CN217212484U

CN217212484U - Desalination device of chromatogram-mass spectrum antithetical couplet usefulness

Info

Publication number: CN217212484U
Application number: CN202123446036.7U
Authority: CN
Inventors: 钟新林; 方洁
Original assignee: Zhongke Puyan Guangzhou Testing Co ltd
Current assignee: Zhongke Puyan Guangzhou Testing Co ltd
Priority date: 2021-12-30
Filing date: 2021-12-30
Publication date: 2022-08-16
Anticipated expiration: 2031-12-30

Abstract

The utility model discloses a desalination device combining chromatography and mass spectrometry, which comprises a desalination device main body, wherein a power source, a control system and a membrane desalination device are arranged in the desalination device main body; the membrane desalting device is used for removing salt in the separation liquid; the power source is used for providing a regeneration water source for desalination to the membrane desalination device; the control system is connected with the control power source and the membrane desalination device; the power source is connected with the membrane desalination device through a pipeline; the utility model discloses can let the desalination work last and the efficient goes on, the desalination effect is more high-efficient, and the specially adapted high salt mobile phase or sample are in the desalination work before getting into the mass spectrum.

Description

Desalination device of chromatogram-mass spectrum antithetical couplet usefulness

Technical Field

The utility model relates to a detection and analysis field, concretely relates to desalination device that chromatogram-mass spectrum allies oneself with.

Background

The basic working principle of the chromatography-mass spectrometry combination is that a chromatogram is used as a sample feeding system of a mass spectrum, complex chemical components are separated to form a separation flow, and then the mass spectrum is used as a detector to perform quantitative and qualitative analysis on the separation flow.

Among them, chromatography, which is a separation analysis method, is most characterized in that a complex mixture is separated into respective related components and then individually detected. In general, in the chromatographic process, different components are exchanged between two phases which are relatively moving and immiscible, one phase which is relatively static is called a stationary phase, the other phase which is relatively moving is called a mobile phase, and the different components are separated by mass exchange between the two phases continuously and repeatedly by utilizing the tiny differences of properties such as adsorption, distribution, ion exchange, affinity or molecular size.

The basic principle of mass spectrometry is to analyze the mass-to-charge ratio of ionized sample to realize qualitative and quantitative analysis of the tested compound. When a sample to be detected enters a mass spectrometer, in an ion source of the mass spectrometer, a compound is bombarded by ions to ionize into molecular ions and fragment ions, the ions are in a mass analyzer, due to different mass-to-charge ratios and different motion tracks, signals amplified through the detection of an electron multiplier tube are transmitted to a display, and a complete mass spectrogram is displayed.

However, in the existing chromatography, salt mobile phase is often used, but the mass spectrometer detector is not compatible with non-volatile salts. Conventional chromatography-mass spectrometry combinations encounter non-volatile salts such as phosphates in the mobile phase, and can only be desalted by mobile phase inversion using two-dimensional chromatography, but the desalting is intermittent and requires ring collection and then re-entry into a second mass-compatible mobile phase system for separation, with the salts not remaining and being stripped off. Therefore, the work is intermittent work and non-continuous work. Only a fraction of the peak is collected into the mass spectrum in a short time and is not available for components that are not or weakly retained on the reverse phase chromatography column.

SUMMERY OF THE UTILITY MODEL

The utility model discloses an it is not enough to overcome above-mentioned condition, aims at providing the technical scheme that can solve above-mentioned problem.

A chromatography-mass spectrometry combined desalting device comprises a desalting device main body, wherein a power source, a control system and a membrane desalting device are arranged in the desalting device main body; the membrane desalination device is used for removing salt in the separation liquid; the power source is used for providing a regenerated water source for desalination to the membrane desalination device; the control system is connected with and controls the power source and the membrane desalination device; the power source is connected with the membrane desalination device through a pipeline.

Further, a first interface is arranged on one side of the membrane desalination device and used for connecting a chromatographic column; and a second interface is also arranged on the other side of the membrane desalination device and used for connecting a mass spectrum.

Further, a third interface is also arranged on the membrane desalination device; the third interface is used for connecting a water outlet of the power source; and a fourth interface is further arranged on the membrane desalting device and used for discharging salt-containing waste liquid.

Further, the third interface is close to the second interface; the fourth interface is proximate to the first interface.

Further, the membrane desalination device also comprises an electrolytic membrane suppressor.

Further, the electrolytic membrane suppressor comprises an anionic electrolytic membrane suppressor and a cationic electrolytic membrane suppressor, which are respectively used for removing the salt components with negative charges and the salt components with positive charges in the separation liquid.

Furthermore, the power source is a small-flow peristaltic pump, and the peristaltic pump comprises a water outlet and a water inlet.

Further, the regenerated water source is pure water.

Further, the control system comprises a flow rate control system and a current control system.

Furthermore, the flow rate control system comprises a flow rate display screen and a flow rate adjusting button which are respectively used for displaying and adjusting the flow rate of the liquid of the power source; the current control system comprises a current display screen and a current adjusting button which are respectively used for displaying and adjusting the current of the membrane desalination device.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses in chromatogram-mass spectrum allies oneself with demineralizer of antithetical couplet, can realize the desorption that lasts through the electrolyte membrane inhibitor and have the salt composition of electric charge, not only solved the problem that original two-dimentional desalination system is interrupted work, and can make the part do not have the component that remains in the reversed phase chromatographic column and also can advance to the mass spectrum and carry out the analysis.

2. The utility model discloses in chromatogram-mass spectrum allies oneself with demineralizer of antithetical couplet, come to the salt composition desorption work of different concentrations through the velocity of flow of setting for not equidimension electrolytic film inhibitor electric current and peristaltic pump, let the desalination work have more corresponding, also more high-efficient.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the description below are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without inventive labor.

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic view of the flow structure of the present invention.

In the figure:

1. a desalination apparatus main body;

2. a power source; 21. a water outlet; 22. a water inlet;

3. a control system; 31. a flow rate control system; 32. a current control system; 311. a flow rate display screen; 312. a flow rate adjustment button; 321. a current display screen; 322. a current adjustment button;

4. a membrane desalination unit; 41. a first interface; 42. a second interface; 43. a third interface; 44. a fourth interface; 45. an electrolytic film suppressor; 451. an anionic electrolyte membrane suppressor; 452. cation electrolytic membrane suppressor.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it should be understood that the described embodiments are only some embodiments of the present invention, but not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-2, in an embodiment of the present invention, a chromatography-mass spectrometry combined desalination apparatus includes a desalination apparatus main body 1, wherein a power source 2, a control system 3, and a membrane desalination apparatus 4 are disposed in the desalination apparatus main body 1; the membrane desalting device 4 is used for removing salt in the separation liquid; the power source 2 is used for providing a regeneration water source for desalination to the membrane desalination device 4; the control system 3 is connected with the control power source 2 and the membrane desalination device 4; the power source 2 is connected with the membrane desalination device 4 through a pipeline.

Specifically, in some embodiments, the membrane desalination device 4 can isolate and remove a large amount of charged salt components under the action of the driving power supply, and allow other components of the separation solution to pass through and enter the mass spectrum to be detected; the salt component separated and removed is dissolved in a regeneration water source provided by the power source 2 to form waste liquid and is discharged; the control system 3 plays a role in control and monitoring, and can accurately control the process of removing the salt components and the removal effect of the salt components.

One side of the membrane desalination device 4 is provided with a first interface 41, and the first interface 41 is used for connecting a chromatographic column; the other side of the membrane desalination device 4 is further provided with a second interface 42, and the second interface 42 is used for connecting a mass spectrum.

Specifically, the chromatographic separation stream in the chromatographic column flows into the membrane desalination device 4 through the first interface 41 for desalination, and the separation stream after desalination flows into the mass spectrometer through the second interface 42 for quantitative and qualitative analysis.

In particular, the first port 41 and the second port 42 should be located on opposite sides of the first port

The membrane desalination device 4 is also provided with a third interface 43; the third interface 43 is used for connecting the water outlet 21 of the power source 2; the membrane desalination device 4 is further provided with a fourth interface 44, and the fourth interface 44 is used for discharging the salt-containing waste liquid.

