CN216798928U

CN216798928U - Purification equipment of biological antibody production usefulness

Info

Publication number: CN216798928U
Application number: CN202220120139.XU
Authority: CN
Inventors: 俞翠萍
Original assignee: Shanghai Hangxin Biotechnology Co ltd
Current assignee: Shanghai Hangxin Biotechnology Co ltd
Priority date: 2022-01-18
Filing date: 2022-01-18
Publication date: 2022-06-24
Anticipated expiration: 2032-01-18

Abstract

The utility model belongs to the technical field of biological antibody production equipment, in particular to a purification device for producing biological antibodies, which comprises a device frame, a purification component, a sealing component and a decontamination component, wherein the purification component is arranged on the device frame and comprises a purification cylinder, a filter screen is inserted in the purification cylinder, filter cloth is fixedly arranged in the filter screen, a feeding pipe is fixedly arranged at the middle position of the lower surface of the purification cylinder, discharging pipes are fixedly arranged at both sides of the lower end of the purification cylinder, the sealing component comprises an air bag ring, the air bag ring is positioned between the filter screen and the purification cylinder, the decontamination component is positioned in the filter screen, the purification efficiency is improved by simultaneously operating a plurality of purification cylinders, the filter screen and the filter cloth which are detachable are convenient to detach and clean after being used for a long time, the operation is convenient, the decontamination component is used for avoiding impurities from blocking the filter cloth and improving the purification speed, through gasbag ring, when using, be convenient for install filter screen and filter cloth, improve the stability when using.

Description

Purification equipment of biological antibody production usefulness

Technical Field

The utility model belongs to the technical field of biological antibody production equipment, and particularly relates to purification equipment for biological antibody production.

Background

Antibody refers to a protein having protective action produced by the body due to stimulation by an antigen, which is a large Y-shaped protein secreted by plasma cells and used by the immune system to identify and neutralize foreign substances such as bacteria, viruses, etc., which are only found in body fluids such as blood of vertebrates, and the cell membrane surface of B cells thereof, and which is a unique feature that can recognize a specific foreign object, which is called an antigen.

When producing biological antibody, in order to purify biological antibody, filter out the impurity in the biological antibody, present purification equipment exists efficiency when using, and when using, inconvenient installation and the dismantlement of filter cloth wash, be not convenient for use, influence purification efficiency.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

Aiming at the defects of the prior art, the utility model provides purification equipment for producing a biological antibody, which has the advantages of being convenient to install and disassemble a filter screen and filter cloth and avoiding impurities from blocking the filter cloth, and solves the problem that the existing device is inconvenient to use.

(II) technical scheme

In order to achieve the purpose, the utility model provides the following technical scheme: a purification device for producing biological antibodies comprises a device frame, a purification component, a sealing component and a decontamination component;

the purifying components are uniformly and fixedly arranged on the equipment frame and comprise purifying cylinders, filter screens are inserted into the purifying cylinders, filter cloth is fixedly arranged in the filter screens, a feeding pipe is fixedly arranged in the middle of the lower surfaces of the purifying cylinders and communicated with the filter screens, and discharging pipes are fixedly arranged on two sides of the lower ends of the purifying cylinders;

the sealing assembly comprises an air bag ring which is fixedly arranged at the lower end of the interior of the purifying cylinder, and the air bag ring is positioned between the filter screen and the purifying cylinder;

the scrubbing assembly is located inside the screen.

Preferably, the upper end of the filter screen is fixedly provided with a sealing cover, the filter screen is inserted into the purifying cylinder through the sealing cover, and the sealing cover is in threaded connection with the upper end of the purifying cylinder.

Through adopting above-mentioned scheme, through sealed lid, when using, it is right to be convenient for the upper end of a purification section of thick bamboo seals, and then makes the biological antibody pass through the inlet pipe enters into behind the inside of filter screen, through the filter cloth enters into after purifying the inside of a purification section of thick bamboo, and process the discharging pipe is discharged, gets off impurity filtration, is convenient for carry out the purification operation, just sealed lid with threaded connection mutually between the purification section of thick bamboo is convenient for will sealed lid is unscrewed, will the filter screen with the filter cloth is followed the inside of a purification section of thick bamboo is taken out, conveniently washs and clears away impurity.

Preferably, the lower extreme fixed mounting of gasbag ring has the air supply pipe, just the intermediate position fixed mounting of air supply pipe has the valve.

Through adopting above-mentioned scheme, through the air supply pipe is convenient for right the inside of gasbag ring carries out the air feed, and then makes gasbag ring inflation makes the gasbag ring is right the filter screen with gap between the purification section of thick bamboo is sealed, avoids biological antibody not pass through the filter cloth directly enters into the inside of purification section of thick bamboo, and process the discharging pipe is discharged, conveniently carries out the purification.

Preferably, the gasbag ring is located the inlet pipe with in the middle of the discharging pipe, just the lower extreme pressure of filter screen is held the upper end of gasbag ring.

