CN216605610U - Instrument for enriching, separating and extracting targeted biological components - Google Patents
Instrument for enriching, separating and extracting targeted biological components Download PDFInfo
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- CN216605610U CN216605610U CN202122665011.XU CN202122665011U CN216605610U CN 216605610 U CN216605610 U CN 216605610U CN 202122665011 U CN202122665011 U CN 202122665011U CN 216605610 U CN216605610 U CN 216605610U
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- magnetic head
- head cap
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- enriching
- biological components
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Abstract
The utility model discloses an instrument for enriching, separating and extracting targeted biological components, which comprises an equipment base, a movable cavity and a magnetic head body, wherein the equipment base is arranged at the bottom of the movable cavity, the magnetic head body is arranged in the movable cavity, the top of the magnetic head body is provided with a magnetic head handle, and a magnetic head cap body matched with the magnetic head body is arranged in the movable cavity. The utility model is installed with the magnetic head cap body and the magnetic head cap brim, when the device is operated, the main function of the magnetic head cap body is to isolate the magnetic head body, which is convenient for the falling of the magnetic particles.
Description
Technical Field
The utility model relates to the technical field of cell separation equipment, in particular to an instrument for enriching, separating and extracting targeted biological components.
Background
When current magnetic head adsorption equipment absorbs magnetic particle in six hole culture plate, all be miniature bar magnet or electro-magnet and carry out the coverage scanning in six hole culture plate's haplopore constantly usually, but during actual operation, the scanning area that often can appear magnetic rod or electro-magnet is difficult even covers whole six hole culture plate haplopore, and the scanning time is longer relatively, influence magnetic particle's adsorption efficiency, current enrichment separation still has antibiotic effect poor with the instrument of drawing target biological component when specifically using in addition, the defect of difficult clearance maintenance, this is unfavorable for the long-term popularization of device.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide an instrument for enriching, separating and extracting targeted biological components, which solves the problems of difficult operation, poor cell separation effect, poor antibacterial effect and difficult cleaning and maintenance in the background technology.
In order to achieve the purpose, the utility model provides the following technical scheme: the utility model provides an enrichment separation and draw instrument of target biological component, includes equipment base, activity cavity and magnetic head body, the equipment base sets up in the bottom of activity cavity, the magnetic head body is installed in the inside of activity cavity, just the top of magnetic head body is provided with the magnetic head handle, the internally mounted of activity cavity have with magnetic head body assorted magnetic head cap body, be provided with on the activity cavity and catch groove, first wash tank, release tank and second wash tank, the bottom of magnetic head cap body is provided with magnetic head cap bottom outer plane, just the inside of magnetic head cap body is provided with the magnetic head cap inner chamber, the edge at magnetic head cap body top is provided with the magnetic head cap brim of a hat.
Preferably, four corners of equipment base bottom all are provided with reserves the pilot hole, just the inside wall of reserving the pilot hole is provided with the internal thread for the device is convenient for assemble.
Preferably, the anti-skidding gasket is bonded at the middle position of the bottom of the equipment base, and is made of silica gel, so that the anti-skidding stability of the device when the device is directly placed is improved.
Preferably, the inner side wall of the movable chamber is provided with a nano silver antibacterial layer, so that the antibacterial effect inside the movable chamber is improved, and the pollution condition is reduced.
Preferably, the outer side wall of the movable cavity is provided with an electroplating protective layer, so that the appearance and corrosion resistance of the outer part of the device are improved.
Preferably, the magnetic head handle is made of a magnetic conductive material, so that the structure of the device is optimized.
Preferably, the magnetic head cap body is made of medical plastics, so that the safety of the magnetic head cap body in use is improved.
Preferably, the inner side walls of the capture tank, the first washing tank, the release tank and the second washing tank are all provided with nano ceramic anti-adhesion layers, so that the anti-adhesion and corrosion-resistant effects in the capture tank, the first washing tank, the release tank and the second washing tank are improved, and the cleaning and maintenance are facilitated.
