CN216837989U - Nucleic acid detecting device - Google Patents
Nucleic acid detecting device Download PDFInfo
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- CN216837989U CN216837989U CN202220399385.3U CN202220399385U CN216837989U CN 216837989 U CN216837989 U CN 216837989U CN 202220399385 U CN202220399385 U CN 202220399385U CN 216837989 U CN216837989 U CN 216837989U
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- amplification
- nucleic acid
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Abstract
The utility model provides a nucleic acid detection device, include: an outer case having an accommodating space formed therein; a nucleic acid lysis component arranged in the accommodating space; the amplification assembly is arranged in the accommodating space; a detection module, which is arranged adjacent to the amplification module and can detect the reaction liquid in the amplification module; and the control component can adjust the temperature of the nucleic acid cracking component and the amplification component and can acquire the detection result of the detection component. The utility model discloses, simple structure is compact, the volume is less, and convenient to carry can satisfy different use scenes such as individual, enterprise, school.
Description
Technical Field
The utility model belongs to the technical field of the instantaneous detection, concretely relates to nucleic acid detection device.
Background
With the improvement of living standards and the development of biotechnology, the pursuit and the attention of people to health are more and more prominent, and with the acceleration of life rhythm of people, time and efficiency become the most concerned aspects of people no matter in work or life, and particularly in the aspect of medical detection, the tedious inspection, the complex operation and the large amount of result waiting time consumption become a big problem.
SUMMERY OF THE UTILITY MODEL
Therefore, the to-be-solved technical problem of the utility model is to provide a nucleic acid detection device, simple structure is compact, the volume is less, and convenient to carry can satisfy different use scenes such as individual, enterprise, school.
In order to solve the above problem, the present invention provides a nucleic acid detecting apparatus, including:
an outer case having an accommodating space formed therein;
a nucleic acid lysis component arranged in the accommodating space;
the amplification assembly is arranged in the accommodating space;
a detection module, which is arranged adjacent to the amplification module and can detect the reaction liquid in the amplification module;
and the control component can adjust the temperature of the nucleic acid cracking component and the amplification component and can acquire the detection result of the detection component.
In some embodiments, the nucleic acid lysis component comprises:
a pyrolysis heat transfer block on which a pyrolysis heating hole for accommodating a pyrolysis reagent tube is constructed;
and the cracking heating film is arranged at the bottom end or the side surface of the cracking heat transfer block.
In some embodiments, the amplification module comprises:
an amplification heat transfer block on which an amplification heating hole for accommodating an amplification reagent tube is configured;
and an amplification heating film disposed at a bottom end or a side surface of the amplification heat transfer block.
In some embodiments, the nucleic acid lysis component further comprises:
the cracking temperature sensor is used for detecting the real-time heating temperature of the cracking heating film;
the cracking overheat protector is used for cutting off a heating power supply of the cracking heating film when the heating temperature of the cracking heating film exceeds a corresponding upper limit temperature threshold value; alternatively, the first and second electrodes may be,
the amplification assembly further comprises:
an amplification temperature sensor for detecting a real-time heating temperature of the amplification heating film;
and the amplification overheating protector is used for cutting off the heating power supply of the amplification heating film when the heating temperature of the amplification heating film exceeds a corresponding upper limit temperature threshold value.
In some embodiments of the present invention, the substrate is,
the outer shell is provided with an upward through hole, and the cracking reagent tube and the amplification reagent tube can be respectively arranged in the cracking heat transfer block and the amplification heat transfer block through the through hole and can be respectively taken out of the cracking heat transfer block and the amplification heat transfer block through the through hole.
In some embodiments of the present invention, the substrate is,
a gland is arranged at the top of the outer shell, and one side of the gland is rotatably connected with the outer shell so that the gland can close or open the through hole in an openable manner; alternatively, the amplification module has a plurality of amplification modules.
In some embodiments of the present invention, the substrate is,
the shell body comprises a lower shell and an upper shell which is assembled into a whole with the lower shell, the through hole is formed in the upper shell, and the gland is connected with the upper shell.
In some embodiments of the present invention, the substrate is,
the upper shell is provided with a user operation area, and a key switch and a result indicating component are arranged in the user operation area.
In some embodiments of the present invention, the substrate is,
the result indicating component comprises a red-green indicator light.
In some embodiments of the present invention, the substrate is,
the cracking heat transfer block and the amplification heat transfer block are made of one of aluminum, copper and nylon; alternatively, the first and second electrodes may be,
the cracking heating film and the amplification heating film are made of one of a PI heating film, a Peltier and a resistance wire.
