CN216629755U

CN216629755U - Novel full-automatic chromatographic column

Info

Publication number: CN216629755U
Application number: CN202122555656.8U
Authority: CN
Inventors: 张洪; 曹源涛; 石海涛
Original assignee: Boglong Zhejiang Biotechnology Co ltd
Current assignee: Boglong Zhejiang Biotechnology Co ltd
Priority date: 2021-10-23
Filing date: 2021-10-23
Publication date: 2022-05-31
Anticipated expiration: 2031-10-23

Abstract

The utility model relates to a novel full-automatic chromatographic column which is characterized by comprising a column, an upper column head, a top plate, a lower column head, a bottom plate, a first lifting mechanism, a mechanism frame, a transfer mechanism and a cleaning mechanism which are arranged on the mechanism frame, the cleaning mechanism comprises a second lifting mechanism, a motor fixing disc, a direct-drive rotating motor, a supporting piece, a connecting cylinder, a connecting rod, a spring, a roller supporting frame and a roller, the second lifting mechanism is used for realizing the movement of the roller in the axial direction of the pipe column, the direct-drive rotating motor is used for driving the roller to roll in the circumferential direction of the pipe column, thereby cleaning operation is carried out, the arrangement of the connecting rod, the connecting cylinder and the spring leads the roller to be tightly attached to the inner wall of the pipe column under the action of centrifugal force in a rotating state, when the cleaning operation is finished, the actuating part of the direct-drive rotating motor stops rotating, and at the moment, the roller can contract towards the direction of the direct-drive rotating motor under the action of the return force of the spring.

Description

Novel full-automatic chromatographic column

Technical Field

The utility model relates to the field of industrial chromatography, in particular to a novel full-automatic chromatographic column.

Background

Column chromatography separation methods are classical techniques for separating and purifying substances that are commonly used in the fields of scientific research and production, such as chemistry, pharmaceutical chemistry, organic chemistry, bioscience, chemical and pharmaceutical engineering, and the like, and the application range thereof is increasingly expanded.

Chromatography columns are important equipment in the chromatography industry for purifying process liquids and separating desired substances from process liquids, and are typically used in large-scale preparative purification of biological products by various large extract manufacturers, pharmaceutical companies, cosmetics, food companies, and the like. With the development of industry, automatic chromatography is becoming the mainstream apparatus of chromatography industry with its high degree of automation, process controllability and high chromatography efficiency.

Because current chromatography column is not convenient for clear up the inner wall of chromatography column after using to influence next use, influence the availability factor, to above-mentioned technical problem, need design a novel full-automatic chromatography column.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problems and overcome the defects in the prior art, the utility model provides a novel full-automatic chromatographic column, which comprises a column, an upper column head, a top plate, a lower column head, a bottom plate, a first lifting mechanism, a mechanism frame, a transfer mechanism and a cleaning mechanism, wherein the transfer mechanism and the cleaning mechanism are arranged on the mechanism frame; the cleaning mechanism comprises a second lifting mechanism, a motor fixing disc, a direct-drive rotating motor, a supporting piece, a connecting cylinder, a connecting rod, a spring, a roller supporting frame and a roller, the second lifting mechanism is arranged at the top of the mechanism frame, the motor fixing disc is fixedly connected at the lower end of the second lifting mechanism, the direct-drive rotating motor is fixedly connected at the lower end of the motor fixing disc, the supporting piece is C-shaped and is fixedly connected at the middle part of an actuating part of the direct-drive rotating motor, the connecting cylinders are symmetrically connected at the two ends of the supporting piece, one end of the connecting rod penetrates through the inside of the connecting cylinder, the other end of the connecting rod extends to the outside of the connecting cylinder, the spring is arranged inside the connecting cylinder, one end of the spring is fixedly connected with the supporting piece, the other end of the spring is fixedly connected with one end of the connecting rod, and the other end of the connecting rod is vertically connected with the roller supporting frame, the rotary drum is characterized in that a rotating shaft is arranged on the rotary drum supporting frame, the rotary drum is rotatably connected to the rotary drum supporting frame through the rotating shaft, the rotary drum supporting frame is C-shaped, and one end of the rotary drum supporting frame is provided with a balancing weight.

