CN216998362U

CN216998362U - Coupling type bioreactor

Info

Publication number: CN216998362U
Application number: CN202122168306.6U
Authority: CN
Inventors: 林茂; 辛晓桐; 尹美琳; 郑真献
Original assignee: Zhejiang Rongkai Technology Development Co ltd
Current assignee: Zhejiang Rongkai Technology Development Co ltd
Priority date: 2021-09-09
Filing date: 2021-09-09
Publication date: 2022-07-19
Anticipated expiration: 2031-09-09

Abstract

The utility model discloses a coupling bioreactor, aiming at solving the problems that shearing force generated by the existing stirring mode can damage cells and influence the efficiency and quality of biological reaction. The key points of the technical scheme are as follows: including the mounting bracket and jar body, be provided with the drive arrangement who is used for driving jar body and removes on the mounting bracket, drive arrangement including rotate with the mounting bracket be connected gear one and with gear one engaged with gear two, gear two rotates with the mounting bracket to be connected, be provided with on the gear one rather than sliding connection's carriage release lever, carriage release lever and jar body fixed connection, the axle center department of gear two is provided with rather than fixed connection's sector gear, be provided with a plurality of latches with sector gear engagement on the carriage release lever. According to the utility model, the tank body is moved at a constant speed in the horizontal direction, so that the liquid in the tank body shakes, the reaction is more sufficient, the mode is more mild and uniform, the survival of cells is facilitated, and the reaction quality is improved.

Description

Coupling type bioreactor

Technical Field

The utility model relates to the technical field of biology, in particular to a coupling type bioreactor.

Background

Bioreactor refers to any manufacturing or engineering equipment that provides a biologically active environment, in one case a vessel that performs chemical processes involving the production of biologically or biochemically active substances from a particular organism, either aerobically or anaerobically, and is generally cylindrical in shape, ranging in volume from a few liters to several cubic meters, and is often made of stainless steel; the bioreactor is a device system for carrying out biochemical reaction in vitro by utilizing the biological function of enzyme or organism (such as microorganism), is a biological function simulator, such as a fermentation tank, an immobilized enzyme or an immobilized cell reactor and the like, and has important application in the aspects of wine, medicine production, concentrated jam, fruit juice fermentation and organic pollutant degradation.

Traditional bioreactor rotates through the inside (mixing) shaft of motor drive bioreactor and implements the stirring, and at the initial stage of starter motor, the motor drives the sudden rotation of (mixing) shaft and often can make the inside some part of bioreactor react too fast and exert an influence to the cell, and the shearing force that used stirring mode produced still can cause the damage to the cell, is unfavorable for surviving of cell, can cause cell death even, influences the efficiency and the quality of reaction.

There is therefore a need to propose a solution to this problem.

SUMMERY OF THE UTILITY MODEL

Aiming at the defects in the prior art, the utility model aims to provide a coupling bioreactor, which can lead the liquid in the tank body to shake by moving the tank body at a constant speed in the horizontal direction, so that the reaction is more sufficient, the mode is more mild and uniform, the survival of cells is facilitated, and the reaction quality is improved.

The technical purpose of the utility model is realized by the following technical scheme: the utility model provides a coupled bioreactor, includes the mounting bracket and a jar body, be provided with the drive arrangement who is used for driving a jar body and removes on the mounting bracket, drive arrangement rotate the gear one of being connected and with gear one engaged with gear two with the mounting bracket, gear two rotates with the mounting bracket to be connected, gear one is last to be provided with rather than sliding connection's carriage release lever, carriage release lever and jar body fixed connection, the axle center department of gear two is provided with rather than fixed connection's sector gear, be provided with a plurality ofly on the carriage release lever with sector gear engaged's latch.

By adopting the technical scheme, after liquid is added into the tank body, the tank body can be driven by the driving device to move in the horizontal direction, the first gear is rotated, the first gear can drive the second gear which is meshed with the first gear to rotate, the second gear can drive the sector gear which is fixedly connected with the second gear to rotate together after rotating, and the sector gear is meshed with the latch on the movable rod, so that the forward and reverse rotation of the sector gear can drive the movable rod to reciprocate, the movable rod can drive the tank body to reciprocate after moving, the movable rod and the tank body move at a constant speed, the liquid in the tank body can shake due to the movement of the tank body, the liquid in the tank body can generate waves in the shaking process, the liquid and gas in the tank body can react more fully, the damage to cells caused by the shearing force generated by the stirring shaft in a common stirring mode is avoided, and the survival of the cells is facilitated, the reaction process in the bioreactor is uniform, and the influence on cells caused by the fact that a certain part reacts too fast can be avoided.

The utility model is further configured to: an inserting rod rotatably connected with the first gear is arranged at the axis of the first gear, and a slot for the inserting rod to insert and move is formed in one side, close to the inserting rod, of the moving rod.

