CN217219619U - Nano-drug-loaded graphene patch - Google Patents
Nano-drug-loaded graphene patch Download PDFInfo
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- CN217219619U CN217219619U CN202122837089.5U CN202122837089U CN217219619U CN 217219619 U CN217219619 U CN 217219619U CN 202122837089 U CN202122837089 U CN 202122837089U CN 217219619 U CN217219619 U CN 217219619U
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Abstract
The utility model discloses a graphite alkene cloth of pasting of load nanometer medicine belongs to medicine cloth technical field, and its technical scheme main points are: the graphene heating layer comprises a substrate layer and a graphene heating layer; the graphene heating layer comprises a plurality of graphene heating components, and the top surface of the graphene heating layer is bonded with an adhesive laminating layer; the top surface of the viscous attaching layer is bonded with a drug loading layer, and the drug loading layer is loaded with nano-drugs; the basal layer is provided with a groove in a penetrating way, the top surface of the groove is rotationally connected with a cover plate, the end part of the cover plate is clamped with the basal layer, and the outer wall surface of the cover plate is provided with a hot compress switch; a micro battery, a microcontroller and a micro temperature monitor are detachably mounted in the groove. The utility model discloses mainly used accelerates the diffusion and the release of medicine, can effectively shorten the recovery time at patient's focus position, can also heat the part of difference at different periods to can effectively avoid producing uncomfortable sense because of local heating time is too long, and effectively alleviate patient's misery.
Description
Technical Field
The utility model relates to a medicine pastes cloth technical field, especially relates to a graphite alkene pastes cloth of load nanometer medicine.
Background
The plaster therapy is a unique traditional Chinese medicine external therapy in the traditional Chinese medicine, has been for two thousand years, is a therapy which utilizes the medicine to be applied to the body surface or the affected part of a patient, and plays the functions of promoting blood circulation, removing blood stasis, promoting granulation, relieving pain, dredging the channels, inducing resuscitation, penetrating bones, expelling wind and removing cold by means of the absorption of the medicine by the body surface and the channels and collaterals, thereby achieving various treatment effects.
The plaster therapy by using the patch mainly depends on the diffusion effect of the medicine, and the medicine molecules are diffused into the focus, so that the main problems exist at present that the diffusion speed is slow, and the medicine effect cannot be exerted quickly; and when the common hot compress patch is used, discomfort is easily felt due to local overhigh temperature and air impermeability.
In order to solve the problems, a graphene patch loaded with a nano-drug is provided on the basis of the prior art.
Disclosure of Invention
The utility model aims at providing a graphite alkene pastes cloth of load nanometer medicine, the graphite alkene zone of heating in the device can distribute the heat, when using the subsides cloth at the focus position, helps reducing the nervous excitability of this position sense of pain, improves blood circulation, accelerates the diffusion and the release of medicine, can effectively shorten the recovery time of patient's focus position; meanwhile, the graphene heating layer of the device can heat different parts at different time intervals, so that discomfort caused by too long local heating time can be effectively avoided; in addition, the device is ventilative, carry and use convenient, can effectively alleviate patient's misery.
The above technical purpose of the present invention can be achieved by the following technical solutions:
a graphene patch loaded with nano-drugs comprises a basal layer and a graphene heating layer fixedly connected to the top surface of the basal layer; the graphene heating layer comprises a plurality of graphene heating components, and an adhesive laminating layer is bonded on the top surface of the graphene heating layer; a drug loading layer is bonded on the top surface of the adhesive laminating layer, and the drug loading layer is loaded with nano-drugs; the base layer, the graphene heating layer and the adhesive laminating layer are all provided with a plurality of air holes in a penetrating mode; the base layer is provided with a groove in a penetrating mode, the top surface of the groove is rotatably connected with a cover plate, the end part of the cover plate is clamped with the base layer, and the outer wall surface of the cover plate is provided with a hot compress switch; a micro battery, a microcontroller and a micro temperature monitor are detachably mounted in the groove; the hot compress switch, the micro-battery, the miniature temperature monitoring meter and the plurality of graphene heating assemblies are all connected with the microcontroller.
