CN216799055U

CN216799055U - Precipitation device for extracting colistin sulfate

Info

Publication number: CN216799055U
Application number: CN202220193332.6U
Authority: CN
Inventors: 陈震; 王帅
Original assignee: Shandong Pushman Biotechnology Co ltd
Current assignee: Shandong Pushman Biotechnology Co ltd
Priority date: 2022-01-24
Filing date: 2022-01-24
Publication date: 2022-06-24
Anticipated expiration: 2032-01-24

Abstract

The utility model discloses a precipitation device for extracting colistin sulfate, which belongs to the technical field of a precipitation device for extracting colistin sulfate, wherein an electric telescopic rod is fixedly arranged at the bottom of the inner side of a fixing frame, a driving motor arranged at the inner side of the fixing frame is fixed in the middle of the top of a packaging plate, a stirring rod is uniformly and fixedly assembled on the outer side wall of a mounting shaft, a ceramic filter disc matched with the inner cavity of a precipitation box is movably sleeved and assembled on the outer side wall of the bottom end of the mounting shaft, a limiting plate is fixedly assembled at the bottom end of the mounting shaft after penetrating through the ceramic filter disc, a liquid discharge pipe is fixedly assembled at the bottom of the right side wall of the precipitation box, an aeration disc is nested and assembled on the side wall of the inner cavity of the precipitation box, an air guide pipe communicated with the aeration disc is fixedly assembled on the right side wall of the precipitation box, a control panel is fixedly assembled on the front side wall of the precipitation box, and the rapid precipitation preparation of colistin sulfate can be realized, the impurity removal effect is good, so that the conversion rate of colistin is greatly improved.

Description

Precipitation device for extracting colistin sulfate

Technical Field

The utility model relates to the technical field of colistin sulfate extraction and precipitation devices, in particular to a precipitation device for extracting colistin sulfate.

Background

Colistin sulfate is also known as colistin sulfate, colistin E and the like, is alkaline trivial cyclic polypeptide antibiotics obtained from a polymyxa bacillus culture solution, is a mixture of the colistin E1 and E2, is white or off-white powder, is easy to dissolve in water, heat-resistant, not easy to absorb by a digestive tract, quick to excrete, small in toxic and side effects, not easy to generate drug-resistant strains, is one of the safest livestock and poultry growth-promoting antibiotics, is usually prepared by a biological fermentation mode in industry, and is separated by an ion exchange method, and the basic process is as follows: fermentation liquor → acidification, solid-liquid separation → weak acid cation resin → resin desalination, neutralization → activated carbon decolorization → nanofiltration concentration → finished product liquid spray drying, the existing precipitation extraction method is that the pH value of fermentation technology culture is adjusted to 10.0-14.0 by alkaline substances, then the culture is stirred for 30 minutes, solid-liquid separation is carried out to collect bacterial residues to obtain polymyxin free alkali precipitate, then the pH value of the precipitate is adjusted to 1.0-6.0 by acidic substances or solution, concentrated solution containing polymyxin is obtained by solid-liquid separation after dissolution, inorganic salt is removed by filtration, finally spray drying is carried out to obtain the finished product, the method utilizes the solubility difference of polymyxin and impurities in the acidic environment to achieve the purpose of impurity removal, but the method has rough operation mode and poor impurity removal effect, the prepared product has low conversion rate, the extraction content of the polymyxin sulfate is low, and the industrial popularization of the polymyxin sulfate is not good, to this end, we propose a precipitation device for colistin sulfate extraction.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a precipitation device for extracting colistin sulfate so as to solve the problems in the background technology.

