CN217180602U

CN217180602U - Temperature control system for sample analyzer and sample analyzer

Info

Publication number: CN217180602U
Application number: CN202123357242.0U
Authority: CN
Inventors: 肖擎国; 练子富; 李临
Original assignee: Kemei Boyang Diagnostic Technology Shanghai Co ltd
Current assignee: Kemei Boyang Diagnostic Technology Shanghai Co ltd
Priority date: 2021-12-29
Filing date: 2021-12-29
Publication date: 2022-08-12
Anticipated expiration: 2031-12-29

Abstract

The utility model provides a temperature control system for sample analyzer, temperature control system includes: the incubation disc comprises an incubation disc body, wherein different working positions are sequentially distributed at intervals along the circumferential direction of the incubation disc body, and baffles are correspondingly arranged on the radial inner sides of the different working positions respectively; the reaction cup groove is used for suspending a reaction cup; a gas bath cavity formed in the incubation disc body, wherein the reaction cup is suspended in the gas bath cavity; wherein the air bath cavity is constructed to heat the air inside the air bath cavity to a preset temperature and keep the air at a constant temperature, and the heated air can be uniformly distributed to each reaction cup, so that constant temperature conditions are provided for the reaction cups. The utility model also provides a sample analyzer.

Description

Temperature control system for sample analyzer and sample analyzer

Technical Field

The utility model belongs to the technical field of the check out test set, concretely relates to a temperature control system for sample analyzer. The utility model discloses still relate to a sample analyzer.

Background

A sample analyzer is an instrument for performing diagnostic analysis on a sample to be measured, and generally includes a biochemical analyzer, an immunoassay analyzer (chemiluminescence analyzer), and the like. In order to obtain a detection signal, the liquid in the cuvette is usually subjected to a specific reaction, such as a biochemical reaction, an immunological reaction. This reaction generally needs to be carried out under a predetermined temperature condition, and therefore, the temperature control is extremely high. The incubation tray is an important component of the sample analyzer that carries the reaction cups and provides isothermal reaction conditions for the reaction cups. Therefore, temperature control of the incubation plate appears to be very important.

In the course of incubation in the incubation tray, if the reaction temperature does not meet the prescribed temperature, the reaction does not proceed sufficiently and a correct detection signal cannot be obtained. The existing incubation disc is internally provided with a whole circle of baffle plates, and the baffle plates are used for preventing the reaction cups from extending out of the reaction cup grooves and have a heat conduction effect to a certain extent. However, such baffles also affect the uniform distribution of temperature and cause non-uniform temperature rise, thereby reducing the accuracy of temperature control within the incubation plate.

SUMMERY OF THE UTILITY MODEL

To the technical problem as above, the utility model aims at providing a temperature control system for sample analysis appearance, this temperature control system can guarantee that the temperature of hatching the dish is undulant at the within range of regulation all the time, makes temperature distribution more even to for the reaction of reaction cup provides the constant temperature condition, be favorable to very much improving the control accuracy to hatching the dish internal temperature.

To this end, according to a first aspect of the present invention, there is provided a temperature control system for a sample analyzer, the temperature control system comprising: the incubation disc comprises an incubation disc body, wherein different working positions are sequentially distributed at intervals along the circumferential direction of the incubation disc body, and baffles are correspondingly arranged on the radial inner sides of the different working positions respectively; the reaction cup groove is used for suspending a reaction cup; a gas bath cavity formed in the incubation disc body, wherein the reaction cup is suspended in the gas bath cavity; wherein the air bath cavity is constructed to heat the air inside the air bath cavity to a preset temperature and keep the air at a constant temperature, and the heated air can be uniformly distributed to each reaction cup, so that constant temperature conditions are provided for the reaction cups.

In one embodiment, the incubation disc body comprises a cylindrical side plate and a bottom plate, wherein a cup inlet and a cup abandoning opening in different working positions are distributed on the cylindrical side plate at intervals along the circumferential direction, a reaction cup is horizontally pushed into the reaction cup groove from the cup inlet, and the incubation disc body is horizontally pushed out from the cup abandoning opening.

In one embodiment, a through hole is formed in the center of the bottom plate, the through hole is used for a rotating shaft to pass through, a rotating disc is fixed at one end of the rotating shaft, which is located in the incubation disc body, and the dispensing disc is fixedly connected with the rotating disc, so that the rotating shaft can drive the dispensing disc to rotate through the rotating disc.

