CN217093484U - Docetaxel production is with reaction unit of convenient clearance - Google Patents
Docetaxel production is with reaction unit of convenient clearance Download PDFInfo
- Publication number
- CN217093484U CN217093484U CN202220515893.3U CN202220515893U CN217093484U CN 217093484 U CN217093484 U CN 217093484U CN 202220515893 U CN202220515893 U CN 202220515893U CN 217093484 U CN217093484 U CN 217093484U
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- China
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- reaction kettle
- fixedly connected
- rotary column
- spring
- mounting panel
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 57
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title claims abstract description 19
- 229960003668 docetaxel Drugs 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title description 7
- 238000004140 cleaning Methods 0.000 claims abstract description 49
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- 230000006978 adaptation Effects 0.000 claims description 6
- 230000000694 effects Effects 0.000 description 8
- 230000009471 action Effects 0.000 description 4
- 229930012538 Paclitaxel Natural products 0.000 description 3
- 229960001592 paclitaxel Drugs 0.000 description 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 3
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Images
Abstract
The utility model discloses a reaction device which is used for producing docetaxel and is convenient to clean, comprising a reaction kettle, wherein the central position at the top end of the reaction kettle is fixedly connected with a motor, the output end of the motor is fixedly connected with a rotating column, the rotating column is inserted in the reaction kettle, two first mounting plates are symmetrically arranged inside the reaction kettle, one side of each of the two first mounting plates is fixedly connected with a first cleaning block, the two first cleaning blocks are both in close contact with the inner wall of the reaction kettle, the two first mounting plates are connected with the rotating column through two telescopic mechanisms, a first extruding mechanism is arranged between the two first mounting plates and the rotating column, the bottom of the reaction kettle is provided with a second mounting plate, the bottom end of the second mounting plate is fixedly connected with a second cleaning block, the second cleaning block is in close contact with the bottom wall of the reaction kettle, the second cleaning block is connected with the rotating column through a second extruding mechanism, the first cleaning block and the second cleaning block are utilized to clean the inside of the reaction kettle, the manual cleaning is not needed, the time and the labor are saved, and the cleaning is more comprehensive.
Description
Technical Field
The utility model relates to a docetaxel production is with reaction unit of convenient clearance belongs to docetaxel production technical field.
Background
Docetaxel (Docetaxel), a Docetaxel (Docetaxel), acts like Paclitaxel (PTX), and is an M-phase cycle-specific drug that promotes the polymerization of tubules into stable microtubules and inhibits their aggregation, thereby significantly reducing the number of tubules and destroying the microtubule network. In vitro experiments show that the compound has cytotoxic effect on various mouse and human tumor cell strains, and the antitumor spectrum is wider than that of PTX. Has good curative effect on advanced breast cancer, ovarian cancer and non-small cell lung cancer. It also has therapeutic effect on cancer of head and neck, pancreatic cancer, small cell lung cancer, gastric cancer, melanoma, and soft tissue sarcoma.
Docetaxel all needs to carry out various mixing reactions in reation kettle usually in process of production, and current reation kettle inner wall is not convenient for clear up, and the trouble that artifical clearance can be very is more time-consuming again, and the clearance is not enough comprehensive yet, can influence the quality of follow-up docetaxel.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a docetaxel production is with reaction unit who makes things convenient for the clearance to solve the problem that proposes in the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme: a reaction device which is used for producing docetaxel and is convenient to clean, comprising a reaction kettle, wherein the center position of the top end of the reaction kettle is fixedly connected with a motor, the output end of the motor is fixedly connected with a rotary column which is inserted in the reaction kettle, two first mounting plates are symmetrically arranged in the reaction kettle, one side of each of the two first mounting plates is fixedly connected with a first cleaning block, the two first cleaning blocks are tightly contacted with the inner wall of the reaction kettle, the two first mounting plates are connected with the rotary column through two telescopic mechanisms, and a first extruding mechanism is arranged between each of the two first mounting plates and the rotary column, the bottom of the reaction kettle is provided with a second mounting plate, the bottom end of the second mounting plate is fixedly connected with a second cleaning block, the second cleaning block is in close contact with the bottom wall of the reaction kettle, and the second cleaning block is connected with the rotary column through a second extrusion mechanism.