Furthermore, the second lifting mechanism comprises a second lead screw, a guide rod, a connecting disc and a driving mechanism, a guide sleeve matched with the guide rod is arranged on the mechanism frame, the guide rod is connected with the guide sleeve in a sliding mode, one end of the guide rod and one end of the second lead screw are both vertically connected with the motor fixing disc, the other end of the guide rod and the other end of the second lead screw are both vertically connected with the connecting disc, the driving mechanism comprises a servo motor, a speed reducer and a worm gear transmission mechanism, the worm gear is assembled on the top of the mechanism frame through a thrust bearing, threads are formed in the middle of the worm gear, the worm gear is in threaded connection with the second lead screw through the threads, and the servo motor is connected with the worm through the speed reducer so that the worm drives the worm gear to rotate through the worm.

Furthermore, the connecting cylinder is kept away from the one end of support piece has spacing ring, spacing ring with connecting cylinder formula structure as an organic whole, the connecting rod is located the inside one end of connecting cylinder has spacing bulge loop, spacing bulge loop with connecting rod formula structure as an organic whole.

Furthermore, the transfer mechanism comprises a sliding part, third screw rods, synchronous belt wheels and a first servo motor, wherein wedge-shaped sliding grooves with opposite small ends are formed in the inner side walls of the two corresponding ends of the mechanism frame, the two third screw rods are assembled between the inner side walls of the two corresponding ends of the mechanism frame through bearings respectively, the third screw rods are arranged corresponding to the sliding grooves, the first servo motor is fixedly connected to one end of the mechanism frame and is connected with one of the third screw rods through a coupler, the synchronous belt wheels are fixedly connected to the same positions of the two third screw rods respectively and realize transmission through a belt, the sliding part comprises a connecting part, a sliding part and a contact part, the sliding part is connected to the two ends of the connecting part respectively, the sliding part is matched with the wedge-shaped sliding grooves and is connected in the wedge-shaped sliding grooves in a sliding manner, the contact part is arc-shaped and is fixedly connected with the pull rod, the connecting part is provided with threads and is in threaded connection with the third screw rod.

Furthermore, the same positions of the two third screw rods are respectively provided with a limiting bolt.

Furthermore, the upper column cap is connected with a multi-channel upper nozzle, the upper column cap is connected with a top plate through a screw rod, the top plate is connected with a first lifting mechanism, the first lifting mechanism comprises a first screw rod, a guide rod, a connecting disc and a driving mechanism, a guide sleeve matched with the guide rod is arranged on the mechanism frame, the guide rod is in sliding connection with the guide sleeve, one end of the guide rod and one end of the first screw rod are both vertically connected with the top plate, the other end of the guide rod and the other end of the first screw rod are both vertically connected with the connecting disc, the driving mechanism comprises a servo motor, a speed reducer and a worm gear transmission mechanism, the worm gear is assembled at the top of the mechanism frame through a thrust bearing, the middle of the worm gear is provided with threads and is in threaded connection with the first screw rod through the threads, and the servo motor is connected with the worm through the speed reducer so as to drive the worm gear to rotate through the worm. The upper column head comprises an upper distributor back plate, an upper distributor and an upper screen.

Furthermore, a chromatography port is connected to the lower column head, the lower column head is connected with a bottom plate through a screw rod, and a universal wheel with a stop is connected to the lower end of the bottom plate.

Furthermore, the roller is uniformly distributed with bristles.

Compared with the prior art, the utility model has the following beneficial effects: 1. the cleaning mechanism is arranged for thoroughly cleaning the inner wall of the tubular column after each chromatographic operation is finished, and removing residual eluent in the tubular column, so that the next chromatographic operation is facilitated, manual cleaning is avoided, manpower is saved, and the operation efficiency is improved, particularly, the roller is moved in the axial direction of the tubular column through the second lifting mechanism, the roller is driven to roll in the circumferential direction of the tubular column through the direct-drive rotating motor, so that the cleaning operation is performed, the connecting rod, the connecting cylinder and the spring are arranged, so that the roller is stressed by centrifugal force in a rotating state to be tightly attached to the inner wall of the tubular column, the spring is stretched in the connecting cylinder at the moment, the cleaning operation of the tubular column by the roller is facilitated, when the cleaning operation is finished, the actuating part of the direct-drive rotating motor stops rotating, and at the moment, the roller can contract towards the direction of the direct-drive rotating motor under the action of the return force of the spring, the tubular column is moved out under the action of the second lifting mechanism, and the axial direction of the roller is always kept in a vertical state due to the arrangement of the balancing weight, so that the roller can be better attached to the inner wall of the tubular column during cleaning operation, and the cleaning effect is further improved due to the arrangement of the bristles; in the second lifting mechanism, the servo motor is connected with the worm through the speed reducer so as to drive the worm gear to rotate forwards or reversely through the worm, and the worm gear can drive the second screw rod to move up and down in the vertical direction; 2. the limiting circular ring and the limiting convex ring are arranged, so that the connecting rod is prevented from being separated from the connecting cylinder, namely, the limit distance of relative movement of the connecting rod and the connecting cylinder is limited, the limit distance is greater than the diameter of the pipe column, and the safety of equipment is improved; 3. the conveying mechanism is arranged to convey the tubular column and the connecting part thereof to the position right below the cleaning mechanism along a certain track after the chromatographic operation is completed, so that the cleaning operation is facilitated, and particularly, the third screw rod is driven to synchronously rotate through the first servo motor, the synchronous belt pulley and the belt, so that the sliding part is driven to move along the direction of the sliding chute, and the sliding part can drive the tubular column to move, so that the conveying action of the tubular column is realized; 4. the limiting bolt is arranged to limit the maximum transferring distance of the transferring mechanism, and the position of the limiting bolt corresponds to the position of the direct-drive rotating motor.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the prior art descriptions will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

