CN217340176U - A multistage dehydration backward flow water knockout drum for synthetic of larotinib - Google Patents
A multistage dehydration backward flow water knockout drum for synthetic of larotinib Download PDFInfo
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- CN217340176U CN217340176U CN202220528447.6U CN202220528447U CN217340176U CN 217340176 U CN217340176 U CN 217340176U CN 202220528447 U CN202220528447 U CN 202220528447U CN 217340176 U CN217340176 U CN 217340176U
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 142
- 230000018044 dehydration Effects 0.000 title claims abstract description 18
- 238000006297 dehydration reaction Methods 0.000 title claims abstract description 18
- 238000009833 condensation Methods 0.000 claims abstract description 58
- 230000005494 condensation Effects 0.000 claims abstract description 58
- 230000007246 mechanism Effects 0.000 claims abstract description 50
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 238000010992 reflux Methods 0.000 claims description 12
- 238000000926 separation method Methods 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 238000003786 synthesis reaction Methods 0.000 claims description 8
- 230000001360 synchronised effect Effects 0.000 claims description 7
- 230000003111 delayed effect Effects 0.000 claims description 4
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims description 2
- 229960004891 lapatinib Drugs 0.000 claims description 2
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims description 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 6
- 229960001433 erlotinib Drugs 0.000 claims 6
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 6
- 239000003960 organic solvent Substances 0.000 description 12
- 239000007788 liquid Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 239000010410 layer Substances 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- NYNZQNWKBKUAII-KBXCAEBGSA-N (3s)-n-[5-[(2r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide Chemical compound C1[C@@H](O)CCN1C(=O)NC1=C2N=C(N3[C@H](CCC3)C=3C(=CC=C(F)C=3)F)C=CN2N=C1 NYNZQNWKBKUAII-KBXCAEBGSA-N 0.000 description 1
- 108091005682 Receptor kinases Proteins 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
- 102000005937 Tropomyosin Human genes 0.000 description 1
- 108010030743 Tropomyosin Proteins 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940116298 l- malic acid Drugs 0.000 description 1
- 229950003970 larotrectinib Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 101150111535 trk gene Proteins 0.000 description 1
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Abstract
The utility model discloses a be used for synthetic multistage dehydration backward flow water knockout drum of larotinib, including main part and the feed inlet of setting in the main part, the fixed support that is provided with in below of main part, be equipped with the motor on the support, be equipped with the stirring rake of being connected with motor drive in the main part, the top intercommunication of main part has the outlet duct, the other end intercommunication of outlet duct has the condensation chamber, be equipped with pressure relief mechanism on the condensation chamber, the bottom intercommunication of condensation chamber has first water diversion mechanism, the output intercommunication of first water diversion mechanism has the second water diversion mechanism, the output and the main part intercommunication of second water diversion mechanism. The utility model provides a multistage dehydration backward flow water knockout drum's easy operation, safe and reliable, long service life.
Description
Technical Field
The utility model relates to a reation kettle device technical field, concretely relates to a multistage dehydration backward flow water knockout drum for the synthesis of larotinib.
Background
larotretinib (the chinese name larotinib) is a potent, oral, selective inhibitor of Tropomyosin Receptor Kinase (TRK), a product of genetic abnormalities that occur when the TRK gene is fused with one of the other genes in cancer cells. larotretinib was developed by ArrayBioPharma, and clinical studies were performed by loxonology. The 6 th and 4 th year 2017, annual American Society for Clinical Oncology (ASCO) announced the results of the clinical trial of larotretinib, which showed: in clinical trials with 17 different types of patients with advanced tumors (including children and adults), remission was achieved in 76% of patients after treatment with larotretinib, and was more durable, with 79% of patients after treatment initiation lasting for 12 months. Currently, larotrectinib is expected to be the first targeted drug approved by the "basket" clinical trial (baskettrial).