In order to achieve the purpose, the utility model provides the following technical scheme: a precipitation device for extracting colistin sulfate comprises a precipitation box, wherein supports are fixed on the left side and the right side of the bottom of the precipitation box, a fixing frame is fixedly assembled at the top of the precipitation box, an electric telescopic rod is fixedly arranged at the bottom of the inner side of the fixing frame, a fixing frame is fixedly assembled at the output end of the electric telescopic rod, a packaging plate matched with the precipitation box is fixedly assembled at the bottom of the fixing frame, a driving motor arranged on the inner side of the fixing frame is fixed in the middle of the top of the packaging plate, a dosing pipe is fixedly assembled on the left side and the right side of the top of the packaging plate, an installation shaft is fixedly assembled after the output end of the driving motor passes through the packaging plate, stirring rods are uniformly and fixedly assembled on the outer side wall of the installation shaft, a ceramic filter disc matched with the inner cavity of the precipitation box is movably sleeved on the outer side wall of the bottom end of the installation shaft, and a limiting plate is fixedly assembled after the bottom end passes through the ceramic filter disc, the bottom of the right side wall of the settling tank is fixedly provided with a liquid discharge pipe, the side wall of the inner cavity of the settling tank is nested with an aeration disc, the right side wall of the settling tank is fixedly provided with an air guide pipe communicated with the aeration disc, and the front side wall of the settling tank is fixedly provided with a control panel.

Preferably, the ceramic filter disc comprises an outer protective frame movably assembled in the inner cavity of the settling box, a ceramic membrane is fixedly assembled on the inner side wall of the outer protective frame, and a mounting hole matched with the mounting shaft is formed in the middle of the ceramic membrane.

Preferably, the size of the packaging plate is matched with the size of the inner cavity of the settling tank, and the telescopic stroke of the electric telescopic rod is matched with the depth of the inner cavity of the settling tank.

Preferably, the outer side wall of the installation shaft is uniformly and fixedly provided with an installation seat, and the stirring rod is assembled on the installation seat in a threaded manner.

Preferably, the aeration disc is an annular disc, and the inner side wall of the aeration disc is flush with the inner cavity side wall of the settling tank.

Preferably, the control panel is electrically connected with the driving motor and the electric telescopic rod.

Compared with the prior art, the utility model has the beneficial effects that:

the utility model has reasonable structural design, fermentation liquor containing colistin is directly led into the settling tank through the medicine feeding pipe, oxalic acid is added through the medicine feeding pipe, the driving motor is started through the control panel to drive the stirring rod on the mounting shaft to rotate, materials in the settling tank can be stirred, the mixing effect is improved, gas is injected into the aeration disc through the gas guide pipe, the material mixing effect in the liquid can be accelerated, the pH of the liquid can be adjusted by utilizing the oxalic acid until the pH value is 2.0-5.0, the precipitation can be accelerated along with the stirring of the stirring rod, then the control panel promotes the electric telescopic rod to retract, the ceramic filter disc can be driven to move upwards, impurities and precipitates can be filtered, the impurities are cleaned after the ceramic filter disc extends out of the settling tank, then the electric telescopic rod is promoted to reset, and then 0.1-5.0% w/v of metal complexing agent and 0.1-5.0% w/v of non-metal complexing agent are added into the settling tank through the medicine feeding pipe A mechanical flocculant for promoting the driving motor to continuously work for 0.5-2.0 hours at normal temperature, during the reaction process, precipitates can be precipitated and gathered on a ceramic filter disc for convenient unified cleaning again, then 2.0-5.0M of alkali solution is added into a precipitation box through a dosing pipe, the pH value of the solution is adjusted to 9.5-13.0, then liquid in the precipitation box is discharged through a liquid discharge pipe, a colistin sulfate filter cake can be obtained after solid-liquid separation, then 1.0-2.5M of sulfuric acid solution is added into the precipitation box through the dosing pipe for dissolving the filter cake, meanwhile, the pH value of the filter cake is adjusted to 3.0-6.0, so that an acidizing fluid can be obtained, then 0.5-2.0% w/v of potassium permanganate and 0.5-2.0% w/v of active carbon are respectively added into the acidizing fluid, the colistin sulfate fluid is obtained after stirring of a stirring rod, and then the colistin sulfate fluid is discharged through the liquid discharge pipe, centrifugal spray drying is carried out on the colistin sulfate, the air temperature is controlled to be about 200 ℃, the air outlet temperature is controlled to be 100 ℃, the precipitation preparation of the colistin sulfate can be realized, the impurity removal effect is good, and the conversion rate of the colistin is greatly improved.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic cross-sectional view of the present invention;

fig. 3 is a schematic structural view of the ceramic filter disc of the present invention.

