CN216735411U

CN216735411U - Kit and device for separating and detecting alpha-fetoprotein heteroplasmon

Info

Publication number: CN216735411U
Application number: CN202123422256.6U
Authority: CN
Inventors: 常静霞; 张丽; 王冰
Original assignee: Qinhuai Medical Area General Hospital of Eastern Theater of Pla
Current assignee: Qinhuai Medical Area General Hospital of Eastern Theater of Pla
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2022-06-14
Anticipated expiration: 2031-12-31

Abstract

The utility model discloses a separation detection kit and a separation detection device for alpha fetoprotein heteroplasmons, wherein the separation detection kit comprises a box body and a cover, the cover is arranged above the box body, a pressing mechanism is arranged between the cover and the box body, the inner side wall of the box body is fixedly connected with a positioning plate, an insertion hole is formed in the positioning plate, a test tube is placed in the insertion hole, the upper surface of the cover is fixedly connected with a handle, clamping assemblies are arranged on the upper surface of the cover and positioned on the front side and the rear side of the handle, the pressing mechanism comprises a pressing plate and a jacking spring, the pressing plate is fixedly connected to the lower surface of the cover, the jacking spring is fixedly connected to the inner bottom of the box body, and the top end of the jacking spring is fixedly connected with a placing plate. According to the reagent tube fixing device, the jacking spring and the placing plate are arranged at the bottom of the box body, and the reagent tube is tightly pressed and fixed by matching with the pressing block on the cover, so that collision between the test tube and the box body in the rotating process of the box body is avoided.

Description

Kit and device for separating and detecting alpha-fetoprotein heteroplasmon

Technical Field

The utility model relates to the technical field of separation and detection of alpha-fetoprotein heteroplasmons, in particular to a separation and detection kit and a separation and detection device for the alpha-fetoprotein heteroplasmons.

Background

Alpha-fetoprotein is a glycoprotein belonging to the family of albumins, which is mainly synthesized by fetal liver cells and yolk sacs. The alpha-fetoprotein has higher concentration in fetal blood circulation, and is reduced after birth until the alpha-fetoprotein is basically replaced by albumin after 2-3 months, so that the alpha-fetoprotein is difficult to detect in blood, and the content of the alpha-fetoprotein in serum of adults is extremely low. Alpha-fetoprotein has many important physiological functions including transport function, bidirectional regulatory function as a growth regulatory factor, immunosuppression, T-lymphocyte induced apoptosis, and the like. The alpha fetoprotein is closely related to the occurrence and development of liver cancer and various tumors, can show higher concentration in various tumors, and can be used as a positive detection index of various tumors. At present, the serum marker is mainly used as a serum marker of primary liver cancer clinically and is used for diagnosis and curative effect monitoring of the primary liver cancer, detection and separation reagents are added into an alpha-fetoprotein sample when the separation detection of heteroplasmons is carried out, and a rotating mechanism is usually needed in the detection and separation processes to fully mix the detection and separation reagents with the alpha-fetoprotein sample.

At present, the alpha fetoprotein sample is taken in the reagent kit, but the taking of the alpha fetoprotein sample is inconvenient, and when the reagent kit is placed on a rotating mechanism for mixing, a test tube for placing the alpha fetoprotein sample collides with the reagent kit.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the defects in the prior art and provides a kit and a device for separating and detecting alpha-fetoprotein heteroplasmons.

In order to achieve the purpose, the utility model adopts the following technical scheme: the kit for separating and detecting the alpha fetoprotein heteroplasmon comprises a box body and a cover, wherein the cover is arranged above the box body, and a pressing mechanism is arranged between the cover and the box body;

the test tube box comprises a box body, a positioning plate and a test tube, wherein the inner side wall of the box body is fixedly connected with the positioning plate, an insertion hole is formed in the positioning plate, and the test tube is placed in the insertion hole;

the upper surface fixed connection of lid has the handle, the front and back front side that the upper surface of lid just is located the handle is provided with the chucking subassembly.

As a further description of the above technical solution: the pressing mechanism comprises a pressing plate and a jacking spring, the pressing plate is fixedly connected to the lower surface of the cover, the jacking spring is fixedly connected to the inner bottom of the box body, the top end of the jacking spring is fixedly connected with a placing plate, and a groove is formed in the upper surface of the placing plate.

As a further description of the above technical solution: the quantity of jack and recess all is provided with a plurality ofly to jack and recess correspond the setting, place board and box body sliding connection to place the board and adopt rubber materials to support.

As a further description of the above technical solution: the clamping assembly comprises a telescopic rod, the telescopic rod is fixedly connected to the cover, a cross rod is fixedly connected to the top end of the telescopic rod, a clamping block is fixedly connected to the lower surface of the cross rod, an extension spring is arranged on the outer surface of the telescopic rod, and the two ends of the extension spring are fixedly connected with the cross rod and the cover respectively.

As a further description of the above technical solution: the base is included, the mounting groove has been seted up to the upper surface of base, the inside of mounting groove is provided with rotates the motor, the output shaft fixedly connected with mounting panel that rotates the motor, the last fixed surface of mounting panel is connected with the install bin, the spacing groove has been seted up to the upper surface of install bin, the inside sliding connection of spacing groove has the stopper, the last fixed surface of stopper is connected with the gland, the card hole has been seted up to the upper surface of gland.

As a further description of the above technical solution: the cross-sectional shapes of the limiting groove and the limiting block are convex, and a plurality of limiting grooves and limiting blocks are arranged.

As a further description of the above technical solution: the box body is matched with the mounting box, the clamping block is arranged corresponding to the clamping hole, and the clamping block is matched with the clamping hole.

The utility model has the following beneficial effects:

1. compared with the prior art, the reagent tube fixing device has the advantages that the jacking spring and the placing plate are arranged at the bottom of the box body, and the reagent tube is tightly pressed and fixed by matching with the pressing block on the cover, so that collision between the test tube and the box body in the rotating process of the box body is avoided.

2. Compared with the prior art, when the cover is opened, the placing plate is controlled to move upwards by utilizing the elastic force of the jacking spring, and the test tube is ejected out of the box body, so that the test tube is convenient to take.

3. Compared with the prior art, the pressing cover is prevented from falling off in the rotating process by arranging the telescopic rod, the cross rod, the clamping block and the extension spring, controlling the cross rod to drive the clamping block to move downwards by utilizing the elasticity of the extension spring, and inserting the clamping block into the clamping hole to fix the pressing cover.

Drawings

FIG. 1 is a schematic diagram of the internal structure of the kit for the detection of the alpha-fetoprotein heteroplasmon;

FIG. 2 is a schematic diagram of structure A of FIG. 2 according to the present invention;

FIG. 3 is a schematic diagram of the overall structure of the device for detecting the separation of alpha-fetoprotein heteroplasmon according to the present invention;

FIG. 4 is a cross-sectional view of the base of the device for detecting the separation of alpha-fetoprotein heteroplasmon according to the present invention;

fig. 5 is a schematic view of a connection structure of a gland and a limiting block of the device for separating and detecting alpha fetoprotein heteroplasmon provided by the utility model.

Illustration of the drawings:

1. a box body; 2. a cover; 3. the spring is tightly propped; 4. placing the plate; 5. a groove; 6. positioning a plate; 7. pressing a plate; 8. a jack; 9. a test tube; 10. a handle; 11. a telescopic rod; 12. a cross bar; 13. a clamping block; 14. an extension spring; 15. a base; 16. mounting grooves; 17. rotating the motor; 18. mounting a plate; 19. installing a box; 20. a limiting groove; 21. a limiting block; 22. a gland; 23. and (6) clamping the hole.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention; the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance, and furthermore, unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.

Referring to fig. 1-5, the utility model provides a kit for separating and detecting alpha-fetoprotein heteroplasmons: the test tube fixing device comprises a box body 1 and a cover 2, wherein the cover 2 is arranged above the box body 1, a pressing mechanism is arranged between the cover 2 and the box body 1 and used for fixing a test tube 9 filled with an alpha fetoprotein sample, and the collision between the test tube 9 and the box body 1 is avoided in a rotating process, the pressing mechanism comprises a pressing plate 7 and a jacking spring 3, the jacking spring 3 is in a compression state after the cover 2 is tightly covered, the test tube 9 in the later period is convenient to take, the pressing plate 7 is fixedly connected to the lower surface of the cover 2, the jacking spring 3 is fixedly connected to the inner bottom of the box body 1, the top end of the jacking spring 3 is fixedly connected with a placing plate 4, the placing plate 4 is in sliding connection with the box body 1, the placing plate 4 is supported by a rubber material, and a groove 5 is formed in the upper surface of the placing plate 4;

a positioning plate 6 is fixedly connected to the inner side wall of the box body 1, a plurality of jacks 8 are formed in the positioning plate 6, the number of the jacks 8 and the number of the grooves 5 are respectively multiple, the jacks 8 are arranged corresponding to the grooves 5, and test tubes 9 are placed in the jacks 8 and used for containing alpha-fetoprotein samples;

upper surface fixedly connected with handle 10 of lid 2, be used for opening lid 2, the front side is provided with the chucking subassembly around the upper surface of lid 2 and be located handle 10, insert card hole 23 in through the fixture block 13 with on the chucking subassembly, be used for fixing gland 22, avoid taking place to drop gland 22 at the pivoted in-process, the chucking subassembly includes telescopic link 11, 11 fixed connection of telescopic link is on lid 2, the top fixedly connected with horizontal pole 12 of telescopic link 11, the lower fixed surface of horizontal pole 12 is connected with fixture block 13, the surface of telescopic link 11 is provided with extension spring 14, extension spring 14 is in tensile state all the time, be used for fixing fixture block 13 in card hole 23, and extension spring 14's both ends respectively with horizontal pole 12, lid 2 fixed connection.

