CN216998405U

CN216998405U - Allantoic fluid antigen harvesting head

Info

Publication number: CN216998405U
Application number: CN202220489841.3U
Authority: CN
Inventors: 赖汉漳; 麦康聪; 刘玲; 于亚南; 詹烜; 盘伟岚; 陈潮锦; 王小芬; 邵明明; 陈思宇; 梁慧婷; 黄丽萍; 陈培军
Original assignee: Zhaoqing Dahuanong Biological Pharmaceutical Co Ltd
Current assignee: Zhaoqing Dahuanong Biological Pharmaceutical Co Ltd
Priority date: 2022-03-05
Filing date: 2022-03-05
Publication date: 2022-07-19
Anticipated expiration: 2032-03-05

Abstract

The utility model discloses an allantoic fluid antigen harvesting head, aiming at improving the liquid inlet efficiency and avoiding the egg yolk pollution caused by allantoic fluid overflow and egg yolk sac rupture in embryonated eggs, the technical proposal is as follows: an allantoic fluid antigen harvesting head comprises a tube body and an internal suction tube, wherein the upper end of the internal suction tube is positioned outside the tube body, the lower end of the internal suction tube is positioned inside the tube body, and a plurality of grid seams are arranged on the outer wall of the tube body, and belongs to the technical field of vaccine production.

Description

Allantoic fluid antigen harvesting head

Technical Field

The utility model belongs to the technical field of vaccine production, and particularly relates to an allantoic fluid antigen harvesting head.

Background

The existing avian influenza vaccines are generally consistent in production process, and generally adopt a chick embryo virus culture method to prepare antigen, and then plum blossom and emulsification are carried out to prepare the inactivated oil emulsion vaccine. When the antigen is prepared, allantoic fluid in embryo eggs needs to be obtained, along with the improvement of technological level, most of allantoic fluid obtaining work is completed by an automatic harvester, and an allantoic fluid harvesting head is a key part in the harvester.

For example, CN202011877U discloses a harvesting head for harvesting embryo fluid of semi-finished avian influenza vaccine, which comprises a sealing cover, a sealing rubber ring, an outer sleeve and an inner suction tube, wherein the upper part of the outer sleeve is additionally provided with an air pressure balancing hole, the lower part of the outer sleeve is additionally provided with an air inlet hole, the inner suction tube is prolonged, and an amniotic sac piercing structure is additionally arranged.

Also, CN212335191U discloses a device for harvesting infectious bronchitis antigens, which comprises a harvesting head, wherein the harvesting head comprises a liquid absorbing rod and an outer sleeve, the outer sleeve is formed by connecting a liquid absorbing rod insertion head and a liquid absorbing rod outer sleeve which are sequentially arranged from top to bottom, the lower end of the liquid absorbing rod outer sleeve is an inclined plane sharp head, and the included angle between the inclined plane of the inclined plane sharp head and the horizontal plane is 30-45 degrees; and the side wall of the outer sleeve of the liquid suction rod, which is at the same side with the sharp end of the inclined plane sharp head, is provided with a plurality of liquid suction holes.

The two devices are used for harvesting allantoic fluid antigens, the structures of the two devices are similar, the lower part of the tube body is provided with the liquid inlet hole to enable allantoic fluid to enter the tube body, according to the description of the specification, the liquid inlet hole is a circular hole, when the two devices are actually used, the liquid inlet speed of the circular hole is low, the allantoic fluid can enter the tube body only when the allantoic fluid overflows the liquid inlet hole, and part of the liquid inlet hole is easily and completely wrapped and buried by the yolk sac membrane to shield the liquid inlet or the liquid inlet is not smooth, so that the allantoic fluid is squeezed out of embryonated eggs after a harvesting head enters the allantoic cavity, and the harvest yield of the allantoic fluid is influenced. In addition, the amniotic sac puncture structure is found by practice to be unable to avoid the yolk sac, and probably puncture the yolk sac to cause allantoic fluid to be polluted by yolk.

