CN216704208U

CN216704208U - Octreotide acetate production is with mixing feeder in advance

Info

Publication number: CN216704208U
Application number: CN202123395661.3U
Authority: CN
Inventors: 孙杰
Original assignee: China National Pharmaceutical Group Chengdu Xinlibang Biopharmaceutical Co ltd
Current assignee: China National Pharmaceutical Group Chengdu Xinlibang Biopharmaceutical Co ltd
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2022-06-10
Anticipated expiration: 2031-12-31

Abstract

The utility model belongs to the technical field of pharmacy. Based on the problem that bulk drugs and adjuvants are not easy to disperse uniformly in the liquid preparation process of the existing liquid preparation system, the utility model discloses a premixing feeder for octreotide acetate production, which comprises a feeding component and a mixing component, wherein the mixing component comprises a feeding cavity and a mixing cavity; the feeding assembly comprises a first cylinder, the top of the first cylinder is provided with a feeding hopper, and the bottom of the first cylinder is provided with a discharging port; the first stirring piece is positioned in the first cylinder; a first motor, thereby driving the first stirring member to rotate; the mixing component comprises a second cylinder body which is horizontally arranged, and a feeding pipe and a discharging pipe are arranged near two ends of the second cylinder body; the feeding pipe is communicated with the discharging hole; the second stirring piece is horizontally arranged in the second cylinder and is provided with a helical blade; a second motor, thereby driving the second stirring piece to rotate; the nozzle groups are provided with a plurality of nozzle units in each group; and the plurality of nozzle units of each group are distributed along the axial direction of the second cylinder body, and each nozzle unit is communicated with the inner cavity of the second cylinder body. The feeder can prevent agglomeration of raw materials and adjuvants.

Description

Octreotide acetate production is with mixing feeder in advance

Technical Field

The utility model belongs to the technical field of pharmacy, and particularly relates to a premixing feeder for octreotide acetate production.

Background

Octreotide acetate is an artificially synthesized derivative of somatostatin octapeptide, can inhibit pathological hypersecretion of growth hormone, thyrotropin, gastrointestinal tract and pancreatic endocrine hormone, has the function of inhibiting the secretion of glucagon and insulin, has stronger action than a natural product, and can reduce portal hypertension.

In the octreotide acetate liquid preparation process, the raw material medicine and the adjuvant medicine are directly added into a liquid preparation system, and the liquid preparation system is stirred and mixed to form uniform liquid medicine. However, the bulk drugs and the adjuvants are put into a liquid preparation system and can be uniformly dispersed after long-time stirring; meanwhile, a small amount of powder balls are formed in the initial stage of liquid preparation of part of the raw materials and the auxiliary materials, which is not beneficial to the dispersion process of the raw materials and the auxiliary materials.

SUMMERY OF THE UTILITY MODEL

Based on the problem that the liquid preparation efficiency is low due to the fact that bulk drugs and adjuvants are not easy to disperse uniformly in the existing liquid preparation system, the utility model aims to provide the premix feeder for the production of the olotropide acetate.

In order to achieve the purpose, the utility model adopts the following technical scheme:

a premix feeder for octreotide acetate production comprises a feeding assembly and a mixing assembly.

The feeding assembly comprises a first cylinder, the top of the first cylinder is provided with a feeding hopper, and the bottom of the first cylinder is provided with a discharging port; the first stirring piece is positioned in the first cylinder; a first motor, whereby said first stirring element is driven in rotation.

The mixing assembly comprises a second barrel body which is horizontally arranged, and a feeding pipe and a discharging pipe are arranged near two ends of the second barrel body; the feeding pipe is communicated with the discharge hole; the second stirring piece is horizontally arranged in the second cylinder and is provided with a helical blade; a second motor, thereby driving the second stirring piece to rotate; the nozzle groups are provided with a plurality of nozzle units in each group; and the plurality of nozzle units in each group are distributed along the axial direction of the second cylinder body, and each nozzle unit is communicated with the inner cavity of the second cylinder body.

In one of the technical schemes disclosed by the utility model, the feeding assembly further comprises a screen which is arranged in the first cylinder and divides the inner cavity of the first cylinder into an upper cavity and a lower cavity which are arranged up and down; the first stirring piece is positioned in the upper cavity body.

