CN217277252U

CN217277252U - Slide processing system

Info

Publication number: CN217277252U
Application number: CN202221038348.6U
Authority: CN
Inventors: 张忠雄; 张俊; 周世红; 肖永军; 魏亮
Original assignee: Wuhan Youzhiyou Medical Technology Co ltd
Current assignee: Wuhan Youzhiyou Medical Technology Co ltd
Priority date: 2022-04-27
Filing date: 2022-04-27
Publication date: 2022-08-23
Anticipated expiration: 2032-04-27

Abstract

The present application provides a slide processing system comprising: the main control unit, the peristaltic pump drive, first peristaltic pump, valve control device and first flow monitoring devices, main control unit is respectively with the peristaltic pump drive, valve control device and first flow monitoring devices are connected, the peristaltic pump drive is connected with first peristaltic pump, the inlet and at least one inlet conduit of first peristaltic pump link up, each inlet conduit all is equipped with switch valve, each inlet conduit is connected the container connection that holds different reagents respectively, the liquid outlet of first peristaltic pump link up with the reaction tank through going out the liquid pipeline, first flow monitoring devices installs in the play liquid pipeline of first peristaltic pump, each switch valve all is connected with valve control device. The first peristaltic pump and the switch valve are controlled to work through the main controller, dependence on manpower is eliminated, time and labor are saved, and possibility of human errors is reduced.

Description

Slide processing system

Technical Field

The application relates to the field of biotechnology, in particular to a slide processing system.

Background

Slide processing systems are automated instruments for sample processing prior to pathological analysis of cytological specimens, histological specimens (specimens of punctured or neutral formalin-fixed paraffin-embedded tissue sections), and blood samples. The slide processing system needs to provide more than 10 reagents for reacting with the sample, such as dewaxing agent, ethanol with different purity, protease, etc., and the slide carrying the sample is placed in the reaction tank.

Conventional slide processing systems require manual operations, such as manual addition of reagents, which can be time consuming and error prone, leading to erroneous results for the test.

Therefore, how to realize automatic control of the slide processing system becomes a problem to be focused on by those skilled in the art.

SUMMERY OF THE UTILITY MODEL

It is an object of the present application to provide a slide processing system to at least partially ameliorate the above problems.

In order to achieve the above purpose, the embodiments of the present application employ the following technical solutions:

in a first aspect, embodiments herein provide a slide processing system comprising: the device comprises a main controller, a peristaltic pump drive, a first peristaltic pump, a valve control device and a first flow monitoring device, wherein the main controller is respectively connected with the peristaltic pump drive, the valve control device and the first flow monitoring device, the peristaltic pump drive is connected with the first peristaltic pump, a liquid inlet of the first peristaltic pump is communicated with at least one liquid inlet pipeline, each liquid inlet pipeline is provided with a switch valve, each liquid inlet pipeline is respectively connected with containers for containing different reagents, a liquid outlet of the first peristaltic pump is communicated with a reaction tank through a liquid outlet pipeline, the first flow monitoring device is installed on the liquid outlet pipeline of the first peristaltic pump, and each switch valve is connected with the valve control device;

the main controller is used for transmitting a first driving instruction to the valve control device when receiving a liquid inlet request so as to enable the valve control device to control a target switch valve to be opened, wherein the liquid inlet request comprises an identifier corresponding to the target switch valve;

the main controller is also used for controlling the first peristaltic pump to convey the reagent in the container corresponding to the target switch valve into the reaction tank through the drive of the peristaltic pump;

the first flow monitoring device is used for monitoring the flow of a first reagent flowing into the reaction tank and transmitting the flow of the first reagent to the main controller;

and the main controller is also used for transmitting a second driving instruction to the valve control device when the flow of the first reagent is greater than or equal to a preset first target flow, so that the valve control device controls the target switch valve to be closed, and simultaneously controls the first peristaltic pump to stop working.