The preparation process of the larotinib involves the salification of L-malic acid and benzylamine, the obtained product is dehydrated at high temperature to generate a five-membered ring, the process needs to continuously remove the generated water to promote the forward reaction, and the loss of the product is reduced.
At present, the reflux water knockout drum commonly used in industry dewaters, the condensation chamber of current reflux water knockout drum does not have the pressure release measure, when leading to once only getting into the gas in the condensation chamber too much, make the high explosion that produces of pressure in the condensation chamber easily, for this reason, it is necessary to design a multistage dehydration reflux water knockout drum that is used for the synthesis of larotinib, the purpose of this kind of multistage dehydration reflux water knockout drum is when the internal pressure of condensation chamber is too high suitably discharges partly high-temperature gas, keep the pressure in the condensation chamber in safety range, the practicality and the security of reflux water knockout drum have been improved.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to overcome the defect that exists among the prior art, provide a high, long service life, simple operation's multistage dehydration backward flow water knockout drum of security. The multi-stage dehydration reflux water separator has the characteristics of simple operation, safety, reliability and long service life.
For realizing the above-mentioned purpose, the technical scheme of the utility model a design a be used for synthetic multistage dehydration backward flow water knockout drum of larotinib, including main part and the feed inlet of setting in the main part, the fixed support that is provided with in below of main part, be equipped with the motor on the support, be equipped with the stirring rake of being connected with motor drive in the main part, the top intercommunication of main part has the outlet duct, the other end intercommunication of outlet duct has the condensation chamber, be equipped with pressure relief mechanism on the condensation chamber, the bottom intercommunication of condensation chamber has first water diversion mechanism, the output intercommunication of first water diversion mechanism has the second water diversion mechanism, the output and the main part intercommunication of second water diversion mechanism.
As an optimized technical scheme, the pressure relief mechanism is a counterpoint hole synchronous pressure relief mechanism, the counterpoint hole synchronous pressure relief mechanism comprises a first pressure relief pipe communicated with the condensation chamber, a plurality of first pressure relief holes symmetrically arranged about a first pressure relief pipe axial line are formed in the first pressure relief pipe, a first guide rod is fixed at the center of the first pressure relief pipe, a first piston is sleeved on the first guide rod, the first piston is cylindrical, a first sealing cover is fixed at one end, far away from the condensation chamber, of the first pressure relief pipe, and a first spring is connected between the first sealing cover and the first piston.
As an optimized technical scheme, the pressure relief mechanism is a staggered hole delay pressure relief mechanism, the staggered hole delay pressure relief mechanism comprises a second pressure relief pipe communicated with the condensing chamber, a plurality of second pressure relief holes which are unequal to the distance between the outer wall of the condensing chamber are formed in the second pressure relief pipe, a second guide rod is fixed at the center of the second pressure relief pipe, a second piston is sleeved on the second guide rod, a second sealing cover is fixed at one end, far away from the condensing chamber, of the second pressure relief pipe, and a second spring is connected between the second sealing cover and the second piston.
As a preferred technical scheme, the transverse interval of the second pressure relief hole is not equal to the distance between the leftmost end and the rightmost end of the second piston.
According to a preferable technical scheme, the first water diversion mechanism comprises a first water diversion chamber communicated with the bottom of the condensation chamber, the bottom of the first water diversion chamber is communicated with the input end of the second water diversion mechanism, a first electromagnetic valve is arranged at the communication position of the condensation chamber and the first water diversion chamber, a first liquid collection chamber is communicated with the top of the first water diversion chamber, a first water drain valve is communicated with the bottom of the first liquid collection chamber, and the top of the first liquid collection chamber is communicated with the main body.
