CN217015418U - Heparin column solid phase extraction device - Google Patents

Abstract

The utility model discloses a heparin column solid-phase extraction device which comprises a main body support and a ventilation pipeline, wherein the main body support comprises a hollow column base, a centrifuge tube supporting plate, a centrifuge tube positioning plate, a heparin column positioning plate and an injector cylinder mounting plate are sequentially arranged on the outer diameter of a hollow column with the hollow column base from bottom to top, a waste liquid disc is arranged on the hollow column base and positioned at the lower side of the centrifuge tube supporting plate, and a panel mounting female adapter is arranged on the injector cylinder mounting plate and positioned at the upper side of the hollow column. The sample loading liquid is stably pressurized through the air pressure and the plug cover, manual extrusion of the column passing is released during the column passing, and meanwhile, the column passing pressure is stabilized; different column passing pressure requirements are controlled through the valves of the four-channel combination valve, so that the sample column passing speed is similar, and the influence of different speeds on the recovery rate is reduced; and can carry out one-time sample loading to a plurality of syringe barrels simultaneously, reduce the trouble of repeated sample loading and improve the efficiency.

Description

Heparin column solid phase extraction device

Technical Field

The utility model relates to the field of liquid sample solid phase extraction, in particular to a heparin column solid phase extraction device.

Background

The solid phase extraction method is a sample pretreatment technology developed in recent years, is developed by combining a liquid-solid extraction column and a liquid chromatography technology, is mainly used for separating, purifying and concentrating samples, can improve the recovery rate of analytes compared with the traditional liquid-liquid extraction method, and can more effectively separate the analytes from interfering components. Heparin column solid phase extraction is one of them, has obvious effect to milk composition analysis, but is difficult in filtering the sample, and efficiency is slower, and the rate of passing through the column influences the rate of recovery simultaneously.

SUMMERY OF THE UTILITY MODEL

The present invention is directed to solving the above problems and to providing a heparin column solid phase extraction device.

The utility model achieves the above purpose through the following technical scheme:

a heparin column solid-phase extraction device comprises a main body support and an air vent pipeline, wherein the main body support comprises a hollow column base, a centrifuge tube supporting plate, a centrifuge tube positioning plate, a heparin column positioning plate and an injector barrel mounting plate are sequentially arranged on the outer diameter of a hollow column with the hollow column base from bottom to top, a waste liquid disc is arranged on the hollow column base and positioned on the lower side of the centrifuge tube supporting plate, a panel mounting female adapter is arranged on the injector barrel mounting plate and positioned on the upper side of the hollow column, and the upper end of the panel mounting female adapter is connected with a one-way rotary adapter; the ventilation pipeline is in including setting up the manifold block of single-pass rotary joint upper end, be provided with quick change coupler on the manifold block gas outlet, quick change coupler one end is connected with four-channel combination valve, the end intercommunication of giving vent to anger of four-channel combination valve has direct adapter, direct adapter is installed on the stopper lid, the stopper lid lower extreme is connected with the syringe barrel, syringe barrel lower extreme is connected with the heparin column, heparin column downside is provided with the centrifuging tube, panel mounting internal thread joint lower extreme intercommunication has the main trachea that passes hollow post, the main trachea other end is connected with the air pump.

Further setting: centrifuging tube layer board centrifuging tube locating plate heparin post locating plate syringe barrel mounting panel is discoid, and the center is provided with and passes the aperture of taking the hollow post of hollow column base, syringe barrel mounting panel with be provided with between the centrifuging tube layer board and pass the centrifuging tube locating plate the support column of heparin post locating plate, be located respectively on the support column the centrifuging tube locating plate the downside all is provided with the solid fixed ring of separation type on the heparin post locating plate.

So set up, through the support column is right the centrifuging tube layer board the centrifuging tube locating plate heparin post locating plate syringe barrel mounting panel is connected fixedly, is convenient for right the syringe barrel heparin post the centrifuging tube supports spacingly.

Further setting: heparin post locating plate is provided with two, just be located between the heparin post locating plate the cover is equipped with the pad high ring on the support column external diameter, the centrifuging tube layer board the centrifuging tube locating plate heparin post locating plate the equipartition has the through-hole that corresponds from top to bottom on the syringe barrel mounting panel circumference, and this through-hole is provided with 12 departments.