Preferably, two telescopic machanism all includes horizontal pole, two loop bars and two slots, the fixed cover of horizontal pole is in the rotary column outside, the horizontal pole both ends all are equipped with the slot, two loop bar one end is all inserted and is established in corresponding the slot, two the loop bar other end respectively with two first mounting panel fixed connection.
Preferably, two first extrusion mechanism all includes two dead levers, two first springs, two telescopic links and two stripper plates, two the equal fixed connection of dead lever is in the rotary column outside, two the dead lever is parallel to each other, stripper plate and first mounting panel in close contact with, equal fixedly connected with telescopic link and first spring between stripper plate and two dead levers, two first spring is established respectively and is established peripherally two telescopic links.
Preferably, second extrusion mechanism includes second spring, holding tank, spliced pole, slider and two spouts, the column bottom is equipped with the holding tank, the spliced pole upper end is inserted and is established in the holding tank, spliced pole bottom and second mounting panel upper end central point put fixed connection, the fixed cover of spliced pole upper end has connect the slider, all be equipped with the spout with slider looks adaptation on the holding tank both sides wall, slider and two spout sliding connection, fixedly connected with second spring between slider and the holding tank roof, the second spring housing is established in the spliced pole periphery.
Preferably, the length of the second cleaning block is matched with the bottom wall of the reaction kettle, and the horizontal height of the upper end of the second mounting plate is smaller than the horizontal height of the bottom ends of the two first mounting plates.
Preferably, the two cross rods are movably connected with the corresponding slots and are matched with the corresponding slots.
Compared with the prior art, the beneficial effects of the utility model are that: the motor is started, the motor drives the rotary column to rotate, the rotary column drives the first mounting plate and the first cleaning block to rotate through the cross rod and the loop bar, the inner wall of the reaction kettle is cleaned through the first cleaning block, simultaneously, the rotary column can drive the second mounting plate and the second cleaning block to rotate through the connecting column, the bottom wall of the reaction kettle is cleaned through the second cleaning block, manual cleaning is not needed, time and labor are saved, cleaning is more comprehensive, when the inner wall of the reaction kettle or the cleaning block is abraded, the first cleaning block can be always in close contact with the inner wall of the reaction kettle through the action of centrifugal force, the first spring is in a compressed state, the first cleaning block is further in close contact with the inner wall of the reaction kettle through the action of the first spring, the cleaning effect is ensured, the second spring is also always in a compressed state, the connecting column pushes the second mounting plate through the action of the second spring, thereby make second clearance piece and reation kettle diapire in close contact with, guarantee the clearance effect.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is an enlarged schematic view of the structure at the position A of the present invention;
FIG. 3 is an enlarged schematic view of the structure at B of the present invention;
fig. 4 is a schematic structural view of the telescopic mechanism of the present invention.
In the figure: 1. a reaction kettle; 2. a motor; 3. turning the column; 4. a telescoping mechanism; 41. a cross bar; 42. a loop bar; 43. a slot; 5. a first pressing mechanism; 51. fixing the rod; 52. a first spring; 53. a telescopic rod; 54. a pressing plate; 6. a second extrusion mechanism; 61. a second spring; 62. accommodating grooves; 63. connecting columns; 64. a slider; 65. a chute; 7. a first mounting plate; 8. a first cleaning block; 9. a second mounting plate; 10. and a second cleaning block.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides a technical solution: a reaction device convenient for cleaning in production of docetaxel comprises a reaction kettle 1, wherein a motor 2 is fixedly connected to the top center position of the reaction kettle 1, a rotary column 3 is fixedly connected to the output end of the motor 2, the rotary column 3 is inserted in the reaction kettle 1, two first mounting plates 7 are symmetrically arranged in the reaction kettle 1, one sides of the two first mounting plates 7 are fixedly connected with first cleaning blocks 8, the two first cleaning blocks 8 are tightly contacted with the inner wall of the reaction kettle 1, the two first mounting plates 7 are connected with the rotary column 3 through two telescopic mechanisms 4, a first extruding mechanism 5 is arranged between the two first mounting plates 7 and the rotary column 3, a second mounting plate 9 is arranged at the bottom of the reaction kettle 1, a second cleaning block 10 is fixedly connected to the bottom end of the second mounting plate 9, the second cleaning block 10 is tightly contacted with the bottom wall of the reaction kettle 1, the second cleaning block 10 is connected with the rotary column 3 through a second extruding mechanism 6, utilize first clearance piece 8 and second clearance piece 10 to clear up reation kettle 1 is inside, do not need artifical clearance, labour saving and time saving, the clearance also more comprehensive.
