CN216594431U - Solid phase extraction column for protein detection - Google Patents
Solid phase extraction column for protein detection Download PDFInfo
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- CN216594431U CN216594431U CN202123200169.6U CN202123200169U CN216594431U CN 216594431 U CN216594431 U CN 216594431U CN 202123200169 U CN202123200169 U CN 202123200169U CN 216594431 U CN216594431 U CN 216594431U
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- Prior art keywords
- pressure release
- phase extraction
- protein detection
- solid phase
- pressure relief
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- 238000002414 normal-phase solid-phase extraction Methods 0.000 title claims abstract description 24
- 238000002331 protein detection Methods 0.000 title claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 239000000945 filler Substances 0.000 claims abstract description 10
- 230000000903 blocking effect Effects 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 238000007789 sealing Methods 0.000 claims description 10
- 238000004804 winding Methods 0.000 claims description 2
- 230000006835 compression Effects 0.000 abstract description 3
- 238000007906 compression Methods 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 8
- 230000009471 action Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The utility model relates to the field of protein detection, in particular to a solid-phase extraction column for protein detection, which comprises a column body, wherein a liquid outlet pipe is arranged in the middle position of the bottom end of the column body, a filler is arranged at the lower end in the column body, a pressure relief box is arranged at the bottom end of one side of the column body, a pressure relief hole is formed in the column body at one side of the pressure relief box, a liquid outlet is formed in one side of the surface of the pressure relief box at an equal angle, pressure relief springs are arranged at one side in the pressure relief box at equal intervals, and a blocking ball matched with the pressure relief hole is arranged at one side of the pressure relief plate. This a solid-phase extraction post for albumen detects, when pressurization carelessly is too big, too big pressure can make the jam ball remove, drives the pressure release board and slides compression pressure release spring, and then sample liquid can flow to the pressure release incasement portion through the clearance that blocks up ball and pressure release hole production to discharge through the leakage fluid dram, and then remind the staff in time to stop the pressurization, avoid the cylinder inner wall damaged, thereby solved the problem that is not convenient for improve safety in utilization.
Description
Technical Field
The utility model relates to the technical field of protein detection, in particular to a solid-phase extraction column for protein detection.
Background
The solid phase extraction column is a sample pretreatment device developed from a chromatography column for extraction, separation and concentration, which has been widely used in many national standards and industry analysis standards, so that the solid phase extraction column is often used in the protein detection process.
In the in-service use in-process, can accomplish through manual mode, connect an injector promptly at solid phase extraction post upper end, extrude the extraction post through the liquid row that extrudees in with the extraction post to the extrusion of injector, and the pressure-bearing of solid phase extraction post inner wall is limited, when pressurization too big carelessly, probably causes the inner wall breakage of solid phase extraction post, influences the albumen and detects the operation, also increases corresponding maintenance cost simultaneously.
SUMMERY OF THE UTILITY MODEL
Aiming at the defects of the prior art, the utility model provides the solid-phase extraction column for protein detection, which has the advantages of convenience in improving the use safety and the like, and solves the problem that the use safety of a common solid-phase extraction column is inconvenient to improve.
In order to achieve the purpose, the utility model provides the following technical scheme: the utility model provides a solid-phase extraction post for albumen detects, includes the cylinder, the drain pipe is installed to the intermediate position department of cylinder bottom, and the inside lower extreme of cylinder installs the filler, the top of cylinder both sides is provided with clamping structure.
The pressure release case is installed to the bottom of cylinder one side, and the inside pressure release hole of having seted up of cylinder of pressure release case one side, the leakage fluid dram has been seted up to one side isogonism on pressure release case surface, and equidistant pressure release spring of installing in one side of pressure release incasement portion, pressure release incasement internally mounted between the pressure release spring one end has the pressure release board, and pressure release board one side install with pressure release hole matched with jam ball.