By adopting the technical scheme, the basal layer is utilized, and the graphene heating layer and the drug loading layer are favorably arranged; the graphene heating layer is utilized, on one hand, the graphene heating layer is beneficial to releasing far infrared rays with the wavelength of 6-14 microns when the graphene is heated, the far infrared rays are almost consistent with the far infrared spectrum of a human body, and have various biological effects of expanding blood capillaries, increasing tissue blood flow, enhancing metabolic repair, adjusting organism unbalance and the like, cells can be subjected to a series of active biochemical and histochemical changes, so that drug absorption can be effectively promoted, arthralgia can be relieved, the immune function of the human body can be improved, and the human body can be in a good health state; on the other hand, the heat that graphite alkene gived off helps promoting the medicine diffusion velocity, makes the medicine can be very fast to play a role to can effectively alleviate patient's misery.
The plurality of graphene heating assemblies are utilized, so that local heating can be performed in batches and at different time periods according to actual conditions, and discomfort caused by long-time heating or fixed-position heating can be effectively avoided; utilize viscidity laminating layer, help connecting medicine load layer and graphite alkene zone of heating.
The utilization of the nano-drug is beneficial to improving the bioavailability, the specific surface area of the nano-carrier is high, the solubility of the drug with poor water solubility in the nano-carrier is relatively enhanced, and the problem that the preparation cannot be prepared by a conventional method can be overcome; the nano carrier can also be made into a targeting positioning system, so that the dosage of the medicament can be effectively reduced, the side effect can be reduced, and the limitation of biological barriers on the medicament effect can be eliminated; the medicine loading layer is beneficial to loading nano medicine, so that the medicine can gradually permeate into the skin through the graphene patch covering the surface of the body and can be internally transmitted to meridians and collaterals and viscera, and the effects of regulating qi and blood, dredging meridians and collaterals, dispelling cold and dampness, eliminating swelling and pain and the like are achieved.
The ventilation holes are utilized, so that the ventilation function can be realized by using the graphene sticking cloth, and discomfort of a patient caused by the graphene sticking cloth loaded with the medicine can be effectively avoided; the groove is utilized to facilitate the installation of the micro battery, the microcontroller and the micro temperature monitor, and the micro battery, the microcontroller and the micro temperature monitor are all detachable and recyclable; the use of the cover plate helps to maintain the stability of the device within the recess. The micro battery is utilized to supply energy to a plurality of groups of graphene heating assemblies, a microcontroller and other devices; the micro temperature monitor is used for monitoring the temperature of the attached cloth and transmitting a signal to the microcontroller; utilize microcontroller, help according to presetting, control the graphite alkene heating element that carries out work to same period to can effectively promote diffusion and the infiltration of medicine through control this period graphite alkene heating element's quantity and distribution, and can make the patient obtain comfortable experience and feel.
By adopting the scheme, when the patch is used at the focus part, the excitability of pain nerve of the part can be reduced, the blood circulation can be improved, the diffusion and the release of the medicine can be accelerated, and the recovery time of the focus part of a patient can be effectively shortened; meanwhile, the graphene heating layer of the device can heat different parts at different time intervals, so that discomfort caused by too long local heating time can be effectively avoided; in addition, the device is ventilative, carry and use convenient, can effectively alleviate patient's treatment misery.
The utility model discloses further set up to: the number of the graphene heating assemblies is at least 7.
Through adopting above-mentioned technical scheme, utilize graphite alkene heating element to be 7 at least, help comparatively comprehensive distribution on the graphite alkene pastes cloth that covers the nanometer medicine to can effectively promote diffusion and the infiltration of medicine.
The utility model discloses further set up to: the adhesive bonding layer has an average thickness of less than 5 μm and a total viscosity of 10 to 100 gf/in.