In the figure: 1. a settling tank; 2. a support; 3. a fixing frame; 4. an electric telescopic rod; 5. a fixed mount; 6. a package board; 7. a drive motor; 8. a medicine feeding pipe; 9. installing a shaft; 10. a stirring rod; 11. a ceramic filter disc; 111. an outer protective frame; 112. a ceramic membrane; 113. mounting holes; 12. a limiting plate; 13. a liquid discharge pipe; 14. an aeration disc; 15. an air duct; 16. a control panel.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1 and fig. 2, the present invention provides a technical solution: a precipitation device for extracting colistin sulfate comprises a precipitation box 1, wherein supports 2 are fixed on the left side and the right side of the bottom of the precipitation box 1, a fixing frame 3 is fixedly assembled at the top of the precipitation box 1, an electric telescopic rod 4 is fixedly arranged at the bottom of the inner side of the fixing frame 3, an output end of the electric telescopic rod 4 is fixedly assembled with a fixing frame 5, a packaging plate 6 matched with the precipitation box 1 is fixedly assembled at the bottom of the fixing frame 5, a driving motor 7 arranged on the inner side of the fixing frame 5 is fixed in the middle of the top of the packaging plate 6, a dosing pipe 8 is fixedly assembled on the left side and the right side of the top of the packaging plate 6, an installation shaft 9 is fixedly assembled after the output end of the driving motor 7 passes through the packaging plate 6, stirring rods 10 are uniformly and fixedly assembled on the outer side wall of the installation shaft 9, a ceramic filter disc 11 matched with the inner cavity of the precipitation box 1 is movably sleeved on the outer side wall of the bottom end of the installation shaft 9, the fixed limiting plate 12 that is equipped with after the installation axle 9 bottom passes ceramic filter disc 11, and the fixed fluid-discharge tube 13 that is equipped with in right side wall bottom of setting tank 1, the nestification is equipped with aeration dish 14 on the inner chamber lateral wall of setting tank 1, and fixed being equipped with and the air duct 15 of aeration dish 14 intercommunication on the right side wall of setting tank 1, fixed being equipped with control panel 16 on the preceding lateral wall of setting tank 1.

Referring to fig. 3, the ceramic filter disc 11 includes an outer frame 111 movably mounted in the inner cavity of the settling tank 1, a ceramic membrane 112 is fixedly mounted on the inner side wall of the outer frame 111, a mounting hole 113 adapted to the mounting shaft 9 is formed in the middle of the ceramic membrane 112, and impurities and precipitates are filtered by the ceramic membrane 112 and are made to be collected on the ceramic membrane 112, so that uniform cleaning is facilitated;

referring to fig. 2, the size of the packaging plate 6 is matched with the size of the inner cavity of the settling tank 1, and the telescopic stroke of the electric telescopic rod 4 is matched with the depth of the inner cavity of the settling tank 1;

the outer side wall of the mounting shaft 9 is uniformly and fixedly provided with a mounting seat, and the stirring rod 10 is assembled on the mounting seat in a threaded manner;

the aeration disc 14 is an annular disc, and the inner side wall of the aeration disc 14 is flush with the inner cavity side wall of the settling tank 1;

the control panel 16 is electrically connected with the driving motor 7 and the electric telescopic rod 4.