Compared with the prior art, the utility model has the beneficial effects that:
(1) when the apparatus for enriching, separating and extracting the targeted biological components is used, a combined body formed by the magnetic head body and the magnetic head cap body is slowly close to a collecting tank of an eight-hole plate, the combined body rotates for N circles by taking the center of a magnetic head handle as a circle center, a magnetic field of the magnetic head body effectively covers a storage container, magnetic particles are absorbed on the outer plane of the bottom of the magnetic head cap, after the magnetic particles are absorbed, the magnetic head cap body is lifted and translated to a first washing tank to clean the outer plane of the bottom of the magnetic head cap, non-magnetic particle substances are removed, then the magnetic head cap body is lifted and translated to a second washing tank to clean the outer plane of the bottom of the magnetic head cap for a second time, impurities are removed, and finally the magnetic head cap body is lifted and translated to a release tank, wherein a reverse magnetic field is given to the combined body formed by the magnetic head body and the magnetic head cap body in the release tank, the magnetic head body moves upwards along the movable cavity, the magnetic field effect of the magnetic head body on the outer plane of the bottom of the magnetic head cap is reduced, specific cells wrapped by magnetic particles adsorbed on the outer plane of the bottom of the magnetic head cap fall into the release groove, the separation of the specific cells in a sample is realized in the whole process, and the separation effect is good;
(2) the instrument for enriching, separating and extracting the targeted biological components optimizes the structure of the device by installing a magnetic head body, a magnetic head handle and a movable cavity, when in use, on one hand, the magnetic head body adopts a square permanent magnet, the size of the magnetic head body is slightly smaller than that of a single hole of an eight-hole culture plate, when specific cells are separated, the square magnet only needs to ensure that the distance between the bottom surface of the magnet and the bottom of the eight-hole culture plate is consistent all the time, the center of the square magnet is aligned with the single hole of the eight-hole culture plate, and the separation of the specific cells in the eight-hole plate can be completed by rotating the square magnet for one circle or N circles, so that the device is convenient to operate and has high practicability, on the other hand, the magnetic head body is combined by two rectangular structures with different sizes, the magnetic head body can be suspended in the movable cavity and can freely move in the vertical direction in the movable cavity, and the size of the movable cavity is slightly larger than the size of the upper half section of the magnetic head body, the magnetic head body and the magnetic head handle are limited, and the magnetic head body can move smoothly in the vertical direction in the cavity just right, the outer wall of the magnetic head body is a cylindrical outer wall, and the size of the outer wall is slightly smaller than a storage container for separating magnetic particles of a target, such as a single hole of an eight-hole culture plate;
(3) the instrument for enriching, separating and extracting the targeted biological components is provided with a first washing tank, a release tank and a second washing tank, so that when the device is operated specifically, the main function of the magnetic head cap body is to isolate the magnetic head body and facilitate the falling of magnetic particles, the instrument comprises a magnetic head cap brim, a magnetic head cap bottom outer plane and a magnetic head cap inner cavity, the magnetic head cap brim is combined with a magnetic head cap clamping groove of a magnetic head handle, the magnetic head cap body is fixed on the magnetic head body to avoid the falling, on the other hand, the inner side wall of the movable chamber is provided with a nano silver antibacterial layer, the antibacterial effect inside the movable chamber is improved, the pollution condition is reduced, and the anti-adhesion and corrosion-resistant effects inside the capture tank, the first washing tank, the release tank and the second washing tank are improved by the nano ceramic anti-adhesion layers arranged on the inner side walls of the capture tank, the first washing tank, the release tank and the second washing tank, is convenient for cleaning and maintenance.
Drawings
FIG. 1 is a structural diagram illustrating an overall structure of the present invention;
FIG. 2 is a schematic perspective view of a movable chamber according to the present invention;
FIG. 3 is a schematic perspective view of a magnetic head cap body according to the present invention;
FIG. 4 is a schematic structural view of a magnetic head and a head cap according to the present invention in a combined state;
FIG. 5 is a schematic bottom view of the base of the apparatus of the present invention.
In the figure: 1. an equipment base; 2. a movable chamber; 3. a magnetic head body; 301. a magnetic head handle; 4. a head cap body; 5. a capture tank; 6. a first washing tank; 7. a relief groove; 8. a second washing tank; 9. a magnetic head cap brim; 10. the outer plane of the bottom of the magnetic head cap; 11. an inner cavity of the magnetic head cap; 12. reserving an assembling hole; 13. an anti-skid gasket.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-5, an embodiment of the present invention is shown: an instrument for enriching, separating and extracting targeted biological components comprises an equipment base 1, a movable chamber 2 and a magnetic head body 3, wherein the equipment base 1 is arranged at the bottom of the movable chamber 2, the magnetic head body 3 is arranged in the movable chamber 2, and the top of the magnetic head body 3 is provided with a magnetic head handle 301;
a magnetic head cap body 4 matched with the magnetic head body 3 is arranged in the movable chamber 2, and a capture tank 5, a first washing tank 6, a release tank 7 and a second washing tank 8 are arranged on the movable chamber 2;
the bottom of the magnetic head cap body 4 is provided with a magnetic head cap bottom outer plane 10, a magnetic head cap inner cavity 11 is arranged inside the magnetic head cap body 4, and the edge of the top of the magnetic head cap body 4 is provided with a magnetic head cap brim 9;
reserved assembly holes 12 are formed in four corners of the bottom of the equipment base 1, and internal threads are formed in the inner side walls of the reserved assembly holes 12;
when the device is used, a user can install the assembling structures such as the sucking discs, the supporting legs and the like with proper specifications at the bottom of the equipment base 1 by utilizing the action of the reserved assembling holes 12 and the internal threads arranged in the reserved assembling holes, so that the device is stably arranged at a proper operation position, and the device is convenient to assemble;
an anti-skid gasket 13 is bonded at the middle position of the bottom of the equipment base 1, and the anti-skid gasket 13 is made of silica gel;
when the device is used, the anti-skid gasket 13 made of silica gel is arranged at the bottom of the equipment base 1, so that the anti-skid stability of the device when the device is directly placed is improved;
the inner side wall of the movable chamber 2 is provided with a nano silver antibacterial layer;
when in use, the nano silver antibacterial layer is utilized, so that the antibacterial effect inside the movable chamber 2 is improved, and the pollution condition is reduced;
an electroplating protective layer is arranged on the outer side wall of the movable chamber 2;
when the device is used, the outer side wall of the movable chamber 2 is provided with the electroplating protective layer, so that the appearance and the corrosion resistance effect of the outer part of the device are improved;
the magnetic head handle 301 is made of a magnetic conductive material, and the rest components of the device except the magnetic head handle 301 are made of the magnetic conductive material;
when the magnetic head device is used, the magnetic head body 3 is combined by two rectangular structures with different sizes, can be suspended in the movable cavity 2 and can freely move in the movable cavity 2 in the vertical direction, the size of the movable cavity 2 is slightly larger than the size of the upper half section of the magnetic head body 3, the magnetic head body 3 and the magnetic head handle 301 are limited, and the magnetic head body 3 can just move smoothly in the vertical direction in the cavity, the outer wall of the magnetic head body 3 is a cylindrical outer wall, and the size of the outer wall is slightly smaller than a storage container for separating magnetic particles, such as a single hole of an eight-hole culture plate;
the magnetic head cap body 4 is made of medical plastics;
the material of the magnetic head cap body 4 is medical plastic, so that the safety of the magnetic head cap body 4 in use is improved;
the inner side walls of the capture tank 5, the first washing tank 6, the release tank 7 and the second washing tank 8 are all provided with nano ceramic anti-sticking layers;
the anti-adhesion and corrosion-resistant effects in the capturing tank 5, the first washing tank 6, the releasing tank 7 and the second washing tank 8 are improved by utilizing the nano ceramic anti-adhesion layer, so that the cleaning and maintenance are facilitated;
the magnetic head handle 301 is provided with a magnetic head cap clamping groove which is clamped with the magnetic head cap brim 9 on the magnetic head cap body 4, so that the magnetic head cap clamping groove and the magnetic head cap brim are conveniently assembled in a butt joint mode.
When the embodiment of the application is used: because the magnetic head body 3 adopts the square permanent magnet, the size of the magnetic head body is slightly smaller than the single hole of the eight-hole culture plate, when separating specific cells, the square magnet can separate the specific cells in the eight-hole plate only by ensuring that the distance between the bottom surface of the magnet and the bottom of the eight-hole culture plate is consistent all the time, the center of the square magnet is aligned with the single hole of the eight-hole culture plate, and rotating the square magnet for one circle or N circles, thereby the device is convenient to operate and has high practicability, meanwhile, the magnetic head body 3 is combined by two rectangular structures with different sizes, the magnetic head body 3 can be ensured to be suspended in the movable chamber 2 and can freely move in the vertical direction in the movable chamber 2, the size of the movable chamber 2 is slightly larger than the upper half size of the magnetic head body 3, the magnetic head body 3 and the magnetic head handle 301 are limited, and the magnetic head body 3 can move smoothly in the vertical direction in the cavity just, the outer wall of the magnetic head body 3 is a cylindrical outer wall, the size of which is slightly smaller than a storage container for separating magnetic particles of a target, such as a single hole of an eight-hole culture plate, in addition, the main function of the magnetic head cap body 4 is to isolate the magnetic head body 3 so as to facilitate the falling of the magnetic particles, the magnetic head cap body comprises a magnetic head cap brim 9, a magnetic head cap bottom outer plane 10 and a magnetic head cap inner cavity 11, the magnetic head cap brim 9 is used for combining with a magnetic head cap clamping groove of a magnetic head handle 301, so that the magnetic head cap body 4 is fixed on the magnetic head body 3 to avoid the falling, and in practical use, the combined body formed by the magnetic head body 3 and the magnetic head cap body 4 is slowly close to the eight-hole plate, the magnetic head cap collecting groove 301 is used as a circle center to rotate for N circles, so that the magnetic field of the magnetic head body 3 effectively covers the storage container, the magnetic particles are absorbed on the magnetic head cap bottom outer plane 10, after the magnetic particles are absorbed, the magnetic head cap body 4 is lifted and horizontally moved to a first washing groove 6 to clean the magnetic head cap bottom outer plane 10, remove except that magnetic particle material, then lift magnetic head cap body 4 and translate to second washing tank 8 again, wash magnetic head cap bottom outer plane 10 for the second time, get rid of impurity, lift magnetic head cap body 4 at last and translate to release tank 7, can give a reverse magnetic field for the combination that magnetic head body 3 and magnetic head cap body 4 constitute in the release tank 7, make magnetic head body 3 along activity cavity 2 upward movement, magnetic field effect that magnetic head body 3 made the magnetic head cap bottom outer plane 10 diminish at this moment, the specific cell that the magnetic particle parcel that adsorbs on magnetic head cap bottom outer plane 10 drops in release tank 7, whole process has realized the separation of specific cell in the middle of the sample, separation effect is better.
Claims (8)
1. The instrument for enriching, separating and extracting targeted biological components is characterized by comprising an equipment base (1), a movable chamber (2) and a magnetic head body (3), wherein the equipment base (1) is arranged at the bottom of the movable chamber (2), the magnetic head body (3) is arranged inside the movable chamber (2), a magnetic head handle (301) is arranged at the top of the magnetic head body (3), a magnetic head cap body (4) matched with the magnetic head body (3) is arranged inside the movable chamber (2), a capture groove (5), a first washing groove (6), a release groove (7) and a second washing groove (8) are arranged on the movable chamber (2), a magnetic head cap bottom outer plane (10) is arranged at the bottom of the magnetic head cap body (4), and a magnetic head cap inner cavity (11) is arranged inside the magnetic head cap body (4), the edge of the top of the magnetic head cap body (4) is provided with a magnetic head cap brim (9).
2. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: four corners of equipment base (1) bottom all are provided with reserves pilot hole (12), just the inside wall of reserving pilot hole (12) is provided with the internal thread.
3. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: the anti-skid device is characterized in that an anti-skid gasket (13) is bonded at the middle position of the bottom of the device base (1), and the anti-skid gasket (13) is made of silica gel.
4. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: the inner side wall of the movable chamber (2) is provided with a nano silver antibacterial layer.
5. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: and an electroplating protective layer is arranged on the outer side wall of the movable chamber (2).
6. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: the magnetic head handle (301) is made of a magnetic conductive material.
7. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: the magnetic head cap body (4) is made of medical plastics.
8. The apparatus for enriching, separating and extracting target biological components according to claim 1, wherein: the inner side walls of the capture tank (5), the first washing tank (6), the release tank (7) and the second washing tank (8) are all provided with nano ceramic anti-sticking layers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122665011.XU CN216605610U (en) | 2021-11-02 | 2021-11-02 | Instrument for enriching, separating and extracting targeted biological components |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122665011.XU CN216605610U (en) | 2021-11-02 | 2021-11-02 | Instrument for enriching, separating and extracting targeted biological components |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216605610U true CN216605610U (en) | 2022-05-27 |
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ID=81696204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122665011.XU Active CN216605610U (en) | 2021-11-02 | 2021-11-02 | Instrument for enriching, separating and extracting targeted biological components |
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| Country | Link |
|---|---|
| CN (1) | CN216605610U (en) |
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2021
- 2021-11-02 CN CN202122665011.XU patent/CN216605610U/en active Active
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