By adopting the technical scheme, in the process that the moving rod moves along with the rotation of the sector gear, the inserted rod can be inserted into the slot to move, so that the moving rod is more stable in the moving process.

The utility model is further configured to: the one end fixedly connected with stopper that the inserted bar inserted the slot, be provided with the spacing groove that supplies the stopper to insert and remove on the inner wall of slot.

Through adopting above-mentioned technical scheme, at the in-process that the inserted bar removed along the slot, the stopper can insert and remove in the spacing groove, makes the carriage release lever more stable at the in-process that removes, prevents that the carriage release lever from can follow gear one and drop.

The utility model is further configured to: the inner wall of the limiting groove is provided with a plurality of universal balls distributed in an array mode, and the universal balls are attached to the surface of the limiting block.

Through adopting above-mentioned technical scheme, at the in-process that the stopper removed along the spacing groove, universal ball can roll along the surface of stopper, has reduced the friction between stopper and the spacing groove, makes the removal of carriage release lever more smooth and easy.

The utility model is further configured to: the tank body comprises a shell and an inner container, and a plurality of elastic pieces distributed in an array are arranged between the inner wall of the shell and the outer wall of the inner container.

Through adopting above-mentioned technical scheme, at the jar in-process that the body removed along with the carriage release lever, because connect through the elastic component between shell and the inner bag, consequently at the in-process that removes, the inner bag can produce certain rocking, and the elastic component can stretch out and draw back along with rocking of inner bag, the range increase of rocking the inner bag, rocking of inner bag just also can drive liquid production wave, the wave that produces is rocked with the inner bag at the translation in-process wave that produces is in different frequency channels, be the gas-liquid in the jar body can more abundant mixing reaction.

The utility model is further configured to: an electric push rod with one end fixedly connected with the inner wall of the shell is arranged on the inner wall of the shell, and a tightly supporting plate used for tightly supporting the inner container is arranged at the other end of the electric push rod.

Through adopting above-mentioned technical scheme, when the inner bag needs the stillness under the circumstances such as maintenance clearance, can promote to support tight board through the electric putter on the shell inner wall, conflict with the outer wall of inner bag until supporting tight board, and all be equipped with electric putter on each inner wall of shell, support tight board on each face and all support tight inner bag after, just can fix the inner bag between a plurality of tight boards, be difficult to produce and remove, made things convenient for going on of work such as maintenance clearance.

The utility model is further configured to: one side of the abutting plate close to the inner container is fixedly connected with an elastic cushion.

Through adopting above-mentioned technical scheme, the material of cushion is high elasticity rubber, and the cushion can prevent to support the board and appear the condition of scratch damage when supporting tightly the inner bag tightly.

In conclusion, the utility model has the following beneficial effects:

according to the utility model, the liquid in the tank body generates waves in the shaking process, so that the liquid and the gas in the tank body react more fully, the damage of shearing force generated by a stirring shaft in a commonly used stirring mode to cells is avoided, the survival of the cells is facilitated, the reaction process in the bioreactor is uniform, the influence on the cells due to the over-fast reaction of a certain part is avoided, and the quality of biological reaction is improved.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention, showing the overall structural features of the present invention;

FIG. 2 is a schematic structural diagram of a driving device of the present invention, showing the structural features of the driving device;

fig. 3 is a schematic structural view of the moving bar of the present invention, showing the internal structural features of the moving bar.

In the figure: 1. a mounting frame; 2. a tank body; 3. a housing; 4. an inner container; 5. a first gear; 6. a second gear; 7. a travel bar; 8. a sector gear; 9. clamping teeth; 10. inserting a rod; 11. inserting slots; 12. a limiting block; 13. a limiting groove; 14. a ball transfer unit; 15. an elastic member; 16. an electric push rod; 17. and tightly abutting against the plate.

Detailed Description

In order to make those skilled in the art better understand the technical solution of the present invention, the following detailed description of the present invention is made with reference to the accompanying drawings and specific embodiments, and it is to be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.

In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.

The present invention will be described in detail below with reference to the accompanying drawings.

A coupling bioreactor is shown in figures 1-3 and comprises a mounting frame 1 and a tank body 2, wherein a liquid adding pipeline on the tank body 2 is fixed on the side wall of the tank body 2, a liquid inlet of the liquid adding pipeline extends out of the tank body 2, and the liquid inlet of the liquid adding pipeline is communicated with an external hose.

Be equipped with the drive arrangement who is used for driving jar body 2 and removes on the mounting bracket 1, drive arrangement including with mounting bracket 1 rotate the gear one 5 be connected and with the gear two 6 of one 5 meshing, install servo motor on the mounting bracket 1, gear one 5 passes through the coupling joint with servo motor's output shaft, gear two 6 rotates with mounting bracket 1 to be connected, be equipped with the carriage release lever 7 rather than sliding connection on the gear one 5, carriage release lever 7 and jar body 2 fixed connection, the axle center department of gear two 6 is equipped with rather than fixed connection's sector gear 8, be equipped with a plurality of latch 9 with sector gear 8 meshing on the carriage release lever 7, servo motor can just good control gear one 5 carry out two ascending uniform rotations in direction.