Fig. 1 is a schematic perspective view (one) of an embodiment 1 of the present invention;

FIG. 2 is an enlarged view of FIG. 1 at A;

fig. 3 is a schematic perspective view (ii) of embodiment 1 of the present invention;

fig. 4 is a schematic perspective view (iii) of embodiment 1 of the present invention.

In the figure: 1. universal wheels, 2, a bottom plate, 3, a mechanism frame, 4, a third screw rod, 5, a pull rod, 6, a column body, 7, a ring, 8, an upper column head, 9, a top plate, 10, a first lifting mechanism, 11, a second lifting mechanism, 111, a servo motor, 112, a worm and gear transmission mechanism, 113, a second screw rod, 114, a connecting disc, 115, a guide rod, 12, a limiting bolt, 13, a balancing weight, 14, a roller, 15, a roller supporting frame, 16, a direct-drive rotating motor, 17, a motor fixing disc, 18, a connecting rod, 19, a connecting cylinder, 20, a first servo motor, 21, a belt, 22, a synchronous pulley, 23, a sliding groove, 24, a sliding piece, 241, a connecting part, 242, a contact part, 25, an upper spray head, 26, a lower column head, 27 and a chromatography port.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.

Example 1.

Referring to fig. 1 to 4, the present embodiment provides a novel full-automatic chromatography column, which includes a column, an upper column head 8, a top plate 9, a lower column head 26, a bottom plate 2, a first lifting mechanism 10, a mechanism frame 3, and a transfer mechanism and a cleaning mechanism disposed on the mechanism frame 3, wherein the column includes a column body 6, detachable rings 7 fixedly connected to the upper and lower end portions of the column body 6, and pull rods 5 connected between the upper and lower rings 7 and uniformly distributed along the circumferential direction of the column body 6; the cleaning mechanism comprises a second lifting mechanism 11, a motor fixing disc 17, a direct-drive rotating motor 16, a support piece, a connecting cylinder 19, a connecting rod 18, a spring (not shown), a roller support frame 15 and a roller 14, wherein the second lifting mechanism 11 is arranged at the top of the machine frame 3, the motor fixing disc 17 is fixedly connected at the lower end of the second lifting mechanism 11, the direct-drive rotating motor 16 is fixedly connected at the lower end of the motor fixing disc 17, the support piece is C-shaped and is fixedly connected at the middle part of an actuating part of the direct-drive rotating motor 16, the connecting cylinders 19 are symmetrically connected at two ends of the support piece, one end of the connecting rod 18 penetrates through the connecting cylinder 19, the other end of the connecting rod 18 extends to the outside of the connecting cylinder 19, the spring is arranged in the connecting cylinder 19, and one end of the spring is fixedly connected with the support piece and the other end of the spring is fixedly connected with one end of the connecting rod 18, the other end of the connecting rod 18 is vertically connected with a roller support frame 15, a rotating shaft is arranged on the roller support frame 15, the roller 14 is rotatably connected to the roller support frame 15 through the rotating shaft, the roller support frame 15 is C-shaped, and a balancing weight 13 is arranged at one end of the roller support frame 15. The second lifting mechanism 11 in the embodiment of the present invention includes a second lead screw 113, a guide rod 115, a connection disc 114 and a driving mechanism, a guide sleeve adapted to the guide rod 115 is disposed on the framework 3, the guide rod 115 is slidably connected to the guide sleeve, one end of each of the guide rod 115 and the second lead screw 113 is vertically connected to the motor fixing disc 17, the other end of each of the guide rod 115 and the second lead screw 113 is vertically connected to the connection disc 114, the driving mechanism includes a servo motor 111, a speed reducer and a worm gear transmission mechanism 112, the worm gear is assembled on the top of the framework 3 through a thrust bearing, has a thread in the middle thereof and is in threaded connection with the second lead screw 113 through the thread, and the servo motor 111 is connected to the worm through the speed reducer so as to drive the worm gear to rotate through the worm. The roller 14 of the present embodiment is uniformly provided with bristles (not shown). In this embodiment, the cleaning mechanism is arranged to thoroughly clean the inner wall of the column after each chromatography operation is completed, so as to remove the residual eluent in the column, thereby facilitating the next chromatography operation, avoiding manual cleaning, saving manpower, and improving the operation efficiency, specifically, the second lifting mechanism 11 is used to move the roller 14 in the axial direction of the column, and the direct-drive rotating motor 16 is used to drive the roller 14 to roll in the circumferential direction of the column, thereby performing the cleaning operation, and the connecting rod 18, the connecting cylinder 19 and the spring are arranged to enable the roller 14 to be tightly attached to the inner wall of the column under the action of centrifugal force in the rotating state, at this time, the spring is elongated in the connecting cylinder 19, thereby facilitating the cleaning of the column by the roller 14, and when the cleaning operation is finished, the actuating part of the direct-drive rotating motor 16 stops rotating, at this time, the roller 14 is retracted towards the direction of the direct-drive rotating motor 16 under the action of the return force of the spring, and then shift out the tubular column under the effect of second elevating system 11, the setting of balancing weight 13 makes the axial of cylinder 14 remain vertical state all the time, and like this, cylinder 14 can form the laminating with the tubular column inner wall better when the cleaning operation, and the setting of brush hair has then further improved the cleaning performance. In the second lifting mechanism 11, the servo motor 111 is connected to the worm through the speed reducer so as to drive the worm wheel to rotate forward or backward through the worm, so that the worm wheel can drive the second lead screw 113 to move up and down in the vertical direction.