So set up, make stable the passing through of heparin post the heparin post locating plate is gone on about both sides and is carried on spacingly, makes the centrifuging tube layer board the centrifuging tube locating plate heparin post locating plate the syringe barrel mounting panel can carry out analysis operations to many places simultaneously.

Further setting: centrifuging tube layer board downside is located the hollow post external diameter of taking hollow post base is gone up to overlap and is equipped with solid fixed ring, gu fixed ring upwards is provided with the stopping screw, support column circumference equipartition has three, the support column upper end with syringe barrel mounting panel connects through second countersunk head hexagon socket head.

So set up, be convenient for pass through solid fixed ring the stopping screw is right the centrifuging tube layer board supports spacingly.

Further setting: and the injection molding nut is arranged on the syringe barrel mounting plate and vertically corresponds to the circumferential through hole, and the injection molding nut is in threaded connection with an embossing screw.

So set up, through the impressed watermark screw is in the rotation on the nut of moulding plastics, it is fixed to extrude the syringe barrel.

Further setting: the inlet end of the four-channel combination valve is provided with a first connecting pipe, the other end of the first connecting pipe is provided with an L-shaped joint, the other end of the L-shaped joint is connected with a quick-change joint through a second connecting pipe, the outlet end of the four-channel combination valve is respectively connected with a first combination connecting pipe, a second combination connecting pipe, a third combination connecting pipe and a fourth combination connecting pipe, and the tail end of the first combination connecting pipe, the second combination connecting pipe, the third combination connecting pipe and the fourth combination connecting pipe are connected with a direct adapter.

According to the arrangement, the four-channel combination valve is used for controlling the first combination connecting pipe, the second combination connecting pipe, the third combination connecting pipe and the fourth combination connecting pipe respectively, so that the gas flow is limited conveniently, different speeds are realized and the convenience in operation is improved.

Further setting: l type connects both ends be provided with first takeover the complex step groove is taken over to the second, just first takeover lie in this step groove department on the second takeover external diameter and be provided with the ribbon, on the straight-through adapter with first combination takeover the second combination takeover the third combination takeover the fourth combination takeover department all is provided with the ribbon.

According to the arrangement, the sealing performance of the joint of the first connecting pipe, the second connecting pipe, the first combined connecting pipe, the second combined connecting pipe, the third combined connecting pipe and the fourth combined connecting pipe is improved through the cable ties.

Further setting: the four-channel combined valve is characterized in that three positions are arranged on the mounting plate of the syringe barrel, and the four-channel combined valve is connected with the mounting plate of the syringe barrel through a first countersunk hexagon socket.

So set up, can realize multichannel appearance of going up, improved work efficiency.

Further setting: heparin post locating plate centrifuging tube locating plate hollow column sliding connection of taking hollow column base, the split type grafting of waste liquid dish is in take hollow column base is last.

So set up, be convenient for heparin post locating plate centrifuge tube layer board is in adjust the upper and lower position of taking hollow column base to adapt to the sample demand of different specifications.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a heparin column solid phase extraction device according to the present invention;

FIG. 2 is a schematic structural diagram of the heparin column solid-phase extraction device of the present invention after the pump body is removed;

FIG. 3 is a schematic front view of the structure of FIG. 2;

FIG. 4 is a schematic main sectional view of FIG. 2;

FIG. 5 is a schematic top view of the structure of FIG. 2;

FIG. 6 is a schematic view of a split structure of a waste liquid tray of the heparin column solid-phase extraction device according to the present invention;

FIG. 7 is a schematic view of a part of the connection structure of the ventilation pipeline of the solid phase extraction apparatus for heparin column according to the present invention;

FIG. 8 is an enlarged view of a portion of FIG. 6A;

FIG. 9 is an enlarged view of a portion of the structure of FIG. 6 at B;

FIG. 10 is a schematic view of a part of the structure of the ventilation pipeline of the solid phase extraction apparatus for heparin column according to the present invention;

FIG. 11 is an enlarged partial view of FIG. 10 at C;

fig. 12 is a schematic view of a part of the enlarged structure at D of fig. 11;

FIG. 13 is a schematic view of the connection state of the syringe barrel of the heparin column solid phase extraction device according to the present invention;

FIG. 14 is an enlarged partial view of FIG. 13 at E;

fig. 15 is a schematic structural view in a split state of fig. 13;

FIG. 16 is a schematic view of the fixed structure of the syringe barrel of the heparin column solid phase extraction device according to the present invention;

fig. 17 is a partial enlarged view of the structure of fig. 16 at F;

fig. 18 is a partially enlarged schematic view of the structure at G of fig. 17.