According to a preferable technical scheme, the second water diversion mechanism comprises a second water diversion chamber, the top of the second water diversion chamber is communicated with the bottom of the first water diversion chamber, a second electromagnetic valve is arranged at the communication position of the first water diversion chamber and the second water diversion chamber, the bottom of the second water diversion chamber is communicated with a second water collection chamber, a third electromagnetic valve is arranged at the communication position of the second water diversion chamber and the second water collection chamber, a second water drain valve is communicated with the other side of the bottom of the second water diversion chamber, the top of the second water diversion chamber is communicated with the first water collection chamber, and the bottom of the second water collection chamber is communicated with the main body.
Preferably, the first spring and the second spring are both compression springs.
As a preferred technical scheme, the outer surface of the main body is provided with a heat-insulating layer.
The utility model has the advantages and beneficial effects that: the over-high pressure in the condensation chamber is discharged through the pressure relief mechanism, the condensation chamber is prevented from exploding due to the over-high pressure, the safety and the practicability of the backflow water separator are improved, and the backflow water separator is simple to operate, safe, reliable and long in service life.
Drawings
Fig. 1 is a schematic structural diagram (embodiment one) of the present invention;
FIG. 2 is an enlarged view of portion A of FIG. 1;
FIG. 3 is a side view of the alignment hole synchronous pressure relief mechanism (embodiment one);
FIG. 4 is a schematic structural view of the present invention (embodiment II);
FIG. 5 is an enlarged view of the portion B of FIG. 4;
in the figure: 1. a main body; 2. a feed inlet; 3. a support; 4. a motor; 5. a stirring paddle; 6. an air outlet pipe; 7. a condensing chamber; 8. a first pressure relief tube; 9. a first pressure relief vent; 10. a first guide bar; 11. a first piston; 12. a first cover; 13. a first spring; 14. a second pressure relief tube; 15. a second pressure relief vent; 16. a second guide bar; 17. a second piston; 18. a second cover; 19. a second spring; 20. a first water dividing chamber; 21. a first solenoid valve; 22. a first liquid collection chamber; 23. a first water escape valve; 24. A second water dividing chamber; 25. a second solenoid valve; 26. a second liquid collection chamber; 27. a third solenoid valve; 28. a second water escape valve; 29. And (7) an insulating layer.
Detailed Description
The following description will further describe embodiments of the present invention with reference to the accompanying drawings and examples. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
The first embodiment is as follows: as shown in fig. 1-fig. 3, a multistage dehydration backward flow water knockout drum for lapatinib is synthetic, including main part 1 and the feed inlet 2 of setting on main part 1, the fixed support 3 that is provided with in below of main part 1, be equipped with motor 4 on the support 3, be equipped with the stirring rake 5 of being connected with motor 4 transmission in the main part 1, the top intercommunication of main part 1 has outlet duct 6, the other end intercommunication of outlet duct 6 has condensation chamber 7, be equipped with pressure relief mechanism on the condensation chamber 7, the bottom intercommunication of condensation chamber 7 has first water diversion mechanism, the output intercommunication of first water diversion mechanism has the second water diversion mechanism, the output and the main part 1 intercommunication of second water diversion mechanism.
Pressure relief mechanism is the synchronous pressure relief mechanism in counterpoint hole, the synchronous pressure relief mechanism in counterpoint hole includes the first pressure release pipe 8 that communicates with condensation chamber 7, be equipped with a plurality of first pressure release holes 9 about 8 axis symmetry settings in first pressure release pipe 8, the center of first pressure release pipe 8 is fixed with first guide bar 10, the cover is equipped with first piston 11 on the first guide bar 10, first piston 11's shape is the cylinder, the one end of keeping away from condensation chamber 7 of first pressure release pipe 8 is fixed with first closing cap 12, be connected with first spring 13 between first closing cap 12 and the first piston 11.