The utility model provides a pair of nucleic acid detection device, will nucleic acid schizolysis subassembly, amplification subassembly, determine module and control assembly integrate in the shell, simple structure is compact, the volume is less, and convenient to carry can satisfy different use scenes such as individual, enterprise, school.
Drawings
FIG. 1 is a schematic external perspective view of a nucleic acid detecting apparatus according to an embodiment of the present invention;
FIG. 2 is a disassembled view of the internal structure of the nucleic acid detecting apparatus in FIG. 1 from a perspective (with an outer case omitted);
FIG. 3 is a disassembled view of the internal structure of the nucleic acid detecting apparatus in FIG. 1 from another perspective (with the outer case omitted).
The reference numerals are represented as:
11. a lower housing; 12. an upper housing; 121. a key switch; 122. a result indicating component; 20. a lysis reagent tube; 21. cracking the heat transfer block; 22. cracking the heating film; 30. an amplification reagent tube; 31. amplifying the heat transfer block; 32. amplifying the heating film; 33. an amplification temperature sensor; 34. an amplification overheat protector; 4. a gland; 51. a main control panel; 52. a temperature control panel; 53. a key switch control panel; 54. a power supply component; 61. detecting a light source; 62. a photoelectric sensor.
Detailed Description
Referring to fig. 1 to 3, according to an embodiment of the present invention, there is provided a nucleic acid detecting apparatus including: an outer case having an accommodating space formed therein; a nucleic acid lysis component arranged in the accommodating space; the amplification assembly is arranged in the accommodating space; a detection module, which is arranged adjacent to the amplification module and can detect the reaction liquid in the amplification module; and the control component can adjust the temperature of the nucleic acid cracking component and the amplification component and can acquire the detection result of the detection component. In the technical scheme, the nucleic acid cracking component, the amplification component, the detection component and the control component are integrated in the outer shell, so that the device is simple and compact in structure, small in size and convenient to carry, can meet different use scenes of individuals, enterprises, schools and the like, and is particularly suitable for families.
In some embodiments, the nucleic acid lysis component comprises: a pyrolysis heat transfer block 21 on which a pyrolysis heating hole for receiving the pyrolysis reagent tube 20 is constructed; and a pyrolysis heating film 22 disposed at a bottom end or a side surface of the pyrolysis heat transfer block 21. In the technical scheme, it can be understood that the tube bottom of the cracking reagent tube 20 is located in the cracking heating hole, the cracking heat transfer block 21 can heat the tube bottom (the lower region of the tube, namely the position occupied by the reagent and the sample, the same below) of the cracking reagent tube 20 in all directions, the heating is more stable (constant temperature) and uniform, and the structure of the device which is overlapped up and down can further improve the structural compactness of the device; similarly, the amplification module comprises: an amplification heat transfer block 31 on which an amplification heating hole for accommodating the amplification reagent tube 30 is configured; and an amplification heating film 32 provided at the bottom end or the side surface of the amplification heat transfer block 31. In the technical scheme, the tube bottom of the amplification reagent tube 30 is positioned in the cracking heating hole, the amplification heat transfer block 31 can heat the tube bottom of the amplification reagent tube 30 in an all-around manner, the heating is more stable (constant temperature and uniform), and the structure of the upper layer and the lower layer can further improve the structural compactness of the device. It can be understood that the lysis reagent tube 20 and the amplification reagent tube 30 are consumables, and the device can be shared by family members by replacing different reagent tubes, so that the device can be reused, and the use cost can be reduced.
The nucleic acid lysis assembly further comprises: a pyrolysis temperature sensor (not shown in the drawings, not referenced) for detecting a real-time heating temperature of the pyrolysis heating film 22; a pyrolysis overheat protector (not shown, not referenced) for cutting off a heating power supply to the pyrolysis heating film 22 when a heating temperature of the pyrolysis heating film 22 exceeds a corresponding upper limit temperature threshold; alternatively, the amplification module further comprises: an amplification temperature sensor 33 for detecting a real-time heating temperature of the amplification heating film 32; and an amplification overheat protector 34 for cutting off the heating power supply to the amplification heating film 32 when the heating temperature of the amplification heating film 32 exceeds a corresponding upper limit temperature threshold. Cracking temperature sensor and amplification temperature sensor 33 can guarantee corresponding heating temperature's accurate invariant, cracking overheat protector, amplification overheat protector 34 then can form overheat protection to corresponding heating element, effectively prevent the overheated damage of device.
