the first transfer arm 300 being configured to transfer the slide basket 500 loaded with the substrate from the liquid-based specimen slide preparing and dyeing machine 100 to the coverslipping machine 200 through opposite sides of the liquid-based specimen slide preparing and dyeing machine 100 and the coverslipping machine 200, and the second transfer arm 400 being configured to transfer the slide basket 500 loaded with the coverslipping from the coverslipping machine 200 to the coverslipping machine 600 through opposite sides of the coverslipping machine 200 and the coverslipping machine 600. The transfer of the substrate from the liquid-based sample slide dyeing machine 100 to the mounting machine 200 is achieved by providing a first transfer arm 300; by providing the second transfer arm 400, the transportation of the seal from the sealing machine 200 to the reader 600 is realized. In practice, the transport efficiency is improved by loading the substrate and the mounting sheet into the slide basket 500 for transport. Besides the substrates and the seals, the slide basket 500 can also be loaded with other carriers for carrying samples, and the articles that can be loaded by the slide basket 500 are not limited herein. In this embodiment, referring to fig. 5, the first transfer arm 300 and the second transfer arm 400 are both disposed in the wafer sealing machine 200. It is understood that, in other embodiments, the first transfer arm 300 may be provided in the liquid-based sample preparation and dyeing machine 100, or the first transfer arm 300 may be provided between the liquid-based sample preparation and dyeing machine 100 and the mounting machine 200, or the second transfer arm 400 may be provided in the reader 600, or the second transfer arm 400 may be provided between the mounting machine 200 and the reader 600. For example, referring to fig. 4, the first transfer arm 300 is disposed between the liquid-based specimen slide dyeing machine 100 and the slide sealing machine 200, and the second transfer arm 400 is disposed between the slide sealing machine 200 and the slide reader 600. The embodiment of the present invention does not restrict the installation positions of the first transfer arm 300 and the second transfer arm 400.
Referring to fig. 1 to 3 and 5, the sealing machine 200 includes a housing 10, the housing 10 includes a first sidewall 11, and a second sidewall 12 and a third sidewall 13 respectively connected to two opposite edges of the first sidewall 11, the second sidewall 12 and the third sidewall 13 are disposed opposite to each other, the second sidewall 12 has a first opening 121, and the third sidewall 13 has a second opening 131; the liquid-based specimen slide dyeing machine 100 includes a material taking station disposed opposite the first opening 121, and a first transfer arm 300 for transporting the slide basket 500 loaded with the substrate from the material taking station to a first carrying station located within the coverslipper 200 through the first opening 121; the reader 600 includes a receiving station disposed opposite the second opening 131, and the second transfer arm 400 is used to transfer the slide basket 500 loaded with the coverslips through the second opening 131 from the first discharge station in the coverslipper 200 to the receiving station in the reader 600. With this arrangement, the first opening 121 and the second opening 131 are disposed on two opposite sides of the housing 10, so that the conveying of the slide basket 500 loaded with the substrate and the conveying of the slide basket 500 loaded with the cover slip are respectively performed on two opposite sides of the cover slip machine 200, without interfering with each other, and the overall layout of the liquid-based sample analysis system is facilitated, and the space occupation size of the liquid-based sample analysis system is reduced.
Referring to fig. 1 and 6, the first transfer arm 300 includes a first carrying assembly 301, a second carrying assembly 302 movably connected to the first carrying assembly 301, and a gripping assembly 303 connected to the second carrying assembly 302, wherein the first carrying assembly 301 is mounted on the housing 10; the first carrying assembly 301 is used for driving the second carrying assembly 302 to drive the gripping assembly 303 to pass through the first opening 121 so as to reciprocate between the material taking station and the first carrying station. By providing the gripping assembly 303, the gripping assembly 303 grips the slide basket 500 loaded with the substrate when moving to the take-out station and releases the gripped slide basket 500 loaded with the substrate when moving to the first carrying station, thereby enabling the slide basket 500 loaded with the substrate to be transferred from the take-out station in the liquid-based specimen slice dyeing machine 100 to the first carrying station of the coverslipper 200.