High-temperature gas in main part 1 rises, in 6 entering condensation chamber 7 along outlet duct, high-temperature gas meets cold liquefaction in the condensation chamber, it is more as high-temperature gas, lead to the pressure in condensation chamber 7 too high, at this moment, first piston 11 receives the extrusion and keeps away from condensation chamber 7 along first guide bar 10, after first piston 11 removes the outside to first pressure release hole 9, high-temperature gas discharges along first pressure release hole 9, first spring 13 is in compression state this moment, after pressure reduces, first piston 11 resumes to the normal position under the effect of the restoring force of first spring 13, high-temperature gas continues condensation liquefaction in condensation chamber 7.
Example two: as shown in fig. 4-5, the pressure relief mechanism is a staggered hole delayed pressure relief mechanism, the staggered hole delayed pressure relief mechanism includes a second pressure relief pipe 14 communicated with the condensation chamber 7, a plurality of second pressure relief holes 15 which are not equal to the outer wall of the condensation chamber 7 are arranged on the second pressure relief pipe 14, a second guide rod 16 is fixed at the center of the second pressure relief pipe 14, a second piston 17 is sleeved on the second guide rod 16, a second sealing cover 18 is fixed at one end of the second pressure relief pipe 14, which is far away from the condensation chamber 7, and a second spring 19 is connected between the second sealing cover 18 and the second piston 17.
The lateral spacing of the second pressure relief holes 15 is not equal to the distance between the leftmost end and the rightmost end of the second piston 17.
When the pressure in the condensation chamber 7 is too high, the second piston 17 is far away from the condensation chamber 7 along the second guide rod 16 under the action of pressure difference, after the second piston 17 moves to the outer sides of all the second pressure relief holes 15, the high-temperature gas in the condensation chamber 7 begins to be discharged along the second pressure relief holes 15, at the moment, the second spring 19 is in a compression state, the pressure in the condensation chamber 7 is gradually reduced along with the discharge of the high-temperature gas, after the pressure difference is reduced to a certain range, the restoring force of the second spring 19 drives the second piston 17 to be close to the condensation chamber 7 along the second guide rod 16, in the process, because the transverse interval of the second pressure relief holes 15 is not equal to the interval between the leftmost end and the rightmost end of the second piston 17, when one of the second pressure relief holes 15 is blocked, the other second pressure relief holes 15 still discharge the high-temperature gas, and after the second piston 17 moves to the inner sides of all the second pressure relief holes 15, the high temperature gas continues to condense in the condensation chamber 7.
The difference between the first embodiment and the second embodiment is that the pressure relief end time point of the first embodiment is when the first piston 11 blocks the first pressure relief hole 9, and the pressure relief end time point of the second embodiment is when the second piston 17 blocks the second pressure relief hole 15 closest to the condensation chamber 7, and during the period from when the second piston 17 starts to block the second pressure relief hole 15 farthest from the condensation chamber 7 to when the second piston 17 blocks the second pressure relief hole 15 closest to the condensation chamber 7, the pressure in the condensation chamber 7 is continuously reduced, which has the effect of prolonging the pressure relief time, so that the pressure in the condensation chamber 7 is reduced more, compared with the first embodiment, the second embodiment can reduce the pressure in the condensation chamber 7 as much as possible, so that the time for the pressure in the condensation chamber 7 to reach the critical point again is prolonged, the frequency of use of the pressure relief mechanism is reduced, so that the condensation process is interrupted less times, the condensation process is relatively more stable.
As shown in fig. 1, the first water diversion mechanism includes a first water diversion chamber 20 communicated with the bottom of the condensation chamber 7, the bottom of the first water diversion chamber 20 is communicated with the input end of the second water diversion mechanism, a first electromagnetic valve 21 is arranged at the communication position of the condensation chamber 7 and the first water diversion chamber 20, a first water collection chamber 22 is communicated with the top of the first water diversion chamber 20, a first water drain valve 23 is communicated with the bottom of the first water collection chamber 22, and the top of the first water collection chamber 22 is communicated with the main body 1.