The outer shell body is provided with upward through holes (not marked in the figure), the cracking reagent tube 20 and the amplification reagent tube 30 can be respectively arranged in the cracking heat transfer block 21 and the amplification heat transfer block 31 through the through holes and can be respectively taken out from the cracking heat transfer block 21 and the amplification heat transfer block 31 through the through holes, specifically, the outer shell body comprises a lower outer shell 11 and an upper outer shell 12 assembled into a whole with the lower outer shell 11, the through holes are formed in the upper outer shell 12, the through holes are provided with two corresponding to the cracking reagent tube 20 and the amplification reagent tube 30, the aperture of each through hole is respectively matched with the tube diameters of the two reagent tubes, and therefore, the reagent tubes can be replaced when all parts are packaged in the containing space.
In some embodiments, a gland 4 is disposed on the top of the outer casing, a side of the gland 4 is rotatably connected with the outer casing, so that the gland 4 can be opened and closed to close or open the through hole, the gland 4 is disposed to perform heat preservation and insulation, and at this time, the gland 4 can be configured as a thermal cover. In a particular embodiment, the gland 4 is connected to the upper housing 12 (which may in particular be pivotally connected by a pivot shaft).
In some embodiments, the amplification modules are provided in plural numbers, and the plural amplification modules can be controlled independently of each other, and it is understood that the amplification reagent tubes 30 provided on the upper casing 12 corresponding to the plural amplification modules are provided with corresponding through holes.
The upper housing 12 has a user operation area, and a key switch 121 and a result indication component 122 are arranged in the user operation area, it can be understood that a user can control whether the device is running or not, and control a corresponding detection program and a cracking program (the cracking program is an optional program and can be replaced by normal temperature cracking) through the key switch 121, it should be noted that the key switch 121 can be provided with a plurality of keys for different functions, for example, two keys, specifically, one key controls cracking starting, the other key controls amplification starting, and a key is pressed for a long time to control on/off of the device; the result indicating component 122 can visually feed back the detection result to the user, specifically, for example, the result indicating component 122 includes a red-green indicator light, specifically, the corresponding indicator light is green when the detection result is negative, and the corresponding indicator light is red when the detection result is positive, and of course, other colors or two indicator lights may be used instead. It should be noted that the two-color indication method is qualitative detection, and has the advantages of short detection time, accurate detection result, high detection sensitivity, and the like.
The cracking heat transfer block 21 and the amplification heat transfer block 31 are made of one of aluminum, copper and nylon; alternatively, the lysis heating membrane 22 and the amplification heating membrane 32 are formed by using one of a PI heating membrane, a peltier device, and a resistance wire. It should be noted that, for a sample cracked at normal temperature, the corresponding cracking heating film 22 is not controlled to operate.
It is understood that the detection assembly includes a detection light source 61, a photoelectric sensor 62 to obtain fluorescence or color of the reaction solution. The detection light source 61 may be an LED light source or an ultraviolet light source, light emitted by the detection light source passes through the amplification reagent tube 30, a color reagent or a fluorescent reagent is provided in the amplification reagent tube 30, and the photoelectric sensor 62 determines a real reagent color or a fluorescent color in the amplification reagent tube 30.
The control assembly specifically can include main control panel 51, temperature control panel 52 and key switch control panel 53, and in some embodiments, one can be made to aforementioned three boards, and the utility model discloses in make it respectively three can fold the three and realize reducing the purpose that the space occupied, key switch control panel 53 and temperature control panel 52 wherein can be connected to main control panel 51 on, key switch control panel 53 is just control key circuit, and temperature control panel 52 mainly is control heating membrane, temperature sensor, circuits such as overheat protection, and main control panel 51 is total control module, and it can to adopt current conventional design means in specific connection aspect, the utility model discloses do not do the special limitation.
It is to be understood that the nucleic acid detecting apparatus is further provided with a power supply unit 54 for supplying power to the electric parts of the apparatus (e.g., the main control board 51, the lysis heating membrane 22, the amplification heating membrane 32, etc.), and specifically, a rechargeable battery is preferred, and power may be supplied directly from a household power source, a dry battery, or the like.
Based on intelligent demand, can also set up the bluetooth module on the main control panel 51, can realize interactively with outside mobile terminal (for example cell-phone), can realize looking over earlier of result, of course, can also set up corresponding display screen (or screen control screen) on the shell body of device, realize looking over instrument operating condition in real time, set up functions such as measuring the temperature.
It is readily understood by a person skilled in the art that the advantageous ways described above can be freely combined, superimposed without conflict.