Referring to fig. 1 and 7, the sealing machine 200 further includes a first conveying mechanism 20, a first carrying station is disposed on a moving track of the first conveying mechanism 20, and the first conveying mechanism 20 is configured to move to the first carrying station to receive the slide basket 500 loaded with the substrate. By providing the first conveyance mechanism 20, the first conveyance mechanism 20 can move to the first carrier station, and receive the slide basket 500 loaded with the substrate at the first carrier station, and then convey the slide basket 500 loaded with the substrate to the next station.
In one embodiment, a second loading station is further disposed on the motion trajectory of the first transport mechanism 20, and the first transport mechanism 20 is configured to receive a manually placed slide basket 500 loaded with substrates at the second loading station. Bear the station through setting up the second, when first transport mechanism 20 moved to the second and bears the station, the manual work can be placed the slide basket 500 that has the substrate on first transport mechanism 20, realizes artifical material loading, thereby makes the embodiment of the utility model provides a liquid-based sample analysis system can carry the slide basket 500 that has the substrate voluntarily, can place the slide basket 500 that has the substrate again by the manual work.
Referring to fig. 1, 7 and 8, the sealing machine 200 further includes a positioning mechanism adjacent to the first loading station for initially positioning the first conveying mechanism 20. For convenience of description, the positioning mechanism is referred to as a first positioning mechanism 30. Since the distance between the initial position and the first carrier station, the second carrier station, and other stations on the travel path of the first transport mechanism 20 (such as the slide transfer device 40 described below, the station where the first transport mechanism 20 is located when a substrate in the slide basket 500 on the first transport mechanism 20 is transferred) is fixed, accurate movement of the first transport mechanism 20 to other stations is facilitated by providing the first positioning mechanism 30 to accurately position the first transport mechanism 20 in the initial position.
In one embodiment, the first sidewall 11 is located at the main operation side, and the first sidewall 11 defines a third opening 111, wherein the third opening 111 is used for manually placing the slide basket 500 loaded with the substrate on the first conveying mechanism 20 located at the second loading station. The worker usually operates on the main operation side, and the third opening 111 is provided on the main operation side, so that manual feeding is facilitated. In practice, the main operation side is provided on the front side of the die bonder 200.
Referring to fig. 1, 7 and 8, the sealing machine 200 further includes a slide moving device 40, a dispensing sealing device 50, a slide loading device 60 and a second conveying mechanism 70, wherein the slide moving device 40 is used for moving the substrates in the slide basket 500 on the first conveying mechanism 20; the dispensing and sealing device 50 is used for covering the cover glass on the moved substrate carrying the sample to form a sealing sheet; the slide loading device 60 is used for loading the cover slips into the empty slide basket 500 and conveying the slide basket 500 loaded with the cover slips to the transfer station; the second transport mechanism 70 is used to receive the slide basket 500 loaded with the coverslips at the transfer station and to transport the slide basket 500 loaded with the coverslips from the transfer station to the first outfeed station. Through the arrangement mode, the substrate is taken out of the slide basket 500, the cover slip is covered on the substrate to form the sealing sheet, the sealing sheet is loaded into the slide basket 500, the slide basket 500 loaded with the sealing sheet is conveyed to the first discharging station without manual participation, and the automation degree is high.
