CN216630753U - Activation device for affinity chromatography medium - Google Patents
Activation device for affinity chromatography medium Download PDFInfo
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- CN216630753U CN216630753U CN202122695545.7U CN202122695545U CN216630753U CN 216630753 U CN216630753 U CN 216630753U CN 202122695545 U CN202122695545 U CN 202122695545U CN 216630753 U CN216630753 U CN 216630753U
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- affinity chromatography
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Abstract
The utility model discloses an activation device for an affinity chromatography medium, and relates to the technical field of affinity chromatography. It can rock through the setting and blend the mechanism, can add corresponding catalyst in to the medium, and utilize the shock to the medium container, make medium and catalyst more abundant integration, promote the activation efficiency of medium, through setting up circulation air supply mechanism, can carry out the circulation of air acceleration around the medium when the medium needs the air assistance to activate, further area of contact of promotion medium and air, further promotion the activation efficiency of medium, through setting up first fixed plate, can convenient and fast be fixed in operating position with equipment more, avoid equipment to turn on one's side at the during operation and lead to damaging, through setting up the slipmat, can avoid equipment to take place to slide when placing temporarily on above-ground, further improvement the security of equipment.
Description
Technical Field
The utility model relates to the technical field of affinity chromatography, in particular to an activation device for an affinity chromatography medium.
Background
Affinity chromatography, also known as affinity chromatography, is a chromatographic method for separating molecules by using the binding properties of a stationary phase, in which affinity chromatography links molecules having a certain binding ability to a substance to be separated on a gel filtration column and their binding is reversible, and the two molecules can be separated from each other by changing the conditions of a mobile phase, and can be used to purify or concentrate a molecule from a mixture, and also to remove or reduce the content of a molecule in a mixture.
In the working process of affinity chromatography, a medium is required to be used for purifying or concentrating a target object, and the medium is required to be activated when the medium is used so as to enhance the energy efficiency of the medium; to this end, we provide an activation device for affinity chromatography media that solves the above problems.
SUMMERY OF THE UTILITY MODEL
The utility model aims to make up the defects of the prior art and provides an activation device for an affinity chromatography medium.
In order to achieve the purpose, the utility model provides the following technical scheme: the utility model provides an activation device of affinity chromatography medium, includes base body, base body's last fixed surface is connected with the protection box, the inside of protection box is provided with rocks and mixes the mechanism, the inside of protection box is provided with circulation air supply mechanism, the equal first fixed plate of fixedly connected with in four edges of base body, the reservation wind-tunnel has all been seted up to the left surface and the right flank of protection box, base body's bottom surface fixedly connected with slipmat.
Further, the shaking and blending mechanism comprises a first rotating motor and two first supporting frames, the first rotating motor is fixedly connected to the inner bottom wall of the protective box body, the two first supporting frames are both fixedly connected to the inner bottom wall of the protective box body, and an output shaft of the first rotating motor is fixedly connected with a rotating wheel disc.
Further, the last fixed surface of rotating wheel dish is connected with the drive shaft, the upper portion of first rotating electrical machines is provided with the slip grillage, two first braced frame's upper surface all with the bottom surface sliding connection of slip grillage, the bottom surface fixedly connected with link of slip grillage.
Further, the bottom surface fixedly connected with of link reserves the frid, the drive shaft with reserve frid sliding connection, the outer fixed surface of first rotating electrical machines is connected with first draw-in groove, the bottom surface of first draw-in groove with the interior diapire fixed connection of protection box.
Furthermore, the left side and the right side of a rotating electrical machine are provided with reinforcing rib groups, two the positive side and the back of reinforcing rib group are respectively with two a side fixed connection that first braced frame is close to each other, the last fixed surface of slip grillage is connected with four fixed slots.
Furthermore, the circulating air supply mechanism comprises a second supporting frame, a second rotating motor and two air guide pipes, the second supporting frame is fixedly connected to the inner top wall of the protection box body, the two air guide pipes are fixedly connected to the inner side wall of the protection box body, the two air guide pipes are respectively matched with the two reserved air tunnels, and supporting plates are fixedly connected to the inner walls of the two air guide pipes.
Furthermore, the inner walls of the two supporting plates are rotatably connected with rotating shafts, the outer surfaces of the two rotating shafts are fixedly connected with fan sets, rotating grooves are embedded in one sides of the convex surfaces of the outer surfaces of the two air guide pipes, and two output shaft ends of the second rotating motor respectively penetrate through the two rotating grooves and are fixedly connected with one side faces, close to the two rotating shafts, of the rotating shafts.