Optionally, the slide processing system further comprises: the second peristaltic pump is in driving connection with the peristaltic pump, the other end of a liquid inlet pipeline connected with a liquid inlet of the second peristaltic pump is arranged at the bottom of the reaction tank, a liquid outlet of the second peristaltic pump is communicated with a waste liquid tank through a liquid outlet pipeline, and the second flow monitoring device is arranged on the liquid outlet pipeline of the second peristaltic pump;

the main controller is used for controlling the second peristaltic pump to convey the reagent in the reaction tank into the waste liquid tank through the drive of the peristaltic pump when a liquid discharge request is received;

the second flow monitoring device is used for monitoring the flow of a second reagent flowing into the waste liquid groove and transmitting the flow of the second reagent to the main controller;

and the main controller is also used for controlling the second peristaltic pump to stop working when the flow rate of the second reagent is greater than or equal to a preset second target flow rate.

Optionally, the slide processing system further comprises: the device comprises a swing motor drive, a swing motor and a swing arm, wherein the swing motor drive is respectively connected with the main controller and the swing motor, one end of the swing arm is in transmission connection with the swing motor, and the other end of the swing arm is connected with the reaction tank;

the main controller is also used for controlling the swinging motor to work through the driving of the swinging motor, so that the swinging arm drives the reaction tank to swing.

Optionally, the slide processing system further comprises: the reaction tank comprises a shelter, a first position monitoring device and a second position monitoring device, wherein the first position monitoring device and the second position monitoring device are both connected with the main controller, the shelter swings along with the reaction tank, and the relative position of the shelter and the reaction tank is fixed;

the first position monitoring device is used for sending a first trigger signal to the main controller when monitoring that the shelter swings to a first target position;

the second position monitoring device is used for sending a second trigger signal to the main controller when monitoring that the shelter swings to a second target position;

and the main controller is used for controlling the swing motor to change the swing direction when receiving the first trigger signal or the second trigger signal.

Optionally, the slide processing system further comprises: the cabin door state monitoring device is connected with the main controller;

the cabin door state monitoring device is used for monitoring the state of a cabin door and transmitting the state of the cabin door to the main controller;

the main controller is used for alarming or controlling the experiment to pause when the cabin door is opened.

Optionally, the slide processing system further comprises: the fan drive is connected with the main controller, and each fan is in drive connection with the fan;

the main controller is also used for controlling the fan to work through the fan drive after the glass slide processing system is powered on so as to dissipate heat of the glass slide processing system.

Optionally, the slide processing system further comprises: the temperature sampling unit, the first driving circuit and the second driving circuit are all connected with the main controller, and the first driving circuit and the second driving circuit are all connected with the refrigerating piece;

the temperature sampling unit is used for collecting the current temperature in the reaction tank and transmitting the current temperature to the main controller;

the main controller is used for controlling the refrigeration sheet to heat through the first driving circuit when the current temperature is lower than the target temperature so as to raise the temperature in the reaction tank;

and the main controller is also used for controlling the refrigeration of the refrigeration piece through the second driving circuit when the current temperature is higher than the target temperature so as to reduce the temperature in the reaction tank.

Optionally, the slide processing system further comprises: the display is connected with the main controller through the communication interface module;

the main controller can transmit the current running state to the display through the communication interface module;

the display is used for displaying the current running state, and is convenient for a user to check.

Optionally, the main controller is further configured to, after power-on, start a self-test for detecting whether each component of the slide processing system operates normally;

the main controller is also used for alarming when the self-checking result indicates that any part can not normally run.

With respect to the prior art, the present application provides a slide processing system, including: main control unit, the peristaltic pump drive, first peristaltic pump, valve control device and first flow monitoring devices, main control unit is respectively with the peristaltic pump drive, valve control device and first flow monitoring devices are connected, the peristaltic pump drive is connected with first peristaltic pump, the inlet and at least one feed liquor pipeline of first peristaltic pump link up, each feed liquor pipeline all is equipped with switch valve, each feed liquor pipeline connects the container connection who holds different reagents respectively, the liquid outlet of first peristaltic pump link up with the reaction tank through going out the liquid pipeline, first flow monitoring devices installs in the play liquid pipeline of first peristaltic pump, each switch valve all is connected with valve control device. The first peristaltic pump and the switch valve are controlled to work through the main controller, dependence on manpower is eliminated, time and labor are saved, and possibility of human errors is reduced.

In order to make the aforementioned objects, features and advantages of the present application more comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and it will be apparent to those skilled in the art that other related drawings can be obtained from the drawings without inventive effort.

FIG. 1 is a schematic view of an attachment of a slide processing system provided in an embodiment of the present application;

FIG. 2 is a schematic flow diagram of reagents provided in embodiments of the present application;

FIG. 3 is one of the schematic connection diagrams of a slide processing system provided in an embodiment of the present application;

FIG. 4 is a front view of a reaction tank provided in an embodiment of the present application.

In the figure: 10-a main controller; 11-peristaltic pump driving; 111-a first peristaltic pump; 112-a second peristaltic pump; 12-a valve control device; 121-switching valve; 13-a first flow monitoring device; 14-a second flow monitoring device; 15-driving by a swing motor; 151-a wobble motor; 152-a swing arm; 16-a first position monitoring device; 17-a second position monitoring device; 18-hatch status monitoring device; 19-fan drive; 191-a fan; 20-a temperature sampling unit; 21-a first drive circuit; 22-a second drive circuit; 23-a refrigerating sheet; 24-a communication interface module; 25-a display; 26-a reaction tank; 27-a waste liquid tank; 28-shade.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined or explained in subsequent figures. Meanwhile, in the description of the present application, the terms "first", "second", and the like are used only for distinguishing the description, and are not construed as indicating or implying relative importance.

It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

In the description of the present application, it should be noted that the terms "upper", "lower", "inner", "outer", and the like indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings or orientations or positional relationships conventionally placed when products of the application are used, and are only used for convenience of description and simplification of the description, but do not indicate or imply that the devices or elements referred to must have specific orientations, be constructed in specific orientations, and be operated, and thus, should not be construed as limiting the present application.

In the description of the present application, it is also to be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

Some embodiments of the present application will be described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

The slide processing system can add required reagent into the reaction tank 26 by opening the electromagnetic valve and the peristaltic pump, then accurately control the temperature of the reaction tank 26 to enable the added reagent to react with the sample, and after the reaction is finished, the reagent is discharged into the waste liquid barrel through the peristaltic pump; then adding another reagent, and circulating the steps until the whole pretreatment process is finished. The denaturing hybridization process of the sample and the subsequent washing process of the sample may also be performed in the reaction tank 26. When the traditional instrument performs the process, reagents are added manually, more time is wasted, errors are prone to occurring, and the result of the test is wrong.

In order to reduce manual operation, the embodiment of the present application provides a slide processing system, as shown in fig. 1, and fig. 1 is a connection schematic diagram of the slide processing system provided by the embodiment of the present application. The slide processing system includes: a main controller 10, a peristaltic pump drive 11, a first peristaltic pump 111, a valve control device 12, and a first flow monitoring device 13. The main controller 10 is connected to a peristaltic pump driver 11, a valve control device 12, and a first flow monitoring device 13, respectively, and the peristaltic pump driver 11 is connected to a first peristaltic pump 111.

The liquid inlet of the first peristaltic pump 111 is communicated with at least one liquid inlet pipeline, each liquid inlet pipeline is provided with a switch valve 121, each liquid inlet pipeline is connected with containers for containing different reagents respectively, the liquid outlet of the first peristaltic pump 111 is communicated with the reaction tank 26 through a liquid outlet pipeline, the first flow monitoring device 13 is installed on the liquid outlet pipeline of the first peristaltic pump 111, and each switch valve 121 is connected with the valve control device 12. Specifically, please refer to fig. 2, wherein fig. 2 is a schematic flow diagram of the reagents according to the embodiment of the present disclosure.

The main controller 10 is configured to transmit a first driving instruction to the valve control device 12 when receiving a liquid inlet request, so that the valve control device 12 controls the target switch valve to open, where the liquid inlet request includes an identifier corresponding to the target switch valve.

Optionally, the liquid inlet request may be input by a user through the human-computer interaction module, or may be transmitted by other terminals through the communication module.

It should be noted that the target on-off valve may be any on-off valve 121 connected to the valve control device 12, and the number of the target on-off valves may not be limited to 1, that is, the number thereof may be greater than 1.

The main controller 10 is further configured to control the first peristaltic pump 111 to deliver the reagent in the container corresponding to the target on-off valve into the reaction tank 26 through the peristaltic pump driver 11.

The first flow rate monitoring device 13 is used for monitoring the first reagent flow rate flowing into the reaction tank 26 and transmitting the first reagent flow rate to the main controller 10.

The main controller 10 is further configured to transmit a second driving command to the valve control device 12 when the first reagent flow rate is greater than or equal to a preset first target flow rate, so that the valve control device 12 controls the target switch valve to close and simultaneously controls the first peristaltic pump 111 to stop working.

In summary, the present application provides a slide processing system including: main control unit 10, peristaltic pump drive 11, first peristaltic pump 111, valve control device 12 and first flow monitoring devices 13, main control unit 10 respectively with peristaltic pump drive 11, valve control device 12 and first flow monitoring devices 13 are connected, peristaltic pump drive 11 is connected with first peristaltic pump 111, the inlet of first peristaltic pump 111 link up with at least one inlet channel, each inlet channel all is equipped with switch valve 121, each inlet channel is connected respectively and is held the container connection of different reagents, the liquid outlet of first peristaltic pump 111 link up with reaction tank 26 through going out the liquid pipeline, first flow monitoring devices 13 are installed in the play liquid pipeline of first peristaltic pump 111, each switch valve 121 all is connected with valve control devices 12. The main controller 10 controls the first peristaltic pump 111 and the switch valve 121 to work, so that the dependence on manpower is eliminated, time and labor are saved, and the possibility of human errors is reduced.

On the basis of fig. 1, the embodiment of the present application also provides a possible implementation manner as to how to eliminate the waste liquid or the excess liquid in the reaction tank 26, please refer to fig. 3, and fig. 3 is one of the connection schematic diagrams of the slide processing system provided by the embodiment of the present application. As shown in fig. 3, the slide processing system further includes: the second peristaltic pump 112 is connected with the peristaltic pump drive 11, the other end of the liquid inlet pipeline connected with the liquid inlet of the second peristaltic pump 112 is arranged at the bottom of the reaction tank 26, the liquid outlet of the second peristaltic pump 112 is communicated with the waste liquid tank 27 through a liquid outlet pipeline, and the second flow monitoring device 14 is arranged on the liquid outlet pipeline of the second peristaltic pump 112.

The main controller 10 is used to control the second peristaltic pump 112 to transfer the reagent in the reaction tank 26 to the waste liquid tank 27 by the peristaltic pump drive 11 when a liquid discharge request is received.

The second flow rate monitoring means 14 is for monitoring the flow rate of the second reagent flowing into the waste liquid tank 27 and transmitting the second reagent flow rate to the main controller 10.

The main controller 10 is further configured to control the second peristaltic pump 112 to stop operating when the second reagent flow rate is greater than or equal to a preset second target flow rate.

It will be appreciated that the amount of liquid discharged can be limited by the second flow monitoring device 14, determined by the user's requirements, and controlled flexibly, without requiring complete cleaning.

In the embodiment of the application, the main controller 10 can select the STM32F1 minimum system to use the single chip microcomputer controller STM32F103ZET6 packaged by LQFP-144 as a core, and can be matched with peripheral devices such as an 8M external clock, a power-on manual reset interface, an SWD download interface and the like, and an LED state indication function can also be added.

Alternatively, the first flow rate monitoring device 13 and the second flow rate monitoring device 14 may be, but are not limited to, hall effect type flow meters, and the main controller 10 calculates the amount of reagent passing by reading the number of pulses of the hall effect type flow meters.

With continued reference to fig. 3, in one possible implementation, the slide processing system further includes: the device comprises a swing motor drive 15, a swing motor 151 and a swing arm 152, wherein the swing motor drive 15 is respectively connected with a main controller 10 and the swing motor 151, one end of the swing arm 152 is in transmission connection with the swing motor 151, and the other end of the swing arm 152 is connected with a reaction tank 26.

The main controller 10 is also used to control the operation of the swing motor 151 through the swing motor drive 15, so as to swing the reaction tank 26 through the swing arm 152.

It should be understood that the reaction channel 26 can oscillate to better react the reagents to act on the slide. The main controller 10 may start the swing upon receiving the swing request, or may automatically control the swing after the reagent is supplied to the reaction tank by the first peristaltic pump 111, which is not limited herein.

With continued reference to fig. 3, in one possible implementation, the slide processing system further includes: the device comprises a shelter 28, a first position monitoring device 16 and a second position monitoring device 17, wherein the first position monitoring device 16 and the second position monitoring device 17 are connected with the main controller 10, the shelter 28 swings along with the reaction tank 26, and the relative position of the shelter 28 and the reaction tank 26 is fixed. Specifically, please refer to fig. 4, wherein fig. 4 is a front view of a reaction tank provided in an embodiment of the present application.

It should be noted that fig. 4 only shows one possible position relationship between the second position monitoring device 17 and the shade 28, and is not limiting, and the first position monitoring device 16 is the same.

The first position monitoring device 16 is configured to send a first trigger signal to the master controller 10 when the barrier 28 is swung to a first target position.

The second position monitoring device 17 is used to monitor the swinging of the shade 28 to a second target position and send a second trigger signal to the main controller 10.

The main controller 10 is configured to control the swing motor 151 to change the swing direction when receiving the first trigger signal or the second trigger signal.

Alternatively, the shroud 28 may be, but is not limited to, a flap. The first position monitoring device 16 and the second position monitoring device 17 may be, but are not limited to, U-shaped photosensors. A U-shaped photosensor is placed at the critical position and is coupled to the reaction tank 26 using a shutter. When the blocking piece moves to a critical position, the blocking piece can block two ends of the U-shaped photoelectric sensor to change the level of the output end of the U-shaped photoelectric sensor, and the main controller 10 sends a corresponding instruction to the motor after receiving the level to achieve the purpose of limiting.

In one possible implementation, the shroud 28 is mounted on the swing arm 152 or on the outside wall of the reaction tank 26.

In this embodiment of the application, the driving system with TMC5160 motor driving chip as core may be adopted for the swing motor driver 15 and the peristaltic pump driver 11, the TMC5160 performs precise control on the enabling, direction and step number of the motors (the motors in the first peristaltic pump 111, the second peristaltic pump 112 and the swing motor 151) through communication with the main controller 10, and in addition, the TMC5160 chip further has advantages of two-phase stepping motor driving with coil current as high as 20A, supporting multiple communication modes (SPI and single line UART), 256 micro-step adjustment, low energy consumption, low noise and the like.

With continued reference to fig. 3, in one possible implementation, the slide processing system further includes: the cabin door state monitoring device 18, the cabin door state monitoring device 18 is connected with the main controller 10.

The door state monitoring device 18 is used to monitor the door state and transmit the door state to the main controller 10.

The main controller 10 is used for alarming or controlling the experiment to pause when the cabin door is opened.

Alternatively, the hatch status monitoring device 18 may be, but is not limited to, a proximity switch that generates different high and low level outputs to the main controller 10 when the hatch is approaching and moving away.

It should be understood that by providing the cabin door status monitoring device 18, a protection effect can be achieved, and the situation that the cabin door is opened by mistake to cause failure of an experiment or harm to personal safety can be avoided.

With continued reference to fig. 3, in one possible implementation, the slide processing system further includes: a fan driver 19 and at least one set of fans 191, the fan driver 19 is connected with the main controller 10, and each fan 191 is connected with the fan driver 19.

The main controller 10 is also used to control the operation of the fan 191 via the fan drive 19 after power-up to dissipate heat from the slide processing system.

Optionally, the system cooling fan is equipped with 4 24V rated dc fans, and is controlled by the same output signal of the main controller 10 (i.e. on and off). The fans 191 are installed at different areas of the instrument, respectively, to dissipate heat of the entire system when the instrument is in operation. For example, the fans 191 are separately installed beside the main control board of the system (the main control board integrates the MCU and the corresponding interface), and beside the DCDC power supply, and are arranged as symmetrically as possible to form an air duct.

Alternatively, the fan 191 is started upon power-up of the main controller 10 (MCU).

With continued reference to fig. 3, in one possible implementation, the slide processing system further includes: temperature sampling unit 20, first drive circuit 21, second drive circuit 22 and refrigeration piece 23, temperature sampling unit 20, first drive circuit 21 and second drive circuit 22 all are connected with main controller 10, and first drive circuit 21 and second drive circuit 22 all are connected with refrigeration piece 23.

The temperature sampling unit 20 is used for collecting the current temperature in the reaction tank 26 and transmitting the current temperature to the main controller 10.

The main controller 10 is configured to control the cooling plate 23 to heat through the first driving circuit 21 when the current temperature is lower than the target temperature, so as to raise the temperature in the reaction tank 26.

The main controller 10 is further configured to control the cooling plate 23 to cool through the second driving circuit 22 when the current temperature is greater than the target temperature, so as to reduce the temperature in the reaction tank 26.

Optionally, the first driving circuit 21 and the second driving circuit 22 may, but are not limited to, adopt an NMOS bridge driving circuit with an EG2104 chip as a core, and the 2 EG2104 chips may control the on and off of the 4 NMOS tubes, so as to control the heating and cooling of the working surface of the semiconductor electric cooling plate, and finally realize the temperature rise and temperature fall operation of the temperature control body.

The semiconductor electric refrigerating sheet adopts HT high-temperature series refrigerating sheets, is designed for harsh high-temperature environment and long-life application, is suitable for high-temperature environment, cold and heat circulation and application of industrial products, and has the maximum temperature difference of the cold and hot surfaces reaching 67 ℃. The two-wire semiconductor refrigerating sheet can switch the refrigeration or heating of the working surface only by switching the wire sequence or changing the electrifying direction.

In order to further know the working state and the working characteristics of the semiconductor refrigerating piece, the current sampling of the semiconductor refrigerating piece is added in the design. The sampling feedback circuit adopts 2 high-precision close-fit gold sampling resistors with 0.01 ohm to be connected in series in the working circuit of the semiconductor chilling plate, and the sampling feedback circuit sends the voltage difference to the MCU for AD sampling after the voltage is amplified by 100-fold and 300-fold, thereby providing reference for the whole working state monitoring of the system.

The temperature sampling unit 20 is used for measuring the current temperature of the controlled body in real time, thereby providing parameter data for implementing control. But not limited to, the temperature control range is 15-100 ℃, the temperature resolution of 0.15 ℃ can be realized through the processing circuit, and high-precision temperature control can be completed.

With continued reference to fig. 3, in one possible implementation, the slide processing system further includes: a communication interface module 24 and a display 25, wherein the display 25 is connected with the main controller 10 through the communication interface module 24.

The master controller 10 may transmit the current operating state to the display 25 via the communication interface module 24.

The display 25 is used for displaying the current operation state, which is convenient for the user to view.

Optionally, the current operation state may be, but is not limited to, the current temperature of the controlled object, the reagent capacity in the reaction tank, the current level of the cooling fins, and a fault indication.

In one possible implementation manner, the fragment processing system further comprises a power conversion circuit. The power conversion circuit can be composed of, but not limited to, an LM2596 buck conversion circuit, an MC7805CDTRKG chip and an ASM1117-3.3 chip.

Optionally, the LM2596 step-down converter circuit is used to convert the 24V power supply of the system input into +12V output, and then the +5V power supply is converted by the MC7805CDTRKG chip, and then the +3.3V power supply is converted by the ASM 1117-3.3. The +24V input power is mainly supplied to the system cooling fan 191, the swing motor 151, the motors of the first peristaltic pump 111 and the second peristaltic pump 112, the switch valve 121 (switch solenoid valve), the cabin door state monitoring device 18 and the like, the converted +12V is mainly used for supplying power to the display serial port screen, the driving chips of the first driving circuit 21 and the second driving circuit 22, the +5V power is mainly used for supplying power to the temperature sampling unit 20, the second position monitoring device 17, the first position monitoring device 16, the signal buffer chip and some other applied integrated ICs, and the +3.3V power is used for supplying power to the MCU controller. Considering the 24V power supply access terminal, a 7.62mm fence type connecting terminal can bear the maximum current of 15A, and 2 connecting terminals are connected in parallel to supply power to the whole system for reliable connection.

In one possible implementation, the main controller 10 is also configured to initiate a self-test after power-up, the self-test being configured to detect whether the various components of the slide processing system are functioning properly.

The main controller 10 is also used for alarming when the self-checking result indicates that any part can not normally operate.

After the system is powered on, initialization and system self-checking are completed firstly. The self-checking items comprise whether the swing limiting function of the reaction tank is normal, whether the working state of a motor of the peristaltic pump is normal, whether the temperature reading of the reaction tank is normal and the like. If the self-checking process is abnormal, the display screen can be popped up to display specific abnormal components, a user can check and overhaul the components, and the instrument is restarted to repeat the process after the overhaul is finished. After the self-checking is passed, the user inputs a password to enter the main interface, an experimental scheme can be set, the reaction tank is selected to carry out a pretreatment experiment, and in the experimental process, the user can pause or stop the experiment at any time and can also start the experiment continuously at any time.

Reagent adding, temperature control, liquid inlet and outlet and the like of the whole slide processing system all use the main controller 10 to issue control instructions, and only corresponding experimental schemes are required to be set for operation, so that full-automatic operation is basically realized, and time and labor cost are saved.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

It will be evident to those skilled in the art that the present application is not limited to the details of the foregoing illustrative embodiments, and that the present application may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the application being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. A slide processing system, comprising: the main controller is respectively connected with the peristaltic pump drive, the valve control device and the first flow monitoring device, the peristaltic pump drive is connected with the first peristaltic pump, a liquid inlet of the first peristaltic pump is communicated with at least one liquid inlet pipeline, each liquid inlet pipeline is provided with a switch valve, each liquid inlet pipeline is respectively connected with containers containing different reagents, a liquid outlet of the first peristaltic pump is communicated with a reaction tank through a liquid outlet pipeline, the first flow monitoring device is installed on a liquid outlet pipeline of the first peristaltic pump, and each switch valve is connected with the valve control device;

and the main controller is also used for transmitting a second driving instruction to the valve control device when the flow of the first reagent is greater than or equal to a preset first target flow, so that the valve control device controls the target switch valve to be closed and controls the first peristaltic pump to stop working at the same time.

2. The slide processing system of claim 1, further comprising: the second peristaltic pump is in driving connection with the peristaltic pump, the other end of a liquid inlet pipeline connected with a liquid inlet of the second peristaltic pump is arranged at the bottom of the reaction tank, a liquid outlet of the second peristaltic pump is communicated with the waste liquid tank through a liquid outlet pipeline, and the second flow monitoring device is arranged on the liquid outlet pipeline of the second peristaltic pump;

the main controller is used for controlling the second peristaltic pump to convey the reagent in the reaction tank to the waste liquid tank through the drive of the peristaltic pump when a liquid discharge request is received;

3. The slide processing system of claim 1, further comprising: the device comprises a swing motor drive, a swing motor and a swing arm, wherein the swing motor drive is respectively connected with the main controller and the swing motor, one end of the swing arm is in transmission connection with the swing motor, and the other end of the swing arm is connected with the reaction tank;

4. The slide processing system of claim 3, further comprising: the device comprises a shielding object, a first position monitoring device and a second position monitoring device, wherein the first position monitoring device and the second position monitoring device are both connected with the main controller, the shielding object swings along with the reaction tank, and the relative position of the shielding object and the reaction tank is fixed;

5. The slide processing system of claim 1, further comprising: the cabin door state monitoring device is connected with the main controller;

6. The slide processing system of claim 1, further comprising: the fan drive is connected with the main controller, and each fan is in drive connection with the fan;

the main controller is also used for controlling the fan to work through the fan drive after being electrified so as to dissipate heat of the slide processing system.

7. The slide processing system of claim 1, further comprising: the temperature sampling unit, the first driving circuit and the second driving circuit are all connected with the main controller, and the first driving circuit and the second driving circuit are all connected with the refrigerating sheet;

8. The slide processing system of claim 1, further comprising: the display is connected with the main controller through the communication interface module;

the main controller transmits the current running state to the display through the communication interface module;

9. The slide processing system of any of claims 1-8, wherein the main controller is further configured to initiate a self-test after power up, the self-test being configured to detect whether components of the slide processing system are functioning properly;

and the main controller is also used for alarming when the self-checking result indicates that any part cannot normally run.