SUMMERY OF THE UTILITY MODEL

The utility model mainly aims to provide an allantoic fluid antigen harvesting head, which aims to improve the liquid inlet efficiency and avoid allantoic fluid in embryonated eggs from overflowing.

According to a first aspect of the utility model, an allantoic fluid antigen harvesting head is provided, and comprises a tube body and an internal suction tube, wherein the upper end of the internal suction tube is positioned outside the tube body, the lower end of the internal suction tube is positioned inside the tube body, and a plurality of grid seams are arranged on the outer wall of the tube body.

In the allantoic fluid antigen harvesting head, the grid seams are a plurality of straight seams, broken line seams or curved seams which are arranged at intervals along the axial direction of the pipe body.

In the allantoic fluid antigen harvesting head, the grid seams are a plurality of strips arranged around the circumference of the tube body.

In the allantoic fluid antigen harvesting head, the gate seam extends from top to bottom to the lower end of the tube body.

In the allantoic fluid antigen harvesting head, the lower end of the internal suction tube is lower than the upper end of the gate slit.

In the allantoic fluid antigen harvesting head, the lower end of the pipe body is a bullet-shaped cambered surface end part or a beveled surface end part or a sharp end part.

In the allantoic fluid antigen harvesting head, the upper end of the tube body is an open end, the open end is provided with a cover body, and the internal suction tube penetrates through the cover body and enters the tube body.

One of the above technical solutions of the present invention has at least one of the following advantages or beneficial effects:

according to the utility model, allantoic fluid enters the tube body through the grid seam, and the grid seam has larger passing area and smoother passing performance compared with the traditional circular hole, even if the lower end of the grid seam is wrapped and shielded by the yolk sac and the like, the allantoic fluid can flow into the tube body from the upper end of the grid seam for the first time while the liquid level rises, so that the allantoic fluid in the embryonated egg is prevented from overflowing, meanwhile, the upper end of the grid seam can also be used as a ventilation grid seam, the effect of maintaining the balance of the internal and external air pressures of the harvesting head is achieved, and the yolk sac is prevented from being broken due to the negative pressure in the tube body; in addition, the width of the grid seam is relatively small, so that the yolk sac can be shielded from being extruded into the tube.

Drawings

The utility model is further described below with reference to the accompanying drawings and examples;

FIG. 1 is a schematic structural view of embodiment 1 of the present invention;

fig. 2 is a schematic structural diagram of embodiment 2 of the present invention.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.

The following disclosure provides many different embodiments, or examples, for implementing different aspects of the utility model.

Example 1

Referring to fig. 1, in one embodiment of the utility model, an allantoic fluid antigen harvesting head comprises a tube body 1 and an internal suction tube 2, wherein the upper end of the internal suction tube 2 is positioned outside the tube body 1, the lower end of the internal suction tube 2 is positioned inside the tube body 1, and a plurality of grid seams 3 are arranged on the outer wall of the tube body 1;

allantoic fluid enters the tube body 1 through the gate seam 3, and compared with a traditional circular hole, the gate seam 3 has larger passing area and smoother passing performance, and even if the lower end of the gate seam 3 is wrapped and shielded by a yolk sac and the like, the allantoic fluid can flow into the tube body 1 from the upper end of the gate seam 3 at the first time while the liquid level rises, so that the allantoic fluid in the embryonated eggs is prevented from overflowing; meanwhile, the upper end of the grid seam 3 can also be used as a ventilation grid seam, so that the effect of maintaining the balance of the internal and external air pressure of the harvesting head is achieved, and the yolk sac is prevented from being broken due to the negative pressure in the tube body 1; in addition, the width of the grid seam 3 is relatively small, so that the yolk sac can be shielded from being extruded into the tube.

In this embodiment, the gate slits 3 are arranged around the circumference of the tube body 1, so that allantoic fluid can contact the gate slits 3 in a wide range, and the allantoic fluid can rapidly enter the tube body 1.