Further, the clamping structure includes the centre gripping case, the top at the cylinder both sides is installed to the centre gripping case, and one side of centre gripping incasement portion is provided with the holding frame, holding frame one side extends to the cylinder inside and installs flexible piece, and holding frame opposite side intermediate position department transversely installs the pull rod that extends to the centre gripping incasement portion, the inside winding of centre gripping incasement on pull rod surface has the centre gripping spring.
Furthermore, the inclination angle of the flexible block and the vertical direction is fifteen degrees, and the top view of the flexible block is arc-shaped.
Furthermore, the inside both ends of centre gripping case have transversely seted up the spout, and clamping frame one side both ends install with spout matched with slider.
Furthermore, the clamping frame is U-shaped, and the clamping frame and the inside of the sliding groove form a sliding structure through the sliding block.
Furthermore, the column body internally mounted on filler top has an upper sieve, and the column body internally mounted of filler bottom has a lower sieve.
Furthermore, a sealing ring is annularly arranged on one side of the surface of the blocking ball, and the area of the cross section of the sealing ring is larger than that of the cross section of the pressure relief hole.
Compared with the prior art, the technical scheme of the application has the following beneficial effects:
1. this a solid-phase extraction post for albumen detects, through being provided with the pressure release case, block up the ball, pressure release hole and leakage fluid dram, when carelessly pressurizeing too big, too big pressure can make and block up the ball removal, drive pressure release board slip compression pressure release spring, and then sample liquid can be through the clearance flow direction pressure release incasement portion that blocks up ball and pressure release hole production, and discharge through the leakage fluid dram, and then remind the staff in time to stop the pressurization, avoid the cylinder inner wall damaged, simultaneously when pressure disappears or not reach a definite value, under pressure release spring's spring action, make pressure release board slip to drive and block up the ball and block up the pressure release hole, and utilize the sealing ring, further improve the leakproofness between the two, avoid sample liquid to leak, make sample liquid can only flow out through the drain pipe, the albumen of being convenient for detects going on of operation, thereby the problem of the improvement safety in utilization of being not convenient for has been solved.
2. This a solid-phase extraction column for albumen detects, through being provided with flexible piece, the centre gripping case, centre gripping spring and holding frame, through the pulling pull rod, make the holding frame slide and drive flexible piece and remove to the centre gripping incasement portion, later with the stopper form card of external pipeline in the inside upper end of cylinder, not hard up pull rod again, utilize the elasticity of centre gripping spring, make the holding frame slide to drive flexible piece and hug closely stopper form surface, realize the quick block of stopper form and the inside upper end of cylinder, it adds the sample to be convenient for, avoid the stopper form on the external pipeline less inconvenience that leads to with the cylinder block, the practicality of cylinder is improved, thereby the problem of the less stopper form body of centre gripping of being not convenient for has been solved.
Drawings
FIG. 1 is a schematic front sectional view of the present invention;
FIG. 2 is a schematic top cross-sectional view of the present invention;
FIG. 3 is a schematic perspective view of a flexible block according to the present invention;
FIG. 4 is an enlarged schematic view of the pressure relief tank of the present invention;
FIG. 5 is an enlarged view of the portion A of FIG. 2 according to the present invention.
In the figure: 1. a clamping structure; 101. a flexible block; 102. a pull rod; 103. a clamping box; 104. a clamping spring; 105. a clamping frame; 106. a chute; 107. a slider; 2. a cylinder; 3. an upper sieve plate; 4. a lower sieve plate; 5. a liquid outlet pipe; 6. a pressure relief tank; 7. a filler; 8. a seal ring; 9. blocking the ball; 10. a pressure relief vent; 11. a liquid discharge port; 12. a pressure relief spring; 13. and (4) releasing the pressure plate.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-5, the solid phase extraction column for protein detection in the present embodiment includes a column body 2, a liquid outlet pipe 5 installed at the middle position of the bottom end of the column body 2, a filler 7 installed at the lower end of the inside of the column body 2, and a clamping structure 1 installed at the top end of the two sides of the column body 2.
Referring to fig. 1, 2 and 3, in the embodiment, the clamping structure 1 includes a clamping box 103, the clamping box 103 is installed at the top end of the two sides of the column body 2, a clamping frame 105 is disposed at one side of the inside of the clamping box 103, one side of the clamping frame 105 extends into the column body 2 and is installed with a flexible block 101, a pull rod 102 extending to the outside of the clamping box 103 is transversely installed at the middle position of the other side of the clamping frame 105, and a clamping spring 104 is wound inside the clamping box 103 on the surface of the pull rod 102.
It should be noted that, through pulling the pull rod 102, make the clamping frame 105 slide and compress the clamping spring 104 and drive the flexible block 101 to move to inside the clamping box 103, later with the stopper form card of external pipeline in the inside upper end of cylinder 2, not hard up pull rod 102 again, utilize the elasticity of clamping spring 104, make the clamping frame 105 slide and drive flexible block 101 and hug closely the stopper form surface, realize the quick block of stopper form and the inside upper end of cylinder 2, it adds the sample to be convenient for.
Referring to fig. 1, fig. 2 and fig. 3, in the present embodiment, an inclination angle of the flexible block 101 to the vertical direction is fifteen degrees, and a top view of the flexible block 101 is an arc shape.
It should be noted that, by arranging the inclined arc-shaped flexible block 101, the contact area of the plug-shaped object for the external pipeline is increased conveniently, and the clamping limiting effect is better.
Referring to fig. 2 and 5, in the present embodiment, sliding grooves 106 are transversely formed at two ends of the interior of the clamping box 103, and sliding blocks 107 matched with the sliding grooves 106 are installed at two ends of one side of the clamping frame 105.
It should be noted that the slide block 107 slides inside the slide groove 106, so that the movement of the clamping frame 105 is more stable.
Referring to fig. 1 and 2, in the present embodiment, the holding frame 105 is U-shaped, and the holding frame 105 forms a sliding structure with the inside of the sliding groove 106 through the sliding block 107.
It should be noted that the U-shaped holder 105 facilitates multi-point fixation with the flexible block 101, and improves the connection tightness between the two.
Referring to fig. 1, in the present embodiment, an upper sieve plate 3 is installed inside a column body 2 at the top end of a filler 7, and a lower sieve plate 4 is installed inside the column body 2 at the bottom end of the filler 7.
It should be noted that, by arranging the upper sieve plate 3 and the lower sieve plate 4, the filtering effect on the sample is improved.
Referring to fig. 1 and 4, in the present embodiment, a sealing ring 8 is annularly installed on one side of the surface of the blocking ball 9, and the area of the cross section of the sealing ring 8 is larger than that of the cross section of the pressure relief hole 10.
By providing the seal ring 8, the sealing performance between the blocking ball 9 and the pressure release hole 10 is improved, and leakage is avoided.
It can be understood that, this a solid phase extraction post for albumen detection, automatic pressure release that can realize the pressure boost is too big improves the safety in utilization, simultaneously can be convenient for with the quick-operation joint of external pipeline, be convenient for add the sample.
The working principle of the above embodiment is as follows:
when the clamping device works, firstly, the clamping frame 105 is enabled to slide more stably to compress the clamping spring 104 and drive the flexible block 101 to move into the clamping box 103 by pulling the pull rod 102 and utilizing the sliding of the sliding block 107 in the sliding groove 106, then, the stopper-shaped object externally connected with a pipeline is clamped at the upper end in the cylinder 2, then, the pull rod 102 is loosened, and the clamping frame 105 is enabled to slide to drive the flexible block 101 to be tightly attached to the surface of the stopper-shaped object by utilizing the elastic force of the clamping spring 104, so that the stopper-shaped object is rapidly clamped with the upper end in the cylinder 2, and a sample is conveniently added;
adding a sample, after the sample is added, pulling out the external pipeline, pulling the pull rod 102 at the same time to enable the flexible block 101 to enter the clamping box 103, then extending an external corresponding injector into the cylinder 2, sealing the injector and the cylinder 2 mutually, and then extruding the injector to enable the sample to more quickly pass through the upper sieve plate 3, the filler 7 and the lower sieve plate 4, so that the finally detected sample flows out through the liquid outlet pipe 5;
simultaneously when carelessly pressurizeing too big, too big pressure can make and block up ball 9 and remove, drive pressure release board 13 at the inside sliding compression pressure release spring 12 of pressure release case 6, and then sample liquid can flow to pressure release case 6 inside through the clearance that blocks up ball 9 and pressure release hole 10 produced, and discharge through leakage fluid dram 11, and then remind the staff in time to stop the pressurization, avoid 2 inner walls of cylinder damaged, simultaneously when pressure disappears or when not reaching a definite value, under pressure release spring 12's elastic force effect, make pressure release board 13 slide to drive and block up ball 9 and block up pressure release hole 10, and utilize sealing ring 8, further improve the leakproofness between the two, avoid leaking.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A solid phase extraction column for protein detection, comprising a cartridge (2), characterized in that: a liquid outlet pipe (5) is arranged in the middle of the bottom end of the column body (2), a filler (7) is arranged at the lower end of the inside of the column body (2), and clamping structures (1) are arranged at the top ends of the two sides of the column body (2);
pressure release case (6) are installed to the bottom of cylinder (2) one side, and pressure release hole (10) have been seted up to cylinder (2) inside of pressure release case (6) one side, leakage fluid dram (11) have been seted up to one side on pressure release case (6) surface equiangular, and equidistant pressure release spring (12) of installing in one side of pressure release case (6) inside, pressure release case (6) internally mounted between pressure release spring (12) one end has pressure release board (13), and pressure release board (13) one side install with pressure release hole (10) matched with jam ball (9).
2. The solid phase extraction column for protein detection according to claim 1, wherein: clamping structure (1) includes centre gripping case (103), install the top in cylinder (2) both sides on centre gripping case (103), and the inside one side of centre gripping case (103) is provided with clamping frame (105), clamping frame (105) one side extends to cylinder (2) inside and installs flexible piece (101), and clamping frame (105) opposite side intermediate position department transversely installs pull rod (102) that extend to centre gripping case (103) outside, the inside winding of centre gripping case (103) on pull rod (102) surface has centre gripping spring (104).
3. The solid phase extraction column for protein detection according to claim 2, wherein: the inclination angle of the flexible block (101) and the vertical direction is fifteen degrees, and the top view of the flexible block (101) is arc-shaped.
4. The solid phase extraction column for protein detection according to claim 2, wherein: the inside both ends of centre gripping case (103) are transversely seted up spout (106), and clamping frame (105) one side both ends install with spout (106) matched with slider (107).
5. The solid phase extraction column for protein detection according to claim 2, wherein: the clamping frame (105) is U-shaped, and the clamping frame (105) forms a sliding structure with the inside of the sliding groove (106) through the sliding block (107).
6. The solid phase extraction column for protein detection according to claim 1, wherein: the column (2) internally mounted who packs (7) top has last sieve (3), and the column (2) internally mounted who packs (7) bottom has lower sieve (4).
7. The solid phase extraction column for protein detection according to claim 1, wherein: and a sealing ring (8) is annularly arranged on one side of the surface of the blocking ball (9), and the area of the cross section of the sealing ring (8) is larger than that of the cross section of the pressure relief hole (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123200169.6U CN216594431U (en) | 2021-12-16 | 2021-12-16 | Solid phase extraction column for protein detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123200169.6U CN216594431U (en) | 2021-12-16 | 2021-12-16 | Solid phase extraction column for protein detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216594431U true CN216594431U (en) | 2022-05-24 |
Family
ID=81614968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202123200169.6U Expired - Fee Related CN216594431U (en) | 2021-12-16 | 2021-12-16 | Solid phase extraction column for protein detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216594431U (en) |
-
2021
- 2021-12-16 CN CN202123200169.6U patent/CN216594431U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220524 |
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| CF01 | Termination of patent right due to non-payment of annual fee |