In one embodiment, the air bath chamber comprises a heating plate disposed on the bottom plate for heating the air in the air bath chamber to a predetermined temperature and a plurality of fans disposed on the heating plate for uniformly distributing the heated air to the reaction cup wells.

In one embodiment, a plurality of the fans are evenly circumferentially spaced apart.

In one embodiment, a base is provided at the bottom of the fan, which base allows the fan to be tilted.

In one embodiment, the working position further comprises a sample adding position, a detection position and a reagent adding position which are sequentially distributed along the circumferential direction, and the sample adding position and the reagent adding position are positions which are at fixed angles relative to the cup inlet.

In one embodiment, the detection position is configured as a protruding platform formed on the incubation tray body, the protruding platform is used for installing a detection unit, and a reaction cup to be detected is positioned below the detection unit.

In one embodiment, an inner cover plate and an outer cover plate arranged above the inner cover plate are provided at the open end of the incubation tray body.

In one embodiment, the incubation disc body and the inner cover plate are made of metal and the outer cover plate is made of plastic. Preferably, the incubation disc body and the inner cover plate are made of aluminum.

In one embodiment, the outer peripheral surface of the cylindrical side plate is provided with an outer shell, and an insulating layer is arranged between the outer shell and the cylindrical side plate.

According to a second aspect of the present invention, a sample analyzer is provided, comprising the temperature control system as described above.

In one embodiment, the sample analyzer is a chemiluminescence analyzer, in particular a light-activated chemiluminescence analyzer.

Compared with the prior art, the method has the advantages that:

according to the utility model discloses a temperature control system for sample analysis appearance can heat the air of gas bath intracavity to predetermined temperature through the heating plate to keep constant temperature, can make the air after the heating evenly spread the position department in reaction cup groove simultaneously, thereby provide the constant temperature condition for the reaction cup. Use according to the utility model discloses a temperature control system can ensure the accuracy that sample analysis appearance detected. The baffle can prevent the reaction cup from deviating from the preset position at the corresponding working position due to the prior rotation of the dispensing disc, thereby effectively preventing the reaction cup from shaking at the working position. Through setting the baffle to the mode that the circumference interval distributes to and through the fan air supply heat dissipation, be favorable to guaranteeing to heat up evenly, improved greatly and hatched the control accuracy of interior temperature of dish. In addition, the temperature control system has small volume, compact structure and convenient operation.

Drawings

The present invention will be described with reference to the accompanying drawings.

Fig. 1 schematically shows the structure of a temperature control system (excluding a dispenser tray) for a sample analyzer according to the present invention.

Fig. 2 schematically shows the structure of the incubation tray body (excluding the detection site) in the temperature control system shown in fig. 1.

Fig. 3 is a cross-sectional view of the temperature control system shown in fig. 1 (without the rotating shaft).

Fig. 4 schematically shows the mounting structure of the inner deck.

Fig. 5 schematically shows a mounting structure of the outer cover plate.

In the present application, all the figures are schematic and are only intended to illustrate the principles of the present invention and are not drawn to scale.

Detailed Description

Fig. 1 schematically shows the structure of a temperature control system 100 for a sample analyzer according to the present invention. As shown in fig. 1, the temperature control system 100 includes an incubation disc body 1, a dispensing disc 9, different working positions sequentially spaced along the circumferential direction of the incubation disc body 1, and a gas bath cavity 10 formed in the incubation disc body 1. The work position includes into rim of a cup 11 and abandons rim of a cup 12, advances rim of a cup 11 and abandons rim of a cup 12 and distributes on hatching dish body 1 along circumference interval. The dispensing disc 9 is configured as a flat disc, a reaction cup groove (not shown) extending along the circumferential direction is arranged on the dispensing disc 9, the reaction cup 2 can be horizontally pushed into the reaction cup groove from the cup inlet 11, and the incubation disc body 1 can be horizontally pushed out from the cup abandoning opening 12. The radial inner sides of different working positions are respectively and correspondingly provided with a baffle 3. The reaction cup slot is used for hanging the reaction cup 2, so that the reaction cup 2 can be suspended in the air bath cavity 10. The air bath chamber 10 is constructed to heat the air therein to a predetermined temperature and maintain a constant temperature, and to uniformly distribute the heated air to the position of the cuvette tank, thereby providing a constant temperature condition for the cuvette 2. Constant temperature is here understood to be within a set temperature range.