The two telescopic mechanisms 4 respectively comprise a cross rod 41, two loop bars 42 and two slots 43, the cross rod 41 is fixedly sleeved outside the rotary column 3, the slots 43 are respectively arranged at two ends of the cross rod 41, one end of each loop bar 42 is inserted into the corresponding slot 43, the other end of each loop bar 42 is respectively fixedly connected with the two first mounting plates 7, when the inner wall of the reaction kettle 1 or a cleaning block is worn, the first cleaning block 8 can be always in close contact with the inner wall of the reaction kettle 1 through the action of centrifugal force, each first extrusion mechanism 5 comprises two fixing rods 51, two first springs 52, two telescopic rods 53 and two extrusion plates 54, each two fixing rod 51 is fixedly connected outside the rotary column 3, the two fixing rods 51 are parallel to each other, the extrusion plates 54 are in close contact with the first mounting plates 7, the telescopic rods 53 and the first springs 52 are fixedly connected between the extrusion plates 54 and the two fixing rods 51, the two first springs 52 are respectively sleeved on the peripheries of the two telescopic rods 53, and because the first springs 52 are in a compressed state, the first cleaning block 8 is further in close contact with the inner wall of the reaction kettle 1 by the acting force of the first springs 52, so that the cleaning effect is ensured, the second extrusion mechanism 6 comprises a second spring 61, an accommodating groove 62, a connecting column 63, a sliding block 64 and two sliding grooves 65, the accommodating groove 62 is arranged at the bottom end of the rotary column 3, the upper end of the connecting column 63 is inserted into the accommodating groove 62, the bottom end of the connecting column 63 is fixedly connected with the central position of the upper end of the second mounting plate 9, the sliding block 64 is fixedly sleeved at the upper end of the connecting column 63, the sliding grooves 65 matched with the sliding block 64 are respectively arranged on the two side walls of the accommodating groove 62, the sliding block 64 is in sliding connection with the two sliding grooves 65, the second spring 61 is fixedly connected between the top wall of the sliding block 64 and the top wall of the accommodating groove 62, the second spring 61 is sleeved on the periphery of the connecting column 63, and the second spring 61 is always in a compressed state, spliced pole 63 promotes second mounting panel 9 through second spring 61's effort, thereby make second clearance piece 10 and 1 diapire in close contact with of reation kettle, guarantee the clearance effect, second clearance piece 10 length and 1 diapire looks adaptation of reation kettle, second mounting panel 9 upper end level is less than 7 bottom level of two first mounting panels, first mounting panel 7 and 9 mutual noninterference of second mounting panel, two horizontal poles 41 all with correspond slot 43 swing joint, two horizontal poles 41 all with correspond slot 43 looks adaptation, guarantee horizontal pole 41 freely flexible in slot 43, thereby make the contact of first clearance piece 8 and reation kettle 1 inner wall.
Specifically, when the utility model is used, the motor 2 is started, the motor 2 drives the rotary column 3 to rotate, the rotary column 3 drives the first mounting plate 7 and the first cleaning block 8 to rotate through the cross rod 41 and the loop bar 42, the inner wall of the reaction kettle 1 is cleaned by the first cleaning block 8, meanwhile, the rotary column 3 can drive the second mounting plate 9 and the second cleaning block 10 to rotate through the connecting post 63, the bottom wall of the reaction kettle 1 is cleaned by the second cleaning block 10 without manual cleaning, time and labor are saved, the cleaning is more comprehensive, when the inner wall or the cleaning block of the reaction kettle 1 is worn, the first cleaning block 8 can be always in close contact with the inner wall of the reaction kettle 1 through the effect of centrifugal force, because the first spring 52 is in a compression state, the first cleaning block 8 is further in close contact with the inner wall of the reaction kettle 1 through the acting force of the first spring 52, the cleaning effect is ensured, second spring 61 is also in compression state all the time, and spliced pole 63 promotes second mounting panel 9 through second spring 61's effort to make second clearance piece 10 and 1 diapire in close contact with of reation kettle, guarantee the clearance effect.
In the description of the present invention, it is to be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "one side", "top", "inner", "front", "center", "both ends", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are merely for convenience of description and simplification of the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.
