CN217119532U - Exosome purification experimental apparatus - Google Patents
Exosome purification experimental apparatus Download PDFInfo
- Publication number
- CN217119532U CN217119532U CN202120881407.5U CN202120881407U CN217119532U CN 217119532 U CN217119532 U CN 217119532U CN 202120881407 U CN202120881407 U CN 202120881407U CN 217119532 U CN217119532 U CN 217119532U
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- China
- Prior art keywords
- filter screen
- transverse plate
- diaphragm
- outer tube
- tube
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- Expired - Fee Related
Links
- 210000001808 exosome Anatomy 0.000 title claims abstract description 22
- 238000000746 purification Methods 0.000 title claims abstract description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 5
- 239000011148 porous material Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 230000000903 blocking effect Effects 0.000 abstract description 2
- 239000012634 fragment Substances 0.000 abstract description 2
- 230000010355 oscillation Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 101100293261 Mus musculus Naa15 gene Proteins 0.000 abstract 1
- 239000012535 impurity Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Abstract
The utility model relates to a biological equipment technical field specifically is an exosome purification experimental apparatus, including the outer tube, slidable mounting has in the outer tube inner chamber \21274, the shape mounting bracket, \21274theshape mounting bracket includes the joint board, lower diaphragm and last diaphragm, the inner chamber left side of outer tube is equipped with the holding tank, joint board fixed connection S-shaped shell fragment, outer tube inner chamber right side is equipped with two sets of slots, the slidable mounting of diaphragm and last diaphragm is in the slot down, the other end fixed connection joint board of diaphragm and last diaphragm down, diaphragm fixed mounting has first inner tube down, the bottom of first inner tube is provided with the second filter screen, it has the second inner tube to go up diaphragm fixed mounting, the bottom of second inner tube is provided with first filter screen. Through the v-21274of variable-speed motion, the shape mounting frame can realize the intermittent oscillation effect of the first filter screen and the second filter screen, and can greatly reduce the adhesion of substances with higher relative molecular mass on the filter screens, thereby effectively reducing the possibility of the blocking of the filter holes.
Description
Technical Field
The utility model relates to a biological equipment technical field specifically is an exosome purification experimental apparatus.
Background
The application number is CN201920062705.4 Chinese utility model discloses a casing filter device of normal atmospheric temperature separation purification exosome, the female joint comprises an outer pipe, outer tube top both ends are the fixed draw-in groove that is equipped with all, the equal fixed fixture block that is equipped with in the draw-in groove, the fixed filter body that is equipped with between two fixture blocks, the fixed liquid entry that is equipped with in filter body top, the fixed micro motor that is equipped with in filter body top, micro motor's output fixedly connected with pivot, the pivot is passed filter body fixedly connected with dead lever, the fixed stirring vane that is equipped with on the dead lever, the fixed plate that is equipped with of dead lever, the fixed a plurality of through-hole that is equipped with on the fixed plate, the fixed brush body that is equipped with in fixed plate bottom, this internal fixed second filter screen that is equipped with of first filter screen filter device that filters, filter the fixed liquid outlet that is equipped with in device body bottom, the device can reduce the impure protein quantity in the exosome to a certain extent.
However, the device cleans the surface of the filter screen through the brush body, the cleaning effect is general, and the brush can be stained with a large amount of impurities after being used for a period of time and needs to be replaced in time.
In view of this, we propose an experimental apparatus for exosome purification.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide an exosome purification experimental apparatus to solve the problem that proposes in the above-mentioned background art.
In order to achieve the above purpose, the utility model provides a following technical scheme: the utility model provides an exosome purification experimental apparatus, includes the outer tube, slidable mounting has a shape mounting bracket, 21274, shape mounting bracket is driven by drive arrangement and carries out sharp reciprocating motion in the outer tube, v 21274, the shape mounting bracket includes union plate, lower diaphragm and last diaphragm, the inner chamber left side of outer tube seted up with union plate sliding fit' S holding tank, the right side middle part fixed connection S shape shell fragment of union plate, two sets of slots have been seted up in proper order on outer tube inner chamber right side, the one end slidable mounting of lower diaphragm and last diaphragm is in the slot, the other end of diaphragm and last diaphragm stretches into holding tank and fixed connection union plate down, fixed mounting has first inner tube on the diaphragm down, the bottom of first inner tube is provided with the second filter screen, goes up fixed mounting on the diaphragm and has the second inner tube, and the bottom of second inner tube is provided with first filter screen.
Preferably, circular chamber has been seted up to outer tube right side wall, is equipped with drive arrangement in the circular chamber, and drive arrangement includes carousel, incomplete circular drive block and projection, the carousel is driven rotatoryly by the drive shaft, and incomplete circular drive block and carousel coaxial welding, projection setting are in the space department and the fixed connection carousel of incomplete circular drive block.
Preferably, the right end of the lower transverse plate extends into the slot and is fixedly connected with the limiting block, and the limiting block is sequentially in sliding contact with the incomplete round driving block and the convex column.
Preferably, first inner tube and second inner tube all set up to funnel-shaped structure, and the filtration pore diameter of first filter screen and second filter screen diminishes in proper order.
Preferably, the first filter screen and the second filter screen can be sequentially fixed on the second inner tube and the first inner tube through a detachable structure, and the detachable structure is a screw fixing structure or a buckle fixing structure.
Preferably, the top middle end of outer tube is fixed and is provided with the inlet pipe, and the bottom of outer tube is provided with the liquid outlet.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the utility model discloses utilize first filter screen to filter the back, impurity in the liquid reduces, when filtering through first filter screen, can make the filterable cleaner of liquid, and the exosome that filters flows into the outer tube to obtain the exosome of higher purity.
2. The utility model has the advantages of, use through setting up the carousel, the cooperation of incomplete circular drive block and projection, can realize \21274, change deceleration motion on the shape mounting bracket horizontal direction, and more uniform motion, the vibration effect of the intermittent type formula of variable speed motion \21274canbe realized to the shape mounting bracket, can significantly reduce the adhesion of the higher material of relative molecular mass on the filter screen, thereby effectively reduce the possibility that the obstructed condition of filtration pore took place.
Drawings
FIG. 1 is a schematic structural view of the present invention;
fig. 2 is a schematic view of the driving device of the present invention.
In the figure: the device comprises an outer tube 1, a combination plate 2, a lower transverse plate 3, an upper transverse plate 4, a first inner tube 5, a second inner tube 6, an S-shaped elastic sheet 7, a rotary table 8, an incomplete circular driving block 9, a convex column 10, a limiting block 11, a first filter screen 12, a second filter screen 13, a feeding tube 14 and a liquid outlet 15.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1 to 2, the present invention provides a technical solution: the utility model provides an exosome purification experimental apparatus, includes outer tube 1, and the top middle-end of outer tube 1 is fixed and is provided with inlet pipe 14, and the bottom of outer tube 1 is provided with liquid outlet 15. The device comprises an outer pipe 1, a v-21274and a v-21274, wherein the inner cavity of the outer pipe 1 is provided with a v-21274a mounting frame which is driven by a driving device and performs linear reciprocating motion in the outer pipe 1, the v-21274b mounting frame comprises a combination plate 2, a lower transverse plate 3 and an upper transverse plate 4, the left side of the inner cavity of the outer pipe 1 is provided with a holding tank in sliding fit with the combination plate 2, the middle part of the right side of the combination plate 2 is fixedly connected with an S-shaped elastic sheet 7, the right side of the inner cavity of the outer pipe 1 is sequentially provided with two groups of slots, one ends of the lower transverse plate 3 and the upper transverse plate 4 are slidably mounted in the slots, the other ends of the lower transverse plate 3 and the upper transverse plate 4 extend into the holding tank and are fixedly connected with the combination plate 2, a first inner pipe 5 is fixedly mounted on the lower transverse plate 3, the bottom of the first inner pipe 5 is provided with a second filter screen 13, the upper transverse plate 4 is fixedly mounted with a second inner pipe 6, the bottom of the second inner pipe 6 is provided with a first filter screen 12, the first inner pipe 5 and the second inner pipe 6 are both set into funnel-shaped structure, the funnel-shaped structure facilitates liquid to flow into the first inner tube 5 and the second inner tube 6 in sequence, and the phenomena of leakage and the like can not occur; the diameters of the filter holes of the first filter 12 and the second filter 13 become smaller in order. After first filter screen 12 filters, the impurity in the liquid reduces, when filtering through first filter screen 12, can make the filterable cleaner of liquid, and the exosome that filters flows into the outer tube to obtain the exosome of higher purity.
As shown in fig. 1 and 2, circular chamber has been seted up to outer tube 1 right side wall, the circular intracavity is equipped with drive arrangement, drive arrangement includes carousel 8, incomplete circular drive block 9 and projection 10, carousel 8 is driven rotatoryly by the drive shaft, incomplete circular drive block 9 and 8 coaxial weldings of carousel, projection 10 sets up in the space department and the fixed connection carousel 8 of incomplete circular drive block 9, slot and fixed connection stopper 11 are stretched into to the right-hand member of lower diaphragm 3, stopper 11 slides with incomplete circular drive block 9 and projection 10 in proper order and contradicts. When the filter screen is used, the driving shaft drives the rotary table 8 to rotate, the rotary table 8 sequentially drives the incomplete circular driving block 9 and the convex column 10 to do circular motion, when the outer wall of the incomplete circular driving block 9 is abutted to the limiting block 11, the limiting block 11 is forced to drive the 21274, the S-shaped elastic sheet 7 is extruded by the shape mounting frame to move towards the right side, and when the limiting block 11 is disconnected from the incomplete circular driving block 9 and is abutted to the rotary table 8, the 21274is forced to move towards the left side under the action of the rebound force of the S-shaped elastic sheet 7, and compared with uniform motion, the 21274is forced to move at variable speed.
The working principle is as follows: in practical use, liquid flows into the second inner pipe 6 and the first inner pipe 5 in sequence through the feeding pipe 14 and is filtered for multiple times through the first filter screen 12 and the second filter screen 13, impurities in the liquid are reduced after being filtered by the first filter screen 12, the liquid can be filtered cleaner when being filtered by the first filter screen 12, the filtered exosome flows into the outer pipe, so that a high-purity exosome is obtained, in the process, the driving shaft is used for driving the rotary disc 8 to rotate, the rotary disc 8 drives the incomplete circular driving block 9 and the convex column 10 to perform circular motion in sequence, when the outer wall of the incomplete circular driving block 9 is in contact with the limiting block 11, the limiting block 11 is forced to drive the 21274, the S-shaped elastic sheet 7 is extruded by the shape mounting frame to move towards the right side, and when the limiting block 11 is disconnected with the incomplete circular driving block 9 and is in contact with the rotary disc 8, the 21274, the shape mounting frame is under the reverse elasticity action of the S-shaped elastic sheet 7, the V-shaped mounting frame can realize the intermittent oscillation effect of the first filter screen 12 and the second filter screen 13, can greatly reduce the adhesion of substances with higher relative molecular mass on the filter screens, and further effectively reduces the possibility of blocking the filter holes.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. An exosome purification experimental apparatus, includes outer tube (1), its characterized in that: the inner cavity of the outer pipe (1) is provided with a shape mounting frame in a sliding manner, the shape mounting frame is driven by a driving device and performs linear reciprocating motion in the outer pipe (1), the shape mounting frame comprises a combination plate (2), a lower transverse plate (3) and an upper transverse plate (4), the left side of the inner cavity of the outer pipe (1) is provided with a containing groove in sliding fit with the combination plate (2), the middle part of the right side of the combination plate (2) is fixedly connected with an S-shaped elastic sheet (7), the right side of the inner cavity of the outer pipe (1) is sequentially provided with two groups of inserting grooves, one ends of the lower transverse plate (3) and the upper transverse plate (4) are slidably mounted in the inserting grooves, the other ends of the lower transverse plate (3) and the upper transverse plate (4) extend into the containing groove and are fixedly connected with the combination plate (2), a first inner pipe (5) is fixedly mounted on the lower transverse plate (3), a second filter screen (13) is arranged at the bottom of the first inner pipe (5), a second inner pipe (6) is fixedly mounted on the upper transverse plate (4), the bottom of the second inner pipe (6) is provided with a first filter screen (12).
2. An exosome purification experimental apparatus according to claim 1, characterized in that: circular chamber has been seted up to outer tube (1) right side wall, is equipped with drive arrangement in the circular chamber, and drive arrangement includes carousel (8), incomplete circular drive block (9) and projection (10), carousel (8) are driven rotatoryly by the drive shaft, incomplete circular drive block (9) and carousel (8) coaxial bonding, and projection (10) set up in the space department and fixed connection carousel (8) of incomplete circular drive block (9).
3. An exosome purification experimental apparatus according to claim 2, characterized in that: the right end of the lower transverse plate (3) extends into the slot and is fixedly connected with a limiting block (11), and the limiting block (11) is in sliding contact with the incomplete circular driving block (9) and the convex column (10) in sequence.
4. An exosome purification experimental device according to claim 3, characterized in that: first inner tube (5) and second inner tube (6) all set up to funnel-shaped structure, and the filtration pore diameter of first filter screen (12) and second filter screen (13) diminishes in proper order.
5. An exosome purification experimental device according to claim 4, characterized in that: the first filter screen (12) and the second filter screen (13) can be sequentially fixed on the second inner pipe (6) and the first inner pipe (5) through a detachable structure, and the detachable structure is a screw fixing structure or a buckle fixing structure.
6. An exosome purification experimental apparatus according to claim 5, characterized in that: the top middle end of the outer tube (1) is fixedly provided with a feeding tube (14), and the bottom of the outer tube (1) is provided with a liquid outlet (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120881407.5U CN217119532U (en) | 2021-04-27 | 2021-04-27 | Exosome purification experimental apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120881407.5U CN217119532U (en) | 2021-04-27 | 2021-04-27 | Exosome purification experimental apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217119532U true CN217119532U (en) | 2022-08-05 |
Family
ID=82615098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120881407.5U Expired - Fee Related CN217119532U (en) | 2021-04-27 | 2021-04-27 | Exosome purification experimental apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217119532U (en) |
-
2021
- 2021-04-27 CN CN202120881407.5U patent/CN217119532U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220805 |