The above description is only exemplary of the present invention and should not be construed as limiting the present invention, and any modifications, equivalents and improvements made within the spirit and principles of the present invention are intended to be included within the scope of the present invention. The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A nucleic acid detecting apparatus, comprising:
an outer case having an accommodating space formed therein;
a nucleic acid lysis component arranged in the accommodating space;
the amplification assembly is arranged in the accommodating space;
a detection module, which is arranged adjacent to the amplification module and can detect the reaction liquid in the amplification module;
and the control component can adjust the temperature of the nucleic acid cracking component and the amplification component and can acquire the detection result of the detection component.
2. The nucleic acid detecting apparatus according to claim 1, wherein the nucleic acid cleaving assembly includes:
a pyrolysis heat transfer block (21) on which a pyrolysis heating hole for accommodating the pyrolysis reagent tube (20) is configured;
and a pyrolysis heating film (22) provided at the bottom end or the side surface of the pyrolysis heat transfer block (21).
3. The nucleic acid detecting apparatus according to claim 2, wherein the amplification module includes:
an amplification heat transfer block (31) on which an amplification heating hole for accommodating an amplification reagent tube (30) is configured;
and an amplification heating film (32) provided at the bottom end or the side surface of the amplification heat transfer block (31).
4. The nucleic acid detecting apparatus according to claim 3, wherein the nucleic acid cleaving assembly further comprises:
a pyrolysis temperature sensor for detecting a real-time heating temperature of the pyrolysis heating film (22);
the cracking overheat protector is used for cutting off the heating power supply of the cracking heating film (22) when the heating temperature of the cracking heating film (22) exceeds a corresponding upper limit temperature threshold value; alternatively, the first and second electrodes may be,
the amplification assembly further comprises:
an amplification temperature sensor (33) for detecting a real-time heating temperature of the amplification heating membrane (32);
and an amplification overheating protector (34) for cutting off the heating power supply to the amplification heating film (32) when the heating temperature of the amplification heating film (32) exceeds a corresponding upper limit temperature threshold value.
5. The nucleic acid detecting apparatus according to claim 4,
the outer shell is provided with an upward through hole, the cracking reagent tube (20) and the amplification reagent tube (30) can be respectively arranged in the cracking heat transfer block (21) and the amplification heat transfer block (31) through the through hole and can be respectively taken out of the cracking heat transfer block (21) and the amplification heat transfer block (31) through the through hole.
6. The nucleic acid detecting apparatus according to claim 5,
a gland (4) is arranged at the top of the outer shell, one side of the gland (4) is rotatably connected with the outer shell, so that the gland (4) can close or open the through hole in an openable manner; alternatively, the amplification module has a plurality of amplification modules.
7. The nucleic acid detecting apparatus according to claim 6,
the shell body comprises a lower shell (11) and an upper shell (12) assembled into a whole with the lower shell, the through hole is formed in the upper shell (12), and the gland (4) is connected with the upper shell (12).
8. The nucleic acid detecting apparatus according to claim 7,
the upper shell (12) is provided with a user operation area, and a key switch (121) and a result indicating part (122) are arranged in the user operation area.
9. The nucleic acid detecting apparatus according to claim 8,
the result indicating component (122) comprises a red-green two-color indicator light.
10. The nucleic acid detecting apparatus according to claim 3,
the cracking heat transfer block (21) and the amplification heat transfer block (31) are made of one of aluminum, copper and nylon; alternatively, the first and second electrodes may be,
the cracking heating film (22) and the amplification heating film (32) are made of one of a PI heating film, a Peltier and a resistance wire.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220399385.3U CN216837989U (en) | 2022-02-26 | 2022-02-26 | Nucleic acid detecting device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220399385.3U CN216837989U (en) | 2022-02-26 | 2022-02-26 | Nucleic acid detecting device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216837989U true CN216837989U (en) | 2022-06-28 |
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ID=82091716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220399385.3U Active CN216837989U (en) | 2022-02-26 | 2022-02-26 | Nucleic acid detecting device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216837989U (en) |
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2022
- 2022-02-26 CN CN202220399385.3U patent/CN216837989U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Room 1401, building 1, No. 188, Fuchunjiang Road, high tech Zone, Suzhou, Jiangsu 215151 Patentee after: Hongwei TEX (Suzhou) Bioengineering Co.,Ltd. Address before: Room 1401, building 1, No. 188, Fuchunjiang Road, high tech Zone, Suzhou, Jiangsu 215151 Patentee before: Jiangsu hongweites Biotechnology Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |