CN217339754U

CN217339754U - Accurate targeting drug delivery device and system

Info

Publication number: CN217339754U
Application number: CN202122689834.6U
Authority: CN
Inventors: 巴劲伟; 余容英; 高猛; 叶乐
Original assignee: Advanced Institute of Information Technology AIIT of Peking University; Hangzhou Weiming Information Technology Co Ltd
Current assignee: Advanced Institute of Information Technology AIIT of Peking University; Hangzhou Weiming Information Technology Co Ltd
Priority date: 2021-11-04
Filing date: 2021-11-04
Publication date: 2022-09-02
Anticipated expiration: 2031-11-04

Abstract

The utility model relates to the field of medical equipment, specifically disclose an accurate targeting device and system of dosing, including the casing and set up anther sac, electroosmosis pump, controller, battery, sensor, pipe and receiving coil in the casing, wherein, the battery is connected with electroosmosis pump, controller and sensor, and the controller is connected with sensor, electroosmosis pump, and the electroosmosis pump sets up between anther sac and pipe, and the sensor setting is between electroosmosis pump and pipe for acquire the fluid index information of liquid medicine, receiving coil with the controller is connected. The utility model discloses select electroosmosis pump drive and sensor feedback closed-loop control for use, can realize accurate target and dose, and compare with traditional mechanical pump, the electroosmosis pump does not have mechanical motion, and the friction heat production is few, and the equal available biocompatible material preparation of spare part more is suitable for to plant the use for a long time.

Description

Accurate targeted drug delivery device and system

Technical Field

The utility model relates to the field of medical equipment, specifically disclose an accurate targeting device and system of dosing.

Background

Chronic diseases become the leading cause of death in China, and in recent years, the number of deaths caused by chronic diseases such as cerebrovascular diseases and the like continuously accounts for more than 80% of the total number of deaths in China. The most common administration modes in clinic and life are oral administration, intravenous injection and other systemic administration modes. Due to the limited availability of drugs, high incidence of global side effects, slow effect and the like, targeted drug delivery has become an important long-term development direction. The targeted drug delivery has the advantages of precise drug delivery, quick response, proper drug delivery and no side effect. The traditional mechanical pump has a complex structure, is mostly a quick-wear part, is high in use cost, is easy to damage due to friction and heat generation of mechanical movement and breaks down, and is high in long-term implanted use safety risk.

Disclosure of Invention

The present invention aims to solve the above technical problems in the related art at least to some extent. Therefore, the utility model provides an accurate target is dosed device and system solves above-mentioned at least one technical problem.

In order to realize the above object, the utility model provides a precise targeting drug delivery device, including the casing and set up in anther sac, electroosmosis pump, controller, battery, sensor, pipe and receiving coil in the casing, wherein, the battery with electroosmosis pump, controller and sensor are connected, the controller with the sensor electroosmosis pump is connected, the electroosmosis pump sets up the anther sac with between the pipe, the sensor sets up the electroosmosis pump with between the pipe for acquire the fluid index information of liquid medicine, receiving coil with the controller is connected.

The utility model discloses the second aspect provides an accurate target drug delivery system, including intelligent terminal and as above

The accurate targeting drug delivery device, wherein, intelligent terminal includes: the wireless signal receiving unit, central processing unit and with the transmitting coil of wireless signal receiving unit connection.

In addition, the utility model discloses an accurate targeting device of dosing can also have following additional technical characterstic:

according to some embodiments of the present invention, further comprising:

the sensor also comprises a one-way valve arranged in the shell, and the one-way valve is arranged between the electroosmosis pump and the sensor.

According to some embodiments of the utility model, the casing includes upper housing and lower casing, the upper housing lid is located on the casing down, the casing has down and holds the chamber, anther sac, electroosmosis pump, controller, battery, sensor and check valve are located hold the intracavity.

According to some embodiments of the utility model, the surface of casing is provided with the connecting pipe down, the one end of connecting pipe with the pipe intercommunication, the other end runs through down the casing with the liquid outlet intercommunication of electroosmosis pump, the check valve and the sensor setting is in on the connecting pipe.

According to some embodiments of the invention, the receiving coil is fixed to an inner surface or an outer surface of the upper case.