In the embodiment of the present invention, a limiting ring (not shown) is disposed at an end of the connecting cylinder 19 away from the supporting member, the limiting ring and the connecting cylinder 19 are of an integral structure, a limiting convex ring (not shown) is disposed at an end of the connecting rod 18 located inside the connecting cylinder 19, and the limiting convex ring and the connecting rod 18 are of an integral structure. The stop ring and the stop collar are provided to prevent the connecting rod 18 from disengaging from the connecting cylinder 19, i.e. to define a limit distance for the relative movement of the connecting rod 18 and the connecting cylinder 19, where the limit distance is greater than the diameter of the pipe string.

The transfer mechanism in the embodiment of the utility model comprises a sliding part 24, third screw rods 4, a synchronous pulley 22 and a first servo motor 20, wherein wedge-shaped sliding grooves 23 with opposite small ends are arranged on the inner side walls of the two corresponding ends of the framework 3, the two third screw rods 4 are respectively assembled between the inner side walls of the two ends of the framework 3 through bearings, the third screw rods 4 are correspondingly arranged with the sliding grooves 23, the first servo motor 20 is fixedly connected with one end of the framework 3 and is connected with one of the third screw rods 4 through a coupler, the synchronous pulley 22 is respectively and fixedly connected with the same positions of the two third screw rods 4 and realizes transmission through a belt 21, the sliding part 24 comprises a connecting part 241, and a sliding part and a contact part 242 which are respectively connected with the two ends of the connecting part 241, the sliding part is matched with the wedge-shaped sliding groove 23 and is connected in the wedge-shaped sliding groove 23 in a sliding manner, the contact portion 242 is arc-shaped and is fixedly connected with the pull rod 5, and the connecting portion 241 is provided with threads and is in threaded connection with the third screw rod 4. In this embodiment, the transfer mechanism is configured to transfer the column and the connecting portion 241 thereof to the position right under the cleaning mechanism along a certain track after completing the chromatography operation, so as to facilitate the cleaning operation, specifically, the third lead screw 4 is driven by the first servo motor 20, the synchronous pulley 22 and the belt 21 to rotate synchronously, so as to drive the sliding member 24 to move along the direction of the sliding groove 23, and thus, the sliding member 24 can drive the column to move, thereby realizing the transfer action of the column.