In the arrangement mode, the gate slit 3 extends to the lower end of the tube body 1 from top to bottom, allantoic fluid can flow into the gate slit 3 at the first time after the harvest head enters the allantoic cavity, and accordingly allantoic fluid in the embryonated egg is prevented from overflowing; when the grid seams 3 extend from top to bottom, one type of grid seams extends vertically downwards, so that the length direction of the grid seams 3 is positioned on a vertical plane; the other is that the pipe body 1 extends downwards along the outer wall of the pipe body in a curve or a folding line.

In a specific embodiment, the lower end of the internal suction pipe 2 is lower than the upper end of the grid seam 3, so that allantoic fluid entering from the grid seam 3 can contact the internal suction pipe 2 and be sucked away by the internal suction pipe 2 in time;

more preferably, the lower end of the inner straw 2 is flush with or lower than the lower end of the slit 3, so that even a small amount of allantoic fluid entering from the slit 3 can be sucked by the inner straw 2.

In the embodiment, the lower end of the tube body 1 is a bullet-shaped cambered end part, and the end part in the shape can ensure that the inner suction tube 2 can maximally enter the depth of the embryonated egg to absorb allantoic fluid as much as possible, so that the tube body 1 is prevented from puncturing yolk, and the probability of breaking the yolk is reduced; and because the technology of the existing automatic harvester is more and more advanced, before allantoic fluid is harvested, the top of the embryo egg is firstly shelled, and the harvest head is not needed to break the shell.

Specifically, the upper end of the pipe body 1 is an open end, the open end is provided with a cover body 4, and the inner suction pipe 2 penetrates through the cover body 4 and enters the inside of the pipe body 1, so that the inner suction pipe 2 is fixed.

In actual use, the grid seam 3 is far higher than the depth of allantoic fluid, so that the allantoic fluid cannot be completely immersed, the leaked grid seam 3 can be used for ventilation, the air pressure balance inside and outside the tube body 1 is kept, and the egg yolk sac is prevented from being broken by negative pressure suction formed by the tube body 1.

Example 2

Referring to fig. 2, the structure is substantially the same as that of example 1, except that: the lower end of the pipe body 1 is a beveled end or a sharp end; when the automatic harvester does not pre-break the shell, the lower end of the tube body 1 can directly puncture the top of the embryo egg;

in this case, the inner straw 2 may be inclined inside the tube body 1, and the closer the lower end of the inner straw 2 is to the lower end of the tube body 1, the better, the easier to quickly suck allantoic fluid.

Preferably, the lower end of the pipe body 1 is a tapered end, and the inner suction pipe 2 can be inclined without bending;

further, the conical angle of the conical end part is 90-120 degrees; more preferably, the taper angle of the tapered end is 90 degrees, 100 degrees, 110 degrees or 120 degrees.

While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the utility model, the scope of which is defined by the claims and their equivalents.

Claims

1. The allantoic fluid antigen harvesting head comprises a tube body and an internal suction tube, wherein the upper end of the internal suction tube is positioned outside the tube body, and the lower end of the internal suction tube is positioned inside the tube body.

2. The allantoic fluid antigen harvesting head of claim 1, wherein said grid slits are a plurality of strips spaced axially along the tube.

3. The allantoic fluid antigen harvesting head of claim 1, wherein the grid slits are a plurality of strips disposed circumferentially around the tube.

4. The allantoic fluid antigen harvesting head of claim 3, wherein the gate slit extends from top to bottom to the lower end of the tube.

5. The allantoic fluid antigen harvesting head of claim 4, wherein a lower end of the internal suction tube is below an upper end of the gate slit.

6. An allantoic fluid antigen harvesting head as defined in claim 3, wherein the lower end of the tube is bullet-shaped, cambered or beveled or sharp.

7. The allantoic fluid antigen harvesting head of claim 1, wherein the upper end of the tube is open, the open end having a cap, the intake tube passing through the cap into the interior of the tube.