CN216603626U - Hyaluronic acid coating zinc alloy barrier repair film - Google Patents
Hyaluronic acid coating zinc alloy barrier repair film Download PDFInfo
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- CN216603626U CN216603626U CN202122541171.3U CN202122541171U CN216603626U CN 216603626 U CN216603626 U CN 216603626U CN 202122541171 U CN202122541171 U CN 202122541171U CN 216603626 U CN216603626 U CN 216603626U
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Abstract
The utility model relates to the field of medical instruments, in particular to a hyaluronic acid coating zinc alloy barrier repair film. The repair film comprises a zinc alloy film layer and a hyaluronic acid coating; the zinc alloy film layer is provided with a plurality of holes with the diameter of 50-80 mu m, and the porosity on the zinc alloy film layer is 20-85%. The utility model adopts degradable zinc alloy as the film material, the zinc alloy is arranged into a porous structure and coated with the hyaluronic acid coating, and the shielding repair film which has stable supporting performance, controllable degradation rate and promotion effect on soft tissue repair and regeneration is obtained.
Description
Technical Field
The utility model relates to the field of medical instruments, in particular to a hyaluronic acid coating zinc alloy barrier repair film.
Background
Guided bone tissue regeneration techniques were first initiated in guided tissue regeneration technical studies in the field of periodontics. Nowadays, the technology is widely applied in the medical fields of alveolar surgery, periodontics, oral implantology and the like.
In guided bone regeneration techniques, the barrier membrane plays a crucial role, determining the success or failure of guided bone regeneration techniques. A good barrier film should have several conditions: (1) good biocompatibility and tissue and cell affinity, and can not cause rejection reaction and inflammatory reaction in the organism; (2) can provide better mechanical barrier action and space protection action, isolate soft tissues, prevent epithelial cells and connective tissue fibroblasts which interfere bone formation from invading a bone defect area and preferentially growing; (3) the medicine has no toxicity, pyrogenicity and immunogenicity, has good stability and is not easy to react with tissues; (4) covering the bone defect area, can better laminate in the bone surface, clinical treatment is easy to operate, and the guide bone regeneration barrier membrane variety that is available clinically at present is many, and is divided into two categories according to whether can be absorbed (degradation): non-absorbable barrier films and absorbable barrier films. Non-absorbable barrier films suffer from the following significant disadvantages: (1) because of no biodegradability, the material needs to be removed by a secondary operation; (2) the membrane may cause soft tissue dehiscence, thereby increasing the likelihood of wound infection and prolonging the healing period of the wound; (3) secondary surgery can increase patient discomfort and pain, and increase patient medical costs. Due to the above drawbacks, the clinical use of non-absorbable barrier membranes has been limited. Compared with the non-absorbable barrier film, the absorbable barrier film has good biocompatibility and biodegradability, avoids secondary operations of patients, and accordingly reduces the pain and medical cost of the patients, and great progress is made in recent years.
However, the absorbable barrier film in the prior art has poor shaping effect and obvious defects of too fast loss of mechanical property during in vivo degradation. The development of degradable barrier membranes that are degradable and have good mechanical properties has become the direction and focus of current research.
SUMMERY OF THE UTILITY MODEL
The utility model provides a repairing film which adopts degradable zinc alloy as a film material, is provided with a porous structure on the zinc alloy and is coated with a hyaluronic acid coating, and has stable supporting performance, controllable degradation rate and promotion effect on soft tissue repairing and regeneration.
In order to achieve the above object, embodiments of the present invention provide a hyaluronic acid coated zinc alloy barrier repair film, comprising a zinc alloy film layer and a hyaluronic acid coating layer;
the zinc alloy film layer is provided with a plurality of holes with the diameter of 50-80 mu m, and the porosity on the zinc alloy film layer is 20-85%.
Further, the number of the zinc alloy film layers is 1-5; the hyaluronic acid coating is arranged on one side or two sides of the zinc alloy film layer.
Furthermore, the single-layer thickness of the zinc alloy film layer is 10-100 μm.
Furthermore, the surface of the zinc alloy film layer is a rough surface, the thickness of the single-layer zinc alloy film layer is 10 mu m, delta is less than or equal to 20 mu m, and Ra is not less than 0.4 mu m; the thickness of the single-layer zinc alloy film layer is 20 mu m delta less than or equal to 40 mu m, and Ra is not less than 0.8 mu m; the thickness of the single-layer zinc alloy film layer is 40 mu m delta less than or equal to 60 mu m, and Ra is not less than 1.6 mu m; the thickness of the single-layer zinc alloy film layer is 60 mu m < delta < 100 mu m, and Ra is not less than 3.2 mu m.
Further, the thickness of the hyaluronic acid coating is 5-2000 μm.
Has the advantages that:
the degradable zinc alloy is used as the membrane material, compared with a high polymer material, the degradable zinc alloy has excellent mechanical property and stable supporting performance, and can meet the requirements of different repairing structure shaping of the barrier membrane; and the zinc ion has better biocompatibility, and the zinc ion released after degradation can promote the growth of bone tissues and improve the bone repair speed and the bone formation quality. The use amount of the material can be controlled by the porosity of the porous zinc alloy film layer, so that the degradation rate of the product is controlled, and meanwhile, the barrier repair film is endowed with excellent plasticity. The utility model is also provided with a hyaluronic acid coating, which has excellent physiological functions of soft tissue repair, damage prevention and the like, can promote the repair and regeneration of the contact surface of soft tissue, simultaneously makes up the shielding effect of the structure of a porous part, forms a barrier diaphragm for soft tissue repair and hard tissue repair, does not influence the penetration of blood and growth factors, and can further promote the tissue repair.
Drawings
Fig. 1 is a schematic view of a hyaluronic acid coated zinc alloy barrier repair film provided in example 1 of the present invention;
fig. 2 is a schematic view of a hyaluronic acid coated zinc alloy barrier repair film provided in example 2 of the present invention;
FIG. 3 is a schematic view of a hyaluronic acid coated zinc alloy barrier repair film provided in example 3 of the present invention;
FIG. 4 is a schematic view of a hyaluronic acid coated zinc alloy barrier repair film provided in example 4 of the present invention;
FIG. 5 is a schematic view of a hyaluronic acid coated zinc alloy barrier repair film provided in example 5 of the present invention;
FIG. 6 is a schematic view of a hyaluronic acid coated zinc alloy barrier repair film provided in example 6 of the present invention;
fig. 7 is a schematic view of a zinc alloy film layer provided by the present invention.
[ description of reference ]
1-1, a first hyaluronic acid coating; 1-2 parts of a single-layer zinc alloy film layer, 1-3 parts of a second hyaluronic acid coating; 2-1, coating hyaluronic acid; 2-2, a single zinc alloy film layer; 3-1, a first hyaluronic acid coating; 3-2, three layers of zinc alloy film layers; 3-3, a second hyaluronic acid coating; 4-1, a first hyaluronic acid coating; 4-2, three zinc alloy film layers; 4-3, a second coating of hyaluronic acid; 5-1, coating with hyaluronic acid; 5-2, three layers of zinc alloy film layers; 6-1, coating of hyaluronic acid; 6-2, three zinc alloy film layers; 7-1 parts of zinc alloy film layer, 7-2 parts of zinc alloy film hole.
Detailed Description
In order to make the technical problems, technical solutions and advantages of the present invention more apparent, the following detailed description is given with reference to the accompanying drawings and specific embodiments.
The utility model provides a hyaluronic acid coating zinc alloy barrier repair film, and aims to solve the technical problems that an absorbable barrier film in the prior art is poor in molding effect and has obvious defects of too fast mechanical property loss in-vivo degradation.
In the embodiment of the utility model, as shown in fig. 1 to 7, the hyaluronic acid coating zinc alloy barrier repair film comprises a zinc alloy film layer and a hyaluronic acid coating, wherein the zinc alloy film layer is provided with a plurality of holes 7-2 with the diameter of 50-80 μm, the porosity on the zinc alloy film layer is 20-85%, and the number of the zinc alloy film layers is 1-5; the hyaluronic acid coating is arranged on one side or two sides of the zinc alloy film layer; the single-layer thickness of the zinc alloy film layer is 10-100 mu m; the surface of the zinc alloy film layer is a rough surface, the thickness of the single-layer zinc alloy film layer is 10 mu m, delta is less than or equal to 20 mu m, and Ra is not less than 0.4 mu m; the thickness of the single-layer zinc alloy film layer is 20 mu m delta less than or equal to 40 mu m, and Ra is not less than 0.8 mu m; the thickness of the single-layer zinc alloy film layer is 40 mu m delta less than or equal to 60 mu m, and Ra is not less than 1.6 mu m; the thickness of the single-layer zinc alloy film layer is 60 mu m delta less than or equal to 100 mu m, and Ra is not less than 3.2 mu m; the thickness of the hyaluronic acid coating is 5-2000 μm.
Example 1
As shown in fig. 1, the hyaluronic acid coated zinc alloy barrier repair membrane of the present embodiment includes a single zinc alloy membrane layer 1-2 and two hyaluronic acid coatings 1-1, 1-3, wherein the thickness of the zinc alloy membrane layer 1-2 is 60 μm, Ra is not less than 1.6 μm, the zinc alloy membrane layer 1-2 has pores with a diameter of 100 μm and a porosity of 60%, and the hyaluronic acid layers 1-1, 1-3 are zinc hyaluronate coatings wrapped with parathyroid hormone bone-promoting drugs and have a thickness of 400 μm.
Example 2
As shown in fig. 2, the hyaluronic acid coating zinc alloy barrier repair film of the present embodiment includes a single zinc alloy film layer 2-2, a single hyaluronic acid coating layer 2-1; the thickness of the zinc alloy film layer 2-2 is 80 micrometers, Ra is not less than 3.2 micrometers, holes with the diameter of 200 micrometers are formed in the zinc alloy film layer 2-2, the porosity is 50%, the hyaluronic acid coating layer 2-1 is a calcium hyaluronate coating layer and wraps fluoride bone-promoting medicines, and the thickness is 700 micrometers.
Example 3
As shown in fig. 3, the hyaluronic acid coated zinc alloy barrier repair film of the present embodiment includes a single zinc alloy film layer 3-2, a single hyaluronic acid coating layer 3-1; the thickness of the zinc alloy film layer 3-2 is 60 micrometers, Ra is not less than 1.6 micrometers, the zinc alloy film material 3-2 is provided with holes with the diameter of 300 micrometers, the porosity is 45%, the hyaluronic acid coating 3-1 is a sodium hyaluronate coating, and the thickness is 100 micrometers.
Example 4
As shown in fig. 4, the hyaluronic acid coating zinc alloy barrier repair membrane of the embodiment comprises three zinc alloy membrane layers 4-2, and hyaluronic acid coatings 4-1 and 4-3 are arranged on two sides of the membrane; the thickness of a single layer of the zinc alloy film layer 4-2 is 30 micrometers, Ra is not less than 0.8 micrometer, holes with the diameter of 400 micrometers are formed in the zinc alloy film layer 4-2, the porosity is 75%, the hyaluronic acid coating 3-1 is a copper hyaluronate coating which wraps growth hormone bone-promoting medicines, and the thickness is 100 micrometers.
Example 5
As shown in fig. 5, the hyaluronic acid coating zinc alloy barrier repair film of the present embodiment comprises three zinc alloy film layers 5-2, a single hyaluronic acid coating 5-1; the single-layer thickness of the zinc alloy film layer 5-2 is 25 micrometers, Ra is not less than 0.8 micrometer, three layers of zinc alloy film materials are formed through rolling and rolling, the thickness of the three layers of zinc alloy film layers is 60 micrometers, holes with the diameter of 8/00 micrometers are formed in the zinc alloy film material 5-2, the porosity is 30%, the hyaluronic acid coating layer 5-1 is a magnesium hyaluronate coating layer, and the thickness is 2000 micrometers.
Example 6
As shown in fig. 6, the hyaluronic acid coated zinc alloy barrier repair film of the present embodiment comprises three zinc alloy film layers 6-2, a single hyaluronic acid coating 6-1; the single-layer thickness of the zinc alloy film layer 6-2 is 35 micrometers, Ra is not less than 0.8 micrometer, three layers of zinc alloy film materials are formed through rolling and rolling, the thickness of the three layers of zinc alloy film materials is 90 micrometers, holes with the diameter of 8/00 micrometers are formed in the zinc alloy film material 6-2, the porosity is 30%, the hyaluronic acid coating 6-1 is a silver hyaluronate coating and wraps statin bone-promoting drugs, and the thickness is 2000 micrometers.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the utility model as defined in the appended claims.
Claims (5)
1. The hyaluronic acid coating zinc alloy barrier repair film is characterized by comprising a zinc alloy film layer and a hyaluronic acid coating;
the zinc alloy film layer is provided with a plurality of holes with the diameter of 50-80 mu m, and the porosity on the zinc alloy film layer is 20-85%.
2. The hyaluronic acid coated zinc alloy barrier repair film of claim 1, wherein the number of layers of the zinc alloy film layer is 1-5; the hyaluronic acid coating is arranged on one side or two sides of the zinc alloy film layer.
3. The hyaluronic acid coated zinc alloy barrier repair film of claim 1, wherein the monolayer thickness of the zinc alloy film layer is 10-100 μ ι η.
4. The hyaluronic acid coated zinc alloy barrier repair film of claim 1, wherein the surface of the zinc alloy film layer is a rough surface, the thickness of the single-layer zinc alloy film layer is 10 μm < δ ≦ 20 μm, and Ra is not less than 0.4 μm; the thickness of the single-layer zinc alloy film layer is 20 mu m delta less than or equal to 40 mu m, and Ra is not less than 0.8 mu m; the thickness of the single-layer zinc alloy film layer is 40 mu m delta less than or equal to 60 mu m, and Ra is not less than 1.6 mu m; the thickness of the single-layer zinc alloy film layer is 60 mu m < delta < 100 mu m, and Ra is not less than 3.2 mu m.
5. The hyaluronic acid coated zinc alloy barrier repair film according to claim 1, wherein the hyaluronic acid coating has a thickness of 5-2000 μm.
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| CN202122541171.3U CN216603626U (en) | 2021-10-21 | 2021-10-21 | Hyaluronic acid coating zinc alloy barrier repair film |
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| CN202122541171.3U CN216603626U (en) | 2021-10-21 | 2021-10-21 | Hyaluronic acid coating zinc alloy barrier repair film |
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Effective date of registration: 20221228 Address after: 410600 room 205, building 1, Hunan University Science and Technology Industrial Park, No. 001, Jinzhou North Road, Ningxiang high tech Industrial Park, Changsha City, Hunan Province Patentee after: Hunan Huaxiang Medical Technology Co.,Ltd. Address before: 410600 Jinzhou North Road, Ningxiang high tech Industrial Park, Changsha, Hunan, 001 Patentee before: HUNAN HUAYAO BAIAO MEDICAL TECHNOLOGY Co.,Ltd. |
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