The reference numerals are explained below:

1. a single-pass swivel joint; 2. installing an internal thread joint on the panel; 3. a straight-through adapter; 4. a plug cover; 5. a syringe barrel; 6. a heparin column; 7. centrifuging the tube; 8. a fixing ring; 9. a retaining screw; 10. a waste liquid tray; 11. a main air pipe; 12. a base with a hollow column; 13. a centrifuge tube supporting plate; 14. a centrifuge tube positioning plate; 15. a heparin column positioning plate; 16. a syringe barrel mounting plate; 17. injection molding a nut; 18. embossing screws; 19. a heightening ring; 20. a separation type fixing ring; 21. a support pillar; 22. a manifold block; 23. a four-channel combination valve; 24. a first countersunk hexagon socket; 25. a quick-change connector; 26. binding a belt; 27. a fourth combined connecting pipe; 28. a third combined connecting pipe; 29. a second combined connecting pipe; 30. a first combined connecting pipe; 31. a second countersunk head hexagon socket; 32. a first adapter tube; 33. an L-shaped joint; 34. and a second connecting pipe.

Detailed Description

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The utility model is further described below with reference to the accompanying drawings:

as shown in fig. 1-7, a heparin column solid phase extraction device comprises a main body support and a ventilation pipeline, wherein the main body support comprises a hollow column base 12, a centrifuge tube supporting plate 13, a centrifuge tube positioning plate 14, a heparin column positioning plate 15 and an injector cylinder mounting plate 16 are sequentially arranged on the outer diameter of a hollow column with the hollow column base 12 from bottom to top, a waste liquid tray 10 is arranged on the hollow column base 12 and positioned at the lower side of the centrifuge tube supporting plate 13, a panel mounting female adapter 2 is arranged on the injector cylinder mounting plate 16 and positioned at the upper side of the hollow column, and a single-pass rotary adapter 1 is connected to the upper end of the panel mounting female adapter 2 and is used for communicating a main air pipe 11 and a manifold block 22; the ventilation pipeline comprises a manifold block 22 arranged at the upper end of a single-way rotary joint 1, a quick-change connector 25 is arranged on an air outlet of the manifold block 22, the quick-change connector is convenient to connect with a second connecting pipe 34 quickly, one end of the quick-change connector 25 is connected with a four-channel combination valve 23, an air outlet end of the four-channel combination valve 23 is communicated with a direct-connection adapter 3, the direct-connection adapter 3 is installed on a plug cover 4, the lower end of the plug cover 4 is connected with an injector cylinder 5, the lower end of the injector cylinder 5 is connected with a heparin column 6, a centrifugal tube 7 is arranged on the lower side of the heparin column 6, the lower end of a panel-mounted female connector 2 is communicated with a main air tube 11 penetrating through a hollow column, and the other end of the main air tube 11 is connected with an air pump.