Furthermore, the outer surface of the second rotating motor is fixedly connected with a second clamping groove, the upper surface of the second clamping groove is fixedly connected with the bottom surface of the second supporting frame, the outer surfaces of two output shafts of the second rotating motor are respectively sleeved with a limiting frame, and the upper surfaces of the limiting frames are fixedly connected with the inner top wall of the protective box body.
Compared with the prior art, the activation device of the affinity chromatography medium has the following beneficial effects:
1. according to the utility model, the shaking and mixing mechanism is arranged, so that a corresponding catalyst can be added into the medium, the medium and the catalyst can be more fully fused by utilizing the oscillation of the medium container, the activation efficiency of the medium is improved, the circulating air supply mechanism is arranged, so that the air circulation around the medium can be accelerated when the medium is activated by air assistance, the contact area between the medium and the air is further improved, and the activation efficiency of the medium is further improved.
2. According to the utility model, the first fixing plate is arranged, so that the equipment can be more conveniently and rapidly fixed at the working position, the equipment is prevented from being damaged due to rollover during working, the equipment can be prevented from sliding when temporarily placed on the ground through the anti-slip mat, and the safety of the equipment is further improved.
Drawings
FIG. 1 is a schematic front view of a three-dimensional structure according to the present invention;
FIG. 2 is a schematic bottom view of the three-dimensional structure of the present invention;
FIG. 3 is a schematic perspective view of the shaking and blending mechanism of the present invention;
fig. 4 is a schematic perspective view of the circulating air supply mechanism of the present invention.
In the figure: the device comprises a base body 1, a protective box body 2, a shaking and blending mechanism 3, a first rotating motor 301, a first supporting frame 302, a rotating wheel disc 303, a driving shaft 304, a sliding plate frame 305, a connecting frame 306, a reserved groove plate 307, a first clamping groove 308, a reinforcing rib group 309, a fixed groove 310, a circulating air supply mechanism 4, a second supporting frame 401, a second rotating motor 402, an air guide pipe 403, a supporting plate 404, a rotating shaft 405, a fan group 406, a rotating groove 407, a second clamping groove 408, a limiting frame 409, a first fixing plate 5, a reserved air tunnel 6 and an antiskid mat 7.
Detailed Description
The principles and features of this invention are described below in conjunction with the following drawings, which are set forth by way of illustration only and are not intended to limit the scope of the utility model.
The embodiment provides an activation device for an affinity chromatography medium, which can accelerate the activation reaction of the affinity chromatography medium and effectively improve the working efficiency of affinity chromatography.
Referring to fig. 1-4, an activation device for affinity chromatography media comprises a base body 1, wherein a protective box 2 is fixedly connected to the upper surface of the base body 1.
Here base body 1 and protection box 2 are the support basis and the protection basis of equipment, and its edges and corners department should pass through passivation treatment, avoids its edges and corners accidental injury staff.
The purpose of setting up protection box 2 is in order to avoid the comparatively violent medium spill accidental injury staff that leads to of activation reaction, can improve equipment's security effectively, and protection parts such as baffle are installed additional to the front alternative of protection box 2.
The equal fixedly connected with first fixed plate 5 in four edges of base body 1, the left surface and the right flank of protection box 2 have all been seted up and have been reserved wind-tunnel 6, base body 1's bottom surface fixedly connected with slipmat 7.
Through setting up first fixed plate 5, can convenient and fast more be fixed in operating position with equipment, avoid equipment to turn on one's side at the during operation and lead to damaging, simultaneously through setting up slipmat 7, can avoid equipment to place the emergence slip when above ground temporarily, further improvement the security of equipment.
The inside of protection box 2 is provided with rocks and mixes mechanism 3, rocks and mixes mechanism 3 and can vibrate the medium for the medium fully combines with activation reaction catalyst, improves activation reaction's efficiency.
In this embodiment, the shaking blending mechanism 3 includes a first rotating electrical machine 301 and two first supporting frames 302, the first rotating electrical machine 301 is fixedly connected to the inner bottom wall of the protective box 2, both the two first supporting frames 302 are fixedly connected to the inner bottom wall of the protective box 2, and an output shaft of the first rotating electrical machine 301 is fixedly connected to the rotating wheel disc 303.
Further, a driving shaft 304 is fixedly connected to the upper surface of the rotating wheel disc 303, a sliding plate frame 305 is arranged on the upper portion of the first rotating motor 301, the upper surfaces of the two first supporting frames 302 are both slidably connected to the bottom surface of the sliding plate frame 305, and a connecting frame 306 is fixedly connected to the bottom surface of the sliding plate frame 305.
Further, a reserved groove plate 307 is fixedly connected to a bottom surface of the connecting frame 306, the driving shaft 304 is slidably connected to the reserved groove plate 307, a first engaging groove 308 is fixedly connected to an outer surface of the first rotating electrical machine 301, and a bottom surface of the first engaging groove 308 is fixedly connected to an inner bottom wall of the protective housing 2.
Meanwhile, the left side and the right side of the first rotating electrical machine 301 are both provided with a reinforcing rib group 309, the front side and the back side of the two reinforcing rib groups 309 are respectively fixedly connected with one side faces of the two first supporting frames 302, which are close to each other, and the upper surface of the sliding plate frame 305 is fixedly connected with four fixing grooves 310.
The first rotating motor 301 can drive the rotating wheel disc 303 to rotate, so that the driving shaft 304 drives the reserved groove plate 307 to reciprocate left and right, the sliding plate frame 305 and a medium container on the sliding plate frame 305 are driven to shake left and right, and the purpose of fully and uniformly mixing the medium and the catalyst is achieved.
The inside of protection box 2 is provided with circulation air supply mechanism 4, and circulation air supply mechanism 4 can carry out the air when activation reaction needs the air and circulate with higher speed, further improvement activation reaction's reaction efficiency, saved the required time of medium activation reaction.
Here, the circulating air supply mechanism 4 includes a second supporting frame 401, a second rotating electrical machine 402 and two air guide pipes 403, the second supporting frame 401 is fixedly connected to the inner top wall of the protection box 2, the two air guide pipes 403 are both fixedly connected to the inner side wall of the protection box 2, the two air guide pipes 403 are respectively matched with the two reserved air tunnels 6, and the inner walls of the two air guide pipes 403 are both fixedly connected with supporting plates 404.
In detail, the inner walls of the two support plates 404 are rotatably connected with rotating shafts 405, the outer surfaces of the two rotating shafts 405 are fixedly connected with fan sets 406, one side of the convex surface of the outer surface of the two air guide pipes 403 is inlaid with rotating grooves 407, and two output shaft ends of the second rotating motor 402 respectively penetrate through the two rotating grooves 407 and are fixedly connected with one side surfaces of the two rotating shafts 405 which are close to each other.
Still include, the outer fixed surface of second rotating electrical machines 402 is connected with second draw-in groove 408, the upper surface of second draw-in groove 408 and the bottom surface fixed connection of second braced frame 401, and two output shaft surface of second rotating electrical machines 402 all overlap and are equipped with spacing 409, and the upper surface of two spacing 409 all with the interior roof fixed connection of protection box 2.
Can drive two fan groups 406 through second rotating electrical machines 402 and rotate, realize the extraction to the air, reach the purpose of quick circulating air, air duct 403 adopts the U type setting mainly in order to avoid on the air direct action medium on the slide plate frame 305, avoid resulting in the medium to be blown by the air and splash simultaneously.
The working principle is that firstly, the device is fixed at a proper position through the first fixing plate 5, when the medium needs to be activated, the medium is placed in a proper container and fixed inside the fixing groove 310, so that the container is fixed on the sliding plate frame 305, after a proper amount of catalyst is added into the container, the first rotating motor 301 is started, the first rotating motor 301 rotates to drive the rotating plate disc 303 to rotate, the driving shaft 304 on the rotating plate disc 303 moves around the left circumference of the central shaft of the first rotating motor 301, because the driving shaft 304 is connected with the reserved groove plate 307 in a sliding manner, but the reserved groove plate 307 can only move left and right under the restriction of the first supporting frame 302 and the rotating plate 303, the driving shaft 304 can drive the sliding plate frame 305 and the reserved groove plate 307 to reciprocate left and right on the first supporting frame 302, so as to realize uniform and full mixing of the medium and the catalyst in the container, the reaction rate is increased, if the activation reaction needs air to be added, the reaction rate is reduced after the air around the container is diluted, the second rotating motor 402 can be started at the moment, and the second rotating motor 402 can drive the two rotating shafts 405 to rotate, so that the two fan sets 406 are utilized to perform rapid air circulation on the inside of the protective box body 2, and the reaction rate reduction caused by the air dilution around the container is avoided.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the utility model, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (8)
1. An activation device for affinity chromatography media, comprising a base body (1), characterized in that: the upper surface of the base body (1) is fixedly connected with a protection box body (2), the inside of the protection box body (2) is provided with a rocking and mixing mechanism (3), the inside of the protection box body (2) is provided with a circulating air supply mechanism (4), four corners of the base body (1) are fixedly connected with first fixing plates (5), a reserved wind tunnel (6) is arranged on the left side surface and the right side surface of the protection box body (2), and the bottom surface of the base body (1) is fixedly connected with an anti-slip mat (7).
2. The device for activating an affinity chromatography medium according to claim 1, wherein: the shaking blending mechanism (3) comprises a first rotating motor (301) and two first supporting frames (302), the first rotating motor (301) is fixedly connected to the inner bottom wall of the protective box body (2), the two first supporting frames (302) are fixedly connected to the inner bottom wall of the protective box body (2), and a rotating wheel disc (303) is fixedly connected to an output shaft of the first rotating motor (301).
3. The device for activating an affinity chromatography medium according to claim 2, wherein: the last fixed surface of carousel (303) is connected with drive shaft (304), the upper portion of first rotating electrical machines (301) is provided with slip grillage (305), two the upper surface of first braced frame (302) all with the bottom surface sliding connection of slip grillage (305), the bottom surface fixedly connected with link (306) of slip grillage (305).
4. The device for activating an affinity chromatography medium according to claim 3, wherein: the bottom surface of the connecting frame (306) is fixedly connected with a reserved groove plate (307), the driving shaft (304) is in sliding connection with the reserved groove plate (307), the outer surface of the first rotating motor (301) is fixedly connected with a first clamping groove (308), and the bottom surface of the first clamping groove (308) is fixedly connected with the inner bottom wall of the protective box body (2).
5. The device for activating an affinity chromatography medium according to claim 3, wherein: the left side and the right side of first rotating electrical machines (301) all are provided with strengthening rib group (309), two the positive side and the back of strengthening rib group (309) respectively with two a side fixed connection that first braced frame (302) are close to each other, the last fixed surface of slip grillage (305) is connected with four fixed slots (310).
6. The device for activating an affinity chromatography medium according to claim 1, wherein: the circulating air supply mechanism (4) comprises a second supporting frame (401), a second rotating motor (402) and two air guide pipes (403), the second supporting frame (401) is fixedly connected to the inner top wall of the protection box body (2), the two air guide pipes (403) are fixedly connected to the inner side wall of the protection box body (2), the two air guide pipes (403) are respectively matched with the two reserved air tunnels (6), and the inner walls of the two air guide pipes (403) are fixedly connected with supporting plates (404).
7. The device for activating an affinity chromatography medium according to claim 6, wherein: the inner walls of the two supporting plates (404) are rotatably connected with rotating shafts (405), the outer surfaces of the two rotating shafts (405) are fixedly connected with fan sets (406), one sides of the outer surface protruding surfaces of the two air guide pipes (403) are inlaid with rotating grooves (407), and two output shaft ends of the second rotating motor (402) respectively penetrate through the two rotating grooves (407) and are fixedly connected with one side faces, close to each other, of the rotating shafts (405).
8. The device for activating an affinity chromatography medium according to claim 6, wherein: the outer fixed surface of second rotating electrical machines (402) is connected with second draw-in groove (408), the upper surface of second draw-in groove (408) with the bottom surface fixed connection of second braced frame (401), two output shaft surfaces of second rotating electrical machines (402) all overlap and are equipped with spacing (409), two the upper surface of spacing (409) all with the interior roof fixed connection of protection box (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122695545.7U CN216630753U (en) | 2021-11-05 | 2021-11-05 | Activation device for affinity chromatography medium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122695545.7U CN216630753U (en) | 2021-11-05 | 2021-11-05 | Activation device for affinity chromatography medium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216630753U true CN216630753U (en) | 2022-05-31 |
Family
ID=81733407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122695545.7U Active CN216630753U (en) | 2021-11-05 | 2021-11-05 | Activation device for affinity chromatography medium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216630753U (en) |
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2021
- 2021-11-05 CN CN202122695545.7U patent/CN216630753U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 430000 room 01, 20 / F, building 11, phase 3.2, Wuhan Optical Valley International Biomedical enterprise accelerator, No. 388, Gaoxin Second Road, East Lake New Technology Development Zone, Wuhan, Hubei Province (Wuhan area of free trade zone) Patentee after: WUHAN HUIYAN BIOTECHNOLOGY CO.,LTD. Address before: 430000 room 01, 20 / F, building 11, phase 3.2, Wuhan Optical Valley International Biomedical enterprise accelerator, No. 388, Gaoxin Second Road, East Lake New Technology Development Zone, Wuhan, Hubei Province (Wuhan area of free trade zone) Patentee before: WUHAN HUIYAN BIOTECHNOLOGY Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |