CN216837974U

CN216837974U - Daptomycin preparation is with raw materials accuse temperature fermenting installation

Info

Publication number: CN216837974U
Application number: CN202122886244.2U
Authority: CN
Inventors: 张勇辉; 贾伟; 任祥万; 夏颖
Original assignee: Jiangxi Chengzhi Biological Engineering Co ltd
Current assignee: Jiangxi Chengzhi Biological Engineering Co ltd
Priority date: 2021-11-23
Filing date: 2021-11-23
Publication date: 2022-06-28
Anticipated expiration: 2031-11-23

Abstract

The utility model discloses a raw material temperature-control fermentation device for daptomycin preparation, which comprises a fermentation kettle, a feed hopper, a discharge port, a heater, a servo motor, a transmission rod and a stirring rod, wherein the feed hopper for feeding raw materials is arranged on the side of the upper end of the fermentation kettle, the discharge port is arranged in the middle of the lower end of the fermentation kettle, and the heater convenient for temperature adjustment is arranged on the side of the inner part of the fermentation kettle; further comprising: the dispersion disc is arranged on the transmission rod and is arranged inside the fermentation kettle; the fixed rod is fixedly arranged at the bottom of the fermentation kettle, a movable column is arranged at the upper end of the fixed rod, and a connecting magnet is embedded at the top end of the fixed rod; and the guide block is arranged at the top end of the movable column. This raw materials accuse temperature fermenting installation is used in daptomycin preparation can make its even distribution of raw materials inside the device at reinforced in-process, can play good stirring effect to the raw materials simultaneously, and can strike off the raw materials that adheres to on the inner wall.

Description

Daptomycin preparation is with raw materials accuse temperature fermenting installation

Technical Field

The utility model relates to the related technical field of daptomycin preparation, in particular to a raw material temperature-control fermentation device for daptomycin preparation.

Background

Daptomycin is used as a medical product, is commonly used for treating complicated skin and soft tissue infection, staphylococcus aureus and the like, is generally fermented when being prepared, and corresponding substances are extracted from the raw materials, so a fermentation device is generally used for improving the overall fermentation effect when the raw materials are fermented.

However, the conventional fermentation apparatus has the following problems:

1. the existing fermentation device is inconvenient to uniformly add raw materials into the device in the feeding process, so that the raw materials are accumulated and concentrated in the device, and meanwhile, the raw materials are inconvenient to turn over well in the fermentation process, so that the raw materials are heated unevenly everywhere;

2. current fermenting installation is at the in-process of fermentation raw materials, is not convenient for strike off the raw materials that adheres to on the device inner wall to lead to the raw materials to gather the back on the device inner wall, cause the waste of raw materials easily.

Therefore, we have proposed a temperature-controlled fermentation apparatus for raw materials for daptomycin production in order to solve the above-mentioned problems.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a raw material temperature-control fermentation device for preparing daptomycin, which solves the problems that the conventional fermentation device in the market in the background art is inconvenient to uniformly add raw materials into the device in the feeding process, so that the raw materials are accumulated and concentrated in the device, and the raw materials are inconvenient to well turn over in the fermentation process, so that the raw materials are heated unevenly everywhere, and the raw materials attached to the inner wall of the device are inconvenient to scrape in the fermentation process, so that the raw materials are easily wasted after being accumulated on the inner wall of the device.

In order to achieve the purpose, the utility model provides the following technical scheme: the utility model provides a daptomycin preparation is with raw materials accuse temperature fermenting installation, includes fermentation kettle, feeder hopper, discharge gate, heater, servo motor, transfer line and puddler, the feeder hopper of input raw materials is installed to fermentation kettle's upper end avris, and fermentation kettle's lower extreme mid-mounting has the discharge gate, the heater of being convenient for temperature regulation is installed to fermentation kettle's inside avris, and fermentation kettle's upper end mid-mounting has the servo motor that provides the power supply, the transfer line is installed to servo motor's lower extreme, and the avris of transfer line installs the puddler that turns to the raw materials;

further comprising:

the dispersion disc is arranged on the transmission rod and is arranged inside the fermentation kettle;

the fixed rod is fixedly arranged at the bottom of the fermentation kettle, a movable column is arranged at the upper end of the fixed rod, a connecting magnet is embedded at the top end of the fixed rod, and the movable column and the stirring rod are mutually connected through a return spring for providing return elasticity;

the guide block sets up the top of activity post, the guide block is installed on stirring the board, and stirs the avris that the board set up at the puddler, the clearance is installed to the outer end of puddler and is scraped the pole.

Preferably, be the key-type connection between the middle part of dispersion impeller and the puddler, and the dispersion impeller sets up to round platform shape structure to the dispersion impeller sets up in feeder hopper open-ended below.

Through adopting above-mentioned technical scheme, thereby utilize the rotation of puddler can drive fixed connection's dispersion impeller and carry out synchronous revolution, thereby the rotation through the dispersion impeller can throw away the raw materials that drop on it.

Preferably, the fixed rod and the movable column are located on the same vertical straight line, and the connecting magnets are embedded at the upper end of the fixed rod and the lower end of the movable column.

Through adopting above-mentioned technical scheme, thereby can drive the linking magnet of its tip to carry out synchronous motion through the rotation of activity post.

Preferably, the outer wall of activity post and the inner wall of puddler are laminated each other, and are vertical distribution between activity post and the puddler to constitute elastic telescopic structure through reset spring between activity post and the puddler.

Through adopting above-mentioned technical scheme, thereby can make the activity post after the removal rebound to reset through reset spring's setting.

Preferably, the inner wall of the guide block and the outer wall of the poking plate are mutually attached, and the guide block is in sliding connection with the poking plate.

Through adopting above-mentioned technical scheme, laminating each other between guide block and the stirring board to can improve the stability that the guide block removed on stirring the board, prevent that it from appearing rocking the phenomenon.

Preferably, a rotating structure is formed between the end part of the stirring plate and the stirring rod, and the outer wall of the cleaning scraping rod fixedly connected with the outer end of the stirring rod is attached to the inner wall of the fermentation kettle.

Through adopting above-mentioned technical scheme, thereby can drive the clearance scraping rod of its avris through the rotation of puddler and carry out synchronous rotation, clear up adnexed raw materials on the fermentation kettle inner wall from this.

Compared with the prior art, the utility model has the beneficial effects that: the raw material temperature-control fermentation device for preparing daptomycin can ensure that the raw materials are uniformly distributed in the device in the feeding process, can play a good role in stirring the raw materials, and can scrape the raw materials attached to the inner wall;

1. the dispersion plate is arranged, the dispersion plate can be driven to synchronously rotate through the rotation of the transmission rod, raw materials are added into the fermentation kettle through the feed hopper and fall into the surface of the dispersion plate, and then the raw materials can be uniformly sprayed into the fermentation kettle through the rotation of the dispersion plate, so that the raw materials are prevented from being accumulated at one position during feeding;

2. The stirring rod is provided with a stirring plate, the stirring rod can rotate to drive the movable column to synchronously rotate, and the stirring plate can rotate on the stirring rod in a reciprocating manner under the action of a return spring through the change of the distance between a connecting magnet at the lower end of the movable column and a connecting magnet at the upper end of the movable column in the rotating process of the movable column, so that the mixing and stirring effects on the raw materials can be improved through the reciprocating rotation of the stirring plate;

3. be provided with the clearance and scrape the pole, thereby utilize the rotation of puddler to drive the clearance of its outer end and scrape the pole and carry out synchronous revolution, thereby utilize rotatory clearance to scrape the pole and can strike off adnexed raw materials on the fermentation tank inner wall, avoid the raw materials to gather in a large number and then cause the waste of raw materials on the fermentation tank inner wall.

Drawings

FIG. 1 is a front sectional structural view of the present invention;

FIG. 2 is a schematic perspective view of a transmission rod and a dispersion plate according to the present invention;

FIG. 3 is an enlarged view of the structure at A in FIG. 1 according to the present invention;

FIG. 4 is a schematic cross-sectional view of the stirring rod and the movable column of the present invention;

FIG. 5 is an enlarged view of the structure at B in FIG. 1 according to the present invention.

In the figure: 1. a fermentation kettle; 2. a feed hopper; 3. a discharge port; 4. a heater; 5. a servo motor; 6. a transmission rod; 7. a stirring rod; 8. a dispersion tray; 9. fixing the rod; 10. a movable post; 11. a linking magnet; 12. a return spring; 13. a guide block; 14. a poking plate; 15. cleaning the scraping rod.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.

Referring to fig. 1-5, the present invention provides a technical solution: a raw material temperature control fermentation device for preparing daptomycin comprises a fermentation kettle 1, a feed hopper 2, a discharge port 3, a heater 4, a servo motor 5, a transmission rod 6 and a stirring rod 7, wherein the feed hopper 2 for feeding raw materials is arranged on the side of the upper end of the fermentation kettle 1, the discharge port 3 is arranged in the middle of the lower end of the fermentation kettle 1, the heater 4 convenient for adjusting temperature is arranged on the side of the inner part of the fermentation kettle 1, the servo motor 5 for providing a power source is arranged in the middle of the upper end of the fermentation kettle 1, the transmission rod 6 is arranged at the lower end of the servo motor 5, and the stirring rod 7 for stirring the raw materials is arranged on the side of the transmission rod 6; further comprising: a dispersion plate 8 arranged on the transmission rod 6, wherein the dispersion plate 8 is arranged inside the fermentation kettle 1; be the key-type connection between the middle part of dispersion impeller 8 and puddler 7, and dispersion impeller 8 sets up to round platform shape structure to dispersion impeller 8 sets up in 2 open-ended below of feeder hopper. A rotating structure is formed between the end part of the stirring plate 14 and the stirring rod 7, and the outer wall of a cleaning scraping rod 15 fixedly connected with the outer end of the stirring rod 7 is attached to the inner wall of the fermentation kettle 1.

As shown in fig. 1 and 2, when the raw material needs to be fermented, the servo motor 5 is started, the servo motor 5 can be started to drive the dispersion disc 8 to synchronously rotate through the transmission rod 6, then the raw material is added into the fermentation kettle 1 through the feed hopper 2, the raw material falls on the inclined plane of the dispersion disc 8, the raw material can be uniformly sprayed into the fermentation kettle 1 through the rotation of the dispersion disc 8, then the temperature inside the fermentation kettle 1 can be conveniently controlled through the opening of the heater 4, the stirring rod 7 at the side of the stirring rod can be driven to synchronously rotate through the rotation of the transmission rod 6 in the fermentation process, the raw material can be turned through the rotation of the stirring rod 7, the cleaning scraping rod 15 at the outer end of the stirring rod 7 can be driven to rotate in the rotation process, the raw material adhered to the inner wall of the fermentation kettle 1 can be scraped through the rotation of the cleaning scraping rod 15, avoid causing the waste of raw materials.

The fixed rod 9 is fixedly arranged at the bottom of the fermentation kettle 1, the upper end of the fixed rod 9 is provided with a movable column 10, the top end of the fixed rod 9 is embedded with a connecting magnet 11, and the movable column 10 and the stirring rod 7 are mutually connected through a reset spring 12 for providing reset elasticity; the guide block 13 is arranged at the top end of the movable column 10, the guide block 13 is arranged on the poking plate 14, the poking plate 14 is arranged on the side of the stirring rod 7, and the cleaning scraping rod 15 is arranged at the outer end of the stirring rod 7. The fixed rod 9 and the movable column 10 are located on the same vertical straight line, and the upper end of the fixed rod 9 and the lower end of the movable column 10 are both inlaid with a connecting magnet 11. The outer wall of the movable column 10 and the inner wall of the stirring rod 7 are mutually attached, the movable column 10 and the stirring rod 7 are vertically distributed, and an elastic telescopic structure is formed between the movable column 10 and the stirring rod 7 through a return spring 12. The inner wall of the guide block 13 and the outer wall of the toggle plate 14 are attached to each other, and the guide block 13 and the toggle plate 14 are connected in a sliding manner.

As shown in fig. 1 and fig. 3-5, when the stirring rod 7 can drive the movable column 10 thereon to rotate synchronously in the rotating process, when the engaging magnet 11 at the lower end of the movable column 10 and the engaging magnet 11 at the upper end of the fixed rod 9 approach each other in the rotating process of the movable column 10, the movable column 10 can move upwards under the mutual repulsion action of the engaging magnets 11, the movable column 10 can slide on the poking plate 14 by utilizing the movably connected guide block 13 through the movement of the movable column 10, so that the poking plate 14 rotates on the stirring rod 7, when the movable column 10 and the fixed rod 9 are away from each other in the rotating process, the movable column 10 is reset under the action of the reset spring 12, and the poking plate 14 is also reset along with the movable column 10, so that the reciprocating rotation of the poking plate 14 is realized through the circular reciprocating rotation of the poking plate 14, the overturning effect on the raw material can be improved through the reciprocating rotation of the poking plate 14, so that the raw materials can be uniformly heated in the fermentation process.