Preferably, the following components: the centrifugal tube supporting plate 13, the centrifugal tube positioning plate 14, the heparin column positioning plate 15 and the syringe barrel mounting plate 16 are disc-shaped, the center of the centrifugal tube supporting plate is provided with a hole diameter penetrating through a hollow column with a hollow column base 12, a supporting column 21 penetrating through the centrifugal tube positioning plate 14 and the heparin column positioning plate 15 is arranged between the syringe barrel mounting plate 16 and the centrifugal tube supporting plate 13, separation type fixing rings 20 are respectively arranged on the upper side and the lower side of the centrifugal tube positioning plate 14 and the heparin column positioning plate 15 on the supporting column 21, the centrifugal tube supporting plate 13, the centrifugal tube positioning plate 14, the heparin column positioning plate 15 and the syringe barrel mounting plate 16 are connected and fixed through the supporting column 21, and the syringe barrel 5, the heparin column 6 and the centrifugal tube 7 are conveniently supported and limited; the heparin column positioning plate 15 is provided with two positions, a padding ring 19 is sleeved on the outer diameter of the support column 21 between the heparin column positioning plate 15, and through holes corresponding to the heparin column positioning plate 13, the centrifuge tube positioning plate 14, the heparin column positioning plate 15 and the injector cylinder mounting plate 16 are uniformly distributed on the circumferences of the through holes in the vertical direction and are provided with 12 positions, so that the heparin column 6 is stably limited on the upper side and the lower side through the heparin column positioning plate 15, and the centrifuge tube positioning plate 13, the centrifuge tube positioning plate 14, the heparin column positioning plate 15 and the injector cylinder mounting plate 16 can simultaneously perform analysis operation on a plurality of positions; a fixing ring 8 is sleeved on the outer diameter of the hollow column with the hollow column base 12 at the lower side of the centrifuge tube supporting plate 13, retaining screws 9 are radially arranged on the fixing ring 8, three positions are uniformly distributed on the circumference of the supporting column 21, the upper end of the supporting column 21 is connected with the syringe barrel mounting plate 16 through a second countersunk hexagon socket 31, and the centrifuge tube supporting plate 13 is conveniently supported and limited through the fixing ring 8 and the retaining screws 9; an injection molding nut 17 is arranged on the syringe barrel mounting plate 16 in a position vertically corresponding to the circumferential through hole, an embossing screw 18 is connected to the injection molding nut 17 in a threaded manner, and the syringe barrel 5 is extruded and fixed through rotation of the embossing screw 18 on the injection molding nut 17; a first connecting pipe 32 is arranged at the air inlet end of the four-channel combined valve 23, an L-shaped connector 33 is arranged at the other end of the first connecting pipe 32, the other end of the L-shaped connector 33 is connected with the quick-change connector 25 through a second connecting pipe 34, the air outlet end of the four-channel combined valve 23 is respectively connected with a first combined connecting pipe 30, a second combined connecting pipe 29, a third combined connecting pipe 28 and a fourth combined connecting pipe 27, the tail ends of the first combined connecting pipe 30, the second combined connecting pipe 29, the third combined connecting pipe 28 and the fourth combined connecting pipe 27 are respectively connected with a through adapter 3, and the four-channel combined valve 23 is used for respectively controlling the first combined connecting pipe 30, the second combined connecting pipe 29, the third combined connecting pipe 28 and the fourth combined connecting pipe 27, so that the air flow is limited, the simultaneous implementation of different rates is realized, and the convenience in operation is improved; step grooves matched with the first connecting pipe 32 and the second connecting pipe 34 are formed in two ends of the L-shaped joint 33, binding tapes 26 are arranged on the outer diameters of the first connecting pipe 32 and the second connecting pipe 34 and positioned at the step grooves, binding tapes 26 are arranged on the positions, located at the step grooves, of the through joint 3, of the first combined connecting pipe 30, the second combined connecting pipe 29, the third combined connecting pipe 28 and the fourth combined connecting pipe 27, and the tightness of the joints of the first connecting pipe 32, the second connecting pipe 34, the first combined connecting pipe 30, the second combined connecting pipe 29, the third combined connecting pipe 28 and the fourth combined connecting pipe 27 is improved through the binding tapes 26; the four-channel combined valve 23 is provided with three positions on the mounting plate 16 of the syringe cylinder, and the four-channel combined valve 23 is connected with the mounting plate 16 of the syringe cylinder through a first countersunk hexagon socket 24, so that multichannel sample loading can be realized, and the working efficiency is improved; heparin post locating plate 15, centrifuging tube locating plate 14, the hollow post sliding connection who takes hollow column base 12, the split type grafting of waste liquid dish 10 is on taking hollow column base 12, and the upper and lower position that heparin post locating plate 15, centrifuging tube locating plate 14, centrifuging tube layer board 13 of being convenient for take hollow column base 12 is adjusted to the sample demand of adaptation different specifications.

The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, but that various changes and modifications may be made without departing from the spirit and scope of the utility model, and such changes and modifications are within the scope of the utility model as claimed.