By adopting the technical scheme, the adhesive bonding layer has the average thickness lower than 5 mu m and the total viscosity of 10-100 gf/in, so that the adhesive bonding layer is helpful for firmly bonding the patch around a focus and avoiding pain when tearing off the patch.
The utility model discloses further set up to: one side of the sticky laminating layer, which is attached to the drug loading layer, comprises a substrate, 1 rectangular sticky group and a plurality of strip-shaped sticky groups, wherein the area of each rectangular sticky group is the same as that of the drug loading layer.
By adopting the technical scheme, the rectangular adhesive groups are utilized, so that the graphene heating layer and the drug loading layer which are distributed on two sides can be firmly attached; the strip-shaped adhesive layer is beneficial to realizing the ventilation function while stabilizing the cloth pasting position, so that the treatment pain of a patient can be effectively relieved.
The utility model discloses further set up to: the top surface of the drug loading layer is covered with a film coating layer, and the film coating layer is openable.
By adopting the technical scheme, the film coating layer is utilized, so that the cleanness of the medicine surface of the nano-medicine-loaded graphene patch can be kept when the graphene patch is not used, the medicine diffusion can be prevented, and the reduction of curative effect caused by the problems of cleanness and medicine diffusion can be effectively avoided.
To sum up, the utility model discloses following beneficial effect has: the graphene heating layer in the device can emit heat, and when the patch is used at a focus part, the graphene heating layer is beneficial to reducing the excitability of pain nerve of the part, improving blood circulation, accelerating the diffusion and release of medicines, and can effectively shorten the recovery time of the focus part of a patient; meanwhile, the graphene heating layer of the device can heat different parts at different time intervals, so that discomfort caused by too long local heating time can be effectively avoided; in addition, the device is ventilative, carry and use convenient, can effectively alleviate patient's misery.
Drawings
FIG. 1 is a schematic cross-sectional view of an embodiment of the present invention;
fig. 2 is a schematic top view of an embodiment of the present invention;
fig. 3 is a schematic bottom view of the embodiment of the present invention;
fig. 4 is a schematic structural diagram of an adhesive bonding layer according to an embodiment of the present invention;
fig. 5 is a schematic view of a partial structure of a graphene heating layer according to an embodiment of the present invention.
In the figure: 1. a base layer; 2. a graphene heating layer; 3. a graphene heating assembly; 4. an adhesive bonding layer; 5. a drug-loaded layer; 6. nano-drugs; 7. air holes are formed; 8. a groove; 9. covering a plywood; 10. a hot compress switch; 11. a micro battery; 12. a microcontroller; 13. a micro temperature monitor; 14. a rectangular adhesive set; 15. a strip-shaped adhesive group; 16. a film coating layer; 17. a substrate.
Detailed Description
The invention will be described in further detail with reference to the following drawings and embodiments:
example (b): a nano-drug loaded graphene patch is shown in figures 1 to 5 and comprises a substrate layer 1 and a graphene heating layer 2 fixedly connected to the top surface of the substrate layer 1; the basal layer 1 is utilized to facilitate the arrangement of the graphene heating layer 2 and the drug loading layer 5; the graphene heating layer 2 is utilized, on one hand, the graphene heating layer is beneficial to releasing far infrared rays with the wavelength of 6-14 microns when the graphene is heated, the far infrared rays are almost consistent with the far infrared spectrum of a human body, and have various biological effects of expanding blood capillaries, increasing tissue blood flow, enhancing metabolic repair, adjusting organism unbalance and the like, cells can be subjected to a series of active biochemical and histochemical changes, so that drug absorption can be effectively promoted, arthralgia can be relieved, the immune function of the human body can be improved, and the human body can be in a good health state; on the other hand, the heat that graphite alkene gived off helps promoting the medicine diffusion rate, makes the medicine can be very fast to play the effect to can effectively alleviate patient's misery.
The top surface of graphite alkene zone of heating 2 bonds has viscidity laminating 4, utilizes viscidity laminating 4, helps connecting medicine load layer 5 and graphite alkene zone of heating 2. The average thickness of the adhesive bonding layer 4 is 5 mu m, and the total viscosity of the adhesive bonding layer 4 is 70gf/in, so that the patch can be firmly bonded around a focus, and the patch can be torn off to avoid pain; one side of the adhesive laminating layer 4, which is laminated with the drug loading layer 5, comprises a substrate 17, 1 rectangular adhesive group 14 and 12 strip-shaped adhesive groups 15, the area of the rectangular adhesive group 14 is the same as that of the drug loading layer 5, and the rectangular adhesive group 14 is utilized to facilitate firm lamination of the graphene heating layer 2 and the drug loading layer 5 which are distributed on two sides; the strip-shaped adhesive layer is beneficial to stabilizing the cloth sticking position and assisting in realizing the ventilation function so as to effectively relieve the treatment pain of the patient.
The top surface of the adhesive attaching layer 4 is bonded with a drug loading layer 5, the drug loading layer 5 is a fibroin protein layer, and the drug loading layer 5 is utilized to be beneficial to loading nano-drugs, so that the drugs can gradually permeate into the skin through the graphene attaching cloth covering the surface of the body and are transmitted to meridians and viscera, thereby playing the roles of regulating qi and blood, dredging meridians, dispelling cold and dampness, eliminating swelling and pain and the like. The fibroin protein layer is loaded with nano-drugs; the utilization of the nano-drug 6 is beneficial to improving the bioavailability, the specific surface area of the nano-carrier is high, the solubility of the drug with poor water solubility in the nano-carrier is relatively enhanced, and the problem that the preparation cannot be prepared by a conventional method can be overcome; the nano carrier can also be prepared into a targeting positioning system, so that the dosage of the medicament can be effectively reduced, the side effect can be reduced, and the limitation of biological barriers on the action of the medicament can be eliminated.
Stratum basale 1, graphite alkene zone of heating 2 and viscidity laminating layer 4 all run through and are equipped with a plurality of bleeder vents 7, utilize bleeder vents 7 to can realize ventilation function using graphite alkene cloth, can effectively avoid the patient because of the discomfort that the graphite alkene cloth of load medicine produced. The substrate layer 1 is provided with a groove 8 in a penetrating manner, the groove 8 is used for facilitating installation of a micro battery 11, a micro controller 12 and a micro temperature monitor 13, and the micro battery 11, the micro controller 12 and the micro temperature monitor 13 are all detachable and recyclable; the 8 top surfaces of the grooves are rotatably connected with a cover plate 9, the end parts of the cover plate 9 are clamped with the substrate layer 1, and the cover plate 9 is utilized to help to keep the stability of the device in the grooves 8.
The outer wall surface of the cover plate 9 is provided with a hot compress switch 10; a micro battery 11, a microcontroller 12 and a micro temperature monitor 13 are detachably arranged in the groove 8; the hot compress switch 10, the micro battery 11, the micro temperature monitor 13 and the plurality of graphene heating assemblies 3 are all connected with the microcontroller 12, and the micro battery 11 is utilized to contribute to energy supply for a plurality of groups of graphene heating assemblies 3, the microcontroller 12 and other devices; the micro temperature monitor 13 is used for monitoring the temperature of the sticking cloth and transmitting signals to the microcontroller 12; by utilizing the microcontroller 12, the graphene heating assemblies 3 which work at the same time interval can be controlled according to the preset value, so that the diffusion and permeation of the medicine can be effectively promoted by controlling the number and distribution of the graphene heating assemblies 3 at the time interval, and the comfortable experience of the patient can be obtained.
The top surface of the drug loading layer 5 is covered with the film coating layer 16, and the film coating layer 16 is openable, so that the film coating layer 16 is beneficial to keeping the drug surface of the nano-drug loaded graphene sticking cloth clean when not in use, preventing drug diffusion and effectively avoiding the reduction of curative effect caused by the problems of cleaning and drug diffusion.
The working principle is as follows: when the nano-drug loaded graphene patch is used, the drug loading layer 5 faces the skin and is attached to the skin, the hot compress switch 10 is turned on, the controller controls the graphene heating assemblies 3 in the graphene heating layer 2, so that the plurality of graphene heating assemblies 3 are heated in different regions at different time periods, blood circulation can be effectively improved, and diffusion and release of drugs can be accelerated; and the stratum basale 1, graphite alkene zone of heating 2 and the medicine load layer 5 of the device all are equipped with bleeder vent 7, help realizing ventilative function.
In the above embodiment of the present invention, the graphene heating layer 2 in the device can emit heat, which is helpful to reduce excitability of pain nerve at the focus, improve blood circulation, accelerate diffusion and release of drugs, and effectively shorten recovery time of the focus of the patient when the patch is used at the focus; meanwhile, the graphene heating layer 2 of the device can heat different parts at different time intervals, so that discomfort caused by too long local heating time can be effectively avoided; in addition, the device is ventilative, carry and use convenient, can effectively alleviate patient's misery.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications to the present embodiment without inventive contribution as required after reading the present specification, but all of them are protected by patent laws within the scope of the claims of the present invention.
Claims (5)
1. A graphene patch loaded with nano-drugs is characterized in that: the graphene heating layer comprises a substrate layer (1) and a graphene heating layer (2) fixedly connected to the top surface of the substrate layer (1); the graphene heating layer (2) comprises a plurality of graphene heating components (3), and an adhesive laminating layer (4) is bonded on the top surface of the graphene heating layer (2); a drug loading layer (5) is bonded on the top surface of the adhesive laminating layer (4), and the drug loading layer (5) is loaded with a nano-drug (6); the base layer (1), the graphene heating layer (2) and the adhesive laminating layer (4) are provided with a plurality of air holes (7) in a penetrating manner; the base layer (1) is provided with a groove (8) in a penetrating manner, the top surface of the groove (8) is rotatably connected with a cover plate (9), the end part of the cover plate (9) is clamped with the base layer (1), and the outer wall surface of the cover plate (9) is provided with a hot compress switch (10); a micro battery (11), a microcontroller (12) and a micro temperature monitor (13) are detachably arranged in the groove (8); hot compress switch (10), microbattery (11), miniature temperature monitor (13) and a plurality of graphite alkene heating element (3) all link to each other with microcontroller (12).
2. The nano-drug loaded graphene patch according to claim 1, wherein the nano-drug loaded graphene patch is characterized in that: the number of the graphene heating assemblies (3) is at least 7.
3. The nano-drug loaded graphene patch according to claim 1, wherein: the adhesive bonding layer (4) has an average thickness of less than 5 [ mu ] m, and the total viscosity of the adhesive bonding layer (4) is 10 to 100 gf/in.
4. The nano-drug loaded graphene patch according to claim 1, wherein: one side that sticky laminating layer (4) and drug loading layer (5) were laminated includes substrate (17), 1 rectangle viscidity group (14) and a plurality of bar viscidity group (15), the area of rectangle viscidity group (14) with the area of drug loading layer (5) is the same.
5. The nano-drug loaded graphene patch according to claim 1, wherein: the top surface of the drug loading layer (5) is covered with a film coating layer (16), and the film coating layer (16) is openable.
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| CN202122837089.5U CN217219619U (en) | 2021-11-18 | 2021-11-18 | Nano-drug-loaded graphene patch |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159413A (en) * | 2021-11-18 | 2022-03-11 | 中国人民解放军总医院第一医学中心 | Nano-drug-loaded graphene patch |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159413A (en) * | 2021-11-18 | 2022-03-11 | 中国人民解放军总医院第一医学中心 | Nano-drug-loaded graphene patch |
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