In one of the technical solutions disclosed in the present invention, the longitudinal section of the lower cavity is in a frustum shape with a large upper part and a small lower part.

In one of the technical solutions disclosed in the present invention, the nozzle group is located in an upper half area of the second cylinder.

In one of the technical solutions disclosed in the present invention, there are 3 groups of the nozzle groups.

In one of the technical solutions disclosed in the present invention, each of the nozzle units is provided with a check valve.

In one of the technical solutions disclosed in the present invention, each of the nozzle units is provided with an electromagnetic flow valve.

In one of the technical solutions disclosed in the present invention, a plurality of the nozzle units of each group are equidistantly distributed along the axial direction of the second cylinder.

As can be seen from the above description, compared with the prior art, the beneficial effects of the present invention are:

1. through being provided with the feeding subassembly, powder group in the bulk drug and the auxiliary medicine can be broken up to first stirring piece, simultaneously, also can prevent it and agglomerate again.

2. Furthermore, a screen is arranged, so that impurities and large particles in the bulk drugs and the adjuvants can be screened out, and prevented from entering the mixing component.

3. The bulk drugs and the adjuvants are premixed into slurry and added into the solution preparation system, so that the bulk drugs and the adjuvants can be rapidly and uniformly dispersed in the solution preparation system.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the embodiments or technical descriptions will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

Fig. 1 is a front view of the present invention.

Fig. 2 is a side view of the present invention.

FIG. 3 is a schematic cross-sectional view of the present invention.

Reference numerals:

1-a feeding assembly; 11-a first cylinder; 111-a feed hopper; 112-an upper chamber body; 113-a lower cavity; 12-a first electric machine; 13-a first stirring member; 14-a screen mesh;

2-a mixing assembly; 21-a second cylinder; 211-feed pipe; 212-a discharge pipe; 22-a second electric machine; 23-a second stirring member; 24-a nozzle group; 241-nozzle unit.

Detailed Description

In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the utility model and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the utility model.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; the connection can be mechanical connection, electrical connection or communication; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

Embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

Based on the problems that when the existing liquid preparation system is used for preparing liquid, the raw material medicines and the auxiliary medicines are put into the liquid preparation system together, the raw material medicines and the auxiliary medicines can be stirred uniformly after long-time stirring, and the raw material medicines and the auxiliary medicines are easy to form powder balls; the embodiment of the utility model discloses a premix feeder for octreotide acetate production, which has a structure shown in figures 1-3 and comprises a feeding assembly 1 and a mixing assembly 2. The feeder can prevent bulk drug and adjuvant from forming powder mass, and accelerate dispersion speed.

Specifically, the feeding assembly 1 includes a first cylinder 11, a first motor 12, a first stirring member 13 and a screen 14.

The top of the first cylinder 11 is provided with two feed hoppers 111, and the bottom is provided with a discharge hole.

The screen 14 is installed in the first cylinder 11, and divides an inner cavity of the first cylinder 11 into an upper cavity 112 and a lower cavity 113 which are vertically provided. Wherein the longitudinal section of the lower cavity 113 is in the shape of a frustum with a large top and a small bottom, ensuring that the mixture can be completely discharged into the mixing assembly 2.

The first motor 12 is installed at a central region of the top of the first cylinder 11. The first stirring member 13 is located in the upper chamber 112, and its upper end is connected to the output end of the first motor 12.

Adopt above-mentioned structure, bulk drug and auxiliary medicine get into first barrel 1 through feed inlet 111 in, first stirring 13 stirs it, prevents its caking, and simultaneously, screen cloth 14 can be sieved out the piece and other large granule impurity of the wrapping bag in bulk drug and the auxiliary medicine.

The mixing component 2 is communicated with the discharge hole and comprises a second cylinder 21, a second motor 22, a second stirring piece 23 and a nozzle group 24.

A feed pipe 211 and a discharge pipe 212 are provided near both ends of the second cylinder 21, respectively. The feed pipe 211 communicates with the discharge port 112. The discharge pipe 212 is communicated with the liquid preparation system.

The second motor 22 is disposed outside one end of the second cylinder 21. The second stirring member 23 is located in the second cylinder 21, and one end thereof is connected to the second motor 22. Wherein, the second stirring member 23 is provided with a helical blade. The outer edge of the helical blade is in sliding contact with the inner wall of the second cylinder 21.