In one embodiment, the gripper assembly 303 is slidably connected to the second carrier assembly 302 to transport the empty slide basket 500 onto the second transport mechanism 70. With this arrangement, the empty slide basket 500 is transported to the second transport mechanism 70 in a two-stage linked manner. Referring to fig. 6, in the present embodiment, the first transfer arm 300 further includes a third bearing assembly 304, the third bearing assembly 304 is slidably mounted on the second bearing assembly 302, the gripping assembly 303 is mounted on the third bearing assembly 304, and the third bearing assembly 304 drives the gripping assembly 303 to move up and down. Specifically, the first carrier assembly 301 includes a first power assembly 3011 and a first guide rail 3012, the second carrier assembly 302 includes a second power assembly 3021 and a second guide rail 3022, the third carrier assembly 304 includes a third power assembly 3041 and a third guide rail 3042, the first guide rail 3012 and the second guide rail 3022 extend in a horizontal direction, the third guide rail 3042 extends in a vertical direction, the first power assembly 3011 drives the second carrier assembly 302 to drive the third carrier assembly 304 and the gripping assembly 303 to slide along the first guide rail 3012, the second power assembly 3021 drives the third carrier assembly 304 to drive the gripping assembly 303 to slide along the second guide rail 3022, and the third power assembly 3041 drives the gripping assembly 303 to slide along the third guide rail 3042.
The second transport mechanism 70 is also used, as an embodiment, to transport the received unloaded slide basket 500 to the slide loading device 60 for the slide loading device 60 to load a slide into the unloaded slide basket 500.
Referring to fig. 7 and 9, the slide loading device 60 includes a gripper assembly 61 for gripping an empty slide basket 500 positioned on the second transport mechanism 70, and a loading assembly 62 for loading slides into the empty slide basket 500, the gripper assembly 61 also being for transporting the slide basket 500 loaded with slides to a transfer station. With this arrangement, loading of the slides in the empty slide basket 500 is achieved.
Referring to fig. 2, 3, 7 and 10, the second conveying mechanism 70 includes a conveying rail 71 and a conveying assembly 72, the conveying assembly 72 is used for conveying the slide basket 500 loaded with the cover slips along the conveying rail 71, a first notch 711 is formed on one side of the conveying rail 71 facing the second opening 131, and the second transfer arm 400 is used for conveying the slide basket 500 loaded with the cover slips from the first discharging station to the receiving station in the slide reader 600 through the first notch 711 and the second opening 131 in sequence. In this embodiment, the first notch 711 and the second transfer arm 400 are respectively disposed on two opposite sides of the conveying track 71, and the first notch 711, the first discharging station, the second opening 131, and the second transfer arm 400 are located on a straight line.
Referring to fig. 7, 10 and 11, carriage assembly 72 includes a finger 721, a fourth rail 722, and a fourth power assembly 723 for driving finger 721 to slide along fourth rail 722, wherein the fourth rail 722 and carriage track 71 extend in the same direction. The pusher 721 includes a first pusher portion 7211 and a second pusher portion 7212, the first pusher portion 7211 and the second pusher portion 7212 are disposed at intervals along the extending direction of the conveying rail 71, and the slide basket 500 may be constrained to travel along the conveying rail 71 between the first pusher portion 7211 and the second pusher portion 7212, or may be located on the side of the first pusher portion 7211 facing away from the second pusher portion 7212 and pushed by the first pusher portion 7211 to travel along the conveying rail 71. The conveying rail 71 is provided with a conveying through hole 712, and the pusher 721 passes through the conveying through hole 712 and extends into the conveying rail 71.
Referring to fig. 7 and 11, the second transport mechanism 70 further includes a second positioning mechanism 73, and the second positioning mechanism 73 is used for positioning whether the slide basket 500 loaded with the slides is located at the first outfeed station. By providing the second positioning mechanism 73, the slide basket 500 loaded with the cover slips can be accurately positioned at the first ejection station.