Furthermore, the terms "first", "second", "third", "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, whereby the features defined as "first", "second", "third", "fourth" may explicitly or implicitly include at least one such feature.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "disposed," "connected," "fixed," "screwed" and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through an intermediate medium, and may be connected through the inside of two elements or in an interaction relationship between two elements, unless otherwise specifically defined, and the specific meaning of the above terms in the present invention will be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The reaction device comprises a reaction kettle (1) and is characterized in that a motor (2) is fixedly connected to the center of the top end of the reaction kettle (1), a rotary column (3) is fixedly connected to the output end of the motor (2), the rotary column (3) is inserted into the reaction kettle (1), two first mounting plates (7) are symmetrically arranged inside the reaction kettle (1), two first cleaning blocks (8) are fixedly connected to one side of each first mounting plate (7), the two first cleaning blocks (8) are in close contact with the inner wall of the reaction kettle (1), the two first mounting plates (7) are connected with the rotary column (3) through two telescopic mechanisms (4), a first extruding mechanism (5) is arranged between each first mounting plate (7) and the rotary column (3), and a second mounting plate (9) is arranged at the bottom of the reaction kettle (1), second mounting panel (9) bottom fixedly connected with second clearance piece (10), second clearance piece (10) and reation kettle (1) diapire in close contact with, be connected through second extrusion mechanism (6) between second clearance piece (10) and rotary column (3).
2. The conveniently cleaned reaction device for producing docetaxel according to claim 1, wherein: two telescopic machanism (4) all include horizontal pole (41), two loop bars (42) and two slots (43), horizontal pole (41) are fixed cup joints in rotary column (3) outside, horizontal pole (41) both ends all are equipped with slot (43), two loop bars (42) one end all inserts and establishes in corresponding slot (43), two loop bars (42) other end respectively with two first mounting panel (7) fixed connection.
3. The conveniently cleaned reaction device for producing docetaxel according to claim 1, wherein: two first extrusion mechanism (5) all includes two dead levers (51), two first springs (52), two telescopic links (53) and two stripper plates (54), two equal fixed connection in rotary column (3) outside of dead lever (51), two dead lever (51) are parallel to each other, stripper plate (54) and first mounting panel (7) in close contact with, equal fixedly connected with telescopic link (53) and first spring (52), two between stripper plate (54) and two dead levers (51) first spring (52) are established respectively and are established two telescopic links (53) periphery.
4. The conveniently cleaned reaction device for producing docetaxel according to claim 1, wherein: second extrusion mechanism (6) include second spring (61), holding tank (62), spliced pole (63), slider (64) and two spout (65), rotary column (3) bottom is equipped with holding tank (62), spliced pole (63) upper end is inserted and is established in holding tank (62), spliced pole (63) bottom and second mounting panel (9) upper end central point put fixed connection, the fixed cover in spliced pole (63) upper end has connect slider (64), all be equipped with spout (65) with slider (64) looks adaptation on holding tank (62) both sides wall, slider (64) and two spout (65) sliding connection, fixedly connected with second spring (61) between slider (64) and holding tank (62) roof, second spring (61) cover is established at spliced pole (63) periphery.
5. The conveniently cleaned reaction device for producing docetaxel according to claim 1, wherein: second clearance piece (10) length and reation kettle (1) diapire looks adaptation, second mounting panel (9) upper end level is less than two first mounting panel (7) bottom level.
6. The conveniently cleaned reaction device for producing docetaxel according to claim 2, wherein: two horizontal pole (41) all with correspond slot (43) swing joint, two horizontal pole (41) all with correspond slot (43) looks adaptation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220515893.3U CN217093484U (en) | 2022-03-10 | 2022-03-10 | Docetaxel production is with reaction unit of convenient clearance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220515893.3U CN217093484U (en) | 2022-03-10 | 2022-03-10 | Docetaxel production is with reaction unit of convenient clearance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217093484U true CN217093484U (en) | 2022-08-02 |
Family
ID=82603492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220515893.3U Active CN217093484U (en) | 2022-03-10 | 2022-03-10 | Docetaxel production is with reaction unit of convenient clearance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217093484U (en) |
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2022
- 2022-03-10 CN CN202220515893.3U patent/CN217093484U/en active Active
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| GR01 | Patent grant | ||
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A convenient cleaning reaction device for the production of docetaxel Granted publication date: 20220802 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN CALMLAND PHARMACEUTICALS CO.,LTD. Registration number: Y2024980004100 |