The axle center department of gear 5 is equipped with rather than the inserted bar 10 of being connected of rotating, and one side that the carriage release lever 7 is close to inserted bar 10 is equipped with the slot 11 that supplies inserted bar 10 to insert and remove, and the one end fixedly connected with stopper 12 that inserted bar 10 inserted slot 11 is equipped with the spacing groove 13 that supplies stopper 12 to insert and remove on the inner wall of slot 11, is equipped with the universal ball 14 that a plurality of arrays distribute on the inner wall of spacing groove 13, and universal ball 14 and stopper 12's surface laminating.

The tank body 2 comprises a shell 3 and a liner 4, a plurality of elastic pieces 15 distributed in an array are arranged between the inner wall of the shell 3 and the outer wall of the liner 4, the elastic pieces 15 are springs, and two ends of each elastic piece 15 are fixedly connected with the inner wall of the shell 3 and the outer wall of the liner 4 respectively.

Be equipped with a plurality of electric putter 16 on shell 3's the inner wall, be equipped with a plurality of holding tanks that correspond with electric putter 16 position on shell 3's the inner wall, electric putter 16's one end and holding tank fixed connection, electric putter 16's the other end is equipped with the tight board 17 that supports that is used for supporting tight inner bag 4, support one side fixedly connected with cushion that tight board 17 is close to inner bag 4, when supporting tight board 17 and not using, support tight board 17 and electric putter 16 and can retract to the holding tank in, can not influence rocking of inner bag 4.

After liquid is added into the tank body 2, the tank body 2 can be driven by a driving device to move in the horizontal direction, the gear I5 is rotated, the gear I5 can drive the gear II 6 which is meshed with the gear I to rotate after rotating, the gear II 6 can drive the sector gear 8I which is fixedly connected with the gear II to rotate after rotating, and the sector gear 8 is meshed with the latch 9 on the movable rod 7, so that the movable rod 7 can be driven to reciprocate by the forward and reverse rotation of the sector gear 8, the tank body 2 can be driven to reciprocate after the movable rod 7 moves, the movable rod 7 and the tank body 2 move at a constant speed, the liquid in the tank body 2 can shake by the movement of the tank body 2, the liquid in the tank body 2 can generate waves in the shaking process, the reaction between the liquid in the tank body 2 and gas is more sufficient, and the damage of shearing force generated by a stirring shaft in a common stirring mode to cells is avoided, the cell survival is facilitated, the reaction process inside the bioreactor is uniform, the influence on the cells due to the fact that a certain part reacts too fast is avoided, and the quality of the biological reaction is improved.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the utility model may occur to those skilled in the art without departing from the principle of the utility model, and are considered to be within the scope of the utility model.

Claims

1. The utility model provides a coupled bioreactor, includes mounting bracket (1) and jar body (2), be provided with the drive arrangement who is used for driving jar body (2) to remove on mounting bracket (1), its characterized in that: drive device including rotate with mounting bracket (1) be connected gear (5) and with gear (5) engaged gear two (6), gear two (6) rotate with mounting bracket (1) to be connected, be provided with carriage release lever (7) rather than sliding connection on gear (5), carriage release lever (7) and jar body (2) fixed connection, the axle center department of gear two (6) is provided with rather than fixed connection's sector gear (8), be provided with on carriage release lever (7) a plurality of latch (9) with sector gear (8) meshing.

2. A coupled bioreactor according to claim 1, wherein: an inserting rod (10) rotationally connected with the first gear (5) is arranged at the axis of the first gear, and a slot (11) for the inserting rod (10) to insert and move is formed in one side, close to the inserting rod (10), of the moving rod (7).

3. A coupled bioreactor according to claim 2, wherein: one end of the inserted rod (10) inserted into the slot (11) is fixedly connected with a limiting block (12), and a limiting groove (13) for the limiting block (12) to be inserted and moved is arranged on the inner wall of the slot (11).

4. A coupled bioreactor according to claim 3, wherein: be provided with a plurality of array distribution's universal ball (14) on the inner wall of spacing groove (13), universal ball (14) and the laminating of the surface of stopper (12).

5. A coupled bioreactor according to claim 1, wherein: the tank body (2) comprises a shell (3) and an inner container (4), and a plurality of elastic pieces (15) distributed in an array are arranged between the inner wall of the shell (3) and the outer wall of the inner container (4).

6. A coupled bioreactor according to claim 5, wherein: an electric push rod (16) with one end fixedly connected with the shell is arranged on the inner wall of the shell (3), and a tight supporting plate (17) used for supporting the inner container (4) is arranged at the other end of the electric push rod (16).

7. A coupled bioreactor according to claim 6, wherein: one side of the abutting plate (17) close to the inner container (4) is fixedly connected with an elastic pad.