Through adopting above-mentioned scheme, through gasbag ring improves the filter screen with leakproofness when purifying a section of thick bamboo is connected is convenient for use.

Preferably, waist-shaped holes are uniformly and vertically formed in the outer side of the filter screen, and the filter cloth is communicated with the purifying cylinder through the waist-shaped holes.

Through adopting above-mentioned scheme, through waist type hole, when using, the raw materials pass through waist type hole is followed the inside of filter screen enters into the inside of a purification section of thick bamboo, the convenient biological antibody carries out purification processing.

Preferably, the scrubbing subassembly includes the mount, just mount fixed mounting be in the inside lower extreme of filter screen, just intermediate position rotates on the mount and installs reciprocal lead screw, just threaded connection has the scraper blade on the reciprocal lead screw, just the other end of reciprocal lead screw rotates and installs on the closing cap.

Through adopting above-mentioned scheme reciprocal lead screw when rotating, makes the scraper blade is in the inside of filter screen reciprocates, and then makes the scraper blade is right the impurity that filters off on the filter cloth is scraped, makes things convenient for biological antibody process, avoids impurity right the filter cloth produces the jam, improves purification speed, facilitates the use.

Preferably, the sealing cover and the fixing frame are located, guide rods are fixedly mounted on two sides of the reciprocating screw rod, the scraper is sleeved on the guide rods, a driving motor is fixedly mounted at the upper end of the sealing cover, and the output end of the driving motor is fixedly connected with the reciprocating screw rod.

By adopting the above scheme, through the guide bar, make when reciprocating screw rotates, the scraper blade carries out lifting movement, avoids taking place to rotate, and passes through driving motor, be convenient for right reciprocating screw drives, right impurity on the filter cloth is got rid of.

(III) advantageous effects

Compared with the prior art, the utility model provides a purification device for producing biological antibodies, which has the following beneficial effects:

this technical scheme carries out the concurrent operation through adopting a plurality of purification section of thick bamboo, improves purification efficiency, and through detachable filter screen and filter cloth, is convenient for pull down the washing after using for a long time, and convenient operation, and through the scrubbing subassembly, when using, avoid the impurity to block up the filter cloth, improve purification speed, and through the gasbag ring, be convenient for install filter screen and filter cloth when using, improve the stability when using.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a partial schematic view of the present invention;

FIG. 3 is a schematic view of a screen according to the present invention;

FIG. 4 is a schematic structural view of the desmear assembly of the present invention;

in the figure:

1. an equipment rack;

2. a purification component; 21. a purification cartridge; 22. filtering with a screen; 23. filtering cloth; 24. a feed pipe; 25. a discharge pipe; 26. a sealing cover; 27. a kidney-shaped hole;

3. a seal assembly; 31. a balloon ring; 32. a gas supply pipe; 33. a valve;

4. a decontamination assembly; 41. a fixed mount; 42. a reciprocating screw; 43. a squeegee; 44. a guide bar; 45. the motor is driven.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

A purification device for producing biological antibody comprises a device frame 1, a purification component 2, a sealing component 3 and a decontamination component 4;

the purification component 2 is uniformly and fixedly arranged on the equipment frame 1, the purification component 2 comprises a purification cylinder 21, a filter screen 22 is inserted into the purification cylinder 21, a filter cloth 23 is fixedly arranged in the filter screen 22, a feed pipe 24 is fixedly arranged in the middle of the lower surface of the purification cylinder 21, the feed pipe 24 is communicated with the filter screen 22, and discharge pipes 25 are fixedly arranged on two sides of the lower end of the purification cylinder 21;

the sealing assembly 3 comprises a gas bag ring 31, the gas bag ring 31 is fixedly arranged at the lower end of the interior of the purifying cylinder 21, and the gas bag ring 31 is positioned between the filter screen 22 and the purifying cylinder 21;

the desmear assembly 4 is located inside the screen 22.

The upper end of the filter screen 22 is fixedly provided with a sealing cover 26, the filter screen 22 is inserted into the purifying cylinder 21 through the sealing cover 26, and the sealing cover 26 is in threaded connection with the upper end of the purifying cylinder 21.

The lower end of the air bag ring 31 is fixedly provided with an air supply pipe 32, and the middle position of the air supply pipe 32 is fixedly provided with a valve 33.

The bladder ring 31 is located intermediate the inlet pipe 24 and the outlet pipe 25, and the lower end of the screen 22 is pressed against the upper end of the bladder ring 31.

Waist-shaped holes 27 are uniformly and vertically formed in the outer side of the filter screen 22, and the filter cloth 23 is communicated with the purifying cylinder 21 through the waist-shaped holes 27.