The working principle is as follows: directly leading fermentation liquor containing colistin into the settling tank 1 through the medicine adding pipe 8, simultaneously adding oxalic acid through the medicine adding pipe 8, starting the driving motor 7 through the control panel 16, driving the stirring rod 10 on the mounting shaft 9 to rotate, stirring materials in the settling tank 1, improving the mixing effect, simultaneously injecting gas into the aeration disc 14 through the gas guide pipe 15, accelerating the material mixing effect in the liquid, adjusting the pH of the liquid by utilizing the oxalic acid until the pH value is 2.0-5.0, accelerating the sedimentation along with the stirring of the stirring rod 10, then enabling the electric telescopic rod 4 to contract inwards through the control panel 16, driving the ceramic filter disc 11 to move upwards, filtering impurities and sediments, cleaning the impurities after the ceramic filter disc 11 extends out of the settling tank 1, then enabling the electric telescopic rod 4 to reset, then adding 0.1-5.0% w/v metal complexing agent and 0.1- 5.0% w/v of inorganic flocculant to promote the driving motor 7 to continue working for 0.5-2.0 hours at normal temperature, during the reaction process, precipitates can be precipitated and gathered on the ceramic filter disc 11 to be convenient for uniform cleaning again, then 2.0-5.0M of alkali solution is added into the precipitation box 1 through the medicine adding pipe 8, the PH value of the solution is adjusted to 9.5-13.0, then liquid in the precipitation box 1 is discharged through the liquid discharge pipe 13, thus obtaining colistin sulfate filter cakes after solid-liquid separation, then 1.0-2.5M of sulfuric acid solution is added through the medicine adding pipe 8 to dissolve the filter cakes, meanwhile, the PH value of the filter cakes is adjusted to 3.0-6.0, thus obtaining acidizing fluid, then 0.5-2.0% w/v of potassium permanganate and 0.5-2.0% w/v of active carbon are respectively added into the acidizing fluid, thus obtaining the colistin sulfate fluid after the stirring of the stirring rod 10, and then discharging the colistin sulfate liquid through a liquid discharge pipe 13, and carrying out centrifugal spray drying on the colistin sulfate liquid, wherein the air temperature is controlled to be about 200 ℃, and the air outlet temperature is controlled to be 100 ℃, so that the preparation of the colistin sulfate through precipitation can be realized.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a colistin sulfate draws with sediment device, includes precipitation tank (1), the bottom left and right sides of precipitation tank (1) all is fixed with support (2), its characterized in that: the top of the settling tank (1) is fixedly provided with a fixed frame (3), the bottom of the inner side of the fixed frame (3) is fixedly provided with an electric telescopic rod (4), the output end of the electric telescopic rod (4) is fixedly provided with a fixed frame (5), the bottom of the fixed frame (5) is fixedly provided with a packaging plate (6) matched with the settling tank (1), the middle of the top of the packaging plate (6) is fixedly provided with a driving motor (7) arranged at the inner side of the fixed frame (5), the left side and the right side of the top of the packaging plate (6) are both fixedly provided with a dosing pipe (8), the output end of the driving motor (7) passes through the packaging plate (6) and is fixedly provided with an installation shaft (9), the outer side wall of the installation shaft (9) is uniformly and fixedly provided with a stirring rod (10), the outer side wall of the bottom end of the installation shaft (9) is movably sleeved with a ceramic filter disc (11) matched with the inner cavity of the settling tank (1), the fixed limiting plate (12) that is equipped with after installing axle (9) bottom and passing ceramic filter dish (11), the fixed fluid-discharge tube (13) that is equipped with in right side wall bottom of setting tank (1), the nestification is equipped with aeration dish (14) on the inner chamber lateral wall of setting tank (1), fixed air duct (15) that are equipped with and aeration dish (14) intercommunication on the right side wall of setting tank (1), fixed control panel (16) that is equipped with on the preceding lateral wall of setting tank (1).

2. The apparatus for extracting and precipitating colistin sulfate according to claim 1, wherein: the ceramic filter disc (11) comprises an outer protective frame (111) movably assembled in an inner cavity of the settling box (1), a ceramic membrane (112) is fixedly assembled on the inner side wall of the outer protective frame (111), and a mounting hole (113) matched with the mounting shaft (9) is formed in the middle of the ceramic membrane (112).

3. The apparatus for extracting and precipitating colistin sulfate according to claim 1, wherein: the size of the packaging plate (6) is matched with the size of the inner cavity of the settling box (1), and the telescopic stroke of the electric telescopic rod (4) is matched with the depth of the inner cavity of the settling box (1).

4. The apparatus for extracting and precipitating colistin sulfate according to claim 1, wherein: the outer side wall of the mounting shaft (9) is uniformly and fixedly provided with a mounting seat, and the stirring rod (10) is assembled on the mounting seat in a threaded manner.

5. The apparatus for extracting and precipitating colistin sulfate according to claim 1, wherein: the aeration disc (14) is an annular disc, and the inner side wall of the aeration disc (14) is flush with the inner cavity side wall of the settling tank (1).

6. The apparatus for extracting and precipitating colistin sulfate according to claim 1, wherein: the control panel (16) is electrically connected with the driving motor (7) and the electric telescopic rod (4).