According to some embodiments of the utility model, the internal surface or the surface of going up the casing are seted up flutedly, receiving coil place in the recess.

According to some embodiments of the invention, the receiving coil is wound on the connecting tube.

According to some embodiments of the utility model, the casing still include in the baffle that sets up in the lower casing, the baffle will it separates into first installation cavity and second installation cavity to hold the chamber, the controller and the battery is located first installation cavity, anther sac, electroosmosis pump, sensor and check valve are located the second installation cavity.

According to some embodiments of the present invention, the housing further comprises a sealing plate, the sealing plate is covered on the lower housing, and the lower housing and the partition plate enclose a first closed installation cavity.

Compared with the prior art, the utility model discloses following beneficial effect has:

1. the utility model discloses select electroosmosis pump drive and sensor feedback closed-loop control for use, can realize accurate target and dose. The electroosmosis pump has simple structure and lower use cost;

2. compared with the traditional mechanical pump, the electroosmosis pump has no mechanical movement, generates little heat by friction, can be made of biocompatible materials for parts and components, and is more suitable for long-term implantation.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a block diagram of an accurate targeted drug delivery device in an embodiment of the present invention;

fig. 2 is an exploded view of a module of an accurate targeted drug delivery device in an embodiment of the present invention;

fig. 3 is a plan exploded view of a precise targeted drug delivery system in an embodiment of the present invention, wherein a receiving coil is disposed on the outer surface of the upper housing;

FIG. 4 is a perspective view of FIG. 3;

FIG. 5 is a schematic structural view of a sealing plate added on the basis of FIG. 4;

fig. 6 is a plan exploded view of a precise targeted drug delivery system in accordance with another embodiment of the present invention, wherein the receiver coil is disposed on the inner surface of the upper housing;

FIG. 7 is a perspective view of FIG. 6;

fig. 8 is a plan exploded view of an accurate targeted drug delivery system in accordance with another embodiment of the present invention, wherein the receiver coil is wound around the connecting tube;

fig. 9 is a perspective view of fig. 8.

The objects, features and advantages of the present invention will be further described with reference to the accompanying drawings.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention.

In the field of interventional medical devices, the end of a medical device implanted in a human or animal body closer to an operator is generally referred to as the "proximal end", the end farther from the operator is referred to as the "distal end", and the "proximal end" and the "distal end" of any component of the medical device are defined according to this principle. "axial" generally refers to the length of the medical device as it is being delivered, and "radial" generally refers to the direction of the medical device perpendicular to its "axial" direction, and defines both "axial" and "radial" directions for any component of the medical device in accordance with this principle.

The technical solution of the present invention will be further described in detail with reference to the following specific examples.

Referring to fig. 1-9, an embodiment of the present invention provides an accurate targeted drug delivery system, including an accurate targeted drug delivery device 100 and an intelligent terminal 200, wherein the accurate targeted drug delivery device 100 can perform wireless data communication with the intelligent terminal 200 outside the body, and further realize the autonomous drug delivery of the external control of the accurate targeted drug delivery device 100. The precise targeted drug delivery device 100 comprises a shell 10, a drug bag 11, an electroosmotic pump 12, a controller 13, a battery 14, a sensor 15, a conduit 16, a receiving coil 17 and a one-way valve 18, wherein the drug bag 11, the electroosmotic pump 12, the controller 13 and the sensor 15 are arranged in the shell 10, the battery 14 is connected with the electroosmotic pump 12, the controller 13 is connected with the sensor 15 and the electroosmotic pump 12, the electroosmotic pump 12 is arranged between the drug bag 11 and the conduit 16, the sensor 15 is arranged between the electroosmotic pump 12 and the conduit 16 and used for acquiring fluid index information of liquid medicine, the receiving coil 17 is connected with the controller 13, the battery 14 is connected with the controller 13 and used for wirelessly charging the battery 14, and the one-way valve 18 is arranged between the electroosmotic pump 12 and the sensor 15.

In this embodiment, the housing 10 may be made of metal titanium or titanium alloy, or made of bio-ceramic or glass, the housing 10 includes an upper housing 101 and a lower housing 102, the upper housing 101 is covered on the lower housing 102, the lower housing 102 has a containing cavity, and the medicine bag 11, the electroosmotic pump 12, the controller 13, the battery 14, the sensor 15 and the one-way valve 18 are located in the containing cavity.

The medicine bag 11 in this embodiment is used for storing medicine liquid, the medicine bag 11 may be made of a biocompatible flexible material such as silica gel, and is fixed to the lower case 102 by gluing, the electroosmotic pump 12 serves as a power unit for driving the medicine liquid in the medicine bag 11 to flow into the conduit 16, the electroosmotic pump 12 may be made of polymethyl methacrylate (PMMA), or may be made of a biocompatible material such as Polycarbonate (PC), polyethylene terephthalate (PET), or Polydimethylsiloxane (PDMS), and the electroosmotic pump 12 may be fixed to the lower case 102 by gluing, but is not limited to this fixing.

With continued reference to fig. 1-2, a controller 13 is coupled to the electroosmotic pump 12 for controlling the electroosmotic pump 12. the controller 13 may be formed of a ceramic or glass biocompatible material as a substrate, or the controller 13 may be encapsulated in a package.

Further, the one-way valve 18 can ensure one-way circulation of the medicine to prevent backflow from polluting the medicine in the medicine bag 11, the one-way valve 18 is connected to the electroosmosis pump 12 to achieve one-way flow of the medicine, the one-way valve 18 can be made of medical resin or biocompatible materials such as ABS, and can be processed in an injection molding mode or formed in a 3D printing mode.

With continued reference to fig. 1, the sensor 15 in this embodiment feeds back the detected indicator information of the medical fluid to the controller 13, and the sensor 15 may be a flow sensor, a pressure sensor, or a combination of multiple sensors.

The precise targeting drug delivery device 100 in this embodiment can be made into an implantable type, so that the drug bag 11, the electroosmotic pump 12, the controller 13, the battery 14, the sensor 15 and the one-way valve 18 need to be integrated into a whole, the three-dimensional heterogeneous integration is needed to distinguish and package the flow channel from the circuit, and the air-tight protection of the whole device is needed to prevent the body fluid from permeating into the shell 10 and the non-biocompatible material in the shell 10 from diffusing into the body.

With continued reference to FIG. 3, the outer surface of the lower housing 102 is provided with a connection tube 103, one end of the connection tube 103 is communicated with the conduit 16, the other end penetrates through the lower housing 102 to be communicated with the liquid outlet of the electroosmotic pump 12, and the check valve 18 and the sensor 15 are provided on the connection tube 103.

In some embodiments of the present invention, as shown in fig. 3-7, the receiving coil 17 is coated with a biocompatible material, and the receiving coil 17 is then secured to the housing 10 with a biocompatible glue. Specifically, the receiving coil 17 may be adhered to the inner surface or the outer surface of the upper case 101. However, the present invention is not limited to this, and a groove may be formed on the inner surface or the outer surface of the upper case 101, and the receiving coil 17 may be embedded in the groove for fixing.

When the receiving coil 17 can be adhered to the outer surface of the upper casing 101, the receiving coil 17 can be an enameled wire insulated from the casing, and in this case, the receiving coil 17 can be connected to the controller 13 through the upper casing 101 by a feed-through technique, and the controller 13 is connected to the battery 14, so as to realize wireless charging of the battery 14.

In other embodiments of the present invention, as shown in fig. 8-9, the receiving coil 17 may also be wound on the connecting tube 103. The utility model discloses do not limit to receiving coil 17's fixed position, fixed mode, technical personnel in the field can select in a flexible way as required.

It should be noted that, since the liquid in the medicine bag 11 and the electroosmotic pump 12 may have diffusibility and simultaneously have electrolyte components, which may corrode circuit components, in order to solve the above problems, with continued reference to fig. 3-5, in the present embodiment, the housing 10 further includes a partition plate 104 disposed in the lower housing 102, the partition plate 104 partitions the accommodating chamber into a first mounting chamber and a second mounting chamber, the controller 13 and the battery 14 are located in the first mounting chamber, and the medicine bag 11, the electroosmotic pump 12, the sensor 15 and the check valve 18 are located in the second mounting chamber. The housing 10 further includes a sealing plate 105, and the sealing plate 105 covers the lower housing 102 and encloses a first closed installation cavity with the lower housing 102 and the partition plate 104. Specifically, the utility model discloses encapsulate circuit element such as controller 13 and battery 14 alone, protected the circuit, prolong the life of complete equipment.