The third port 43 is close to the second port 42; the fourth interface 44 is close to the first interface 41.

Specifically, in some embodiments, the flow of the desalter regeneration water source is opposite to the flow of the chromatographic separation stream, so that the desalting can be performed better, the efficiency is higher, and the salt component can be removed more completely.

The membrane desalination device 4 further comprises an electrolytic membrane suppressor 45.

The electrolytic membrane suppressor 45 includes an anionic electrolytic membrane suppressor 451 and a cationic electrolytic membrane suppressor 452 for removing a negatively charged salt component and a positively charged salt component from the separated liquid, respectively.

The power source 2 is a small flow peristaltic pump, which includes a water outlet 21 and a water inlet 22.

Specifically, in some embodiments, the peristaltic pump is easier to control and adjust, has a small and precise flow rate, facilitates precise control, and meets the working and using requirements of precise desalination.

The regeneration water source is pure water.

Particularly, the pure water contains few impurities such as mineral substances and the like, so that the desalting effect is better, and more salt components can be dissolved and removed by the pure water with the same volume; on the other hand, the method can also avoid the influence of foreign impurities on the detection result due to the fact that the foreign impurities enter the mass spectrum along with the separation flow, and reduce the influence of external adverse factors on the detection result.

The control system 3 includes a flow rate control system 31 and a current control system 32.

The flow rate control system 31 comprises a flow rate display screen 311 and a flow rate adjusting button 312, which are respectively used for displaying and adjusting the flow rate of the liquid of the power source 2; the current control system 32 includes a current display 321 and a current adjustment button 322 for displaying and adjusting the current level of the membrane desalination apparatus 4.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims

1. A chromatography-mass spectrometry combined desalting device comprises a desalting device main body, and is characterized in that a power source, a control system and a membrane desalting device are arranged in the desalting device main body; the membrane desalting device is used for removing salt in the separation liquid; the power source is used for providing a regenerated water source for desalination to the membrane desalination device; the control system is connected with and controls the power source and the membrane desalination device; the power source is connected with the membrane desalination device through a pipeline.

2. The chromatography-mass spectrometry desalting device as claimed in claim 1, wherein a first interface is provided at one side of the membrane desalting device, and the first interface is used for connecting a chromatographic column; and a second interface is also arranged on the other side of the membrane desalination device and used for connecting a mass spectrum.

3. The chromatography-mass spectrometry desalting device as claimed in claim 2, wherein a third interface is further provided on the membrane desalting device; the third interface is used for connecting a water outlet of the power source; and a fourth interface is further arranged on the membrane desalting device and used for discharging salt-containing waste liquid.

4. The desalinization apparatus for chromatography-mass spectrometry of claim 3, wherein the third interface is proximate to the second interface; the fourth interface is proximate to the first interface.

5. The chromatography-mass spectrometry desalting apparatus according to claim 1, wherein said membrane desalting apparatus further comprises an electrolytic membrane suppressor.

6. The chromatography-mass spectrometry desalting apparatus according to claim 5, wherein said electrolyte membrane suppressor comprises an anionic electrolyte membrane suppressor and a cationic electrolyte membrane suppressor for removing a negatively charged salt component and a positively charged salt component from the separated liquid, respectively.

7. The chromatography-mass spectrometry desalination apparatus as claimed in claim 1, wherein the power source is a small-flow peristaltic pump, and the peristaltic pump comprises a water outlet and a water inlet.

8. The desalination apparatus for chromatography-mass spectrometry of claim 1, wherein the source of regenerated water is pure water.

9. The chromatography-mass spectrometry desalting apparatus according to claim 1, wherein said control system comprises a flow rate control system and a current control system.

10. The desalination apparatus for chromatography-mass spectrometry of claim 9, wherein the flow rate control system comprises a flow rate display screen and a flow rate adjustment button for displaying and adjusting the flow rate of the liquid in the power source; the current control system comprises a current display screen and a current adjusting button which are respectively used for displaying and adjusting the current of the membrane desalination device.