Referring to fig. 2, 10 and 12, the second transfer arm 400 includes a pushing assembly 401 mounted on the housing 10, the pushing assembly 401 being configured to push the slide basket 500 loaded with the cover slips from the first discharging station to a receiving station in the slide reader 600 through the first notch 711 and the second opening 131 in sequence. In this embodiment, the pushing assembly 401 includes a pushing portion 4011, a fifth guide rail 4012, and a fifth power assembly 4013 for driving the pushing portion 4011 to slide along the fifth guide rail 4012, the first notch 711, the first discharging station, the second opening 131, and the pushing portion 4011 are located on a straight line, and the extending direction of the fifth guide rail 4012 is parallel to the straight line where the first notch 711, the first discharging station, the second opening 131, and the pushing portion 4011 are located.
As an embodiment, the first sidewall 11 is located at the main operation side, and the first opening 121 is formed at an end of the second sidewall 12 away from the first sidewall 11; the second opening 131 is formed at an end of the third sidewall 13 close to the first sidewall 11. It is understood that in other embodiments, the first opening 121 may be formed at an end of the second sidewall 12 close to the first sidewall 11, or the second opening 131 may be formed at an end of the third sidewall 13 far from the first sidewall 11.
Referring to fig. 1, 3, 7 and 10, the second conveying mechanism 70 further has a second discharging station on the motion track, the first sidewall 11 further has a fourth opening 112 corresponding to the second discharging station, and the second conveying mechanism 70 is further configured to convey the slide basket 500 loaded with the cover slips from the second discharging station through the fourth opening 112 to the outside of the cover slips machine 200 for manually taking the slide basket 500 loaded with the cover slips. With this arrangement, the slide basket 500 loaded with the coverslips can be either automatically transported to the slide reader 600 by the second transfer arm 400 or manually removed from the slide reader 200. In practice, the second transport mechanism 70 receives the slide basket 500 loaded with the slides at the transfer station and transports the slide basket 500 loaded with the slides from the transfer station to the second outfeed station. In this embodiment, the fourth opening 112 is formed on the first sidewall 11, and the first sidewall 11 is located on the main operation side, so as to facilitate manual material taking.
Referring to fig. 3, 5 and 13, the liquid-based specimen slide preparation and dyeing machine 100 includes a first detector 101, the first detector 101 for detecting whether a slide basket 500 loaded with substrates is present at a take-out station. In practice, after the first detector 101 detects that the slide basket 500 loaded with the substrate is located at the material taking station, the first transfer arm 300 extends into the liquid-based specimen slide preparation and dyeing machine 100, picks up the slide basket 500 loaded with the substrate from the material taking station, and conveys the slide basket 500 to the coverslipper 200.
Referring to fig. 3, 5 and 13, the liquid-based specimen slide dyeing machine 100 further includes a second detector 102, and the second detector 102 is configured to detect whether the first transfer arm 300 extends to the material-taking station. The second detector 102 is arranged to ensure that the first transfer arm 300 is accurately positioned to the material taking station when extending into the liquid-based sample preparation and dyeing machine 100, so that the slide basket 500 at the material taking station can be accurately clamped.
Example two:
the embodiment of the utility model provides a conveying method of slide basket 500, include following step:
step S1, the liquid-based sample slide-making and dyeing machine 100 transports the slide basket 500 loaded with the substrate to a side of the liquid-based sample slide-making and dyeing machine 100 disposed toward the coverslipper 200;
step S2-1, the coverslipper 200 receives the slide basket 500 loaded with the substrate from the liquid-based sample slide-making and dyeing machine 100 from a side facing the liquid-based sample slide-making and dyeing machine 100;
step S2-2, the coverslipper 200 transports the slide basket 500 loaded with the coverslips to the side of the coverslipper 200 facing the reader 600;
in step S3, the slide reader 600 receives the slide basket 500 loaded with the cover slips from the slide sealer 200 from the side facing the slide sealer 200.
The liquid-based sample slide-dyeing machine 100 is the liquid-based sample slide-dyeing machine 100 described in the first embodiment, the slide sealing machine 200 is the slide sealing machine 200 described in the first embodiment, and the slide reading machine 600 is the slide reading machine 600 described in the first embodiment. In practical applications, the liquid-based specimen slide-making and dyeing machine 100, the slide sealing machine 200 and the slide reader 600 are controlled by a controller (not shown) to perform operations.
By adopting the technical scheme, the slide basket 500 loaded with the substrate is automatically conveyed into the slide sealing machine 200 through the opposite sides of the liquid-based sample slide-making dyeing machine 100 and the slide sealing machine 200, and the slide basket 500 loaded with the slide is automatically conveyed into the slide reading machine 600 through the opposite sides of the slide sealing machine 200 and the slide reading machine 600, so that the slide basket can be finished without manual intervention.
In one embodiment, a first transfer arm 300 is disposed on one of the liquid-based sample slide dyeing machine 100 and the coverslipper 200, the coverslipper 200 includes a housing 10, the housing 10 defines a first opening 121; step S2-1 includes: the first transfer arm 300 is controlled to transfer the slide basket 500 loaded with the substrate from the take-out station in the liquid-based specimen slide preparation and dyeing machine 100 to the first carrier station in the coverslipper 200 through the first opening 121. With this arrangement, the transfer of the slide basket 500 loaded with the substrate from the liquid-based specimen slide-dyeing machine 100 to the mounting machine 200 is achieved. In this embodiment, the first transfer arm 300 is provided in the sealing machine 200.
In one embodiment, the second transfer arm 400 is disposed on one of the sheet sealing machine 200 and the sheet reading machine 600, the sheet sealing machine 200 includes a housing 10, the housing 10 defines a second opening 131; step S3 includes: the second transfer arm 400 is controlled to transfer the slide basket 500 loaded with the coverslips from the first outfeed station in the coverslipper 200 through the second opening 131 to the receiving station in the coverslipper 600. With this arrangement, the slide basket 500 loaded with the coverslips is transported from the coverslipper 200 to the reader 600. In this embodiment, the second transfer arm 400 is provided in the sealing machine 200.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention cannot be limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are all within the protection scope of the present invention.
Claims (13)
1. A liquid-based sample analysis system, comprising:
a liquid-based sample slide-dyeing machine for carrying the sample onto the substrate;
the mounting device comprises a mounting machine, a liquid-based sample preparation and dyeing machine and a cover glass, wherein the mounting machine is arranged adjacent to the liquid-based sample preparation and dyeing machine and is used for receiving a substrate bearing a sample and covering a cover glass on the substrate bearing the sample to form a mounting; and
the film reading machine is arranged adjacent to the film sealing machine and used for obtaining the sealing film from the film sealing machine and reading the sealing film;
wherein the liquid-based sample slide staining machine and the coverslipper convey substrates through opposite sides; the film sealing machine and the film reading machine transmit the sealing sheets through opposite sides.
2. The liquid-based sample analysis system of claim 1, further comprising:
a first transfer arm provided to the liquid-based sample slice-dyeing machine or the coverslipper, the first transfer arm being configured to transfer a slide basket loaded with a substrate from the liquid-based sample slice-dyeing machine to the coverslipper through opposite sides of the liquid-based sample slice-dyeing machine and the coverslipper;
the second transfer arm is used for conveying the slide basket loaded with the seal to the slide reader from the seal through opposite sides of the seal and the slide reader.
3. The system for analyzing a liquid-based sample according to claim 2, wherein the wafer sealing machine comprises a housing, the housing comprises a first sidewall and a second sidewall and a third sidewall respectively connected to two opposite edges of the first sidewall, the second sidewall and the third sidewall are disposed opposite to each other, the second sidewall defines a first opening, and the third sidewall defines a second opening;
the liquid-based sample slice and dyeing machine comprises a material taking station arranged opposite to the first opening, and the first transfer arm is used for conveying the slide basket loaded with the substrate from the material taking station to a first bearing station in the mounting machine through the first opening;
the slide reader comprises a receiving station arranged opposite to the second opening, and the second transfer arm is used for conveying the slide basket loaded with the slide seals to the receiving station in the slide reader from the first discharging station in the slide sealing machine through the second opening.
4. The liquid-based sample analysis system of claim 3, wherein the first transfer arm comprises a first carrier assembly, a second carrier assembly movably coupled to the first carrier assembly, and a gripper assembly coupled to the second carrier assembly, the first carrier assembly being mounted to the housing;
the first bearing assembly is used for driving the second bearing assembly to drive the clamping assembly to penetrate through the first opening so as to reciprocate between the material taking station and the first bearing station.
5. The liquid-based sample analysis system of claim 4, wherein the coverslipper further comprises a first transport mechanism, the first carrier station being disposed on a motion trajectory of the first transport mechanism, the first transport mechanism for moving to the first carrier station to receive the slide basket loaded with substrates.
6. The liquid-based specimen analysis system of claim 5, wherein a second loading station is further disposed on a motion trajectory of the first transport mechanism, and the first transport mechanism is configured to receive the manually placed slide basket loaded with substrates at the second loading station.
7. The liquid-based sample analysis system of claim 5 or 6, wherein the coverslipper further comprises:
the slide moving device is used for moving the substrate in the slide basket on the first conveying mechanism;
the dispensing and sealing device is used for covering the cover glass on the moved substrate carrying the sample to form the sealing piece;
the slide loading device is used for loading the mounting piece into the unloaded slide basket and conveying the slide basket carrying the mounting piece to a transfer station;
the second conveying mechanism is used for receiving the slide basket loaded with the sealing sheets at the transfer station and conveying the slide basket loaded with the sealing sheets from the transfer station to the first discharging station.
8. The liquid-based sample analysis system of claim 7, wherein the gripper assembly is slidably connected to the second carrier assembly to transport the empty slide basket onto the second transport mechanism; the slide loading device includes a gripper assembly for gripping the empty slide basket on the second transport mechanism and a loading assembly for loading a coverslip into the empty slide basket, the gripper assembly also being adapted to transport the slide basket with the coverslip loaded thereon to the transfer station.
9. The liquid-based specimen analysis system of claim 7, wherein the second transport mechanism comprises a transport track and a transport assembly for transporting the slide basket loaded with the coverslips along the transport track, the transport track having a first notch cut into a side thereof facing the second opening, the second transfer arm for transporting the slide basket loaded with the coverslips from the first outfeed station to a receiving station within the slide viewer through the first notch and the second opening in sequence.
10. The liquid-based sample analysis system of claim 9, wherein the second transfer arm is disposed within the coverslipper.
11. The liquid-based specimen analysis system of claim 9, wherein the second transfer arm includes a pushing assembly mounted on the housing for pushing the slide basket loaded with the coverslips from the first outfeed station sequentially through the first notch, the second opening, and to a receiving station within the slide reader.
12. The liquid-based sample analysis system of claim 3, wherein the first sidewall is located on a primary operating side, and the first opening is formed at an end of the second sidewall remote from the first sidewall; and/or the second opening is formed at one end of the third side wall close to the first side wall.
13. The liquid-based sample analysis system of claim 3, wherein the liquid-based sample slide-dyeing machine comprises a first detector for detecting whether the slide basket carrying a substrate is present at the take-out station; and/or the presence of a gas in the atmosphere,
the liquid-based sample preparation and dyeing machine further comprises a second detector, and the second detector is used for detecting whether the first transfer arm extends into the material taking station or not.
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| CN202011475584X | 2020-12-15 | ||
| CN202011475584 | 2020-12-15 |
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| CN202111535721.9A Pending CN114636600A (en) | 2020-12-15 | 2021-12-15 | Liquid-based sample analysis system and method for conveying slide basket |
| CN202123160810.8U Active CN217359210U (en) | 2020-12-15 | 2021-12-15 | Liquid-based sample analysis system |
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