In order to realize the interaction with the precise targeted drug delivery device 100, the intelligent terminal 200 in the embodiment includes: the wireless charging device comprises a wireless signal receiving unit, a wireless charging transmitting unit, a central processing unit, a display unit and a transmitting coil connected with the wireless signal receiving unit and the wireless charging transmitting unit. Specifically, after the precise targeted drug delivery device 100 reaches the pulmonary artery position, the controller 13 receives the signal collected by the sensor 15, and the controller 13 controls the operation of the electroosmotic pump 12 according to the received signal, thereby controlling the automatic drug delivery. Meanwhile, the controller 13 transmits signals to the wireless signal transmitting unit in the precise targeting drug delivery device 100, the wireless signal transmitting unit transmits the signals to the receiving coil 17 so as to transmit the signals to the transmitting coil on the intelligent terminal 200, the transmitting coil transmits the signals to the wireless signal receiving unit after receiving the signals, and then the signals are transmitted to the central processing unit, and the central processing unit displays data monitored by the sensor 15 through the display unit. Meanwhile, the central processing unit transmits a signal to the wireless charging transmitting unit and further transmits the signal to the transmitting coil, the accurate targeting drug administration device 100 located in the body receives wireless charging energy through the receiving coil 17 and transmits the wireless charging energy to the wireless charging receiving unit in the accurate targeting drug administration device 100, and the controller 13 charges the battery 14 according to the charging signal and the electric quantity on the battery 14.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. The accurate targeted drug delivery device is characterized by comprising a shell, a drug bag, an electroosmotic pump, a controller, a battery, a sensor, a conduit and a receiving coil, wherein the drug bag, the electroosmotic pump, the controller, the battery, the sensor, the conduit and the receiving coil are arranged in the shell, the battery is connected with the electroosmotic pump, the controller is connected with the sensor and the electroosmotic pump, the electroosmotic pump is arranged between the drug bag and the conduit, the sensor is arranged between the electroosmotic pump and the conduit and used for acquiring fluid index information of a drug solution, and the receiving coil is connected with the controller.

2. The precise targeted drug delivery device of claim 1, further comprising a one-way valve disposed within the housing, the one-way valve disposed between the electroosmotic pump and the sensor.

3. The device according to claim 2, wherein the housing comprises an upper housing and a lower housing, the upper housing covering the lower housing, the lower housing having a receiving cavity, the drug capsule, the electroosmotic pump, the controller, the battery, the sensor and the one-way valve being located in the receiving cavity.

4. The device of claim 3, wherein the outer surface of the lower housing is provided with a connecting tube, one end of the connecting tube is communicated with the conduit, the other end of the connecting tube penetrates through the lower housing to be communicated with the liquid outlet of the electroosmotic pump, and the one-way valve and the sensor are arranged on the connecting tube.

5. The precise targeted drug delivery device of claim 4, wherein the receiving coil is affixed to an inner or outer surface of the upper housing.

6. The precise targeted drug delivery device of claim 5, wherein a groove is formed in the inner surface or the outer surface of the upper shell, and the receiving coil is placed in the groove.

7. The device of claim 4, wherein the receiving coil is wound around the connecting tube.

8. The device of claim 4, wherein the housing further comprises a partition disposed in the lower housing, the partition dividing the receiving chamber into a first mounting chamber and a second mounting chamber, the controller and the battery being located in the first mounting chamber, and the capsule, the electroosmotic pump, the sensor and the one-way valve being located in the second mounting chamber.

9. The precise targeted drug delivery device of claim 8, wherein the housing further comprises a sealing plate, and the sealing plate covers the lower housing and encloses a closed first installation cavity with the lower housing and the partition plate.

10. An accurate targeted drug delivery system, comprising an intelligent terminal and the accurate targeted drug delivery device according to any one of claims 1 to 9, wherein the intelligent terminal comprises: the wireless signal receiving unit, central processing unit and with the transmitting coil of wireless signal receiving unit connection.