Claims (9)

1. A heparin column solid phase extraction device which characterized in that: the device comprises a main body support and an air vent pipeline, wherein the main body support comprises a hollow column base (12), a centrifugal tube supporting plate (13), a centrifugal tube positioning plate (14), a heparin column positioning plate (15) and an injector barrel mounting plate (16) are sequentially arranged on the outer diameter of a hollow column with the hollow column base (12) from bottom to top, a waste liquid disc (10) is arranged on the hollow column base (12) and is positioned on the lower side of the centrifugal tube supporting plate (13), a panel-mounted female adapter (2) is arranged on the injector barrel mounting plate (16) and is positioned on the upper side of the hollow column, and a single-way rotary adapter (1) is connected to the upper end of the panel-mounted female adapter (2); the ventilation line is including setting up manifold block (22) of single expert rotary joint (1) upper end, be provided with quick change coupler (25) on manifold block (22) gas outlet, quick change coupler (25) one end is connected with four-channel combination valve (23), the end intercommunication of giving vent to anger of four-channel combination valve (23) has direct adapter (3), install on gag (4) direct adapter (3), gag (4) lower extreme is connected with syringe barrel (5), syringe barrel (5) lower extreme is connected with heparin post (6), heparin post (6) downside is provided with centrifuging tube (7), panel mounting female connection (2) lower extreme intercommunication has main trachea (11) that pass hollow post, main trachea (11) other end and air pump are connected.

2. The heparin column solid phase extraction device of claim 1, which is characterized in that: centrifuging tube layer board (13) centrifuging tube locating plate (14) heparin column locating plate (15) syringe barrel mounting panel (16) are discoid, and the center is provided with and passes take the aperture of hollow column base (12) hollow column, syringe barrel mounting panel (16) with be provided with between centrifuging tube layer board (13) and pass centrifuging tube locating plate (14) support column (21) of heparin column locating plate (15), be located respectively on support column (21) centrifuging tube locating plate (14) heparin column locating plate (15) go up the downside and all be provided with the solid fixed ring of parting type (20).

3. The heparin column solid-phase extraction device according to claim 2, which is characterized in that: heparin column locating plate (15) are provided with two departments, just heparin column locating plate (15) are meta-position in the cover is equipped with on support column (21) external diameter and fills up high ring (19), centrifuging tube layer board (13) centrifuging tube locating plate (14) heparin column locating plate (15) the equipartition has the through-hole that corresponds from top to bottom on syringe barrel mounting panel (16) circumference, and this through-hole is provided with 12 departments.

4. The heparin column solid phase extraction device of claim 2, which is characterized in that: centrifuging tube layer board (13) downside is located the cover is equipped with solid fixed ring (8) on the hollow post external diameter of hollow post base (12) in area, gu fixed ring (8) radially is provided with stopping screw (9), support column (21) circumference equipartition has three departments, support column (21) upper end with connect through second countersunk head hexagon socket head (31) between syringe barrel mounting panel (16).

5. The heparin column solid phase extraction device of claim 3, wherein: and an injection molding nut (17) is arranged on the syringe barrel mounting plate (16) and vertically corresponds to the circumferential through hole, and an embossing screw (18) is connected to the injection molding nut (17) in a threaded manner.

6. The heparin column solid phase extraction device according to claim 1, which is characterized in that: four-channel combination valve (23) inlet end is provided with first takeover (32), L type joint (33) are installed to first takeover (32) other end, L type joint (33) other end through second takeover (34) with quick change coupler (25) are connected, the end of giving vent to anger of four-channel combination valve (23) is connected with first combination respectively and takes over (30), second combination takeover (29), third combination takeover (28), fourth combination takeover (27), just first combination takeover (30), second combination takeover (29) third combination takeover (28) the end of fourth combination takeover (27) all is connected with through adapter (3).

7. The heparin column solid-phase extraction device according to claim 6, which is characterized in that: l type connects (33) both ends be provided with first takeover (32) the complex step groove is taken over to the second (34), just first takeover (32) lie in this step groove department on the second takeover (34) external diameter and be provided with ribbon (26), on direct adapter (3) with first combination takeover (30) second combination takeover (29) third combination takeover (28) fourth combination takeover (27) department all is provided with ribbon (26).

8. The heparin column solid-phase extraction device according to claim 6, which is characterized in that: the four-channel combined valve (23) is arranged at three positions on the syringe cylinder mounting plate (16), and the four-channel combined valve (23) is connected with the syringe cylinder mounting plate (16) through a first countersunk hexagon socket (24).

9. The heparin column solid phase extraction device of claim 1, which is characterized in that: heparin column locating plate (15), centrifuging tube locating plate (14), centrifuging tube layer board (13) with take the hollow column sliding connection of hollow column base (12), waste liquid dish (10) split type grafting is in take on hollow column base (12).

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