In the embodiment of the utility model, the same positions of the two third screw rods 4 are respectively provided with a limiting bolt 12. The position of the limit bolt 12 is set to limit the maximum transfer distance of the transfer mechanism, and the position of the limit bolt 12 corresponds to the position of the direct drive rotating motor 16.

The multi-channel upper nozzle 25 is connected on the upper column head 8 in the embodiment of the utility model, the upper column head 8 is connected with the top plate 9 through a screw rod, the top plate 9 is connected with a first lifting mechanism 10, the first lifting mechanism 10 comprises a first screw rod, a guide rod, a connecting disc and a driving mechanism, a guide sleeve matched with the guide rod is arranged on the mechanism frame 3, the guide rod is connected with the guide sleeve in a sliding way, one end of each guide rod and one end of each first screw rod are vertically connected with the top plate 9, the other end of each guide rod and the other end of each first screw rod are vertically connected with the connecting disc, the driving mechanism comprises a servo motor, a speed reducer and a worm gear transmission mechanism, the worm gear is assembled at the top of the framework 3 through a thrust bearing, the middle part of the worm gear is provided with threads and is in threaded connection with the first screw rod through the threads, the servo motor is connected with the worm through the speed reducer so as to drive the worm wheel to rotate through the worm. The upper column head 8 comprises an upper distributor back plate, an upper distributor and an upper screen. In this embodiment, the first lifting mechanism 10 drives the upper column head 8 to move up and down and provide pressure for chromatography operation, the first lifting mechanism 10 is substantially the same as the second lifting mechanism 11, and the structures and working forms of the upper column head 8 and the multi-channel upper nozzle 25 are the prior art, and will not be described herein again.

In the embodiment of the utility model, a chromatography port 27 is connected to the lower column head 26, the lower column head 26 is connected with the bottom plate 2 through a screw, and the lower end of the bottom plate 2 is connected with the universal wheel 1 with a stopper. The universal wheel 1 is arranged to facilitate the transferring operation of the column and the connecting part 241 thereof, and the universal wheel 1 can be locked during the chromatography operation, so the operation is very simple. The construction and operation of the lower post head 26 are conventional and will not be described further herein.

All kinds of parts are standard parts in this application file, can purchase from the market, and the specific connection mode of each part all adopts conventional means such as ripe bolt, rivet and welding among the prior art, and machinery, part and electrical equipment all adopt conventional model among the prior art, and conventional connection mode among the prior art is adopted in the circuit connection, and electrical equipment all communicates with external safe power supply, does not make specific statement here again.

In the description of the present invention, it is to be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "one side", "top", "inner", "front", "center", "both ends", and the like are used in the orientations and positional relationships indicated in the drawings only for the convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and therefore, are not to be construed as limiting the present invention.

Furthermore, the terms "first", "second", "third", "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or as implying any number of indicated technical features, whereby the features defined as "first", "second", "third", "fourth" may explicitly or implicitly include at least one such feature.

In the present invention, unless otherwise explicitly stated or limited, the terms "mounted," "disposed," "connected," "fixed," "screwed" and the like are to be understood broadly, for example, as being fixedly connected, detachably connected, or integrated; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate agent, and may be used for communicating the inside of two elements or interacting relation of two elements, unless otherwise specifically defined, and the specific meaning of the terms in the present invention can be understood by those skilled in the art according to specific situations.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A novel full-automatic chromatographic column is characterized by comprising a column, an upper column head (8), a top plate (9), a lower column head (26), a bottom plate (2), a first lifting mechanism (10), a mechanism frame (3), a conveying mechanism and a cleaning mechanism which are arranged on the mechanism frame (3), wherein the column comprises a column body (6), detachable rings (7) which are fixedly connected to the upper end part and the lower end part of the column body (6) and pull rods (5) which are connected between the upper ring and the lower ring (7) and are uniformly distributed along the circumferential direction of the column body (6); the cleaning mechanism comprises a second lifting mechanism (11), a motor fixing disc (17), a direct-drive rotating motor (16), a support piece, a connecting cylinder (19), a connecting rod (18), a spring, a roller supporting frame (15) and a roller (14), wherein the second lifting mechanism (11) is arranged at the top of the framework (3), the motor fixing disc (17) is fixedly connected to the lower end of the second lifting mechanism (11), the direct-drive rotating motor (16) is fixedly connected to the lower end of the motor fixing disc (17), the support piece is C-shaped and is fixedly connected to the middle of an actuating part of the direct-drive rotating motor (16), the connecting cylinders (19) are symmetrically connected to the two ends of the support piece, one ends of the connecting rods (18) penetrate through the inside of the connecting cylinder (19) and the other ends of the connecting rods (18) extend to the outside of the connecting cylinder (19), the spring is arranged in the connecting cylinder (19), one end of the spring is fixedly connected with the supporting piece, the other end of the spring is fixedly connected with one end of the connecting rod (18), the other end of the connecting rod (18) is vertically connected with the roller supporting frame (15), a rotating shaft is arranged on the roller supporting frame (15), the roller (14) is rotatably connected to the roller supporting frame (15) through the rotating shaft, the roller supporting frame (15) is C-shaped, and one end of the roller supporting frame is provided with a balancing weight (13).

2. The novel full-automatic chromatography column as claimed in claim 1, wherein the second lifting mechanism (11) comprises a second lead screw (113), a guide rod (115), a connecting disc (114) and a driving mechanism, a guide sleeve matched with the guide rod (115) is arranged on the mechanism frame (3), the guide rod (115) is connected with the guide sleeve in a sliding way, one end of each guide rod (115) and one end of each second screw rod (113) are vertically connected with the motor fixing disc (17), the other end of each guide rod is vertically connected with the connecting disc (114), the driving mechanism comprises a servo motor (111), a speed reducer and a worm and gear transmission mechanism (112), the worm wheel is assembled at the top of the frame (3) through a thrust bearing, the middle of the worm wheel is provided with threads and is in threaded connection with a second screw rod (113) through threads, the servo motor (111) is connected with the worm through the speed reducer so as to drive the worm wheel to rotate through the worm.

3. The novel full-automatic chromatography column as claimed in claim 1, characterized in that the end of the connecting cylinder (19) far away from the support member is provided with a limiting ring, the limiting ring is of an integral structure with the connecting cylinder (19), the end of the connecting rod (18) inside the connecting cylinder (19) is provided with a limiting convex ring, and the limiting convex ring is of an integral structure with the connecting rod (18).

4. The novel full-automatic chromatography column as claimed in claim 1, wherein the transfer mechanism comprises a sliding member (24), third lead screws (4), a synchronous pulley (22) and a first servo motor (20), the inner side walls of the two corresponding ends of the framework (3) are provided with wedge-shaped chutes (23) with opposite small ends, the two third lead screws (4) are respectively assembled between the inner side walls of the two ends of the framework (3) through bearings, the third lead screws (4) are arranged corresponding to the chutes (23), the first servo motor (20) is fixedly connected to one end of the framework (3) and is connected with one of the third lead screws (4) through a coupler, the synchronous pulley (22) is fixedly connected to the same position of the two third lead screws (4) and realizes transmission through a belt (21), slider (24) include connecting portion (241) and connect sliding part and contact site (242) at connecting portion (241) both ends respectively, the sliding part with wedge spout (23) phase-match and sliding connection are in wedge spout (23), contact site (242) be the arc and with pull rod (5) fixed connection, be equipped with on connecting portion (241) the screw thread and with third lead screw (4) threaded connection.

5. The novel full-automatic chromatographic column according to claim 4, characterized in that a limiting bolt (12) is further arranged at the same position of the two third screw rods (4).

6. The novel full-automatic chromatographic column as claimed in claim 1, wherein the upper column cap (8) is connected with a multi-channel upper nozzle (25), the upper column cap (8) is connected with a top plate (9) through a screw, the top plate (9) is connected with a first lifting mechanism (10), the first lifting mechanism (10) comprises a first lead screw, a guide rod, a connecting disc and a driving mechanism, the framework (3) is provided with a guide sleeve adapted to the guide rod, the guide rod is connected with the guide sleeve in a sliding manner, one end of the guide rod and one end of the first lead screw are both connected with the top plate (9) and the other end thereof are both connected with the connecting disc in a perpendicular manner, the driving mechanism comprises a servo motor, a speed reducer and a worm gear transmission mechanism, the worm gear is assembled at the top of the framework (3) through a thrust bearing, has a thread in the middle part thereof and is connected with the first lead screw through a thread, the servo motor is connected with the worm through the speed reducer, so that the worm drives the worm wheel to rotate through the worm.

7. The novel full-automatic chromatographic column is characterized in that a chromatographic port (27) is connected to the lower column head (26), the lower column head (26) is connected with a bottom plate (2) through a screw rod, and a universal wheel (1) with a stop is connected to the lower end of the bottom plate (2).

8. The novel full-automatic chromatography column as claimed in claim 1, characterized in that the roller (14) is uniformly distributed with bristles.