The working principle is as follows: when using this raw materials accuse temperature fermenting installation for daptomycin preparation, at first according to shown in fig. 1-5, can make its raw materials that falls on 8 inclined planes of dispersion impeller through 8 rotations of dispersion impeller, even spilling is to the inside of fermentation tank 1, thereby utilize the rotation of puddler 7 to turn the raw materials, the clearance scraping bar 15 that can drive its outer end through the rotation of puddler 7 simultaneously rotates, and then strike off the raw materials on fermentation tank 1 inner wall, movable column 10 utilizes and dead lever 9 mutual distance change at the pivoted in-process, thereby can make setting plate 14 carry out reciprocating rotation, improve the effect of turning to the raw materials through setting plate 14's reciprocating rotation, make its raw materials can the thermally equivalent at the in-process of fermentation.

Those not described in detail in this specification are within the skill of the art.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the utility model can be made, and equivalents and modifications of some features of the utility model can be made without departing from the spirit and scope of the utility model.

Claims

1. A raw material temperature control fermentation device for daptomycin preparation comprises a fermentation kettle (1), a feed hopper (2), a discharge port (3), a heater (4), a servo motor (5), a transmission rod (6) and a stirring rod (7), wherein the feed hopper (2) for feeding raw materials is installed at the upper end side of the fermentation kettle (1), the discharge port (3) is installed at the lower end middle part of the fermentation kettle (1), the heater (4) convenient for temperature adjustment is installed at the inner side of the fermentation kettle (1), the servo motor (5) for providing a power source is installed at the upper end middle part of the fermentation kettle (1), the transmission rod (6) is installed at the lower end of the servo motor (5), and the stirring rod (7) which is turned over the raw materials is installed at the side of the transmission rod (6);

It is characterized by also comprising:

the dispersion plate (8) is arranged on the transmission rod (6), and the dispersion plate (8) is arranged in the fermentation kettle (1);

the fermentation tank comprises a fixed rod (9) which is fixedly arranged at the bottom of the fermentation tank (1), a movable column (10) is arranged at the upper end of the fixed rod (9), a connecting magnet (11) is embedded at the top end of the fixed rod (9), and the movable column (10) and a stirring rod (7) are connected with each other through a return spring (12) for providing return elasticity;

guide block (13), set up the top of activity post (10), install on stirring board (14) guide block (13), and stir board (14) and set up the avris at puddler (7), clearance scraper bar (15) are installed to the outer end of puddler (7).

2. The temperature-controlled fermentation device for preparing the raw materials of daptomycin according to claim 1, characterized in that: be the key-type connection between the middle part of dispersion impeller (8) and puddler (7), and dispersion impeller (8) set up to round platform shape structure to dispersion impeller (8) set up in feeder hopper (2) open-ended below.

3. The raw material temperature-controlled fermentation device for preparing daptomycin according to claim 1, characterized in that: the fixed rod (9) and the movable column (10) are located on the same vertical straight line, and the upper end of the fixed rod (9) and the lower end of the movable column (10) are inlaid with connecting magnets (11).

4. The temperature-controlled fermentation device for preparing the raw materials of daptomycin according to claim 3, characterized in that: the magnetism of the connecting magnet (11) at the lower end of the movable column (10) is the same as that of the connecting magnet (11) at the upper end of the fixed rod (9), and the upper end of the movable column (10) is movably connected with the guide block (13).

5. The raw material temperature-controlled fermentation device for preparing daptomycin according to claim 4, characterized in that: the outer wall of the movable column (10) is attached to the inner wall of the stirring rod (7), the movable column (10) and the stirring rod (7) are vertically distributed, and the movable column (10) and the stirring rod (7) form an elastic telescopic structure through a return spring (12).

6. The raw material temperature-controlled fermentation device for preparing daptomycin according to claim 1 or 4, characterized in that: the inner wall of the guide block (13) and the outer wall of the poking plate (14) are mutually attached, and the guide block (13) is in sliding connection with the poking plate (14).

7. The raw material temperature-controlled fermentation device for preparing daptomycin according to claim 6, characterized in that: a rotating structure is formed between the end part of the stirring plate (14) and the stirring rod (7), and the outer wall of the cleaning scraping rod (15) fixedly connected with the outer end of the stirring rod (7) is attached to the inner wall of the fermentation kettle (1).