A separation detection device of alpha fetoprotein heteroplasmon for the alpha fetoprotein sample in test tube 9 mixes with detect reagent and separation reagent evenly, including base 15, the upper surface of base 15 has seted up mounting groove 16, the inside of mounting groove 16 is provided with rotating motor 17, be used for controlling mounting panel 18 to rotate, the output shaft fixedly connected with mounting panel 18 of rotating motor 17, the upper surface fixedly connected with install bin 19 of mounting panel 18, be used for placing box body 1, box body 1 and install bin 19 looks adaptation, the upper surface of install bin 19 has seted up spacing groove 20, the cross-sectional shape of spacing groove 20 and stopper 21 is the convex, and the quantity of spacing groove 20 and stopper 21 all is provided with a plurality ofly, the inside sliding connection of spacing groove 20 has stopper 21, the upper surface fixedly connected with gland 22 of stopper 21, avoid box body 1 to drop from the install bin 19, the upper surface of gland 22 has seted up calorie hole 23, the latch 13 is disposed corresponding to the latch hole 23, and the latch 13 is adapted to the latch hole 23.

The working principle is as follows: during the use, at first place box body 1 in install bin 19, then place the test tube 9 that holds the alpha fetoprotein sample, later add detect reagent and separation reagent, then cover 2, fix box body 1 in install bin 19 through promoting gland 22, insert fixture block 13 in card hole 23 through utilizing extension spring 14's elasticity, and fix gland 22, at last control box body 1 through rotating motor 17 and rotate, and with the alpha fetoprotein sample in test tube 9, detect reagent, the separation reagent misce bene, after the misce bene, at first extract fixture block 13 from calorie hole 23, later remove gland 22 from box body 1, then open lid 2 through handle 10, test tube 9 is followed box body 1 under the effect of top stop spring 3 in, at last staff takes out test tube 9 and carries out operation on next step.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the utility model.

Claims

1. Kit for separating and detecting alpha-fetoprotein heteroplasmon, comprising a kit body (1) and a cover (2), and is characterized in that: the cover (2) is arranged above the box body (1), and a pressing mechanism is arranged between the cover (2) and the box body (1);

a positioning plate (6) is fixedly connected to the inner side wall of the box body (1), an insertion hole (8) is formed in the positioning plate (6), and a test tube (9) is placed in the insertion hole (8);

the upper surface of lid (2) is fixedly connected with handle (10), the upper surface of lid (2) just is located the front and back front side of handle (10) and is provided with chucking subassembly.

2. The kit for the isolated detection of an alpha-fetoprotein heteroplasmon according to claim 1, wherein: hold-down mechanism includes clamp plate (7) and top tension spring (3), clamp plate (7) fixed connection is on the lower surface of lid (2), top tension spring (3) fixed connection is at the interior bottom of box body (1), top tension spring's (3) top fixedly connected with places board (4), the upper surface of placing board (4) is seted up flutedly (5).

3. The kit for the isolated detection of an alpha-fetoprotein heteroplasmon according to claim 2, wherein: the quantity of jack (8) and recess (5) all is provided with a plurality ofly to jack (8) correspond the setting with recess (5), place board (4) and box body (1) sliding connection, and place board (4) and adopt rubber materials to support.

4. The kit for the isolated detection of an alpha-fetoprotein heteroplasmon according to claim 1, wherein: the clamping assembly comprises a telescopic rod (11), the telescopic rod (11) is fixedly connected to the cover (2), a cross rod (12) is fixedly connected to the top end of the telescopic rod (11), clamping blocks (13) are fixedly connected to the lower surface of the cross rod (12), an extension spring (14) is arranged on the outer surface of the telescopic rod (11), and the two ends of the extension spring (14) are fixedly connected with the cross rod (12) and the cover (2) respectively.

5. The separation detection device for placing the separation detection kit for the alpha-fetoprotein heteroplasmon as claimed in claim 4, comprising a base (15), characterized in that: the upper surface of the base (15) is provided with a mounting groove (16), a rotating motor (17) is arranged inside the mounting groove (16), an output shaft of the rotating motor (17) is fixedly connected with a mounting plate (18), the upper surface of the mounting plate (18) is fixedly connected with a mounting box (19), the upper surface of the mounting box (19) is provided with a limiting groove (20), the inside of the limiting groove (20) is slidably connected with a limiting block (21), the upper surface of the limiting block (21) is fixedly connected with a gland (22), and the upper surface of the gland (22) is provided with a clamping hole (23); the box body (1) is matched with the mounting box (19), the clamping block (13) is arranged corresponding to the clamping hole (23), and the clamping block (13) is matched with the clamping hole (23).

6. The device for the separation and detection of alpha-fetoprotein heteroplasmons according to claim 5, wherein: the cross-sectional shapes of the limiting groove (20) and the limiting block (21) are both convex, and a plurality of limiting grooves (20) and limiting blocks (21) are arranged.