The nozzle groups 24 are provided in three groups and are mounted on the upper half area of the second cylinder 21. Each nozzle group 24 has a plurality of nozzle units 241, which communicate with the inner cavity of the second cylinder 21. The plurality of nozzle units of each group are arranged at equal intervals along the axial direction of the second cylinder 21.

By adopting the structure, the bulk drugs and the adjuvants are made into slurry and then added into the liquid preparation system, which is beneficial to the rapid and uniform dispersion of the bulk drugs and the adjuvants in the liquid preparation system.

As an optimized solution of this embodiment, each nozzle unit 241 is provided with a check valve (not shown in the drawings) and an electromagnetic flow valve (not shown in the drawings), which can prevent the slurry from being diverted, and can control and calculate the addition amount of the solvent.

As an optimized solution of this embodiment, a flow valve (not shown in the drawings) is disposed on the tapping pipe 212.

The working mode of the embodiment of the utility model is as follows:

the bulk drug and the adjuvant enter the first cylinder body 11 through the feed hopper 111, and the bulk drug and the adjuvant are stirred and mixed by the first stirring piece 13, so that agglomeration of the bulk drug and the adjuvant can be prevented, and meanwhile, powder agglomerates can be broken up; the screen 14 screens out packaging bag fragments and large particles in the raw materials and the auxiliary materials; the mixture after the screening falls into the second cylinder 21, the second stirring part 23 is provided with a helical blade to drive the mixture to move towards the discharge pipe 212, and in the moving process, the solvent is added into the inner cavity of the second cylinder 21 through the nozzle group 24 to form slurry with the mixture. And then added to the liquid preparation system.

As can be seen from the above description, the embodiments of the present invention have the following beneficial effects:

by arranging the feeding assembly, the first stirring piece can break up powder balls in the bulk drugs and the adjuvants and can prevent the powder balls from agglomerating again; furthermore, a screen is arranged, so that impurities and large particles in the bulk drugs and the adjuvants can be screened out and prevented from entering the mixing component; and finally, premixing the raw material medicines and the auxiliary medicines to prepare slurry, and adding the slurry into the liquid preparation system, so that the raw material medicines and the auxiliary medicines are rapidly and uniformly dispersed in the liquid preparation system.

The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. The utility model provides an octreotide acetate production is with mixing feeder which characterized in that includes:

a feeding assembly and a mixing assembly;

wherein the feed assembly comprises:

the top of the first cylinder is provided with a feed hopper, and the bottom of the first cylinder is provided with a discharge hole;

the first stirring piece is positioned in the first cylinder;

a first motor, thereby driving the first stirring member to rotate;

the mixing assembly includes:

the second cylinder is horizontally arranged, and a feeding pipe and a discharging pipe are arranged near two ends of the second cylinder; the feeding pipe is communicated with the discharge hole;

the second stirring piece is horizontally arranged in the second cylinder and is provided with a helical blade;

a second motor, thereby driving the second stirring piece to rotate;

the nozzle groups are provided with a plurality of nozzle units in each group; and the nozzle units of each group are distributed along the axial direction of the second cylinder body, and each nozzle unit is communicated with the inner cavity of the second cylinder body.

2. The premix feeder for octreotide acetate production according to claim 1, wherein the feed assembly further comprises a screen installed in the first barrel to divide the inner cavity of the first barrel into an upper cavity and a lower cavity which are arranged up and down; the first stirring piece is positioned in the upper cavity body.

3. The premix feeder for octreotide acetate production according to claim 2, wherein a longitudinal section of the lower chamber has a frustum shape with a large upper part and a small lower part.

4. The premix feeder for octreotide acetate production according to claim 1, wherein the nozzle group is located in an upper half region of the second cylinder.

5. The premix feeder for octreotide acetate production according to claim 1 or 4, wherein the nozzle group has 3 groups.

6. The premix feeder for octreotide acetate production according to claim 1, wherein a check valve is provided on each nozzle unit.

7. The premix feeder for octreotide acetate production according to claim 1 or 6, wherein each of the nozzle units is provided with an electromagnetic flow valve.

8. The premix feeder for octreotide acetate production according to claim 1, wherein a plurality of the nozzle units of each group are equally spaced in the axial direction of the second barrel.