The baffle plate not only ensures the positioning of the reaction cups at the working position and prevents the reaction cups from being misaligned with the corresponding operating units, but also guides the hot air, so that the hot air can form an annular air flow along the reaction cup groove by means of the baffle plate.

The temperature control system herein is intended to be installed in a sample analyzer (see below). In this application, it is noted that a sample analyzer is an apparatus for performing diagnostic analysis on a sample to be tested.

As shown in fig. 1 and 2, the incubation disc body 1 includes a cylindrical side plate and a bottom plate, and the cup inlet 11 and the cup abandoning 12 are circumferentially distributed on the cylindrical side plate at intervals and both are configured as open grooves penetrating through the cylindrical side plate. The reaction cup 2 can be horizontally pushed into the reaction cup groove from the cup inlet 11, and the incubation disc body 1 can be horizontally pushed out from the cup abandoning opening 12.

The cup inlet 11 can be opposite to a cup arranging device in the sample analyzer, and the reaction cup 2 can be horizontally conveyed to a reaction cup groove on the incubation tray body 1 from a cup arranging device rail.

As shown in fig. 2, a through hole 14 is provided in the center of the bottom plate of the incubation plate body 1, and the through hole 14 is used for the rotation shaft 6 to pass through. The rotating shaft 6 is installed on the driving motor, and a rotating disc 61 is fixedly installed on a flange of one end of the rotating shaft 6, which is positioned in the incubation disc body 1. The dispensing disk 9 is fixedly connected to the turntable 61 via a mounting member. Thereby, the rotary shaft 6 can rotate the dispensing disk 9 by the turntable 61. The incubation disc body 1 is not supported on the rotating shaft but on another support (not shown), so that the incubation disc body remains stationary.

The reaction cup 2 is placed in the reaction cup well of the dispensing disk 9 and suspended in the air bath chamber 10. Thus, the cuvette 2 is not blocked at the lower side and is fixedly placed inside the incubation plate body 1 only by the cuvette groove. This is very advantageous in that the temperature in the gas bath chamber 10 is uniformly distributed to the positions of the respective reaction cups 2, particularly, to the bottoms thereof. This design of the invention is particularly advantageous for temperature control of the cuvette bottom, since the sample to be measured or the sample reagent mixture is necessarily located at the bottom of the cuvette.

According to the utility model discloses, as shown in fig. 1 and fig. 2, the work position still includes along the application of sample position 1A that circumference distributes in proper order, detect position 1C to and add reagent position 1B. It should be understood here that the sample addition site 1A and the reagent addition site 1B are not fixedly provided on the incubation tray body 1, but are at a fixed angle with respect to the cup inlet 11 and correspond to the positions of the reaction cups 2. Thus, interference among the sample dispensing mechanism, the reagent dispensing mechanism and the cup arranging device can be avoided. In addition, in the present embodiment, two reagent adding sites 1B (see fig. 5) are provided, and only one of them is shown here for simplicity. Of course, each reagent addition site is provided with a baffle.

In the present embodiment, the detection position 1C is configured as a protruding platform formed on the incubation tray body 1, the protruding platform is used for installing a detection unit, and the reaction cup to be detected is located below the detection unit.

After the reaction cups 2 are added, the rotating shaft 6 can drive the dispensing disc 9 to rotate, so that each reaction cup 2 sequentially reaches the sample adding position 1A, and samples from the sample rack can be added into the corresponding reaction cup 2 through the sample distributing mechanism at the sample adding position 1A. Then, the reaction cups 2 can sequentially reach the reagent adding positions 1B by rotating the rotating shaft 6, and at the two reagent adding positions 1B, corresponding reagents can be added into the corresponding reaction cups 2 through the reagent dispensing mechanism, so as to obtain a sample reagent mixture in each reaction cup 2. Thereafter, the cuvette 2 can be rotated to the detection position 1C as a specimen to be detected by the rotation shaft 6.

Here, it is understood that the inlet port 11 and the discard port 12 serve as work stations for adding and discarding reaction cups. That is, the different working positions collectively include the sample addition position 1A, the detection position 1C, and the reagent addition position 1B, as well as the position of the inlet opening 11 and the position of the disposal opening 12.

Moreover, it should be understood that the respective working positions are not changed by the rotation of the dispensing disc 9.

According to the utility model discloses, baffle 3 sets up in the radial inboard of hatching the tube-shape lateral wall of dish body 1, and is corresponding to the position department of each work position. The baffle plates 3 extend axially upward to positions corresponding to the radially inner sides of the reaction cups 2 while being circumferentially spaced apart. The baffle 3 can prevent the reaction cups 2 from deviating from a predetermined position at the corresponding working positions due to the prior rotation of the dispensing disc 9, thereby effectively preventing the reaction cups 2 from shaking at the working positions.

In one embodiment, the baffle 3 is an arc-shaped plate-shaped structure which can be matched with the cylindrical inner wall of the incubation disc body 1 in parallel. The lower end part of the baffle 3 is fixedly connected with the cylindrical side wall through a fixing block, and the upper end part and the cylindrical inner wall jointly limit and form parallel constraint spaces, so that the reaction cup 2 correspondingly positioned in the constraint spaces is constrained and limited in the radial direction. The mode that the baffles 3 are circumferentially distributed at intervals is favorable for ensuring uniform temperature rise and is very favorable for improving the control precision of the temperature in the incubation disc.

According to the present invention, as shown in fig. 1 and 3, a gas bath chamber 10 is formed in the inner space of the incubation tray body 1, and the gas bath chamber 10 includes a heating sheet 5 provided on the bottom plate and a plurality of fans 4 arranged on the heating sheet 5. The heating plate 5 may preferably be configured as a disc, and the heating plate 5 is fixed to the base plate. The heating sheet 5 serves to heat the air in the air bath chamber 10 to a predetermined temperature. The fan 4 may be fixed to the heater chip 5 by a mounting seat, for example. The plurality of fans 4 are evenly spaced apart in the circumferential direction, and the plurality of fans 4 are preferably arranged on the same circumference. The fan 4 can uniformly distribute the heated air to the reaction cup groove. Thereby, a constant temperature condition can be provided to the reaction cup 2. Preferably, the position of the fan corresponds to the operating position, so that exposure of the reaction cup to the hot gas flow from the start of loading can be ensured in particular, so that it is heated up rapidly.

A base 41 is disposed at the bottom of the fan 4, and the base 41 causes the fan to tilt upward by a certain angle, for example, about 10 degrees. Preferably, the base 41 is a metal block with a bevel. Therefore, the fan 4 is inclined, so that the air outlet of the fan 4 forms a certain inclination angle. In one embodiment, the base 41 can be configured, for example, as an inclined support plate, so that the fan is inclined by the support plate. Like this, can avoid the air current that fan 4 sent to bounce back at the bottom plate and do benefit to and guarantee that the intensification is even, and can further improve the control accuracy of hatching the interior temperature of dish.

Preferably, 3 fans 4 are provided, and 3 fans 4 are uniformly distributed along the circumferential direction at intervals of 60 degrees, so that the optimum air supply speed can be achieved, and the temperature can be kept stable.

According to the present invention, as shown in fig. 3 to 5, an inner cover plate 7 and an outer cover plate 8 arranged above the inner cover plate 7 are provided at the open end of the incubation tray body 1. The inner cover plate 7 is made of aluminum, and the outer cover plate 8 is made of plastic. In addition, the incubation plate body 1 is also made of aluminum. This can improve the thermal insulation performance of the gas bath cavity 10, and is very favorable for ensuring the temperature control performance of the temperature control system 100, thereby ensuring that the temperature of the incubation plate fluctuates within a specified range all the time.

In addition, an outer case is provided on the outer peripheral surface of the cylindrical side plate of the incubation plate body 1, and a heat insulating layer is provided between the outer case and the cylindrical side plate. In one embodiment, the insulation layer may be, for example, foam. The insulation layer can further improve the insulation performance of the temperature control system 100.

The utility model discloses still provide a sample analyzer, this sample analyzer includes above-mentioned temperature control system 100. The temperature control system 100 is mounted on the body of the sample analyzer. Use according to the utility model discloses a temperature control system 100 can ensure the accuracy that sample analysis appearance detected. The sample analyzer may be, for example, a chemiluminescent analyzer.

According to the utility model discloses a temperature control system 100 can heat the air in gas bath chamber 10 to the predetermined temperature through heating plate 5 to keep constant temperature, can make the air after the heating evenly spread the position department in reaction cup groove simultaneously, thereby provide the constant temperature condition for reaction cup 2. Use according to the utility model discloses a temperature control system 100 can ensure the accuracy that sample analysis appearance detected. The baffle 3 can prevent the reaction cups 2 from deviating from a predetermined position at the corresponding working positions due to the prior rotation of the dispensing disc 9, thereby effectively preventing the reaction cups 2 from shaking at the working positions. Through setting baffle 3 to the mode that the circumference interval distributes to and through fan 4 air supply heat dissipation, be favorable to guaranteeing to heat up evenly, improved greatly and hatched the control accuracy of interior temperature of dish. In addition, the temperature control system 100 is small, compact and convenient to operate.

In the description of the present invention, it should be understood that the terms "upper", "lower", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are merely for convenience of description and simplification of description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

Furthermore, in the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

In the description of the present specification, reference to the description of "one embodiment," "some embodiments," "an example," "a specific example," or "some examples" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and should not be construed as limiting the present invention in any way. Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing examples, or that equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A temperature control system for a sample analyzer, the temperature control system comprising:

the incubation disc comprises an incubation disc body (1), different working positions are sequentially distributed at intervals along the circumferential direction of the incubation disc body, and baffles (3) are correspondingly arranged on the radial inner sides of the different working positions respectively;

the reaction cup device comprises a separate injection disc (9), wherein a reaction cup groove extending along the circumferential direction is formed in the separate injection disc and is used for hanging a reaction cup (2);

a gas bath cavity (10) formed in the incubation disc body, wherein the reaction cup is suspended in the gas bath cavity;

wherein the air bath cavity is constructed to heat the air inside the air bath cavity to a preset temperature and keep the air at a constant temperature, and the heated air can be uniformly distributed to each reaction cup, so that constant temperature conditions are provided for the reaction cups.

2. The temperature control system of claim 1, wherein the incubation tray body comprises a cylindrical side plate and a bottom plate, cup inlet openings (11) and cup abandoning openings (12) in different working positions are distributed on the cylindrical side plate at intervals along the circumferential direction,

the reaction cup is horizontally pushed into the reaction cup groove from the cup inlet, and the incubation disc body is horizontally pushed out from the cup abandoning opening.

3. Temperature control system according to claim 2, characterized in that the base plate is provided with a through hole (14) in the center for a rotation shaft (6) to pass through, a rotation disc (61) is fixed at one end of the rotation shaft in the incubation disc body,

the dispensing disc is fixedly connected with the turntable, so that the rotating shaft can drive the dispensing disc to rotate through the turntable.

4. Temperature control system according to claim 2 or 3, wherein the gas bath chamber comprises a heater chip (5) provided on the soleplate and a plurality of fans (4) arranged on the heater chip,

the heating plate is used for heating the air in the air bath cavity to a preset temperature, and the fan can uniformly distribute the heated air to the reaction cup groove.

5. The temperature control system of claim 4, wherein the plurality of fans are evenly circumferentially spaced apart.

6. Temperature control system according to claim 4, characterized in that a base (41) is provided at the bottom of the fan, which base causes the fan to be tilted.

7. The temperature control system of claim 2, wherein the working position further comprises a sample adding position (1A), a detection position (1C) and a reagent adding position (1B) which are distributed in sequence along the circumferential direction,

the sample adding position and the reagent adding position are positions which are at fixed angles relative to the cup inlet.

8. The temperature control system of claim 7, wherein the detection site is configured as a protruding platform formed on the incubation tray body for mounting a detection unit under which a reaction cup to be detected is located.

9. A temperature control system according to any of claims 1 to 3, wherein an inner cover plate (7) and an outer cover plate (8) arranged above the inner cover plate are provided at the open end of the incubation tray body.

10. The temperature control system of claim 9, wherein the incubation tray body and the inner cover plate are made of metal and the outer cover plate is made of plastic.

11. The temperature control system according to claim 2 or 3, wherein an outer shell is provided on an outer peripheral surface of the tube-shaped side plate, and an insulating layer is provided between the outer shell and the tube-shaped side plate.

12. A sample analyser characterised by comprising a temperature control system according to any one of claims 1 to 11.

13. The sample analyzer of claim 12, wherein the sample analyzer is a chemiluminescent analyzer.