The second water diversion mechanism comprises a second water diversion chamber 24 with the top communicated with the bottom of the first water diversion chamber 20, a second electromagnetic valve 25 is arranged at the communication position of the first water diversion chamber 20 and the second water diversion chamber 24, a second water collection chamber 26 is communicated with the bottom of the second water diversion chamber 24, a third electromagnetic valve 27 is arranged at the communication position of the second water diversion chamber 24 and the second water collection chamber 26, a second water drain valve 28 is communicated with the other side of the bottom of the second water diversion chamber 24, the top of the second water diversion chamber 24 is communicated with the first water collection chamber 22, and the bottom of the second water collection chamber 26 is communicated with the main body 1.
The first spring 13 and the second spring 19 are both compression springs.
The outer surface of the main body 1 is provided with an insulating layer 29.
When the high-temperature gas enters the condensing chamber 7 along the gas outlet pipe 6 to be condensed, the obtained organic solvent and water flow into the first water collecting chamber 20 along the first electromagnetic valve 21, if the density of the organic solvent is smaller than that of the water, the organic solvent floats on the surface layer and flows into the first water collecting chamber 22 along the pipeline at the top of the first water collecting chamber 20, the organic solvent in the first water collecting chamber 22 still has residual moisture, at this time, the second separation is performed, the liquid level in the first water collecting chamber 22 is continuously raised, so that the organic solvent floating on the surface flows back into the main body 1 along the pipeline at the top of the first water collecting chamber 22, the residual moisture is discharged along the first drain valve 23, the moisture in the first water collecting chamber 20 falls into the second water collecting chamber 24 along the second electromagnetic valve 25, the organic solvent remaining in the moisture floats on the surface, and flows into the first water collecting chamber 22 along the pipeline at the top of the second water collecting chamber 24, then continuously flows back into the main body 1 along the pipeline at the top of the first liquid collecting chamber 22, and the moisture in the second water dividing chamber 24 is discharged along the third electromagnetic valve 28;
when the density of the organic solvent is greater than that of water, the organic solvent entering the first water dividing chamber 20 sinks to the bottom of the first water dividing chamber 20, when the liquid level rises, the water flows into the first water dividing chamber 22 along the pipeline at the top of the first water dividing chamber 20, the organic solvent falls into the second water dividing chamber 24 along the second electromagnetic valve 25, in the process, a part of water flows into the second water dividing chamber 24 along with the organic solvent, after standing for a period of time, the water floats above the organic solvent, at the moment, the water flows into the first water dividing chamber 22 along the pipeline at the top of the second water dividing chamber 24, is discharged along the first electromagnetic valve 23 together with the water previously flowing into the first water dividing chamber 22, and the organic solvent after secondary water division in the second water dividing chamber 24 enters the second water dividing chamber 26 along the third electromagnetic valve 27 and then flows back into the main body 1.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and decorations can be made without departing from the technical principle of the present invention, and these improvements and decorations should also be regarded as the protection scope of the present invention.
Claims (7)
1. The utility model provides a multistage dehydration backward flow water knockout drum for lapatinib is synthetic, includes main part (1) and sets up feed inlet (2) on main part (1), its characterized in that, the fixed support (3) that is provided with in below of main part (1), be equipped with motor (4) on support (3), be equipped with in main part (1) and stir rake (5) of being connected with motor (4) transmission, the top intercommunication of main part (1) has outlet duct (6), the other end intercommunication of outlet duct (6) has condensation chamber (7), be equipped with pressure release mechanism on condensation chamber (7), the bottom intercommunication of condensation chamber (7) has first water diversion mechanism, the output intercommunication of first water diversion mechanism has second water diversion mechanism, the output and main part (1) intercommunication of second water diversion mechanism.
2. The multi-stage dehydration reflux water separator for the synthesis of erlotinib according to claim 1, it is characterized in that the pressure relief mechanism is a synchronous pressure relief mechanism of an alignment hole, the synchronous pressure relief mechanism of the alignment hole comprises a first pressure relief pipe (8) communicated with a condensation chamber (7), the first pressure relief pipe (8) is provided with a plurality of first pressure relief holes (9) which are symmetrically arranged around the axis of the first pressure relief pipe (8), a first guide rod (10) is fixed at the center of the first pressure relief pipe (8), a first piston (11) is sleeved on the first guide rod (10), the first piston (11) is in a cylinder shape, one end of the first pressure relief pipe (8) far away from the condensation chamber (7) is fixed with a first sealing cover (12), a first spring (13) is connected between the first cover (12) and the first piston (11).
3. The multistage dehydration reflux water separator for the synthesis of erlotinib according to claim 1, wherein the pressure release mechanism is a staggered hole delayed pressure release mechanism, the staggered hole delayed pressure release mechanism comprises a second pressure release pipe (14) communicated with the condensation chamber (7), a plurality of second pressure release holes (15) which are not equal to the outer wall of the condensation chamber (7) in distance are arranged on the second pressure release pipe (14), a second guide rod (16) is fixed at the center of the second pressure release pipe (14), a second piston (17) is sleeved on the second guide rod (16), a second sealing cover (18) is fixed at one end, far away from the condensation chamber (7), of the second pressure release pipe (14), and a second spring (19) is connected between the second sealing cover (18) and the second piston (17).
4. The multistage dehydration reflux splitter for the synthesis of erlotinib according to claim 3, wherein the lateral spacing of said second pressure relief holes (15) is not equal to the distance between the leftmost and rightmost ends of the second piston (17).
5. The multistage dehydration reflux water separator for the synthesis of erlotinib according to claim 1, wherein the first water separating mechanism comprises a first water separating chamber (20) communicated with the bottom of the condensation chamber (7), the bottom of the first water separating chamber (20) is communicated with the input end of the second water separating mechanism, a first electromagnetic valve (21) is arranged at the communication position of the condensation chamber (7) and the first water separating chamber (20), a first water collecting chamber (22) is communicated with the top of the first water separating chamber (20), a first drain valve (23) is communicated with the bottom of the first water collecting chamber (22), and the top of the first water collecting chamber (22) is communicated with the main body (1).
6. The multistage dehydration reflux water separator for the synthesis of erlotinib according to claim 1, wherein the second water separation mechanism comprises a second water separation chamber (24) having a top communicated with the bottom of the first water separation chamber (20), a second electromagnetic valve (25) is arranged at a communication position of the first water separation chamber (20) and the second water separation chamber (24), a second water collection chamber (26) is communicated with the bottom of the second water separation chamber (24), a third electromagnetic valve (27) is arranged at a communication position of the second water separation chamber (24) and the second water collection chamber (26), a second drain valve (28) is communicated with the other side of the bottom of the second water separation chamber (24), the top of the second water separation chamber (24) is communicated with the first water collection chamber (22), and the bottom of the second water collection chamber (26) is communicated with the main body (1).
7. The multistage dehydration reflux water separator for the synthesis of erlotinib according to claim 1, characterized in that the outer surface of said main body (1) is provided with an insulating layer (29).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220528447.6U CN217340176U (en) | 2022-03-11 | 2022-03-11 | A multistage dehydration backward flow water knockout drum for synthetic of larotinib |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220528447.6U CN217340176U (en) | 2022-03-11 | 2022-03-11 | A multistage dehydration backward flow water knockout drum for synthetic of larotinib |
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| Publication Number | Publication Date |
|---|---|
| CN217340176U true CN217340176U (en) | 2022-09-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220528447.6U Expired - Fee Related CN217340176U (en) | 2022-03-11 | 2022-03-11 | A multistage dehydration backward flow water knockout drum for synthetic of larotinib |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217340176U (en) |
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2022
- 2022-03-11 CN CN202220528447.6U patent/CN217340176U/en not_active Expired - Fee Related
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Granted publication date: 20220902 |