Referring to fig. 1-4, in use, an external feeding pipe is connected to the feeding pipe 24 and an external collecting pipe is connected to the discharging pipe 25, the filter net 22 is inserted into the purifying cylinder 21, the filter net 22 is fixed inside the purifying cylinder 21 through the sealing cover 26, the air supply pipe 32 is connected to the external air supply pipe, the valve 33 is opened to allow air to enter the air bag ring 31, so that the air bag ring 31 is expanded, the air bag ring 31 fills the gap between the purifying cylinder 21 and the filter net 22 to prevent the unpurified biological antibody from being discharged from the discharging pipe 25, the valve 33 is closed to fill the raw material into the inside of the filter net 22 through the feeding pipe 24, so that the biological antibody enters the purifying cylinder 21 through the filter cloth 23 and the kidney-shaped hole 27 and is discharged through the discharging pipe 25, so that the biological antibody is filtered by the filter cloth 23, the impurities are filtered, the purification operation is carried out, and after the filter screen is used for a long time, the sealing cover 26 is unscrewed, so that the filter screen 22 is taken out from the inside of the purification cylinder 21, and the filter screen 22 and the filter cloth 23 are convenient to clean and operate.

Example two

The way of removing the impurities adhered on the filter cloth 23 is added on the basis of the first embodiment.

The decontamination assembly 4 comprises a fixing frame 41, the fixing frame 41 is fixedly arranged at the lower end of the inside of the filter screen 22, a reciprocating lead screw 42 is rotatably arranged at the middle position on the fixing frame 41, a scraping plate 43 is connected to the reciprocating lead screw 42 in a threaded manner, and the other end of the reciprocating lead screw 42 is rotatably arranged on the sealing cover 26.

The guide rods 44 are fixedly mounted on two sides of the reciprocating screw rod 42 between the sealing cover 26 and the fixing frame 41, the scraping plate 43 is sleeved on the guide rods 44, the driving motor 45 is fixedly mounted at the upper end of the sealing cover 26, and the output end of the driving motor 45 is fixedly connected with the reciprocating screw rod 42.

Referring to fig. 1-4, when the device is used, the driving motor 45 is started to rotate the reciprocating screw 42, so that the scraper 43 moves up and down along the guide rod 44 along with the reciprocating screw 42, and the impurities adhered on the filter cloth 23 are removed by the scraper 43, thereby preventing the impurities from blocking the filter cloth 23, preventing the impurities from affecting the passing of biological antibodies, and improving the purification speed.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A purification apparatus for the production of biological antibodies, characterized in that: comprises an equipment frame (1), a purification component (2), a sealing component (3) and a decontamination component (4);

the purification component (2) is uniformly and fixedly installed on the equipment frame (1), the purification component (2) comprises a purification cylinder (21), a filter screen (22) is inserted into the purification cylinder (21), filter cloth (23) is fixedly installed inside the filter screen (22), a feed pipe (24) is fixedly installed in the middle of the lower surface of the purification cylinder (21), the feed pipe (24) is communicated with the filter screen (22), and discharge pipes (25) are fixedly installed on two sides of the lower end of the purification cylinder (21);

the sealing assembly (3) comprises a gas bag ring (31), the gas bag ring (31) is fixedly installed at the inner lower end of the purifying cylinder (21), and the gas bag ring (31) is positioned between the filter screen (22) and the purifying cylinder (21);

the decontaminating component (4) is positioned inside the filter screen (22).

2. The purification apparatus for the production of biological antibodies according to claim 1, wherein: the upper end of the filter screen (22) is fixedly provided with a sealing cover (26), the filter screen (22) is inserted into the purifying cylinder (21) through the sealing cover (26), and the sealing cover (26) is in threaded connection with the upper end of the purifying cylinder (21).

3. The purification apparatus for the production of biological antibodies according to claim 1, wherein: the lower extreme fixed mounting of gasbag ring (31) has air supply pipe (32), just the intermediate position fixed mounting of air supply pipe (32) has valve (33).

4. The purification apparatus for the production of biological antibodies according to claim 1, wherein: gasbag ring (31) are located inlet pipe (24) with in the middle of discharging pipe (25), just the lower extreme pressure of filter screen (22) is held the upper end of gasbag ring (31).

5. The purification apparatus for the production of biological antibodies according to claim 1, wherein: waist-shaped holes (27) are uniformly and vertically formed in the outer side of the filter screen (22), and the filter cloth (23) is communicated with the purifying cylinder (21) through the waist-shaped holes (27).

6. A purification apparatus for the production of a biological antibody according to claim 2, wherein: scrubbing subassembly (4) are including mount (41), just mount (41) fixed mounting be in the inside lower extreme of filter screen (22), just intermediate position rotates on mount (41) and installs reciprocal lead screw (42), just threaded connection has scraper blade (43) on reciprocal lead screw (42), just the other end of reciprocal lead screw (42) rotates and installs on sealed lid (26).

7. The purification apparatus for the production of biological antibodies according to claim 6, wherein: the sealing cover (26) and the fixing frame (41) are located between the sealing cover and the fixing frame, guide rods (44) are fixedly mounted on two sides of the reciprocating lead screw (42), the scraping plate (43) is sleeved on the guide rods (44), a driving motor (45) is fixedly mounted at the upper end of the sealing cover (26), and the output end of the driving motor (45) is fixedly connected with the reciprocating lead screw (42).