CN217092459U - System for refining tetracaine hydrochloride into salt - Google Patents

Abstract

The utility model discloses a salt system is become in refining of tetracaine hydrochloride, this system include decoloration jar, filtration system, crystallization kettle, hydrochloric acid dropwise add jar, centrifuge and DCS control system. The discharge gate of decoloration jar and filtration system's feed inlet connect, filtration system's discharge gate and crystallization kettle's feed inlet are connected, the discharge gate and the hydrochloric acid feed inlet of crystallization kettle of hydrochloric acid dropwise add jar are connected, the discharge gate and the centrifuge's of crystallization kettle feed inlet are connected to utilize DCS system to carry out automatically regulated to crystallization kettle's pH. The utility model discloses production efficiency is high, has detached foreign matter and impurity effectively, has improved the quality of product greatly, has improved the market competition ability of product, has better economic value and practical spreading value.

Description

Refined salt system that becomes of tetracaine hydrochloride

Technical Field

The utility model relates to a chemical reaction device, more specifically relates to a refined salt system that becomes of tetracaine hydrochloride.

Background

Tetracaine hydrochloride is a high-efficiency local anesthetic for reversibly blocking nerve functions, is clinically used for infiltration anesthesia, nerve block anesthesia, epidural anesthesia and the like, is one of recognized clinical strong-efficiency anesthetics, and has the advantages of stable physicochemical properties, quick action, long maintenance time and the like. The main dosage form of the tetracaine hydrochloride is injection, which puts high requirements on the quality of tetracaine hydrochloride raw material medicine, and especially puts high requirements on impurities, foreign matters, purity and the like of the product.

CN201210242596.7, CN201610170954.6, and CN201811630115.3 respectively proposed different preparation techniques of tetracaine hydrochloride, but none of them proposed new technical solutions for the design of a refined crystal production system of tetracaine hydrochloride.

SUMMERY OF THE UTILITY MODEL

In order to further improve the quality level of the tetracaine hydrochloride, the invention provides a novel system for refining the tetracaine hydrochloride into salt on the basis of a large number of tests.

The utility model discloses specifically adopt following technical scheme:

a system for refining tetracaine hydrochloride into salt comprises a decoloring tank, a bag filter, a crystallization kettle, a hydrochloric acid dripping tank and a centrifuge;

the decoloring tank is provided with a feed inlet a, a nitrogen inlet a, an exhaust port a and a discharge port a;

the bag filter is provided with a feed inlet b, a discharge outlet b) and an exhaust outlet b;

a feed inlet c, a hydrochloric acid liquid inlet, an exhaust port c, a discharge port c and a pH test port are arranged on the crystallization kettle;

the hydrochloric acid dripping tank is provided with a feeding hole d, a discharging hole d and an exhaust hole d;

the centrifuge is provided with a feed inlet e, a nitrogen inlet b and a mother liquor outlet;

the device comprises a decoloring tank, a bag filter, a hydrochloric acid dripping tank, a centrifugal machine, a spray head, a water inlet, a water outlet, a water inlet, a water outlet, a and a water outlet, a and a water outlet, a water outlet and a water outlet, a and a water outlet, a and a water outlet, a and a DCS and a and.

Further, in the above technical scheme, a precision filter is arranged between the bag filter and the crystallization kettle.

Further, in the above technical scheme, an electronic control valve is arranged at a discharge port d of the hydrochloric acid dropping tank.

Further, in the above technical scheme, the electronic regulation and control valve includes an information access port, and the information access port is connected with the DCS control system.

Further, in the above technical scheme, a pipeline filter is arranged between the electronic control valve and the hydrochloric acid liquid inlet.

Furthermore, in the above technical solution, the spray head is composed of a nozzle, a disperser and a bracket; the liquid outlet end of the hydrochloric acid liquid inlet is connected with the nozzle, the disperser is coaxial with the nozzle and has a certain distance, and the disperser is connected with the nozzle through the support.

Further, in the above technical scheme, stirring devices are arranged in the decoloring tank and the crystallization kettle.

Further, in the above technical scheme, a heating device is arranged on the decolorizing tank.

Compared with the prior art, the beneficial effects of the utility model are that:

the tetracaine hydrochloride refining salt system of the utility model adopts an all-dimensional and multi-level filtering system, thus greatly reducing the content of foreign matters in the product; and the nozzle is arranged at the hydrochloric acid dripping port of the crystallization kettle, so that the mixing speed and the uniformity of a hydrochloric acid and material system are accelerated, the regularity of material crystal forms is improved, the content of impurities is reduced, and the purity of materials is improved. The utility model discloses promote the quality of medicine effectively, improved the market competition ability of product, had better social value and economic value. System production efficiency is high, has detached foreign matter and impurity effectively, has improved the quality of product greatly, has improved the market competition ability of product, has better economic value and practical spreading value.

Drawings

Fig. 1 is a schematic structural diagram of a system for refining tetracaine hydrochloride into salt according to the present invention.

Fig. 2 is a front view of the spray head.

Fig. 3 is a bottom view of the showerhead.

In the figure, 1, a decolorizing tank; 11. a feed inlet a; 12. a nitrogen inlet a; 13. an exhaust port a; 14. a discharge port a; 2. A bag filter; 21. a feed inlet b; 22. a discharge hole b; 23. an exhaust port b; 3. a precision filter; 4. a crystallization kettle; 41. a feed port c; 42. an exhaust port c; 43. a hydrochloric acid liquid inlet; 431. a spray head; 4311. a nozzle; 4312. A disperser; 4313. a support; 44. a discharge port c; 45. a pH test port; 5. a hydrochloric acid dripping tank; 51. a feed inlet d; 52. a discharge port d; 53. an exhaust port d; 54. an electronic regulating valve; 541. an information access port; 6. a line filter; 7. a centrifuge; 71. a feed port e; 72. a nitrogen inlet b; 73. and (4) a mother liquor outlet.

Detailed Description

The following non-limiting examples will allow one of ordinary skill in the art to more fully understand the present invention, but are not intended to limit the invention in any way.

Example 1

Referring to fig. 1-3, a system for refining and salting tetracaine hydrochloride comprises a decoloring tank 1, a bag filter 2, a crystallization kettle 4, a hydrochloric acid dropping tank 5, and a centrifuge 7;

the decolorizing tank 1 is provided with a feeding hole a 11, a nitrogen inlet a 12, an exhaust hole a 13 and a discharge hole a 14;

the bag filter 2 is provided with a feed inlet b 21, a discharge outlet b 22 and an exhaust outlet b 23;

a feeding hole c 41, a hydrochloric acid liquid inlet 43, an exhaust hole c 42, a discharging hole c 44 and a pH testing hole 45 are formed in the crystallization kettle 4;

the hydrochloric acid dripping tank 5 is provided with a feeding hole d 51, a discharging hole d 52 and an exhaust hole d 53;

a feed inlet e 71, a nitrogen inlet b 72 and a mother liquor outlet 73 are formed in the centrifuge 7;

preferably, the discharge port a 14 of the decoloring tank 1 is connected with the feed port b 21 of the bag filter 2, the discharge port b 22 of the bag filter 2 is connected with the feed port c 41 of the crystallization kettle 4, the discharge port d 52 of the hydrochloric acid dropping tank 5 is connected with one end of the hydrochloric acid liquid inlet 43 of the crystallization kettle 4, the other end of the hydrochloric acid liquid inlet 43 is connected with the spray head 431, the spray head 431 is located inside the crystallization kettle 4, the discharge port c 44 of the crystallization kettle 4 is connected with the feed port e 71 of the centrifuge 7, and the data output end of the pH test port 45 is connected with the DCS control system.

Preferably, a precision filter 3 is arranged between the bag filter 2 and the crystallization kettle 4.

Preferably, an electronic control valve 54 is arranged at a discharge port d 52 of the hydrochloric acid dripping tank 5, the electronic control valve 54 includes an information access port 541, and the information access port 541 is connected with the DCS control system.

Preferably, a pipeline filter 6 is further arranged between the electronic control valve 54 and the hydrochloric acid liquid inlet 43.

Preferably, the spray head 431 is composed of a nozzle 4311, a disperser 4312 and a support 4313. The liquid outlet end of the hydrochloric acid liquid inlet 43 is connected with a nozzle 4311, the disperser 4312 is coaxial with and spaced from the nozzle 4311 by a certain distance of 0.8-2cm, and the disperser 4312 is connected with the nozzle 4311 through a support 4313.

Preferably, stirring devices are arranged inside the decoloring tank 1 and the crystallization kettle 4.

Preferably, a heating device is arranged on the decolorizing tank 1.

Example 2

The process of the system for refining tetracaine hydrochloride into salt in the embodiment 1 comprises the following steps:

transferring the material containing the crude tetracaine into a decolorizing tank, adding a certain amount of activated carbon, heating to 60-80 ℃, stirring for decolorizing for 30 minutes, and introducing nitrogen into the decolorizing tank through a nitrogen inlet a during stirring. The material in the decoloration jar is through two-stage filtration (filtering through bag filter and precision filter in proper order), and the mother liquor shifts to the crystallization kettle in, opens the stirring, opens electronic control valve, and dropwise add the hydrochloric acid solution of passing through the line filter filtration in to the system, hydrochloric acid solution passes through the line filter and gets into hydrochloric acid import, further spouts through the shower nozzle. And (3) automatically adjusting the pH of the crystallization kettle by using a DCS (distributed control system), and when the pH of the system is less than 3.3, automatically closing the electronic regulating valve and finishing the operation of adjusting the pH. And gradually cooling, and adjusting the stirring speed in the crystallization kettle to slowly crystallize the material. And then preserving the heat and stirring for 2 hours, centrifuging the product in a centrifugal machine, collecting a solid product, drying and packaging to obtain a refined tetracaine hydrochloride product.

Claims (8)

1. A refined into salt system of tetracaine hydrochloride which characterized in that: the system comprises a decoloring tank (1), a bag filter (2), a crystallization kettle (4), a hydrochloric acid dripping tank (5) and a centrifuge (7);

a feed inlet a (11), a nitrogen inlet a (12), an exhaust port a (13) and a discharge port a (14) are arranged on the decolorizing tank (1);

a feed inlet b (21), a discharge outlet b (22) and an exhaust outlet b (23) are arranged on the bag filter (2);

a feeding hole c (41), a hydrochloric acid liquid inlet (43), an exhaust hole c (42), a discharging hole c (44) and a pH testing hole (45) are formed in the crystallization kettle (4);

the hydrochloric acid dripping tank (5) is provided with a feed inlet d (51), a discharge outlet d (52) and an exhaust outlet d (53);

a feed inlet e (71), a nitrogen inlet b (72) and a mother liquor outlet (73) are arranged on the centrifugal machine (7);

the device is characterized in that a discharge port a (14) of the decoloring tank (1) is connected with a feed port b (21) of the bag filter (2), a discharge port b (22) of the bag filter (2) is connected with a feed port c (41) of the crystallization kettle (4), a discharge port d (52) of the hydrochloric acid dripping tank (5) is connected with one end of a hydrochloric acid liquid inlet (43) of the crystallization kettle (4), the other end of the hydrochloric acid liquid inlet (43) is connected with a spray head (431), the spray head (431) is located inside the crystallization kettle (4), a discharge port c (44) of the crystallization kettle (4) is connected with a feed port e (71) of a centrifugal machine (7), and a data output end of a pH test port (45) is connected with a DCS control system.

2. The refined salt-forming system of tetracaine hydrochloride of claim 1, wherein: a precise filter (3) is arranged between the bag filter (2) and the crystallization kettle (4).

3. The refined salt formation system of tetracaine hydrochloride according to claim 1, wherein: and an electronic regulating valve (54) is arranged at a discharge hole d (52) of the hydrochloric acid dripping tank (5).

4. The refined salt formation system of tetracaine hydrochloride according to claim 3, wherein: the electronic regulation and control valve (54) comprises an information access port (541), and the information access port (541) is connected with the DCS control system.

5. The refined salt formation system of tetracaine hydrochloride according to claim 3, wherein: a pipeline filter (6) is arranged between the electronic regulating valve (54) and the hydrochloric acid liquid inlet (43).

6. The refined salt formation system of tetracaine hydrochloride according to claim 1, wherein: the spray head (431) consists of a nozzle (4311), a disperser (4312) and a bracket (4313); the liquid outlet end of the hydrochloric acid liquid inlet (43) is connected with a nozzle (4311), the disperser (4312) is coaxial with and at a certain distance from the nozzle (4311), and the disperser (4312) is connected with the nozzle (4311) through a support (4313).

7. The refined salt formation system of tetracaine hydrochloride according to claim 1, wherein: and stirring devices are arranged in the decoloring tank (1) and the crystallization kettle (4).

8. The refined salt formation system of tetracaine hydrochloride according to claim 1, wherein: and a heating device is arranged on the decoloring tank (1).

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